Optimization of the extraction of total flavonoids from Scutellaria baicalensis Georgi using the response surface methodology

Response surface methodology (RSM) as a tool for optimization in analytical chemistry

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Modeling and optimization I: Usability of response surface methodology

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In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds

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Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi

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Study on the interaction mechanism between DNA and the main active components in Scutellaria baicalensis Georgi

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Optimisation of ultrasound assisted extraction of phenolic compounds from Sparganii rhizoma with response surface methodology

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Separation methods used for Scutellaria baicalensis active components

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Response surface optimization of ultrasound‐assisted flavonoids extraction from the flower of Citrus aurantium L. var. amara Engl

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Optimization of total flavonoids content extracted from Flos Populi using response surface methodology

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Anti-inflammatory effects of Scutellaria baicalensis extract via suppression of immune modulators and MAP kinase signaling molecules

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Difference of growth-inhibitory effect of Scutellaria baicalensis-producing flavonoid wogonin among human cancer cells and normal diploid cell

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Optimisation of solid state fermentation of potato peel for the production of cellulolytic enzymes

dos Santos, T. C., Gomes, D. P. P., Bonomo, R. C. F., & Franco, M. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.11.115 · Cited by 106 · see citing works

Application of response surface methodology to optimise extraction of flavonoids from fructus sophorae

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Potent Inhibitory Effect of Flavonoids inScutellaria baicalensison Amyloid β Protein-Induced Neurotoxicity

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Application of response surface methodology to optimise supercritical carbon dioxide extraction of essential oil from Cyperus rotundus Linn.

Wang, H., Liu, Y., Wei, S., & Yan, Z. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.10.075 · Cited by 100 · see citing works

Protective effect of flavonoids from Scutellaria baicalensis Georgi on cerebral ischemia injury

Zhang, Y., Wang, X., Wang, X., Xu, Z., Liu, Z., Ni, Q., Chu, X., Qiu, M., Zhao, A., & Jia, W. P. (2006) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2006.05.022 · Cited by 84 · see citing works

Selective fraction of Scutellaria baicalensis and its chemopreventive effects on MCF-7 human breast cancer cells

Wang, C., Li, X., Wang, Q., Mehendale, S. R., & Yuan, C. (2009) · Phytomedicine · doi:10.1016/j.phymed.2009.07.003 · Cited by 83 · see citing works

Flavonoids and phenylethanoids from hairy root cultures of Scutellaria baicalensis

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Investigation of flavonoid profile of Scutellaria bacalensis Georgi by high performance liquid chromatography with diode array detection and electrospray ion trap mass spectrometry

Liu, G., Ma, J., Chen, Y., Tian, Q., Shen, Y., Wang, X., Chen, B., & Yao, S. (2009) · Journal of Chromatography A · doi:10.1016/j.chroma.2009.04.021 · Cited by 81 · see citing works

Identification of flavonoids in the stems and leaves of Scutellaria baicalensis Georgi

Liu, G., Rajesh, N., Wang, X., Zhang, M., Wu, Q., Li, S., Chen, B., & Yao, S. (2011) · Journal of Chromatography B · doi:10.1016/j.jchromb.2011.02.050 · Cited by 81 · see citing works

Comparison of ultrasound-assisted emulsification and dispersive liquid–liquid microextraction methods for the speciation of inorganic selenium in environmental water samples using low density extraction solvents

Najafi, N. M., Tavakoli, H., Abdollahzadeh, Y., & Alizadeh, R. (2011) · Analytica Chimica Acta · doi:10.1016/j.aca.2011.11.063 · Cited by 78 · see citing works

Memory improvement in ibotenic acid induced model rats by extracts of Scutellaria baicalensis

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Korean Scutellaria baicalensis water extract inhibits cell cycle G1/S transition by suppressing cyclin D1 expression and matrix-metalloproteinase-2 activity in human lung cancer cells

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Effects of flavonoids extracted from Scutellaria baicalensis Georgi on hemin–nitrite–H2O2 induced liver injury

Zhao, Y., Li, H., Gao, Z., Gong, Y., & Xu, H. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.02.045 · Cited by 65 · see citing works

Effects of baicalein and wogonin isolated from Scutellaria baicalensis roots on skin damage in acute UVB-irradiated hairless mice

Kimura, Y., & Sumiyoshi, M. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.04.033 · Cited by 60 · see citing works

Effects of Amelioration of Total Flavonoids from Stems and Leaves of Scutellaria baicalensis Georgi on Cognitive Deficits, Neuronal Damage and Free Radicals Disorder Induced by Cerebral Ischemia in Rats

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Antimutagenic and antiradical properties of flavones from the roots of Scutellaria baicalensis Georgi

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Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in the spontaneous sleep–wake regulation

Chang, H.-H., Yi, P.-L., Cheng, C., Lu, C.-Y., Hsiao, Y., Tsai, Y.-F., Li, C., & Chang, F. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.03.023 · Cited by 42 · see citing works

Modeling Vibrio parahaemolyticus inactivation by acidic electrolyzed water on cooked shrimp using response surface methodology

Wang, J. J., Zhang, Z. H., Li, J., Lin, T., Pan, Y. J., & Zhao, Y. (2013) · Food Control · doi:10.1016/j.foodcont.2013.08.031 · Cited by 33 · see citing works

Effect of baicalein from Scutellaria baicalensis on prevention of noise-induced hearing loss

Kang, T. H., Hong, B. N., Park, C., Kim, S. Y., & Park, R. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.12.009 · Cited by 28 · see citing works

Neuroprotective effect of oral S/B remedy (Scutellaria baicalensis Georgi and Bupleurum scorzonerifolfium Willd) on iron-induced neurodegeneration in the nigrostriatal dopaminergic system of rat brain

Lin, A. M., Ping, Y. H., Chang, G., Wang, J., Chiu, J., Kuo, C. D., & Chi, C.-W. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.01.056 · Cited by 23 · see citing works

[Comparative study on selenium and amino acids content in leaves of planted and wild Scutellaria baicalensis].

Sheng, J., Chen, H., & Shen, L. (2009) · PubMed · Cited by 9 · see citing works

Cancer chemoprevention through dietary flavonoids: what’s limiting?

Amawi, H. A., Ashby, C. R., & Tiwari, A. K. (2017) · 癌症：英文版 · doi:10.1186/s40880-017-0217-4 · Cited by 209 · see citing works

Green extraction approach for the recovery of polyphenols from Croatian olive leaves (Olea europea)

Putnik, P., Barba, F. J., Španić, I., Zorić, Z., Dragović‐Uzelac, V., & Kovačević, D. B. (2017) · Food and Bioproducts Processing · doi:10.1016/j.fbp.2017.08.004 · Cited by 103 · see citing works

Cancer Chemoprevention by Flavonoids, Dietary Polyphenols and Terpenoids

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Pharmacological properties of total flavonoids in Scutellaria baicalensis for the treatment of cardiovascular diseases

Tan, Y., Lin, F., Ding, Y.-K., Dai, S., Liang, Y., Zhang, Y., Li, J., & Chen, H. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154458 · Cited by 57 · see citing works

Extraction and Purification of Inulin from Jerusalem Artichoke with Response Surface Method and Ion Exchange Resins

Zhang, X., Zhu, X., Shi, X., Hou, Y., & Yi, Y. (2022) · ACS Omega · doi:10.1021/acsomega.2c00302 · Cited by 38 · see citing works

Antioxidant activity and mechanism exploration for microwave-assisted extraction of flavonoids from Scutellariae Radix using natural deep eutectic solvent

Guo, X., Ren, T., Li, H., Lu, Q., & Di, X. (2024) · Microchemical Journal · doi:10.1016/j.microc.2024.110300 · Cited by 32 · see citing works

Optimization of ultrasound-assisted enzymatic pretreatment for enhanced extraction of baicalein and wogonin from Scutellaria baicalensis roots

Yun, C., Wang, S., Gao, Y., Zhao, Z., Miao, N., Shi, Y., Ri, I., Wang, W., & Wang, H. (2021) · Journal of Chromatography B · doi:10.1016/j.jchromb.2021.123077 · Cited by 31 · see citing works

Optimization of Flavonoid Extraction in Dendrobium officinale Leaves and Their Inhibitory Effects on Tyrosinase Activity

Lu, H.-X., Yang, K., Zhan, L., Lu, T., Chen, X., Cai, X.-M., Zhou, C., Li, H., Qian, L.-Q., Lv, G., et al. (2019) · International Journal of Analytical Chemistry · doi:10.1155/2019/7849198 · Cited by 23 · see citing works

Response Surface Optimized Infrared-Assisted Extraction and UHPLC Determination of Flavonoid Types from Flos Sophorae

Mou, Q., He, J., Yin, R., Yang, B., Fu, M., Fang, J. S., & Li, H. (2017) · Molecules · doi:10.3390/molecules22061000 · Cited by 23 · see citing works

Optimization of Sporulation Conditions for Bacillus subtilis BSNK-5

Tian, Z., Hou, L., Hu, M., Gao, Y., Li, D., Fan, B., Wang, F., & Li, S. (2022) · Processes · doi:10.3390/pr10061133 · Cited by 20 · see citing works

Optimisation of microwave-assisted extraction of flavonoids and phenolics from celery (Apium graveolens L.) leaves by response surface methodology

He, Q., Li, Y., Zhang, P., Zhang, A., & Wu, H. (2016) · Czech Journal of Food Sciences · doi:10.17221/266/2015-cjfs · Cited by 20 · see citing works

Extraction Optimization of Flavonoids from Hypericum formosanum and Matrix Metalloproteinase-1 Inhibitory Activity

Huang, H.-S., & Liaw, E.-T. (2017) · Molecules · doi:10.3390/molecules22122172 · Cited by 20 · see citing works

Extraction of Antioxidant Compounds from Brazilian Green Propolis Using Ultrasound-Assisted Associated with Low- and High-Pressure Extraction Methods

Teixeira, T. D., Machado, B. A. S., Barreto, G. D. A., dos Anjos, J. P., Leal, I. L., Nascimento, R. Q., Hodel, K. V. S., & Umsza‐Guez, M. A. (2023) · Molecules · doi:10.3390/molecules28052338 · Cited by 19 · see citing works

Optimization of Polyphenols Recovery from Schinus molle L. Peel Using Response Surface Methodology (RSM)

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Optimization of Fermentation Conditions for 2,3,5-Trimethylpyrazine Produced by Bacillus amyloliquefaciens from Daqu

Liu, X., Yang, W., Gu, H., Bughio, A. A., & Liu, J. (2024) · Fermentation · doi:10.3390/fermentation10020112 · Cited by 16 · see citing works

Harnessing Aromatic Properties for Sustainable Bio-valorization of Lignin Derivatives into Flavonoids

Zhu, S.-Y., Li, N., Liu, Z.-H., Yuan, Y.-J., & Li, B.-Z. (2025) · Green Carbon · doi:10.1016/j.greenca.2024.11.005 · Cited by 15 · see citing works

Optimization of the extraction of polyphenols and antioxidant capacities from two types of Solanum gilo Raddi using response surface methodology

Miamoto, J. D. B. M., Aazza, S., Ruas, N. R., de Carvalho, A. A., Pinto, J. E. B. P., Resende, L. V., & Bertolucci, S. K. V. (2019) · Journal of Applied Research on Medicinal and Aromatic Plants · doi:10.1016/j.jarmap.2019.100238 · Cited by 16 · see citing works

Oxidative Stress-Mediated Antibacterial Activity of the Total Flavonoid Extracted from the Agrimonia pilosa Ledeb. in Methicillin-Resistant Staphylococcusaureus (MRSA)

He, L., Cheng, H., Chen, F., Song, S., Zhang, H., Sun, W., Bao, X., Zhang, H., & He, C. (2022) · Veterinary Sciences · doi:10.3390/vetsci9020071 · Cited by 13 · see citing works

Optimization of all extraction process for phenolic compounds with maximum antioxidant activity from extract of Taraxacum assemanii by statistical strategies

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Optimisation of polyphenol extraction for the valorisation of spent gin botanicals

Umego, E. C., & Barry‐Ryan, C. (2024) · LWT · doi:10.1016/j.lwt.2024.116114 · Cited by 11 · see citing works

Growth regulators affect the dry weight production, carvacrol and thymol content of Lippia gracilis Schauer

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Flavonoid Biosynthesis in Scutellaria baicalensis Georgi: Metabolomics and Transcriptomics Analysis

Yao, D., Xing, J., Tang, Q., Hou, Y., Chen, B., Yao, W., Li, Z., Wang, J., Niu, Y., & Wang, D. (2024) · Agronomy · doi:10.3390/agronomy14071494 · Cited by 10 · see citing works

Optimization of Ultrasonic-Enzymatic-Assisted Extraction of Flavonoids from Sea Buckthorn (Hippophae rhamnoides L.) Pomace: Chemical Composition and Biological Activities

Suo, W., Wang, W., Li, D., Wu, H., Liu, H., Huang, W., & Ma, Y. (2025) · Foods · doi:10.3390/foods14101656 · Cited by 9 · see citing works

Optimization of Microwave-Assisted extraction for enhanced bioactive efficiency of Tirmania spp. And Terfezia claveryi: Their response surface methodology and Principal component analysis approach

Hussein, H. S., NEDJIP, G., Ugurtay, A., Ahmed, A. A., & Karaoğul, E. (2025) · Microchemical Journal · doi:10.1016/j.microc.2025.114029 · Cited by 9 · see citing works

Therapeutic benefits of gossypin as an emerging phytoconstituents of Hibiscus spp.: a critical review

Jejurkar, G., & Chavan, M. J. (2023) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-023-00547-4 · Cited by 9 · see citing works

PHYTOCHEMICAL SCREENING AND IN VITRO ANTIOXIDANT AND ANTI-DIABETIC POTENTIALS OF PERSEA AMERICANA MILL. (LAURACEAE) FRUIT EXTRACT

Mahadeva Rao, U. S. (2018) · Universal Journal of Pharmaceutical Research · doi:10.22270/ujpr.v3i5.200 · Cited by 8 · see citing works

Optimization of Extraction Process by Response Surface Methodology, Composition Analysis and Antioxidant Activity of Total Flavonoids from Scutellaria baicalensis Georgi

Gan, H., Lan, W., Wang, M., Xu, J., Zhang, K. K., Tang, Y., Gao, X., Kadier, A., Chen, C., Wu, J., et al. (2026) · Molecules · doi:10.3390/molecules31030507 · Cited by 7 · see citing works

A novel hydrogen-incorporated carbon dioxide supercritical system for extracting phytochemicals from grape peels: Response surface methodology–based modeling and optimization

Alwazeer, D., Karaoğul, E., Çiçek, S. A., Ugurtay, A., Çiğdem, A., ‎Engin, T., Bekbayev, K., Abdilova, G., Bolkenov, B., & Орынбеков, Д. Р. (2026) · Results in Engineering · doi:10.1016/j.rineng.2026.109142 · Cited by 6 · see citing works

Antimicrobial evaluation of silver nanoparticles using extracts of Crescentia cujete L.

Sánchez, M. A., & Ladino, J. A. F. (2023) · Brazilian Journal of Biology · doi:10.1590/1519-6984.270215 · Cited by 6 · see citing works

Optimization of Ethanol Concentration and Time for Flavonoid Extraction of Melinjo Peel

Sucipto, S., Husna, I. F. A., & Kumalaningsih, S. (2021) · Advances in engineering research/Advances in Engineering Research · doi:10.2991/aer.k.211221.017 · Cited by 6 · see citing works

Recovery of phytochemicals from cimin black grape seeds with sub/super-critical carbon dioxide extraction

‎Engin, T., Karaoğul, E., Çiçek, S. A., Çiğdem, A., Alwazeer, D., Bekbayev, K., Abdilova, G., & Bolkenov, B. (2026) · The Journal of Supercritical Fluids · doi:10.1016/j.supflu.2026.106894 · Cited by 5 · see citing works

Investigation of biological activity of Alpinia platychilus extracts and its use as a natural preservative in fruits

Wu, L., Hu, X., Li, Y., Lao, Q., Zhong, Y., Li, Q., & Zhang, H. (2023) · Journal of Food Measurement & Characterization · doi:10.1007/s11694-023-02285-w · Cited by 5 · see citing works

Gold nanoparticles biosynthesized from flavonoid extract of Hopea odorata leaves and their catalytic activity for 4-nitrophenol reduction

Dang, K.-P. T., Ngo, V. N., Vu-Quang, H., & Nguyen, T. (2024) · Journal of Engineering Research · doi:10.1016/j.jer.2024.09.011 · Cited by 5 · see citing works

Optimization of the extraction of antioxidants from stinging nettle leaf using response surface methodology

Vajić, U.-J., Živković, J., Ivanov, M., Jovović, D., Šavikin, K., Bugarski, B., & Mihailovic‐Stanojevic, N. (2022) · Macedonian Journal of Chemistry and Chemical Engineering · doi:10.20450/mjcce.2022.2238 · Cited by 5 · see citing works

Supercritical hybrid carbon dioxide-hydrogen extraction for phenolics and antioxidants from mint using response surface methodology, modelling, and optimization

Çiğdem, A., Karaoğul, E., Çiçek, S. A., ‎Engin, T., Alwazeer, D., Bekbayev, K., Abdilova, G., & Bolkenov, B. (2026) · Industrial Crops and Products · doi:10.1016/j.indcrop.2026.122924 · Cited by 3 · see citing works

Scutellaria baicalensis and Lonicera japonica herbal extracts enhanced the performance and physiological responses of pigs subjected to hot and dry season

Sampath, V., Baek, Y., & Kim, I. H. (2026) · Frontiers in Veterinary Science · doi:10.3389/fvets.2025.1740443 · Cited by 4 · see citing works

Effects of Various Physical Field–Assisted Techniques and Combination Methods on Extraction of Flavonoids and Polyphenols From Angelica keiskei

Sun, G., Wang, J., Wang, N., Zhao, S., Zhao, Y., Yan, Y., Tang, S., & Li, Z. (2025) · Separation Science Plus · doi:10.1002/sscp.70000 · Cited by 3 · see citing works

Optimization of Fermentation Conditions for the Production of 2,3,5-Trimethylpyrazine by Recombinant Bacillus licheniformis

Liu, X., Gu, H., Wang, H., Tang, Z., Chen, S., Li, H., & Quan, W. (2025) · Microorganisms · doi:10.3390/microorganisms13071477 · Cited by 2 · see citing works

Optimizing supercritical CO2 extraction of phytochemicals from grape peels using response surface technology: Modeling, characterization, and antioxidant potential

Karaoğul, E., Çiçek, S. A., Ugurtay, A., ‎Engin, T., Çiğdem, A., Alwazeer, D., Bayadilova, A., Bekbayeva, R., Орынбеков, Д. Р., & Bekbayev, K. (2025) · Applied Food Research · doi:10.1016/j.afres.2025.101579 · Cited by 2 · see citing works

Chemical profiling, in vitro antioxidant and antidiabetic assessment of flavonoids from the ethanol extract of Hermannia geniculata root

Adeniran, L. A., Palanisamy, C. P., & Ashafa, A. O. T. (2021) · Sokoto Journal of Veterinary Sciences · doi:10.4314/sokjvs.v19i1.1 · Cited by 2 · see citing works

Cardioprotective effects of the total flavonoids of Polygonum cuspidatum Sieb. et Zucc. Root extract on experimental myocardial infarction in mice

Yu, H.-R., Jiang, Y.-L., Dong, D.-D., & Wang, G. (2019) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v18i2.17 · Cited by 2 · see citing works

Optimization of the flash extraction of flavonoids from the leaves of Salix babylonica using the response surface method and an evaluation of the leaves’ high antioxidant activityPreprint

Chen, H., Diao, L., Zhang, Y., Liu, H., Zhong, M., & Li, G. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/423095 · Cited by 2 · see citing works

Apoptosis and Antiproliferation of Tespong Herbs (Oenanthe javanica (Blume) DC) Fraction Against MCF 7 Breast Cancer Cell

Agustina, P., Haryoto, H., & Indrayudha, P. (2024) · BIO Web of Conferences · doi:10.1051/bioconf/202413505002 · Cited by 1 · see citing works

Green-chemistry of by-products from Sai-Nam-Phueng orange in Thailand (1): Recovering a valuable source of bioactive compounds using response surface methodology, antioxidant, and cytotoxicity

Kodchakorn, K., & Kongtawelert, P. (2024) · Waste Management Bulletin · doi:10.1016/j.wmb.2024.10.004 · Cited by 1 · see citing works

In vitro anti-inflammation, selective cytotoxicity, and inhibition of induced nitric oxide from lipopolysaccharide-stimulated raw 264.7 macrophages activities of flavonoids from Hermannia geniculata eckl and zeyh roots extract

Ariyo, A. L., Nkechinyere, O. J., McGaw, J., & Ashafa, A. T. (2020) · Pharmacognosy Magazine · doi:10.4103/pm.pm_447_19 · Cited by 1 · see citing works

ESTUDO DA EXTRAÇÃO E ACILAÇÃO ENZIMÁTICA DE FLAVONOIDES OBTIDOS A PARTIR DA CASCA DE Passiflora edulis

MARQUES, I. X., SAMPAIO, L. R. V., Silva, B. A. S., SOUSA, J. R., SOUZA, M. C. M., & Gonçalves, L. R. B. (2015) · Congresso Brasileiro de Engenharia Química em Iniciação Científica · doi:10.5151/chemeng-cobeqic2015-276-33124-264698

Kinetics of α-amylase and α-glucosidase Inhibitory Potential of Hermannia geniculata Eckl. & Zehl root Extracts Used in Basotho Traditional Medicine.

Adeniran, L. A., & Ashafa, A. O. T. (2020) · Journal of Veterinary and Biomedical Sciences · doi:10.36108/jvbs/9102.20.0221

Antibacterial Activity of Peruvian Tarasa Species: A Comparative Study of the Antimicrobial Effects of Extracts From Three Different Tarasa Species, T. capitata , T. operculata and T. tenuis , Against Human Pathogens

Yauri, C. R., Trombert, A. N., & Lazarte, A. M. (2025) · International Journal of Microbiology · doi:10.1155/ijm/5546594

Optimization of the extraction of total phenols and flavonoids from Scutellaria litwinowii : A green extraction technique based on response surface methodology and macroporous Resins

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RSM–ANN-driven process engineering for greener polyphenol extraction from kodo millet husk and their translational efficacy against acute lung inflammation in both in vitro and in vivo models

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