The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.
Oocyte aging underlies female reproductive aging: biological mechanisms and therapeutic strategies
Open accessAbstract
In recent years, postponement of marriage and childbearing in women of reproductive age has led to an increase in the incidence of age‐related infertility. The reproductive aging process in women is assumed to occur due to a decrease in both the quantity and quality of the oocytes, with the ultimate result being a decline in fecundity. This age‐related decline in fecundity is strongly dependent on oocyte quality, which is critical for fertilization and subsequent embryo development. Aged oocytes display increased chromosomal abnormality and dysfunction of cellular organelles, both of which factor into oocyte quality. In particular, mitochondrial dysfunction has been suggested as a major contributor to the reduction in oocyte quality as well as to chromosomal abnormalities in aged oocytes and embryos. Participation of oxidative stress in the oocyte aging process has been proposed because oxidative stress has the capacity to induce mitochondrial dysfunction and directly damage many intracellular components of the oocytes such as lipids, protein, and DNA. In an attempt to improve mitochondrial function in aged oocytes, several therapeutic strategies have been investigated using both animal models and assisted reproductive technology. Here, we review the biological mechanisms and present status of therapeutic strategies in the female reproductive aging field and indicate possible future therapeutic strategies.
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“Aging progresses throughout the lifespan can be accentuated at etiologic sites of multiple acute and chronic diseases, including in children6,8–12.”
From Cellular senescence and senolytics: the path to the clinic (2022) · cites this paper as [12]
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“fundamental aging processes can operate even before conception, for example, in the context of aged oocytes linked to Down syndrome12,13.”
From Cellular senescence and senolytics: the path to the clinic (2022) · cites this paper as [12]
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1 retracted
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Cited by
Sorted by citations
Items 101–116 of 116
EFFECT OF OOCYTE AGE AND ACTIVATION AGENTS ON IN VITRO DEVELOPMENT OF MOUSE PARTHENOGENETIC EMBRYOS
Hine, T. M., Nalley, W. M., Uly, K., Manu, A. E., Ly, J., Marawali, A., & Kune, P. (2021) · The Journal of Animal and Plant Sciences · doi:10.36899/japs.2021.5.0326
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Paralichthys olivaceus egg extract improves porcine oocyte quality by decreasing oxidative stress
Lee, S., Park, H.-J., Han, D.-H., Lim, E.-S., Lee, H.-B., Yoon, J., Park, C., Kim, S.-H., Oh, S., Lee, D., et al. (2024) · Journal of Animal Science and Technology · doi:10.5187/jast.2024.e26
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Effect of aging on semen and embryonic developmental scores in assisted reproductive technology
Yamamoto, T., 峯, 克., & Iwata, H. (2025) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12647
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Lowering insulin mitigates female reproductive aging and diet-induced ovarian dysfunctionPreprint
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Axolotls retain fertility throughout lifespan
Haluza, Y., Gruhl, B., Wagner, A., Kurth, T., Tanaka, E. M., & Yun, M. H. (2026) · BMC Biology · doi:10.1186/s12915-026-02545-3
The potential role of p16 in the regulation of endometrial reproductive function
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Reproductive Choices: An Online Survey Among a Convenience Sample of Italian Couples
Paolo, B., Campeotto, G. M., Emanuele, P., Giuseppina, S., Valent, F., Francesco, B., Fornasin, A., Driul, L., & Pietro, M. L. D. (2026) · The Family Journal · doi:10.1177/10664807261483705
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Metadata
- Authors
- Igarashi, H., Takahashi, T., & Nagase, S.
- Affiliations
- Yamagata University (JP)
- Corresponding author
- Igarashi, Hideki
- Venue
- Reproductive Medicine and Biology
- Publisher
- Wiley
- Published
- 2015-05-09
- Volume
- 14
- Issue
- 4
- Pages
- 159-169
- ISSN
- 1445-5781 (ISSN-L)
- 1447-0578
- PMC
- PMC5715832
- OpenAlex
- W636461026
- Cited by
- 116
- References
- 97
- Citations by year
- 2026: 9 · 2025: 18 · 2024: 12 · 2023: 10 · 2022: 18 · 2021: 18 · 2020: 18 · 2019: 11 · 2018: 1
- FWCI
- 0.05
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Reproductive Medicine and Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (26462474)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Keywords
- oocyte aging, female reproductive aging, age-related infertility, oocyte quality, mitochondrial dysfunction, oxidative stress, chromosomal abnormalities, fecundity decline, assisted reproduction, treatment options
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