Higher Baseline Serum Irisin Decreases Risk for Body Mass Index Increment in Chinese Populations: A 3.2-Year Cohort Study
Open accessAbstract
Irisin, a newly discovered myokine, exerts beneficial effects on energy metabolism. However, published results from studies examining the relationship between irisin concentration and obesity have been conflicting. The aim of our study was to investigate the association between serum irisin level and obese individuals with different body mass index (BMI) values and to explore the question of whether serum irisin can predict the risk of increases in the BMI. This study based on the data collected in the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal (REACTION). The cross-sectional cohort study was carried out from May 2011 to August 2011, and a longitudinal cohort study was conducted from July 2014 to October 2014 to complete the first 3.2-year follow-up. We enrolled 93 low-weight subjects (BMI < 18.5 kg/m 2 ), 94 normal-weight subjects (BMI 18.5–23.9 kg/m 2 ), 98 overweight subjects (BMI 24.0–27.9 kg/m 2 ) and 93 obese subjects (BMI ≥ 28 kg/m 2 ). Subjects in the normal-weight, overweight and obese groups were selected to match low-weight subjects by age and sex. Serum samples were obtained from all subjects to determine the irisin level. Subjects with a higher serum irisin level tended to have significantly lower changes in BMI and body fat percentage and higher baseline high-density lipoprotein cholesterol level ( p < 0.05). No significant correlation was observed between serum irisin level and the baseline obesity index. Serum irisin level was positively correlated to an active lifestyle (i.e. physical activity; β = 1.138, p = 0.032) and negatively correlated to fasting plasma glucose level ( β = − 0.996, p = 0.023), changes in BMI ( β = − 0.533, p = 0.002), waist circumference ( β = − 0.102, p = 0.018), body fat percentage ( β = − 0.457, p = 0.001) and Chinese visceral adiposity index ( β = − 0.280, p = 0.028). After adjustment for cofactors, higher baseline serum irisin was an independent factor for a decreased BMI increment (baseline serum irisin: odds ratio 0.747, 95% confidence interval 0.652–0.949, p = 0.002). Higher serum irisin at baseline independently predicted a lower BMI increment in Chinese populations.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Irisin levels negatively correlate with obesity indicators including BMI and fat mass.
“Irisin levels negatively correlate with obesity indicators including BMI and fat mass [44,45].”
From Exercise-Induced Myokines in Obesity-Related Metabolic Disorders and Cardiovascular Protection: A Narrative Review (2026) · cites this paper as [44]
The Results report that higher baseline irisin was negatively correlated with subsequent changes in BMI and body fat percentage, not with those indicators at baseline. The Discussion explicitly says the study found no association between circulating irisin and baseline BMI or body fat percentage, so the unqualified claim overstates the finding. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810 · see citing works
(2002) · PubMed · Cited by 1,755 · see citing works
Body mass index as a measure of body fatness: age- and sex-specific prediction formulas
Deurenberg, P., Weststrate, J., & Seidell, J. C. (1991) · British Journal of Nutrition · doi:10.1079/bjn19910073 · Cited by 1,397 · see citing works
PGC-1α: a key regulator of energy metabolism
Liang, H., & Ward, W. F. (2006) · AJP Advances in Physiology Education · doi:10.1152/advan.00052.2006 · Cited by 1,250 · see citing works
Huh, J. Y., Panagiotou, G., Mougios, V., Brinkoetter, M., Vamvini, M. T., Schneider, B. E., & Mantzoros, C. S. (2012) · Metabolism · doi:10.1016/j.metabol.2012.09.002 · Cited by 1,040 · see citing works
Zhou, Cooperative, B.-F., & on (2002) · 生物医学与环境科学：英文版 · Cited by 992 · see citing works
Moreno-Navarrete, J. M., Ortega, F., Serrano, M., Guerra, E., Pardo, G., Tinahones, F., Ricart, W., & Fernández-Real, J. M. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2749 · Cited by 788 · see citing works
Zhang, Y., Li, R., Meng, Y., Li, S., Donelan, W., Zhao, Y., Qi, L., Zhang, M., Wang, X., Cui, T., et al. (2014) · Diabetes · doi:10.2337/db13-1106 · Cited by 733 · cited 2× · see citing works
“In one study, the administration of r-irisin to obese mice fed a high-fat diet improved glucose tolerance and reduced bodyweight [4].”
BackgroundObesity: Risk factors, complications, and strategies for sustainable long‐term weight management
Fruh, S. M. (2017) · Journal of the American Association of Nurse Practitioners · doi:10.1002/2327-6924.12510 · Cited by 709 · see citing works
Physiology and role of irisin in glucose homeostasis
Perakakis, N., Triantafyllou, G. A., Fernández-Real, J. M., Huh, J. Y., Park, K. H., Seufert, J., & Mantzoros, C. S. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.221 · Cited by 621 · see citing works
Norheim, F., Langleite, T. M., Hjorth, M., Holen, T., Kielland, A., Stadheim, H. K., Gulseth, H. L., Birkeland, K. I., Jensen, J., & Drevon, C. A. (2014) · The FEBS Journal · doi:10.1111/febs.12619 · Cited by 563 · see citing works
Stengel, A., Hofmann, T., Goebel-Stengel, M., Elbelt, U., Kobelt, P., & Klapp, B. (2013) · Peptides · doi:10.1016/j.peptides.2012.11.014 · Cited by 439 · see citing works
Serum irisin levels in new-onset type 2 diabetes
Choi, Y., Kim, M. K., Bae, K.-H., Seo, H.-A., Jeong, J.-Y., Lee, W.-K., Kim, J., Lee, I., & Park, K. (2013) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2013.01.007 · Cited by 422 · see citing works
A indicator of visceral adipose dysfunction to evaluate metabolic health in adult Chinese
Xia, M., Chen, Y., Lin, H., Ma, H., Li, X., Aleteng, Q., Li, Q., Wang, D., Hu, Y., Pan, B., et al. (2016) · Scientific Reports · doi:10.1038/srep38214 · Cited by 300 · see citing works
Pardo, M., Crujeiras, A. B., Amil, M., Agüera, Z., Jiménez‐Múrcia, S., Baños, R., Botella, C., de la Torre, R., Estivill, X., Fagundo, A. B., et al. (2014) · International Journal of Endocrinology · doi:10.1155/2014/857270 · Cited by 216 · see citing works
Crosstalk between adipokines and myokines in fat browning
Rodrı́guez, A., Becerril, S., Ezquerro, S., Méndez-Giménez, L., & Frühbeck, G. (2016) · Acta Physiologica · doi:10.1111/apha.12686 · Cited by 192 · see citing works
Hernández-Alvarez, M. I., Thabit, H., Burns, N., Shah, S., Brema, I., Hatunic, M., Finucane, F., Liesa, M., Chiellini, C., Naon, D., et al. (2010) · Diabetes Care · doi:10.2337/dc09-1305 · Cited by 189 · see citing works
Bi, Y., Lu, J., Wang, W., Mu, Y., Zhao, J., Liu, C., Chen, L., Shi, L., Li, Q., Wan, Q., et al. (2013) · Journal of Diabetes · doi:10.1111/1753-0407.12108 · Cited by 186 · see citing works
Self-citationAssociation of Serum Irisin with Metabolic Syndrome in Obese Chinese Adults
Yan, B., Shi, X., Zhang, H., Pan, L., Ma, Z., Liu, S., Liu, Y., Li, X., Yang, S., & Li, Z. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094235 · Cited by 161 · see citing works
Crujeiras, A. B., Pardo, M., Roca-Rivada, A., Navas‐Carretero, S., Zulet, M. Á., Martínez, J. A., & Casanueva, F. F. (2013) · American Journal of Human Biology · doi:10.1002/ajhb.22493 · Cited by 153 · see citing works
Crujeiras, A., Zulet, M. D. L. Á., Lopez-Legarrea, P., de la Iglesia, R., Pardo, M., Carreira, M., Martinez, J., & Casanueva, F. (2014) · Metabolism: Clinical and Experimental · doi:10.1016/j.metabol.2013.12.007 · Cited by 143 · see citing works
Moreno, M., Moreno‐Navarrete, J. M., Serrano, M., Ortega, F. J., Delgado, E., Sánchez-Ragnarsson, C., Valdés, S., Botas, P., Ricart, W., & Fernández‐Real, J. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124100 · Cited by 88 · see citing works
Sahin-Efe, A., Upadhyay, J., Ko, B., Dincer, F., Park, K., Migdal, A. L., Vokonas, P., & Mantzoros, C. S. (2017) · Metabolism · doi:10.1016/j.metabol.2017.10.011 · Cited by 77 · see citing works
Lopez‐Legarrea, P., de la Iglesia, R., Crujeiras, A. B., Pardo, M., Casanueva, F. F., Zulet, M. Á., & Martínez, J. A. (2014) · Nutrition and Diabetes · doi:10.1038/nutd.2014.7 · Cited by 70 · see citing works
Klangjareonchai, T., Nimitphong, H., Saetung, S., Bhirommuang, N., Samittarucksa, R., Chanprasertyothin, S., Sudatip, R., & Ongphiphadhanakul, B. (2014) · International Journal of Endocrinology · doi:10.1155/2014/261545 · Cited by 55 · see citing works
Circulating irisin levels are associated with lipid and uric acid metabolism in a Chinese population
Tang, S., Zhang, R., Jiang, F., Wang, J., Chen, M., Peng, D., Yan, J. Y., Wang, S., Bao, Y., Hu, C., et al. (2015) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12439 · Cited by 37 · see citing works
Zhou, X., Li, R., Liu, X., Wang, L., Peng, H., Chan, L., Saha, P., & Hu, Z. (2016) · Scientific Reports · doi:10.1038/srep29669 · Cited by 35 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Irisin, an exercise-induced bioactive peptide beneficial for health promotion during aging process
Zhang, H., Wu, X., Liang, J., Kirberger, M., & Chen, N. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101680 · Cited by 88 · see citing works
Dianatinasab, A., Koroni, R., Bahramian, M., Bagheri-Hosseinabadi, Z., Vaismoradi, M., Fararouei, M., & Amanat, S. (2020) · Journal of Exercise Science & Fitness · doi:10.1016/j.jesf.2020.06.004 · Cited by 56 · see citing works
Circulating Irisin Levels as a Marker of Osteosarcopenic-Obesity in Cushing’s Disease
Guarnotta, V., Prinzi, A., Pitrone, M., Pizzolanti, G., & Giordano, C. S. D. S. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s249090 · Cited by 21 · see citing works
Lagzdiņa, R., Rumaka, M., Gersone, G., & Tretjakovs, P. (2020) · Medicina · doi:10.3390/medicina56060274 · Cited by 22 · see citing works
Karolkiewicz, J., Krzywicka, M., Szulińska, M., Musialik, K., Musiałowska, D., Zieliński, J., Bilska, A., & Ratajczak, M. (2024) · Journal of Diabetes Research · doi:10.1155/jdr/6624919 · Cited by 8 · see citing works
Khaledi, K., Hoseini, R., & Gharzi, A. (2024) · Genes & Nutrition · doi:10.1186/s12263-023-00736-z · Cited by 7 · see citing works
Dawood, S. A., Jawad, M. A., & Mossa, H. A. L. (2023) · Al-Rafidain Journal of Medical Sciences · doi:10.54133/ajms.v5i.224 · Cited by 5 · see citing works
Zhang, Y., & Qiu, Y. (2026) · Sports · doi:10.3390/sports14050212 · Cited by 3 · see citing works
“Irisin levels negatively correlate with obesity indicators including BMI and fat mass [44,45].”
Low-volume high-intensity interval training for children with obesity: a commentary
Jürimäe, J. (2020) · Acta Kinesiologiae Universitatis Tartuensis · doi:10.12697/akut.2020.26.01
Feter, N., Cunha, L. L., de Paula, D., Feter, J. S., Caputo, E. L., & Rombaldi, A. J. (2024) · Science & Sports · doi:10.1016/j.scispo.2023.10.005
Gao, R., Zhang, Y., & Quan, L. (2026) · Comprehensive physiology · doi:10.1002/cph4.70248
- Authors
- Liu, R., Shi, L., Peng, N., Zhang, Q., & Li, H.
- Affiliations
- Affiliated Hospital of Guizhou Medical University (CN)
- Corresponding author
- Shi, Lixin
- Venue
- Diabetes Therapy
- Published
- 2019-02-27
- Volume
- 10
- Issue
- 2
- Pages
- 713-723
- ISSN
- 1869-6953 (ISSN-L)
- 1869-6961
- PMC
- PMC6437307
- OpenAlex
- W2917528735
- Cited by
- 11
- References
- 27
- Citations by year
- 2026: 2 · 2024: 3 · 2023: 1 · 2022: 1 · 2020: 4
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Diabetes Therapy (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Eli Lilly and Company
- National Key New Drug Creation and Manufacturing Program, Ministry of Science and Technology (2013BAI09B13, 2012ZX09303006‐001)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- irisin, myokines, body mass index, obesity, weight gain, visceral fat, body fat percentage, physical activity, fasting blood glucose, HDL cholesterol, Chinese adults, obesity prediction, energy metabolism, waist circumference, visceral adiposity index, sex differences
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
