Common Regulatory Targets of NFIA, NFIX and NFIB during Postnatal Cerebellar Development
Open accessAbstract
Transcriptional regulation plays a central role in controlling neural stem and progenitor cell proliferation and differentiation during neurogenesis. For instance, transcription factors from the nuclear factor I (NFI) family have been shown to co-ordinate neural stem and progenitor cell differentiation within multiple regions of the embryonic nervous system, including the neocortex, hippocampus, spinal cord and cerebellum. Knockout of individual Nfi genes culminates in similar phenotypes, suggestive of common target genes for these transcription factors. However, whether or not the NFI family regulates common suites of genes remains poorly defined. Here, we use granule neuron precursors (GNPs) of the postnatal murine cerebellum as a model system to analyse regulatory targets of three members of the NFI family: NFIA, NFIB and NFIX. By integrating transcriptomic profiling (RNA-seq) of Nfia- and Nfix-deficient GNPs with epigenomic profiling (ChIP-seq against NFIA, NFIB and NFIX, and DNase I hypersensitivity assays), we reveal that these transcription factors share a large set of potential transcriptional targets, suggestive of complementary roles for these NFI family members in promoting neural development.
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Although their loci are not very near to each other, Nfia, Nfib and Nfix regulate cell-type differentiation in many tissues, function as homo- or heterodimers, and bind to largely common targets.
“Although their loci are not very near to each other, Nfia, Nfib and Nfix regulate cell-type differentiation in many tissues94–96, function as homo- or heterodimers, and bind to largely common targets97.”
From A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain (2023) · cites this paper as [97]
The Results (page unavailable) show substantial overlap in NFIA, NFIB and NFIX binding sites in postnatal cerebellar cells. The Discussion (page unavailable) says heterodimerisation is known in vitro but its prevalence in vivo is unclear; it does not establish that these proteins function as heterodimers in vivo or address homodimerisation. The earlier claims about locus proximity and differentiation across tissues carry different citations and are not assessed here. (LLM, conf=0.88)
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Cites
Fast gapped-read alignment with Bowtie 2
Langmead, B., & Salzberg, S. L. (2012) · Nature Methods · doi:10.1038/nmeth.1923 · Cited by 56,400 · see citing works
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890 · see citing works
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn923 · Cited by 14,108 · see citing works
Trapnell, C., Roberts, A., Goff, L. A., Pertea, G. M., Kim, D., Kelley, D. R., Pimentel, H., Salzberg, S. L., Rinn, J. L., & Pachter, L. S. (2012) · Nature Protocols · doi:10.1038/nprot.2012.016 · Cited by 11,930 · see citing works
Identifying ChIP-seq enrichment using MACS
Feng, J., Liu, T., Qin, B., Zhang, Y., & Liu, X. S. (2012) · Nature Protocols · doi:10.1038/nprot.2012.101 · Cited by 1,805 · see citing works
Math1 Is Expressed in Temporally Discrete Pools of Cerebellar Rhombic-Lip Neural Progenitors
Machold, R. P., & Fishell, G. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.028 · Cited by 575 · see citing works
Roles of the NFI/CTF gene family in transcription and development
Gronostajski, R. M. (2000) · Gene · doi:10.1016/s0378-1119(00)00140-2 · Cited by 545 · see citing works
Self-citationThe transcription factor NFIA controls the onset of gliogenesis in the developing spinal cord
Deneen, B., Ho, R., Lukaszewicz, A., Hochstim, C. J., Gronostajski, R. M., & Anderson, D. J. (2006) · Neuron · doi:10.1016/j.neuron.2006.11.019 · Cited by 514 · see citing works
Self-citationConsensus Paper: Cerebellar Development
Leto, K., Arancillo, M., Becker, E. B. E., Buffo, A., Chiang, C. C., Ding, B., Dobyns, W. B., Dusart, I., Haldipur, P., Hatten, M. E., et al. (2015) · The Cerebellum · doi:10.1007/s12311-015-0724-2 · Cited by 484 · see citing works
Nfib Promotes Metastasis through a Widespread Increase in Chromatin Accessibility
Denny, S. K., Yang, D., Chuang, C.-H., Brady Jennifer, J., Lim, J. S., Grüner, B. M., Chiou, S., Schep, A. N., Baral, J., Hamard, C., et al. (2016) · Cell · doi:10.1016/j.cell.2016.05.052 · Cited by 358 · see citing works
Redefining the cerebellar cortex as an assembly of non-uniform Purkinje cell microcircuits
Cerminara, N. L., Lang, E. J., Sillitoe, R. V., & Apps, R. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn3886 · Cited by 315 · see citing works
The Transcription Factor Gene Nfib Is Essential for both Lung Maturation and Brain Development
Steele-Perkins, G., Plachez, C., Butz, K. G., Yang, G., Bachurski, C. J., Kinsman, S. L., Litwack, E. D., Richards, L. J., & Gronostajski, R. M. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.2.685-698.2005 · Cited by 310 · see citing works
Self-citationAbnormal Development of Forebrain Midline Glia and Commissural Projections inNfiaKnock-Out Mice
Shu, T., Butz, K. G., Plachez, C., Gronostajski, R. M., & Richards, L. J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00203.2003 · Cited by 213 · see citing works
Self-citationNfix Regulates Fetal-Specific Transcription in Developing Skeletal Muscle
Messina, G., Biressi, S., Monteverde, S., Magli, A., Cassano, M., Perani, L., Roncaglia, E., Tagliafico, E., Starnes, L., Campbell, C. E., et al. (2010) · Cell · doi:10.1016/j.cell.2010.01.027 · Cited by 210 · see citing works
Self-citationThe transcription factor Nfixis essential for normal brain development
Campbell, C. E., Piper, M., Plachez, C., Yeh, Y.-T., Baizer, J. S., Osinski, J. M., Litwack, E. D., Richards, L. J., & Gronostajski, R. M. (2008) · BMC Developmental Biology · doi:10.1186/1471-213x-8-52 · Cited by 179 · see citing works
Self-citationRegulation of chromatin accessibility and Zic binding at enhancers in the developing cerebellum
Frank, C. L., Liu, F., Wijayatunge, R., Song, L., Biegler, M. T., Yang, M. G., Vockley, C. M., Safi, A., Gersbach, C. A., Crawford, G. E., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3995 · Cited by 167 · see citing works
Proteomic analyses reveal distinct chromatin‐associated and soluble transcription factor complexes
Li, X., Wang, W., Wang, J., Malovannaya, A., Xi, Y., Li, W., Guerra, R., Hawke, D. H., Qin, J., & Chen, J. (2015) · Molecular Systems Biology · doi:10.15252/msb.20145504 · Cited by 153 · see citing works
Piper, M., Barry, G., Hawkins, J., Mason, S., Lindwall, C., Little, E. B., Sarkar, A., Smith, A. G., Moldrich, R. X., Boyle, G. M., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.6167-09.2010 · Cited by 147 · see citing works
Self-citationTranscription factor nuclear factor I proteins form stable homo‐ and heterodimers
Kruse, U., & Sippel, A. E. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00585-0 · Cited by 143 · see citing works
Development and malformations of the cerebellum in mice
Chizhikov, V. V., & Millen, K. J. (2003) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2003.08.019 · Cited by 140 · see citing works
Otx genes in brain morphogenesis
Acampora, D., Gulisano, M., Broccoli, V., & Simeone, A. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00042-3 · Cited by 111 · see citing works
Specific Glial Populations Regulate Hippocampal Morphogenesis
Barry, G., Piper, M., Lindwall, C., Moldrich, R. X., Mason, S., Little, E. B., Sarkar, A., Tole, S., Gronostajski, R. M., & Richards, L. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4000-08.2008 · Cited by 95 · see citing works
Self-citationSchüller, U., Zhao, Q. S., Godinho, S. A., Heine, V. M., Medema, R. H., Pellman, D. S., & Rowitch, D. H. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00707-07 · Cited by 95 · see citing works
Nuclear factor I gene expression in the developing forebrain
Plachez, C., Lindwall, C., Sunn, N., Piper, M., Moldrich, R. X., Campbell, C. E., Osinski, J. M., Gronostajski, R. M., & Richards, L. J. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21645 · Cited by 91 · see citing works
Self-citationIsolation and Culture of Post-Natal Mouse Cerebellar Granule Neuron Progenitor Cells and Neurons
Lee, H., Greene, L. A., Mason, C. A., & Manzini, M. C. (2009) · Journal of Visualized Experiments · doi:10.3791/990 · Cited by 89 · see citing works
Harris, L., Genovesi, L. A., Gronostajski, R. M., Wainwright, B. J., & Piper, M. (2014) · Developmental Dynamics · doi:10.1002/dvdy.24182 · Cited by 88 · see citing works
Self-citationNFIX Regulates Neural Progenitor Cell Differentiation During Hippocampal Morphogenesis
Heng, Y. H. E., McLeay, R. C., Harvey, T. J., Smith, A. G., Barry, G., Cato, K., Plachez, C., Little, E. B., Mason, S., Dixon, C. M., et al. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs307 · Cited by 87 · see citing works
Self-citationMechanisms by which transcription factors gain access to target sequence elements in chromatin
Guertin, M. J., & Lis, J. (2012) · Current Opinion in Genetics and Development · doi:10.1016/j.gde.2012.11.008 · Cited by 84 · see citing works
Wang, W., Mullikin-Kilpatrick, D., Crandall, J. E., Gronostajski, R. M., Litwack, E. D., & Kilpatrick, D. L. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0180-07.2007 · Cited by 82 · see citing works
Self-citationNFIB-Mediated Repression of the Epigenetic FactorEzh2Regulates Cortical Development
Piper, M., Barry, G., Harvey, T. J., McLeay, R. C., Smith, A. G., Harris, L., Mason, S., Stringer, B. W., Day, B. W., Wray, N. R., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2319-13.2014 · Cited by 79 · see citing works
Self-citationBetancourt, J., Katzman, S. J., & Chen, B. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23373 · Cited by 67 · see citing works
Multiple non-cell-autonomous defects underlie neocortical callosal dysgenesis in Nfib-deficient mice
Piper, M., Moldrich, R. X., Lindwall, C., Little, E. B., Barry, G., Mason, S., Sunn, N., Kurniawan, N. D., Gronostajski, R. M., & Richards, L. J. (2009) · Neural Development · doi:10.1186/1749-8104-4-43 · Cited by 67 · see citing works
Self-citationA Role for Nuclear Factor I in the Intrinsic Control of Cerebellar Granule Neuron Gene Expression
Wang, W., Stock, R. E., Gronostajski, R. M., Wong, Y. W., Schachner, M., & Kilpatrick, D. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410370200 · Cited by 63 · see citing works
Self-citationMatuzelski, E., Bunt, J., Harkins, D., Lim, J. W. C., Gronostajski, R. M., Richards, L. J., Harris, L., & Piper, M. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.10.019 · Cited by 61 · see citing works
Self-citationNuclear Factor One X in Development and Disease
Piper, M., Gronostajski, R. M., & Messina, G. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.09.003 · Cited by 51 · see citing works
Self-citationPiper, M., Harris, L., Barry, G., Heng, Y. H. E., Plachez, C., Gronostajski, R. M., & Richards, L. J. (2011) · The Journal of Comparative Neurology · doi:10.1002/cne.22721 · Cited by 49 · see citing works
Self-citationTranscriptional regulation of intermediate progenitor cell generation during hippocampal development
Harris, L., Zalucki, O. H., Gobius, I., McDonald, H., Osinki, J., Harvey, T. J., Essebier, A., Vidovic, D., Gladwyn-Ng, I. E., Burne, T. H. J., et al. (2016) · Development · doi:10.1242/dev.140681 · Cited by 42 · see citing works
Self-citationGenes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip
Machold, R. P., Klein, C., & Fishell, G. (2011) · Gene Expression Patterns · doi:10.1016/j.gep.2011.03.007 · Cited by 40 · see citing works
Introduction to “A Handbook of Transcription Factors”
Hughes, T. R. (2011) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-90-481-9069-0_1 · Cited by 39 · see citing works
Chen, K., Harris, L., Lim, J. W. C., Harvey, T. J., Piper, M., Gronostajski, R. M., Richards, L. J., & Bunt, J. (2017) · The Journal of Comparative Neurology · doi:10.1002/cne.24206 · Cited by 38 · see citing works
Self-citationWnt5a is a crucial regulator of neurogenesis during cerebellum development
Subashini, C., Bindu, D. S., Chen, C.-M., Riya, P. A., Meera, V., Divya, T. S., Kuruvilla, R., Buttler, K., & James, J. (2017) · Scientific Reports · doi:10.1038/srep42523 · Cited by 37 · see citing works
Combined allelic dosage of Nfia and Nfib regulates cortical development
Bunt, J., Osinski, J. M., Lim, J. W. C., Vidovic, D., Ye, Y., Zalucki, O. H., O’Connor, T. R., Harris, L., Gronostajski, R. M., Richards, L. J., et al. (2017) · Brain and Neuroscience Advances · doi:10.1177/2398212817739433 · Cited by 37 · see citing works
Self-citationWang, W., Crandall, J. E., Litwack, E. D., Gronostajski, R. M., & Kilpatrick, D. L. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22199 · Cited by 30 · see citing works
Self-citationInsights into the Biology and Therapeutic Applications of Neural Stem Cells
Harris, L., Zalucki, O. H., Piper, M., & Heng, J. I. (2016) · Stem Cells International · doi:10.1155/2016/9745315 · Cited by 26 · see citing works
Self-citationConserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution
Pistocchi, A., Gaudenzi, G., Foglia, E. A., Monteverde, S., Moreno‐Fortuny, A., Pianca, A., Cossu, G., Cotelli, F., & Messina, G. (2013) · Development · doi:10.1242/dev.076315 · Cited by 24 · see citing works
Cell-type-specific expression of NFIX in the developing and adult cerebellum
Fraser, J., Essebier, A., Gronostajski, R. M., Mikael Bodén, A., Wainwright, B. J., Harvey, T. J., & Piper, M. (2016) · Brain Structure and Function · doi:10.1007/s00429-016-1340-8 · Cited by 23 · see citing works
Self-citationCisMapper: predicting regulatory interactions from transcription factor ChIP-seq data
O'Connor, T., Bodén, M., & Bailey, T. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw956 · Cited by 18 · see citing works
Expression of nuclear factor one A and ‐B in the olfactory bulb
Plachez, C., Cato, K., McLeay, R. C., Heng, Y. H. E., Bailey, T. L., Gronostasjki, R. M., Richards, L. J., Puché, A. C., & Piper, M. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23081 · Cited by 16 · see citing works
Self-citationWang, W., Shin, Y., Shi, M., & Kilpatrick, D. L. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-10-0817 · Cited by 14 · see citing works
Fraser, J., Essebier, A., Brown, A. S., Davila, R. A. A., Sengar, A. S., Tu, Y., Ensbey, K. S., Day, B. W., Scott, M. P., Gronostajski, R. M., et al. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1801-3 · Cited by 14 · see citing works
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A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
Yao, Z., van Velthoven, C. T. J., Kunst, M., Zhang, M., McMillen, D., Lee, C., Jung, W., Goldy, J., Abdelhak, A., Aitken, M., et al. (2023) · Nature · doi:10.1038/s41586-023-06812-z · Cited by 1,194 · see citing works
A shared transcriptional code orchestrates temporal patterning of the central nervous system
Sagner, A., Zhang, I., Watson, T., Lázaro, J., Melchionda, M., & Briscoe, J. (2021) · PLoS Biology · doi:10.1371/journal.pbio.3001450 · Cited by 128 · see citing works
Stem cell‐intrinsic mechanisms regulating adult hair follicle homeostasis
Lee, S. A., Li, K. N., & Tumbar, T. (2020) · Experimental Dermatology · doi:10.1111/exd.14251 · Cited by 55 · see citing works
NEUROD1 reinforces endocrine cell fate acquisition in pancreatic development
Bohuslavová, R., Fabriciova, V., Smolík, O., Lebrón‐Mora, L., Abaffy, P., Benesova, S., Žucha, D., Valihrach, L., Berková, Z., Saudek, F., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41306-6 · Cited by 39 · see citing works
Doi, H., Matsuda, T., Sakai, A., Matsubara, S., Hoka, S., Yamaura, K., & Nakashima, K. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2107596118 · Cited by 29 · see citing works
NFIXing Cancer: The Role of NFIX in Oxidative Stress Response and Cell Fate
Ribeiro, V., Martins, S. G., Lopes, A. S., Þorsteinsdóttir, S., Zilhão, R., & Carlos, A. R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054293 · Cited by 21 · see citing works
Valdes, P., Caldwell, A. B., Liu, Q., Fitzgerald, M. Q., Ramachandran, S., Karch, C. M. M., Dominantly Inherited Alzheimer Network (DIAN), Adams, S., Allegri, R., Araki, A., et al. (2025) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01659-6 · Cited by 21 · see citing works
Walker, M., Li, Y., Morales‐Hernández, A., Qi, Q., Parupalli, C., Brown, S., Christian, C. M., Clements, W. K., Cheng, Y., & McKinney‐Freeman, S. (2022) · Blood Advances · doi:10.1182/bloodadvances.2022007811 · Cited by 17 · see citing works
Nuclear Factor I Family Members are Key Transcription Factors Regulating Gene Expression
Pinar, D. M., Göös, H., Tan, Z., Kumpula, E., Chowdhury, I. M., Wang, Z., Zhang, Q., Salokas, K., Keskitalo, S., Wei, G., et al. (2024) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2024.100890 · Cited by 17 · see citing works
Capicua regulates the development of adult-born neurons in the hippocampus
Hourigan, B., Balay, S. D., Yee, G., Sharma, S., & Tan, Q. (2021) · Scientific Reports · doi:10.1038/s41598-021-91168-5 · Cited by 14 · see citing works
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Sarropoulos, I., Sepp, M., Yamada, T., Schäfer, P., Trost, N., Schmidt, J., Schneider, C., Drummer, C., Mißbach, S., Taskiran, I. I., et al. (2026) · Science · doi:10.1126/science.adw9154 · Cited by 4 · see citing works
Shiraishi, R., Cancila, G., Kumegawa, K., Torrejon-Diaz, J., Basili, I., Bernardi, F., da Silva, P. B. G., Wang, W.-C., Chapman, O. S., Yang, L., et al. (2024) · Developmental Cell · doi:10.1016/j.devcel.2024.05.013 · Cited by 11 · see citing works
Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Mouse Corneal Epithelial Cells
Lu, Z., Ye, J.-G., Wang, D., Li, M.-K., Zhang, Q., Liu, Z., Huang, Y., Pan, C., Lin, Y., Shi, Z., et al. (2023) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.64.3.30 · Cited by 9 · see citing works
Trevisan, A. J., Han, K., Chapman, P., Kulkarni, A. S., Hinton, J. M., Ramirez, C., Klein, I., Gatto, G., Gabitto, M. I., Menon, V., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.18.613279 · Cited by 9 · see citing works
Nuclear factor I/B: Duality in action in cancer pathophysiology
Perumal, N., Gopalakrishnan, P., Burkovetskaya, M. E., Doss, D., Dukkipati, S. S., Kanchan, R. K., & Mahapatra, S. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.217349 · Cited by 7 · see citing works
Kawata, K., Chapman, O. S., Narumi, S., & Kawauchi, D. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1569548 · Cited by 7 · see citing works
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Gauberg, J., Moreno, K. B., Jayaraman, K., Abumeri, S., Jenkins, S., Salazar, A. M., Meharena, H. S., & Glasgow, S. M. (2025) · Science Advances · doi:10.1126/sciadv.adu3346 · Cited by 5 · see citing works
Klein, K., Burk, O., Tremmel, R., Buettner, F., Kaestle, L., Schroth, W., Muerdter, T. E., Eccles, D., Schmidt, A.-C., Nieß, H., et al. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107998 · Cited by 6 · see citing works
Postnatal Neurogenesis Beyond Rodents: the Groundbreaking Research of Joseph Altman and Gopal Das
Triarhou, L. C., & Manto, M. U. (2021) · The Cerebellum · doi:10.1007/s12311-021-01314-y · Cited by 5 · see citing works
Hydrocephalus in Nfix−/− Mice Is Underpinned by Changes in Ependymal Cell Physiology
Harkins, D., Harvey, T. J., Atterton, C., Miller, I., Currey, L., Oishi, S., Kasherman, M. A., Davila, R. A. A., Harris, L. E., Green, K., et al. (2022) · Cells · doi:10.3390/cells11152377 · Cited by 5 · see citing works
Self-citationExpression of NFIA and NFIB within the murine spinal cord
Matuzelski, E., Harvey, T. J., Harkins, D., Nguyen, T. D., Ruitenberg, M. J., & Piper, M. (2020) · Gene Expression Patterns · doi:10.1016/j.gep.2020.119098 · Cited by 5 · see citing works
Self-citationNeuronal mimicry generates an ecosystem critical for brain metastatic growth of SCLCPreprint
Qu, F., Cao, S., Michno, W., Madubata, C. J., Puno, A., Drainas, A. P., Lee, M. C., Yang, D., Toland, A. M. S., Kong, C. S., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.10.455426 · Cited by 5 · see citing works
Hes, C., Tomlinson, A. J., Michielsen, L., Murdoch, H. J., Soltani, F., Kokoeva, M. V., & Sabatini, P. V. (2025) · eLife · doi:10.7554/elife.106217 · Cited by 7 · see citing works
Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma
Zhang, J., Ong, W., Rasnitsyn, A., Gonzalez, R. D., Gutierrez, R. L., Balin, P., Saadeldin, A. M., Wu, X., Vladoiu, M. C., López, V. S., et al. (2026) · Nature · doi:10.1038/s41586-026-10264-6 · Cited by 4 · see citing works
Yang, J. M., Jin, N., Zhang, S., Tan, Y., Chen, Z., Huang, X., Li, G., Yu, B., Shi, J., Gu, X., et al. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05665-1 · Cited by 4 · see citing works
Alterations in gene expression in the spinal cord of mice lacking Nfix
Matuzelski, E., Essebier, A., Harris, L., Gronostajski, R. M., Harvey, T. J., & Piper, M. (2020) · BMC Research Notes · doi:10.1186/s13104-020-05278-w · Cited by 3 · see citing works
Self-citationTanner, S., Eisner, A., Novakovic, B., Holland, L., Mansell, T., England-Mason, G., Merrill, S. M., Dewey, D., O’Hely, M., Symeonides, C., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.03.641339 · Cited by 3 · see citing works
Yang, Y., Xie, C., He, Q., & Yang, M. (2025) · GigaScience · doi:10.1093/gigascience/giaf053 · Cited by 1 · see citing works
Zhang, Q., Yuan, G., Albizzati, E., Yang, J., Zhao, Z., Yu, X., Chang, X., Lee, C. H., Du, H., Lao, Z., et al. (2026) · Neuron · doi:10.1016/j.neuron.2026.08.021 · Cited by 1 · see citing works
Self-citationErdogan, S. S., Yilmaz, A. Y., & Kumbasar, A. (2024) · FEBS Letters · doi:10.1002/1873-3468.15010 · Cited by 1 · see citing works
Hes, C., Tomlinson, A. J., Michielsen, L., Murdoch, H. J., Soltani, F., Kokoeva, M. V., & Sabatini, P. V. (2025) · eLife · doi:10.1101/2024.09.19.613879 · Cited by 1 · see citing works
Hes, C., Tomlinson, A. J., Michielsen, L., Murdoch, H. J., Soltani, F., Kokoeva, M. V., & Sabatini, P. V. (2025) · eLife · doi:10.7554/elife.106217.1 · Cited by 1 · see citing works
Jocher, J., Janssen, P., Vieth, B., Edenhofer, F. C., Dietl, T., Térmeg, A., Spurk, P., Geuder, J., Enard, W., & Hellmann, I. (2026) · eLife · doi:10.7554/elife.105398.3
TGIF2 is a major regulator of neural stem cell fate and neurogenic primingPreprint
Li, Y., Krontira, A. C., Vierl, F., Richter, M. L., Wang, W., Merl‐Pham, J., Theis, F. J., Hauck, S. M., & Götz, M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.13.635953
Jocher, J., Janssen, P., Vieth, B., Edenhofer, F. C., Dietl, T., Térmeg, A., Spurk, P., Geuder, J., Enard, W., & Hellmann, I. (2025) · eLife · doi:10.7554/elife.105398.1
Jocher, J., Janssen, P., Vieth, B., Edenhofer, F. C., Dietl, T., Térmeg, A., Spurk, P., Geuder, J., Enard, W., & Hellmann, I. (2025) · eLife · doi:10.7554/elife.105398
Young, D. L., Aguilan, J. T., Cutler, R. R., Stransky, S., DeAngelo, J. D., Roth, J. S., Małachowska, B., Vercellino, J., Bell, B. I., Shechter, D., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.11.647869
Hes, C., Tomlinson, A. J., Michielsen, L., Murdoch, H. J., Soltani, F., Kokoeva, M. V., & Sabatini, P. V. (2025) · eLife · doi:10.7554/elife.106217.2
Zhou, Y., Zou, L., & Li, Y. (2025) · Frontiers in Genetics · doi:10.3389/fgene.2025.1648420
Roles of the NFI/CTF gene family in transcription and development: update 2025
Gronostajski, R. M. (2025) · Academia Biology · doi:10.20935/acadbiol8079
Self-citationZhang, Q., Yuan, G., Albizzati, E., Yang, J., Zhao, Z., Yu, X., Chang, X., Lee, C. H., Du, H., Lao, Z., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.27.696675
Self-citationJocher, J., Janssen, P., Vieth, B., Edenhofer, F. C., Dietl, T., Térmeg, A., Spurk, P., Geuder, J., Enard, W., & Hellmann, I. (2026) · eLife · doi:10.7554/elife.105398.2
Transcriptional repression by TGIF2 coordinates neurogenic priming and neural stem cell maintenance
Li, Y., Krontira, A. C., Vierl, F., Richter, M. L., Wang, W., Merl‐Pham, J., Theis, F. J., Hauck, S. M., & Götz, M. (2026) · Science Advances · doi:10.1126/sciadv.aea9974
Young, D. L., Stransky, S., Molero, M. G., Yamashita, E., Pande, S., Kumar, V., Singh, S., Aguilan, J. T., Cutler, R., Koba, W., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117785
Transcriptomic analysis of spinal V1 interneurons informs their multifunctional role in motor output
Trevisan, A. J., Han, K., Chapman, P., Kulkarni, A. S., Hinton, J. M., Klein, I., Ramirez, C., Lavado, A., Gatto, G., Gabitto, M. I., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-76522-3 · Cited by 8 · see citing works
Tanner, S., Eisner, A., Novakovic, B., Holland, L., Mansell, T., England-Mason, G., Merrill, S., Dewey, D., O’Hely, M., Symeonides, C., et al. (2026) · Med · doi:10.1016/j.medj.2026.101291
- Authors
- Fraser, J., Essebier, A., Brown, A. S., Davila, R. A., Harkins, D., Zalucki, O., Shapiro, L. P., Penzes, P., Wainwright, B. J., Scott, M. P., Gronostajski, R. M., Bodén, M., Piper, M., & Harvey, T. J.
- Affiliations
- The University of Queensland (AU)
- Stanford Medicine (US)
- Northwestern University (US)
- University at Buffalo, State University of New York (US)
- Corresponding author
- Piper, Michael
- Harvey, Tracey J.
- ORCID
- Venue
- The Cerebellum
- Published
- 2019-12-14
- Volume
- 19
- Issue
- 1
- Pages
- 89-101
- ISSN
- 1473-4222 (ISSN-L)
- 1473-4230
- PMC
- PMC7815246
- OpenAlex
- W2994706549
- Cited by
- 46
- References
- 50
- Citations by year
- 2026: 9 · 2025: 18 · 2024: 5 · 2023: 4 · 2022: 2 · 2021: 5 · 2020: 3
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Cerebellum (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Australian Research Council (DP160100368, DP180100017)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- NFIA, NFIX, NFIB, transcriptional regulation, granule neuron precursors, postnatal cerebellar development, transcription factor binding sites, DNase I hypersensitivity, neural stem/progenitor cells
- MeSH terms
- Chromatin Immunoprecipitation Sequencing, Animals, Animals, Newborn, Cerebellum, Female, Male, Mice, Inbred C57BL, Pregnancy, Mice, Knockout, Mice, NFI Transcription Factors, Neurogenesis
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