Memory improvement in ibotenic acid induced model rats by extracts of Scutellaria baicalensis
Abstract
Ethnopharmacological relevance Scutellaria baicalensis Georgi (Labiatae) extracts have been used as traditional Korean medicine, to treat cerebral ischemia in addition to bacterial infection and inflammatory diseases.Aim of the study The improvement effect on learning and memory by the administration of Scutellaria baicalensis extracts was evaluated and the underlying mechanisms were investigated.Materials and methods Memory behavior was tested by the passive avoidance test and Y-maze test. We also investigated the cells expressing neuronal markers related to memory processes by immunofluorescence staining analysis in memory deficient animal model (Ibo model) rats and in hippocampal progenitor cells.Results We found neuronal cells immunoreactive to choline acetyltransferase (ChAT), a marker for cholinergic neurons were increased in the hippocampus, while cells producing GABA and glutamate were not after 30 mg/kg Scutellaria baicalensis administration. Futhermore, Scutellaria baicalensis extracts enhanced the survival of a hippocampal progenitor cell line, HiB5 and its differentiation to ChAT immunoreactive cells. The increased expression of memory related neurotransmitter, NMDA receptor and a reduction of activated microglia in the hippocampus were also observed in the Ibo model when administrated Scutellaria baicalensis extracts.Conclusions These results imply that Scutellaria baicalensis has significant neuroprotective effects in the Ibo model.
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Scutellaria baicalensis improved memory in the ibotenic acid-induced memory deficient model.
“Heo et al. (2009) showed that S. baicalensis improved memory in the ibotenic acid-induced memory deficient model and could be possibly a good therapeutic candidate to treat degenerating neuronal diseases accompanied by memory loss.”
From Multi-target neuroprotective effects of herbal medicines for Alzheimer's disease (2022) · cites this paper as Heo et al., 2009
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- Authors
- Heo, H., Shin, Y., Cho, W., Choi, Y., Kim, H., & Kwon, Y. K.
- Affiliations
- Kyung Hee University (KR)
- Corresponding author
- Kwon, Yunhee Kim
- Venue
- Journal of Ethnopharmacology
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 122
- Issue
- 1
- Pages
- 20-27
- ISSN
- 0378-8741 (ISSN-L)
- OpenAlex
- W2035651308
- Cited by
- 66
- References
- 31
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 1 · 2017: 7 · 2016: 7 · 2015: 4 · 2014: 8 · 2013: 6 · 2012: 5
- FWCI
- 6.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Ethnopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Medicinal Plant Pharmacodynamics Research
- Keywords
- Scutellaria baicalensis, ibotenic acid, memory impairment, learning and memory, choline acetyltransferase, cholinergic neurons, hippocampal progenitor cells, NMDA receptor, microglial activation, neuroprotection, hippocampus, traditional Korean medicine, cerebral ischemia
- MeSH terms
- Animals, Cell Survival, Hippocampus, Ibotenic Acid, Learning, Male, Phytotherapy, Memory, Plant Extracts, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Microglia, Receptors, AMPA, Plant Roots, Excitatory Amino Acid Agonists, Neuroprotective Agents, Maze Learning, Models, Animal, Scutellaria baicalensis, Rats
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