The effects of aerobic, resistance, and combined exercises on the plasma irisin levels, HOMA-IR, and lipid profiles in women with metabolic syndrome: A randomized controlled trial
Open accessAbstract
BACKGROUND/OBJECTIVE: Irisin is suggested to be an exercise beneficial effects mediator. This study aimed to examine the effects of the aerobic exercise (AE), resistance exercise (RE), and combined exercise (CE) on the plasma levels of irisin and some metabolic and anthropometric indices. METHODS: Sixty overweight women with metabolic syndrome were assigned equally into four groups: AE, RE, CE, and control. The study variables were measured before and 24 h after the intervention period. RESULTS: None of the study groups showed statistically significant changes in the serum irisin. However, muscle mass significantly increased in the RE and CE groups. Also, a significant decrease was observed in the body fat percentage in all groups. In addition, compared with the control group, the homeostatic model assessment of insulin resistance in the AE (p = 0.021), RE (p = 0.039), and in the CE (p = 0.003) groups reduced significantly. According to the analysis of indices' changes, serum irisin was significantly correlated with the body fat percentage (r = 0.532) and HOMA-IR (r = 0.424). CONCLUSIONS: The systematic exercise program for 8-weeks did not change circulating irisin and no statistically significant difference was observed between the exercise methods. Also, serum irisin seemed to be associated with the glycemic status, body fat and weight independent of exercise activity. RCT REGISTRATION CODE: IRCT20180806040721N2. REGISTRY NAME: Iranian Registry of Clinical Trials.
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The dual action of resistance training-promoting muscle protein synthesis via mTOR and ERK signaling while enhancing energy expenditure through irisin-mediated pathways-may offer potential advantages for improving body composition.
“The dual action of resistance training—promoting muscle protein synthesis via mTOR and ERK signaling while enhancing energy expenditure through irisin-mediated pathways—may offer potential advantages for improving body composition [46,47].”
From Exercise-Induced Myokines in Obesity-Related Metabolic Disorders and Cardiovascular Protection: A Narrative Review (2026) · cites this paper as [47]
The Introduction and Discussion describe irisin-mediated increases in energy expenditure as a proposed mechanism, and the Abstract Results report increased muscle mass and reduced body-fat percentage with resistance exercise in women with metabolic syndrome. The paper does not identify mTOR or ERK signaling as the cause of muscle gain, and it found no significant change in serum irisin, so it does not establish the claimed dual action of resistance training. Page numbers were not available in our copy. (LLM, conf=0.88)
Experimental — accuracy not yet measuredIrisin activates mTOR and ERK signaling pathways to promote muscle protein synthesis and satellite cell activation.
“Irisin also activates mTOR and ERK signaling pathways to promote muscle protein synthesis and satellite cell activation [46,47], suggesting dual benefits for improving body composition.”
From Exercise-Induced Myokines in Obesity-Related Metabolic Disorders and Cardiovascular Protection: A Narrative Review (2026) · cites this paper as [47]
The Introduction and Discussion describe irisin’s secretion and proposed effects on adipose-tissue browning, but do not address mTOR signaling, muscle protein synthesis, or satellite-cell activation. A References entry mentions ERK signaling only in connection with browning of white adipocytes, not the claimed muscle effects. Searches for the named pathways and muscle effects found no supporting passage in our copy; no page numbers were provided. (LLM, conf=0.76)
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“The dual action of resistance training—promoting muscle protein synthesis via mTOR and ERK signaling while enhancing energy expenditure through irisin-mediated pathways—may offer potential advantages for improving body composition [46,47].”
- Authors
- Dianatinasab, A., Koroni, R., Bahramian, M., Bagheri-Hosseinabadi, Z., Vaismoradi, M., Fararouei, M., & Amanat, S.
- Affiliations
- Shiraz University of Medical Sciences (IR)
- Iran University of Medical Sciences (IR)
- Nord University (NO)
- University of Larestan (IR)
- Corresponding author
- Koroni, Roghayeh
- Amanat, Sasan
- ORCID
- Venue
- Journal of Exercise Science & Fitness
- Publisher
- Elsevier BV
- Published
- 2020-09
- Volume
- 18
- Issue
- 3
- Pages
- 168-176
- ISSN
- 1728-869X (ISSN-L)
- PMC
- PMC7334615
- OpenAlex
- W3036408553
- Cited by
- 56
- References
- 39
- Citations by year
- 2026: 11 · 2025: 7 · 2024: 8 · 2023: 7 · 2022: 13 · 2021: 8 · 2020: 2
- FWCI
- 5.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Exercise Science & Fitness (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Charles Sturt University Research Output (CRO) (submittedVersion, cc-by-nc-nd)
- Cronfa (Swansea University) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Shiraz University of Medical Sciences
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- irisin, aerobic exercise, resistance training, concurrent training, metabolic syndrome, insulin resistance, HOMA-IR, lipid profile, body fat percentage, muscle mass, overweight women, exercise intervention
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