Cited by 216Gut microbiota and healthTryptophan and brain disordersGastrointestinal motility and disorders

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Current Perspectives on Gut Microbiome Dysbiosis and Depression

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Capuco, Alexander, Urits, Ivan, Hasoon, Jamal, Chun, Rebecca, Gerald, Brittany, Wang, Jason K., Kassem, Hisham, Ngo, Anh L., Abd-Elsayed, Alaa, Simopoulos, Thomas, Kaye, Alan D., Viswanath, Omar·2020·Advances in Therapy

DOI 10.1007/s12325-020-01272-7PMC PMC7140737

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Abstract

The human gut microbiome partakes in a bidirectional communication pathway with the central nervous system (CNS), named the microbiota-gut-brain axis. The microbiota-gut-brain axis is believed to modulate various central processes through the vagus nerve as well as production of microbial metabolites and immune mediators which trigger changes in neurotransmission, neuroinflammation, and behavior. Little is understood about the utilization of microbiome manipulation to treat disease. Though studies exploring the role of the microbiome in various disease processes have shown promise, mechanisms remain unclear and evidence-based treatments for most illnesses have not yet been developed. The animal studies reviewed here offer an excellent array of basic science research that continues to clarify mechanisms by which the microbiome may affect mental health. More evidence is needed, particularly as it relates to translating this work to human subjects. The studies presented in this paper largely demonstrate encouraging results in the treatment of depression. Limitations include small sample sizes and heterogeneous methodology. The exact mechanism by which the gut microbiota causes or alters neuropsychiatric disease states is not fully understood. In this review, we focus on recent studies investigating the relationship between gut microbiome dysbiosis and the pathogenesis of depression. This article is based on previously conducted studies and does not contain any studies with human participants or animals performed by any of the authors.

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Additional file 4 of Revealing the composition of the eukaryotic microbiome of oyster spat by CRISPR-Cas Selective Amplicon Sequencing (CCSAS)
Zhong, K. X., Cho, A., Deeg, C. M., Chan, A. M., & Suttle, C. A. (2021) · Figshare · doi:10.6084/m9.figshare.17084300
Additional file 6 of Revealing the composition of the eukaryotic microbiome of oyster spat by CRISPR-Cas Selective Amplicon Sequencing (CCSAS)
Zhong, K. X., Cho, A., Deeg, C. M., Chan, A. M., & Suttle, C. A. (2021) · Figshare · doi:10.6084/m9.figshare.17084309
Additional file 7 of Revealing the composition of the eukaryotic microbiome of oyster spat by CRISPR-Cas Selective Amplicon Sequencing (CCSAS)
Zhong, K. X., Cho, A., Deeg, C. M., Chan, A. M., & Suttle, C. A. (2021) · Figshare · doi:10.6084/m9.figshare.17084315
Additional file 2 of 5-HT attenuates chronic stress-induced cognitive impairment in mice through intestinal flora disruption
Ma, J., Wang, R., Chen, Y., Wang, Z., & Dong, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26566064
Additional file 2 of Revealing the composition of the eukaryotic microbiome of oyster spat by CRISPR-Cas Selective Amplicon Sequencing (CCSAS)
Zhong, K. X., Cho, A., Deeg, C. M., Chan, A. M., & Suttle, C. A. (2021) · Figshare · doi:10.6084/m9.figshare.17084288
Additional file 1 of 5-HT attenuates chronic stress-induced cognitive impairment in mice through intestinal flora disruption
Ma, J., Wang, R., Chen, Y., Wang, Z., & Dong, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26566061
Additional file 3 of Revealing the composition of the eukaryotic microbiome of oyster spat by CRISPR-Cas Selective Amplicon Sequencing (CCSAS)
Zhong, K. X., Cho, A., Deeg, C. M., Chan, A. M., & Suttle, C. A. (2021) · Figshare · doi:10.6084/m9.figshare.17084291
Additional file 5 of Revealing the composition of the eukaryotic microbiome of oyster spat by CRISPR-Cas Selective Amplicon Sequencing (CCSAS)
Zhong, K. X., Cho, A., Deeg, C. M., Chan, A. M., & Suttle, C. A. (2021) · Figshare · doi:10.6084/m9.figshare.17084303
Additional file 1 of Revealing the composition of the eukaryotic microbiome of oyster spat by CRISPR-Cas Selective Amplicon Sequencing (CCSAS)
Zhong, K. X., Cho, A., Deeg, C. M., Chan, A. M., & Suttle, C. A. (2021) · Figshare · doi:10.6084/m9.figshare.17084285
Additional file 8 of Revealing the composition of the eukaryotic microbiome of oyster spat by CRISPR-Cas Selective Amplicon Sequencing (CCSAS)
Zhong, K. X., Cho, A., Deeg, C. M., Chan, A. M., & Suttle, C. A. (2021) · Figshare · doi:10.6084/m9.figshare.17084318
Gut dysbiosis and its potential role in the Pathogenesis of Psychiatric disorders: A literature review
Wajdowicz, H., Warzocha, M., Czerniak, P., Buszek, J., Antoszewska, A., Bargieł, W., Bąk, D., Medygrał, M., & Dydoń-Pikor, M. (2025) · Humanities & Social Sciences Reviews · doi:10.18510/hssr.2025.13241

Authors: Capuco, A., Urits, I., Hasoon, J., Chun, R., Gerald, B., Wang, J. K., Kassem, H., Ngo, A. L., Abd-Elsayed, A., Simopoulos, T., Kaye, A. D., & Viswanath, O.
Affiliations: Georgetown University (US)
Beth Israel Deaconess Medical Center (US)
University of Arizona College of Medicine- Phoenix (US)
Harvard University (US)
Mount Sinai Medical Center (US)
University of Wisconsin–Madison (US)
Louisiana State University Health Sciences Center Shreveport (US)
Creighton University (US)
Corresponding author: Urits, Ivan
ORCID: Urits, Ivan
Hasoon, Jamal
Gerald, Brittany
Kassem, Hisham
Ngo, Anh L.
Abd-Elsayed, Alaa
Simopoulos, Thomas
Kaye, Alan D.
Viswanath, Omar
Venue: Advances in Therapy
Publisher: Springer Science and Business Media LLC
Published: 2020-03-04
Volume: 37
Issue: 4
Pages: 1328-1346
ISSN: 0741-238X (ISSN-L)
1865-8652
DOI: 10.1007/s12325-020-01272-7
PMC: PMC7140737
OpenAlex: W3010636850
Cited by: 216
References: 49
Citations by year: 2026: 18 · 2025: 29 · 2024: 33 · 2023: 59 · 2022: 41 · 2021: 27 · 2020: 7
FWCI: 3.21
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
creativecommons.org/licenses/by-nc/4.0 (tdm)
creativecommons.org/licenses/by-nc/4.0 (vor)
Locations: Advances in Therapy (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: gut dysbiosis, depression, microbiota-gut-brain axis, vagus nerve, microbial metabolites, neuroinflammation, neurotransmission, neuropsychiatric disorders, animal models of depression, microbiota-based therapy
MeSH terms: Gastrointestinal Microbiome, Animals, Brain, Central Nervous System, Depression, Humans, Dysbiosis

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