The Effectiveness of Mediterranean Diet in Nonalcoholic Fatty Liver Disease Clinical Course: An Intervention Study
Abstract
Diet is a modifiable key factor targeted in prevention and management of nonalcoholic fatty liver disease (NAFLD). The aim was to study the effect of Mediterranean Diet (MedDiet) on clinical, biochemical, and inflammatory profile in NAFLD patients with simple steatosis. Potential associations of signal transducer and activator of transcription 3 (STAT3) rs2293152 genotype to diet composition and patients' profile were investigated. In this nonrandomized, open-label, 24-week prospective intervention study, 44 untreated NAFLD patients with nonsignificant fibrosis received nutritional counsel to increase adherence to MedDiet. Adherence to MedDiet was estimated with MedDietScore. Furthermore, we genotyped STAT3 rs2293152 single nucleotide polymorphism and performed clinical and inflammatory measurements. In all patients, MedDietScore increased and anthropometric indices improved, whereas liver imaging, liver fibrosis score, blood pressure, fasting glucose, glycated hemoglobin (HbA1c), C-reactive protein (CRP), visfatin, and oxidized low-density lipoprotein levels were also significantly ameliorated compared with baseline ( P < .05). No association of STAT3 polymorphism with diet composition was found. Comparisons of mean differences between G- and C-carriers at the end point of the trial showed that only visfatin was significantly associated with the STAT3 genotype (−0.0 ± 4.6 vs. −4.2 ± 3.9, P = .04, respectively). Carrying the G-allele was associated with an increase of the visfatin levels (3.4 ± 1.5 ng/mL, P = .028). Our results show amelioration of clinical, biochemical, and inflammatory biomarkers in NAFLD patients in response to MedDiet. STAT3 rs2293152 G-carriers experienced more beneficial changes at the end of the intervention compared with baseline. An association between visfatin levels and STAT3 genotype has been shown for the first time.
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Longitudinal phenotype changes were more pronounced among individuals carrying the STAT3 rs2293152 G allele, which has been linked with greater NAFLD susceptibility and severity.
“Apart from negative variations in circulating visfatin levels, the longitudinal phenotype changes were more pronounced among individuals carrying the signal transducer and activator of transcription 3 (STAT3) rs2293152 “G” allele, which has been linked with greater NAFLD susceptibility and severity [79].”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [79]
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Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases
Mirabelli, M., Chiefari, E., Arcidiacono, B., Corigliano, D. M., Brunetti, F. S., Maggisano, V., Russo, D., Foti, D. P., & Brunetti, A. (2020) · Nutrients · doi:10.3390/nu12041066 · Cited by 272 · see citing works
“Furthermore, a 6-month nutritional counseling to adhere to the MedDiet has proved to be effective in the amelioration of certain disease-specific traits, including liver imaging, liver fibrosis score, inflammatory/oxidative biomarkers and glycemic status indices in non-fibrotic NAFLD patients [79].”
Background
- Authors
- Kaliora, A. C., Gioxari, A., Kalafati, I. P., Diolintzi, A., Kokkinos, A., & Dedoussis, G. V.
- Affiliations
- Harokopio University of Athens (GR)
- Laiko General Hospital of Athens (GR)
- Corresponding author
- Dedoussis, George V.
- ORCID
- Venue
- Journal of Medicinal Food
- Publisher
- SAGE Publications
- Published
- 2019-07
- Volume
- 22
- Issue
- 7
- Pages
- 729-740
- ISSN
- 1096-620X (ISSN-L)
- 1557-7600
- OpenAlex
- W2962036258
- Cited by
- 32
- References
- 47
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 6 · 2023: 2 · 2022: 6 · 2021: 7 · 2020: 2 · 2019: 1
- FWCI
- 3.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Medicinal Food (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Keywords
- Mediterranean diet, non-alcoholic fatty liver disease, simple steatosis, dietary adherence, visfatin, inflammation, liver fibrosis, glycemic control, oxidative stress, C-reactive protein, nutrition counseling
- MeSH terms
- Aged, Alleles, Female, Genotype, Greece, Glycated Hemoglobin, Humans, Lipoproteins, LDL, Male, Middle Aged, Prospective Studies, Polymorphism, Single Nucleotide, Diet, Mediterranean, STAT3 Transcription Factor, Non-alcoholic Fatty Liver Disease
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