The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Core–shell Au@MnO2 nanoparticles for enhanced radiotherapy via improving the tumor oxygenation
Abstract
Local hypoxia in solid tumors often results in resistance to radiotherapy (RT), in which oxygen is an essential element for enhancing DNA damage caused by ionizing radiation. Herein, we developed gold@manganese dioxide (Au@MnO 2 ) core–shell nanoparticles with a polyethylene glycol (PEG) coating as a novel radiosensitizing agent to improve RT efficacy during cancer treatment. In this Au@MnO 2 nanostructure, while the gold core is a well-known RT sensitizer that interacts with X-rays to produce charged particles for improved cancer killing under RT, the MnO 2 shell may trigger the decomposition of endogenous H 2 O 2 in the tumor microenvironment to generate oxygen and overcome hypoxiaassociated RT resistance. As demonstrated by both in vitro and in vivo experiments, Au@MnO 2 -PEG nanoparticles acted as effective radiosensitizers to remarkably enhance cancer treatment efficacy during RT. Moreover, no obvious side effects of Au@MnO 2 -PEG were observed in mice. Therefore, our work presents a new type of radiosensitizer with potential for enhanced RT treatment of hypoxic tumors.
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Cites
The Tumour Microenvironment after Radiotherapy: Mechanisms of Resistance and Recurrence
Barker, H. E., Paget, J. T. E., Khan, A. A., & Harrington, K. J. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3958 · Cited by 2,144 · cited 2×
“Almost 50% of patients with cancer undergo RT at least once during their treatment course [1].”
Cheng, Y., Cheng, H., Jiang, C., Qiu, X., Wang, K., Huan, W., Yuan, A., Wu, J., & Hu, Y. (2015) · Nature Communications · doi:10.1038/ncomms9785 · Cited by 941
Gold nanoparticles for applications in cancer radiotherapy: Mechanisms and recent advancements
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Diagaradjane, P., Shetty, A., Wang, J. C., Elliott, A. M., Schwartz, J., Shentu, S., Park, H. C., Deorukhkar, A., Stafford, R. J., Cho, S. H., et al. (2008) · Nano Letters · doi:10.1021/nl080496z · Cited by 215
Modulation of the tumor vasculature and oxygenation to improve therapy
Siemann, D. W., & Horsman, M. R. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.06.006 · Cited by 169
Cited by
Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy
Song, G., Cheng, L., Chao, Y., Yang, K., & Liu, Z. (2017) · Advanced Materials · doi:10.1002/adma.201700996 · Cited by 771
Self-citationNanoenzyme-Augmented Cancer Sonodynamic Therapy by Catalytic Tumor Oxygenation
Zhu, P., Chen, Y., & Shi, J. (2018) · ACS Nano · doi:10.1021/acsnano.8b00999 · Cited by 572
Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications
Ding, B., Zheng, P., Ma, P., & Lin, J. (2020) · Advanced Materials · doi:10.1002/adma.201905823 · Cited by 521
X-ray-activated nanosystems for theranostic applications
Chen, X., Song, J., Chen, X., & Yang, H. (2019) · Chemical Society Reviews · doi:10.1039/c8cs00921j · Cited by 401
Zhang, R., Song, X., Liang, C., Yi, X., Song, G., Chao, Y., Yang, Y., Yang, K., Feng, L., & Liu, Z. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.05.025 · Cited by 255
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Metadata
- Authors
- Yi, X., Chen, L., Zhong, X., Gao, R., Qian, Y., Wu, F., Song, G., Chai, Z., Liu, Z., & Yang, K.
- Venue
- Nano Research
- Publisher
- Tsinghua University Press
- Published
- 2016-08-05
- Volume
- 9
- Issue
- 11
- Pages
- 3267-3278
- ISSN
- 1998-0000 (ISSN-L)
- 1998-0124
- OpenAlex
- W2504396398
- Cited by
- 180
- References
- 5
- FWCI
- 15.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yi, X., Chen, L., Zhong, X., Gao, R., Qian, Y., Wu, F., Song, G., Chai, Z., Liu, Z., & Yang, K. (2016). Core–shell Au@MnO2 nanoparticles for enhanced radiotherapy via improving the tumor oxygenation. Nano Research. https://doi.org/10.1007/s12274-016-1205-8
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