Oocyte aging underlies female reproductive aging: biological mechanisms and therapeutic strategies
Open accessAbstract
In recent years, postponement of marriage and childbearing in women of reproductive age has led to an increase in the incidence of age‐related infertility. The reproductive aging process in women is assumed to occur due to a decrease in both the quantity and quality of the oocytes, with the ultimate result being a decline in fecundity. This age‐related decline in fecundity is strongly dependent on oocyte quality, which is critical for fertilization and subsequent embryo development. Aged oocytes display increased chromosomal abnormality and dysfunction of cellular organelles, both of which factor into oocyte quality. In particular, mitochondrial dysfunction has been suggested as a major contributor to the reduction in oocyte quality as well as to chromosomal abnormalities in aged oocytes and embryos. Participation of oxidative stress in the oocyte aging process has been proposed because oxidative stress has the capacity to induce mitochondrial dysfunction and directly damage many intracellular components of the oocytes such as lipids, protein, and DNA. In an attempt to improve mitochondrial function in aged oocytes, several therapeutic strategies have been investigated using both animal models and assisted reproductive technology. Here, we review the biological mechanisms and present status of therapeutic strategies in the female reproductive aging field and indicate possible future therapeutic strategies.
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Aging processes can be accentuated at etiologic sites of multiple acute and chronic diseases, including in children.
“Aging progresses throughout the lifespan can be accentuated at etiologic sites of multiple acute and chronic diseases, including in children6,8–12.”
From Cellular senescence and senolytics: the path to the clinic (2022) · cites this paper as [12]
The ‘Contribution of oxidative stress to oocyte aging’ section (page not provided) links oxidative stress to aging and aging-related diseases, and the ‘Calorie restriction’ section names several such diseases. Neither section says that aging is accentuated at the etiologic sites of acute and chronic diseases or that this occurs in children. (LLM, conf=0.79)
Experimental — accuracy not yet measuredFundamental aging processes can act before conception, as with aged oocytes linked to Down syndrome.
“fundamental aging processes can operate even before conception, for example, in the context of aged oocytes linked to Down syndrome12,13.”
From Cellular senescence and senolytics: the path to the clinic (2022) · cites this paper as [12]
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- Authors
- Igarashi, H., Takahashi, T., & Nagase, S.
- Affiliations
- Yamagata University (JP)
- Corresponding author
- Igarashi, Hideki
- Venue
- Reproductive Medicine and Biology
- Publisher
- Wiley
- Published
- 2015-05-09
- Volume
- 14
- Issue
- 4
- Pages
- 159-169
- ISSN
- 1445-5781 (ISSN-L)
- 1447-0578
- PMC
- PMC5715832
- OpenAlex
- W636461026
- Cited by
- 116
- References
- 97
- Citations by year
- 2026: 9 · 2025: 18 · 2024: 12 · 2023: 10 · 2022: 18 · 2021: 18 · 2020: 18 · 2019: 11 · 2018: 1
- FWCI
- 0.05
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Reproductive Medicine and Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (26462474)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Keywords
- oocyte aging, female reproductive aging, age-related infertility, oocyte quality, mitochondrial dysfunction, oxidative stress, chromosomal abnormalities, fecundity decline, assisted reproduction, treatment options
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