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Cited by 134Liver Disease Diagnosis and TreatmentNutritional Studies and DietDiet, Metabolism, and Disease

The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.

Effect of a low glycemic index Mediterranean diet on non-alcoholic fatty liver disease. A randomized controlled clinici trial

Open access
Misciagna, G., del Pilar Díaz, M., Caramia, D.V., Bonfiglio, C., Franco, I., Noviello, M.R., Chiloiro, M., Abbrescia, D.I., Mirizzi, A., Tanzi, M., Caruso, M.G., Correale, M., Reddavide, R., Inguaggiato, R., Cisternino, A.M., Osella, Alberto Rubén·2017·The Journal of nutrition, health and aging
DOI 10.1007/s12603-016-0809-8PMC PMC12879795
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Abstract

INTRODUCTION: Non-Alcoholic Fatty Liver Disease (NAFLD) is currently the most common form of liver disease worldwide affecting all ages and ethnic groups and it has become a consistent threat even in young people. Our aim was to estimate the effect of a Low Glycemic Index Mediterranean Diet (LGIMD) on the NAFLD score as measured by a Liver Ultrasonography (LUS). DESIGN: NUTRIzione in EPAtologia (NUTRIEPA) is a population-based Double-Blind RCT. Data were collected in 2011 and analyzed in 2013-14. SETTING/PARTICIPANTS: 98 men and women coming from Putignano (Puglia, Southern Italy) were drawn from a previous randomly sampled population-based study and identified as having moderate or severe NAFLD. INTERVENTION: The intervention strategy was the assignment of a LGIMD or a control diet. OUTCOME MEASURES: The main outcome measure was NAFLD score, defined by LUS. RESULTS: After randomization, 50 subjects were assigned to a LGIMD and 48 to a control diet. The study lasted six months and all participants were subject to monthly controls/checks. Adherence to the LGIMD as measured by Mediterranean Adequacy Index (MAI) showed a median of 10.1. A negative interaction between time and LGIMD on the NAFLD score (-4.14, 95% CI -6.78,-1.49) was observed, and became more evident at the sixth month (-4.43, 95%CI -7.15, -1.71). A positive effect of the interaction among LGIMD, time and age (Third month: 0.07, 95% CI 0.02, 0.12; Sixth month: 0.08, 95% CI 0.03,0.13) was also observed. CONCLUSIONS: LGIMD was found to decrease the NAFLD score in a relatively short time. Encouraging those subjects who do not seek medical attention but still have NAFLD to follow a LGIMD and other life-style interventions, may reduce the degree of severity of the disease. Dietary intervention of this kind, could also form the cornerstone of primary prevention of Type 2 Diabetes Mellitus (T2DM) and cardiovascular disease.

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Figure 1 NutriEpa Flow Diagram. Putignano (BA), Italy, 2011
Figure 1 NutriEpa Flow Diagram. Putignano (BA), Italy, 2011CC BY-NC-ND · PubMed Central
Figure 2 Effect and Contrast of LIGMD vs Control Diet (with 95% CI) on NAFLD Score. NutriEpa. Putignano (BA), Italy, 2011
Figure 2 Effect and Contrast of LIGMD vs Control Diet (with 95% CI) on NAFLD Score. NutriEpa. Putignano (BA), Italy, 2011CC BY-NC-ND · PubMed Central

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Authors
Misciagna, G., del Pilar Díaz, M., Caramia, D. V., Bonfiglio, C., Franco, I., Noviello, M. R., Chiloiro, M., Abbrescia, D. I., Mirizzi, A., Tanzi, M., Caruso, M. G., Correale, M., Reddavide, R., Inguaggiato, R., Cisternino, A. M., & Osella, A. R.
Affiliations
  • Gastroenterology Hospital "Saverio de Bellis" (IT)
  • Istituti di Ricovero e Cura a Carattere Scientifico (IT)
ORCID
Venue
The Journal of nutrition, health and aging
Publisher
Elsevier BV
Published
2017-04
Volume
21
Issue
4
Pages
404-412
ISSN
1279-7707 (ISSN-L)
DOI
10.1007/s12603-016-0809-8
PMC
PMC12879795
OpenAlex
W2525061232
Cited by
134
References
52
Citations by year
2026: 6 · 2025: 10 · 2024: 8 · 2023: 21 · 2022: 31 · 2021: 12 · 2020: 17 · 2019: 13 · 2018: 12 · 2017: 4
FWCI
9.06
Type
journal article
Language
en
Open access
Licence
Locations
  • The journal of nutrition health & aging (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
Topics
  • Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords
non-alcoholic fatty liver disease, low glycemic index diet, Mediterranean diet, liver ultrasound, NAFLD score, dietary adherence, lifestyle intervention, type 2 diabetes prevention, cardiovascular disease prevention, primary prevention, disease severity reduction
MeSH terms
Adult, Aged, Blood Glucose, Blood Pressure, Body Height, Body Weight, Diabetes Mellitus, Type 2, Double-Blind Method, Female, Humans, Insulin, Italy, Life Style, Male, Middle Aged, Surveys and Questionnaires, Glycemic Index, Diet, Mediterranean, Non-alcoholic Fatty Liver Disease

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