Irisin, an exercise-induced bioactive peptide beneficial for health promotion during aging process

Centers for Disease Control and Prevention

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Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway

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FNDC5 and Irisin in Humans: I. Predictors of Circulating Concentrations in Serum and Plasma and II. mRNA Expression and Circulating Concentrations in Response to Weight Loss and Exercise

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Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models

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Exerkines in health, resilience and disease

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Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans

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Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling

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Physiology and role of irisin in glucose homeostasis

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Neurotrophin signalling in health and disease

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FNDC5/irisin is not only a myokine but also an adipokine

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Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1α muscle-specific knock-out animals.

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Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry

Jedrychowski, M. P., Wrann, C. D., Paulo, J. A., Gerber, K. K., Szpyt, J., Robinson, M. M., Nair, K. S., Gygi, S. P., & Spiegelman, B. M. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.08.001 · Cited by 568 · see citing works

The myokine irisin increases cortical bone mass

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Molecular Biology of Atherosclerosis

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FNDC5 alleviates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via activating AKT

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Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity--correlation with body mass index.

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Exercise hormone irisin is a critical regulator of cognitive function

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Exercise-induced irisin secretion is independent of age or fitness level and increased irisin may directly modulate muscle metabolism through AMPK activation

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Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes.

Liu, T.-Y., Shi, C.-X., Gao, R., Sun, H.-J., Xiong, X.-Q., Ding, L., Chen, Q., Li, Y.-H., Wang, J.-J., Kang, Y.-M., et al. (2015) · Clinical science · doi:10.1042/cs20150009 · Cited by 352 · see citing works

Irisin is a pro-myogenic factor that induces skeletal muscle hypertrophy and rescues denervation-induced atrophy

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Evidence against a Beneficial Effect of Irisin in Humans

Raschke, S., Elsen, M., Gassenhuber, J., Sommerfeld, M. R., Schwahn, U., Brockmann, B., Jung, R., Wisløff, U., Tjønna, A. E., Raastad, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073680 · Cited by 318 · see citing works

Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humans

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Irisin: A Hope in Understanding and Managing Obesity and Metabolic Syndrome

Arhire, L. I., Mihalache, L., & Covașă, M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00524 · Cited by 306 · see citing works

Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice

Colaianni, G., Mongelli, T., Cuscito, C., Pignataro, P., Lippo, L., Spiro, G., Notarnicola, A., Severi, I., Passeri, G., Mori, G., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-02557-8 · Cited by 305 · see citing works

Are skeletal muscle <i>FNDC5</i> gene expression and irisin release regulated by exercise and related to health?

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Irisin promotes osteoblast proliferation and differentiation via activating the MAP kinase signaling pathways

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Irisin alleviates liver ischemia-reperfusion injury by inhibiting excessive mitochondrial fission, promoting mitochondrial biogenesis and decreasing oxidative stress

Bi, J., Zhang, J., Ren, Y., Du, Z., Li, Q., Wang, Y., Wei, S., Yang, L., Zhang, J., Liu, C., et al. (2018) · Redox Biology · doi:10.1016/j.redox.2018.10.019 · Cited by 288 · see citing works

Parkinson's disease, insulin resistance and novel agents of neuroprotection

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Progress and Challenges in the Biology of FNDC5 and Irisin

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FNDC5 overexpression and irisin ameliorate glucose/lipid metabolic derangements and enhance lipolysis in obesity

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The Structure of Irisin Reveals a Novel Intersubunit β-Sheet Fibronectin Type III (FNIII) Dimer

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Irisin Enhances Osteoblast DifferentiationIn Vitro

Colaianni, G., Cuscito, C., Mongelli, T., Oranger, A., Mori, G., Brunetti, G., Colucci, S. C., Cinti, S., & Grano, M. (2014) · International Journal of Endocrinology · doi:10.1155/2014/902186 · Cited by 225 · see citing works

Association of Irisin with Fat Mass, Resting Energy Expenditure, and Daily Activity in Conditions of Extreme Body Mass Index

Pardo, M., Crujeiras, A. B., Amil, M., Agüera, Z., Jiménez‐Múrcia, S., Baños, R., Botella, C., de la Torre, R., Estivill, X., Fagundo, A. B., et al. (2014) · International Journal of Endocrinology · doi:10.1155/2014/857270 · Cited by 216 · see citing works

Irisin protects mitochondria function during pulmonary ischemia/reperfusion injury

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Irisin ameliorates doxorubicin-induced cardiac perivascular fibrosis through inhibiting endothelial-to-mesenchymal transition by regulating ROS accumulation and autophagy disorder in endothelial cells

Pan, J., Zhang, H., Lin, H., Gao, L., Zhang, H., Zhang, J., Wang, C., & Gu, J. F. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102120 · Cited by 197 · see citing works

White matter injury and microglia/macrophage polarization are strongly linked with age-related long-term deficits in neurological function after stroke

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Effects of the exercise‐inducible myokine irisin on malignant and non‐malignant breast epithelial cell behavior in vitro

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Resistance exercise training increases the expression of irisin concomitant with improvement of muscle function in aging mice and humans

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High-intensity exercise causes greater irisin response compared with low-intensity exercise under similar energy consumption

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Exercise-induced irisin in bone and systemic irisin administration reveal new regulatory mechanisms of bone metabolism

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Irisin Mitigates Oxidative Stress, Chondrocyte Dysfunction and Osteoarthritis Development through Regulating Mitochondrial Integrity and Autophagy

Wang, F., Kuo, C.-W., Ko, J., Chen, Y., Wang, S., Ke, H.-J., Kuo, P.-C., Lee, C.-H., Wu, J., Lu, W., et al. (2020) · Antioxidants · doi:10.3390/antiox9090810 · Cited by 170 · see citing works

Roles of myokines in exercise-induced improvement of neuropsychiatric function

Kim, S., Choi, J., Moon, S., Park, D., Kwak, H., & Kang, J. (2019) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-019-02253-8 · Cited by 168 · see citing works

Cardiac, skeletal muscle and serum irisin responses to with or without water exercise in young and old male rats: Cardiac muscle produces more irisin than skeletal muscle

Aydın, S., Kuloğlu, T., Aydin, S., Eren, M. N., Çelik, A., Yılmaz, M., Kalaycı, M. Z., Şahin, İ., Gungor, O., Gürel, A., et al. (2013) · Peptides · doi:10.1016/j.peptides.2013.11.024 · Cited by 165 · see citing works

Irisin, an exercise‐induced myokine as a metabolic regulator: an updated narrative review

Chen, N., Li, Q., Liu, J., & Jia, S. (2015) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2660 · Cited by 164 · see citing works

Irisin alleviates pressure overload-induced cardiac hypertrophy by inducing protective autophagy via mTOR-independent activation of the AMPK-ULK1 pathway

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Effects of myokines on bone

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Irisin and musculoskeletal health

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Exploring the link between glucocerebrosidase mutations and parkinsonism

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Endurance training-induced increase in circulating irisin levels is associated with reduction of abdominal visceral fat in middle-aged and older adults

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Fndc5 knockdown significantly decreased neural differentiation rate of mouse embryonic stem cells

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High circulating irisin levels are associated with insulin resistance and vascular atherosclerosis in a cohort of nondiabetic adult subjects

Sesti, G., Andreozzi, F., Fiorentino, T. V., Mannino, G. C., Sciacqua, A., Marini, M. A., & Perticone, F. (2014) · Acta Diabetologica · doi:10.1007/s00592-014-0576-0 · Cited by 142 · see citing works

Effects and underlying mechanisms of irisin on the proliferation and apoptosis of pancreatic β cells

Liu, S.-W., Du, F., Li, X., Wang, M.-M., Duan, R., Zhang, J.-X., Wu, Y., & Zhang, Q. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175498 · Cited by 138 · see citing works

A role for FNDC5/Irisin in the beneficial effects of exercise on the brain and in neurodegenerative diseases

Young, M. F., Valaris, S., & Wrann, C. D. (2019) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2019.02.007 · Cited by 136 · see citing works

Inhibiting BDNF expression by antisense oligonucleotide infusion causes loss of nigral dopaminergic neurons

Porritt, M. J., Batchelor, P. E., & Howells, D. W. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2004.11.030 · Cited by 135 · see citing works

Irisin Promotes Human Umbilical Vein Endothelial Cell Proliferation through the ERK Signaling Pathway and Partly Suppresses High Glucose-Induced Apoptosis

Song, H.-B., Wu, F., Zhang, Y., Zhang, Y.-Z., Wang, F., Jiang, M., Wang, Z., Zhang, M.-X., Li, S.-W., Yang, L., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110273 · Cited by 129 · see citing works

Exercise-induced myokines and their effect on prostate cancer

Kim, J., Galvao, D. A., Newton, R. U., Gray, E. S., & Taaffe, D. R. (2021) · Nature Reviews Urology · doi:10.1038/s41585-021-00476-y · Cited by 126 · see citing works

Irisin Prevents Disuse-Induced Osteocyte Apoptosis

Storlino, G., Colaianni, G., Sanesi, L., Lippo, L., Brunetti, G., Errede, M., Colucci, S. C., Passeri, G., & Grano, M. (2019) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3944 · Cited by 125 · see citing works

The Myokine Irisin Is Released in Response to Saturated Fatty Acids and Promotes Pancreatic β-Cell Survival and Insulin Secretion

Natalicchio, A., Marrano, N., Biondi, G., Spagnuolo, R., Labarbuta, R., Porreca, I., Cignarelli, A., Bugliani, M., Marchetti, P., Perrini, S., et al. (2017) · Diabetes · doi:10.2337/db17-0002 · Cited by 121 · see citing works

Protective actions of exercise-related FNDC5/irisin in memory and Alzheimer's disease

de Freitas, G. B., Lourenco, M. V., & De Felice, F. G. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15039 · Cited by 120 · see citing works

Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo

Estell, E. G., Le, P. T., Vegting, Y., Kim, H., Wrann, C. D., Bouxsein, M., Nagano, K., Baron, R., Spiegelman, B. M., & Rosen, C. J. (2020) · eLife · doi:10.7554/elife.58172 · Cited by 119 · see citing works

Irisin is associated with osteoporotic fractures independently of bone mineral density, body composition or daily physical activity

Palermo, A., Strollo, R., Maddaloni, E., Tuccinardi, D., D’Onofrio, L., Briganti, S., Defeudis, G., Pascalis, M. D., Lazzaro, M. C., Colleluori, G., et al. (2014) · Clinical Endocrinology · doi:10.1111/cen.12672 · Cited by 118 · see citing works

Serum irisin levels are lower in patients with breast cancer: association with disease diagnosis and tumor characteristics

Provatopoulou, X., Georgiou, G. P., Kalogera, E., Kalles, V., Matiatou, M., Papapanagiotou, I., Sagkriotis, A., Zografos, G., & Gounaris, A. (2015) · BMC Cancer · doi:10.1186/s12885-015-1898-1 · Cited by 118 · see citing works

Irisin, Two Years Later

Novelle, M. G., Contreras, C., Romero, A., López, M., & Diéguez, C. (2013) · International Journal of Endocrinology · doi:10.1155/2013/746281 · Cited by 117 · see citing works

Acute effects of high-intensity interval training and moderate-intensity continuous exercise on BDNF and irisin levels and neurocognitive performance in late middle-aged and older adults

Tsai, C., Pan, C., Tseng, Y., Chen, F., Chang, Y.-C., & Wang, T.-C. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113472 · Cited by 117 · see citing works

FNDC5/Irisin inhibits pathological cardiac hypertrophy

Yu, Q., Kou, W., Xu, X., Zhou, S., Luan, P., Xu, X., Li, H., Zhuang, J., Wang, J., Zhao, Y., et al. (2019) · Clinical Science · doi:10.1042/cs20190016 · Cited by 115 · see citing works

Novel Blood-Based Biomarkers of Cognition, Stress, and Physical or Cognitive Training in Older Adults at Risk of Dementia: Preliminary Evidence for a Role of BDNF, Irisin, and the Kynurenine Pathway

Küster, O. C., Laptinskaya, D., Fissler, P., Schnack, C., Zügel, M., Nold, V., Thurm, F., Pleiner, S., Karabatsiakis, A., von Einem, B., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170447 · Cited by 114 · see citing works

Mental Training Enhances Cognitive Function and BDNF More Than Either Physical or Combined Training in Elderly Women With MCI: A Small-Scale Study

Damirchi, A., Hosseini, F., & Babaei, P. (2018) · American Journal of Alzheimers Disease & Other Dementias · doi:10.1177/1533317517727068 · Cited by 114 · see citing works

The novel myokine irisin: clinical implications and potential role as a biomarker for sarcopenia in postmenopausal women

Park, H., Kim, H. C., Zhang, D., Yeom, H., & Lim, S.-K. (2018) · Endocrine · doi:10.1007/s12020-018-1814-y · Cited by 112 · see citing works

Circulating irisin levels and coronary heart disease: association with future acute coronary syndrome and major adverse cardiovascular events

Aronis, K. N., Moreno, M., Pοlyzos, S. A., Moreno‐Navarrete, J. M., Ricart, W., Delgado, E., de la Hera, J., Sahin-Efe, A., Chamberland, J. P., Berman, R., et al. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.101 · Cited by 111 · see citing works

Irisin Peptide Protects Brain Against Ischemic Injury Through Reducing Apoptosis and Enhancing BDNF in a Rodent Model of Stroke

Asadi, Y., Gorjipour, F., Behrouzifar, S., & Vakili, A. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2569-9 · Cited by 111 · see citing works

Irisin protects against neuronal injury induced by oxygen-glucose deprivation in part depends on the inhibition of ROS-NLRP3 inflammatory signaling pathway

Peng, J., Deng, X., Huang, W. G., Yu, J., Wang, J., Wang, J., Yang, S., Liu, X., Wang, L., Zhang, Y., et al. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.09.014 · Cited by 110 · see citing works

Neuronal Networks in Hypertension

Guyenet, P. G., Stornetta, R. L., Souza, G. M. P. R., Abbott, S. B. G., & Brooks, V. L. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.14521 · Cited by 110 · see citing works

Irisin Levels Are Lower in Young Amenorrheic Athletes Compared with Eumenorrheic Athletes and Non-Athletes and Are Associated with Bone Density and Strength Estimates

Singhal, V., Lawson, E. A., Ackerman, K. E., Fazeli, P. K., Clarke, H., Lee, H., Eddy, K. T., Marengi, D. A., Derrico, N. P., Bouxsein, M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100218 · Cited by 102 · see citing works

FNDC5/Irisin attenuates diabetic cardiomyopathy in a type 2 diabetes mouse model by activation of integrin αV/β5-AKT signaling and reduction of oxidative/nitrosative stress

Lin, C., Guo, Y., Xia, Y., Li, C., Xu, X., Qi, T., Zhang, F., Fan, M., Hu, G., Zhao, H., et al. (2021) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2021.06.013 · Cited by 100 · see citing works

Association between circulating irisin and insulin resistance in non-diabetic adults: A meta-analysis.

Qiu, S., Cai, X., Yin, H., Zügel, M., Sun, Z.-L., Steinacker, J., & Schumann, U. (2016) · Metabolism: Clinical and Experimental · doi:10.1016/j.metabol.2016.02.006 · Cited by 99 · see citing works

Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1α/FNDC5/BDNF Pathway

Belviranlı, M., & Okudan, N. (2018) · NeuroMolecular Medicine · doi:10.1007/s12017-018-8500-3 · Cited by 98 · see citing works

Lower irisin level in patients with type 2 diabetes mellitus: A case‐control study and meta‐analysis

Zhang, C., Ding, Z., Lv, G., Li, J., Zhou, P., & Zhang, J. (2014) · Journal of Diabetes · doi:10.1111/1753-0407.12256 · Cited by 97 · see citing works

Irisin, a novel myokine is an independent predictor for sarcopenia and carotid atherosclerosis in dialysis patients

Lee, M. J., Lee, S. A., Nam, B. Y., Park, S., Lee, S., Ryu, H. J., Kwon, Y. E., Kim, Y. L., Park, K. S., Oh, H. J., et al. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.08.002 · Cited by 97 · see citing works

Irisin activates Opa1-induced mitophagy to protect cardiomyocytes against apoptosis following myocardial infarction

Xin, T., & Lu, C. (2020) · Aging · doi:10.18632/aging.102899 · Cited by 96 · see citing works

Circulating irisin levels are positively associated with endothelium-dependent vasodilation in newly diagnosed type 2 diabetic patients without clinical angiopathy

Xiang, L., Xiang, G., Yue, L., Zhang, J., & Zhao, L. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.04.036 · Cited by 95 · see citing works

How does the skeletal muscle communicate with the brain in health and disease?

Isaac, A. R., Lima‐Filho, R. A. S., & Lourenco, M. V. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108744 · Cited by 95 · see citing works

Central and Peripheral Irisin Differentially Regulate Blood Pressure

Zhang, W.-Z., Chang, L., Zhang, C., Zhang, R., Li, Z.-R., Chai, B.-X., Li, J.-Y., Chen, E., & Mulholland, M. (2015) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-015-6580-y · Cited by 92 · see citing works

Irisin Alleviates Advanced Glycation End Products-Induced Inflammation and Endothelial Dysfunction via Inhibiting ROS-NLRP3 Inflammasome Signaling

Deng, X., Huang, W., Peng, J., Zhu, T., Sun, X.-L., Zhou, X.-Y., Yang, H., Xiong, J., He, H.-Q., Xu, Y.-H., et al. (2017) · Inflammation · doi:10.1007/s10753-017-0685-3 · Cited by 92 · see citing works

Irisin exerts a therapeutic effect against myocardial infarction via promoting angiogenesis

Liao, Q., Qu, S., Tang, L.-X., Li, L.-P., He, D.-F., Zeng, C.-Y., & Wang, W. (2019) · Acta Pharmacologica Sinica · doi:10.1038/s41401-019-0230-z · Cited by 91 · see citing works

Irisin promotes proliferation but inhibits differentiation in osteoclast precursor cells

Ma, Y., Qiao, X., Zeng, R., Cheng, R., Zhang, J., Luo, Y., Nie, Y., Hu, Y., Yang, Z., Zhang, J., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201700983rr · Cited by 90 · see citing works

Irisin Is Regulated by CAR in Liver and Is a Mediator of Hepatic Glucose and Lipid Metabolism.

Mo, L., Shen, J., Liu, Q.-H., Zhang, Y., Kuang, J.-Y., Pu, S.-Y., Cheng, S., Zou, M., Jiang, W., Jiang, C.-T., et al. (2016) · Molecular Endocrinology · doi:10.1210/me.2015-1292 · Cited by 87 · see citing works

Decreased irisin secretion contributes to muscle insulin resistance in high-fat diet mice.

Yang, Z., Xu, C., Chen, Y., & Zhao, Q. (2015) · Europe PMC (PubMed Central) · Cited by 86 · see citing works

Irisin stimulates cell proliferation and invasion by targeting the PI3K/AKT pathway in human hepatocellular carcinoma

Shi, G., Tang, N., Qiu, J., Zhang, D., Huang, F., Cheng, Y., Ding, K., Li, W., Zhang, P., & Tan, X. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.08.148 · Cited by 86 · see citing works

Irisin Exerts Neuroprotective Effects on Cultured Neurons by Regulating Astrocytes

Wang, K., Li, H., Wang, H., Wang, J., Song, F., & Sun, Y. S. (2018) · Mediators of Inflammation · doi:10.1155/2018/9070341 · Cited by 86 · see citing works

The immunomodulatory role of irisin on osteogenesis via AMPK-mediated macrophage polarization

Ye, W., Wang, J., Lin, D., & Ding, Z. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.12.028 · Cited by 86 · see citing works

Irisin immunohistochemistry in gastrointestinal system cancers

Aydın, S., Kuloğlu, T., Özercan, M. R., Albayrak, S., Aydın, S., Bakal, Ü., Yılmaz, M., Kalaycı, M. Z., Yardım, M., Saraç, M., et al. (2016) · Biotechnic & Histochemistry · doi:10.3109/10520295.2015.1136988 · Cited by 85 · see citing works

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

Kim, H., Wrann, C. D., Jedrychowski, M. P., Vidoni, S., Kitase, Y., Nagano, K., Zhou, C., Chou, J., Parkman, V.-J. A., Novick, S. J., et al. (2019) · Cell · doi:10.1016/j.cell.2019.06.028 · Cited by 85 · see citing works

The relationship between circulating irisin levels and endothelial function in lean and obese subjects

Hou, N., Han, F., & Sun, X. (2014) · Clinical Endocrinology · doi:10.1111/cen.12658 · Cited by 84 · see citing works

Irisin attenuates angiotensin II-induced cardiac fibrosis via Nrf2 mediated inhibition of ROS/ TGFβ1/Smad2/3 signaling axis

Chen, R.-R., Fan, X., Chen, G., Zeng, G., Xue, Y., Liu, X., & Wang, C. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.01.031 · Cited by 84 · see citing works

Circulating irisin levels are not correlated with BMI, age, and other biological parameters in obese and diabetic patients

Sanchis‐Gomar, F., Alis, R., Pareja-Galeano, H., Solá, E., Víctor, V. M., Rocha, M., Hernández‐Mijares, A., & Romagnoli, M. (2014) · Endocrine · doi:10.1007/s12020-014-0170-9 · Cited by 83 · see citing works

Effects of 12 Weeks Resistance Training on Serum Irisin in Older Male Adults

Zhao, J., Su, Z., Qu, C., & Dong, Y. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00171 · Cited by 82 · see citing works

High irisin levels are associated with better glycemic control and bone health in children with Type 1 diabetes

Faienza, M. F., Brunetti, G., Sanesi, L., Colaianni, G., Celi, M., Piacente, L., D’Amato, G., Schipani, E., Colucci, S. C., & Grano, M. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2018.03.046 · Cited by 82 · see citing works

Exercise therapy for functional capacity in chronic diseases: an overview of meta-analyses of randomised controlled trials

Pasanen, T., Tolvanen, S., Heinonen, A. O., & Kujala, U. M. (2017) · British Journal of Sports Medicine · doi:10.1136/bjsports-2016-097132 · Cited by 81 · see citing works

The “irisin system”: From biological roles to pharmacological and nutraceutical perspectives

Flori, L., Testai, L., & Calderone, V. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118954 · Cited by 79 · see citing works

A review on irisin, a new protagonist that mediates muscle-adipose-bone-neuron connectivity.

Grygiel‐Górniak, B., & Puszczewicz, M. (2017) · PubMed · Cited by 78 · see citing works

Fibronectin type III domain‐containing 5 improves aging‐related cardiac dysfunction in mice

Hu, C., Zhang, X., Hu, M., Teng, T., Yuan, Y., Song, P. K., Kong, C., Xu, S., Ma, Z., & Tang, Q. (2022) · Aging Cell · doi:10.1111/acel.13556 · Cited by 78 · see citing works

Irisin and leptin concentrations in relation to obesity, and developing type 2 diabetes: A cross sectional and a prospective case-control study nested in the Normative Aging Study

Sahin-Efe, A., Upadhyay, J., Ko, B., Dincer, F., Park, K., Migdal, A. L., Vokonas, P., & Mantzoros, C. S. (2017) · Metabolism · doi:10.1016/j.metabol.2017.10.011 · Cited by 77 · see citing works

Metformin‐induced autophagy and irisin improves INS‐1 cell function and survival in high‐glucose environment via AMPK/SIRT1/PGC‐1α signal pathway

Li, Q.-X., Jia, S.-H., Xu, L., Li, B., & Chen, N. (2019) · Food Science & Nutrition · doi:10.1002/fsn3.1006 · Cited by 77 · see citing works

Irisin inhibits osteocyte apoptosis by activating the Erk signaling pathway in vitro and attenuates ALCT-induced osteoarthritis in mice

He, Z., Li, H., Han, X., Zhou, F., Du, J., Yang, Y., Xu, Q., Zhang, S., Zhang, S., Zhao, N., et al. (2020) · Bone · doi:10.1016/j.bone.2020.115573 · Cited by 76 · see citing works

Cerebrospinal fluid irisin correlates with amyloid‐β, BDNF, and cognition in Alzheimer's disease

Lourenco, M. V., Ribeiro, F. C., Sudo, F. K., Drummond, C., Assunção, N., Vanderborght, B., Tovar-Moll, F. F., Mattos, P., Felice, F. G. D., & Ferreira, S. T. (2020) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12034 · Cited by 76 · see citing works

Circulating Irisin and Myostatin as Markers of Muscle Strength and Physical Condition in Elderly Subjects

Planella-Farrugia, C., Comas, F., Sabater, M., Moreno, M., Moreno‐Navarrete, J. M., Rovira, O., Ricart, W., & Fernández‐Real, J. M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00871 · Cited by 74 · see citing works

Myokine Irisin promotes osteogenesis by activating BMP/SMAD signaling via αV integrin and regulates bone mass in mice

Xue, Y., Hu, S., Chen, C., He, J., Sun, J., Jin, Y., Zhang, Y., Zhu, G., Shi, Q., & Rui, Y. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.63505 · Cited by 74 · see citing works

Irisin ameliorates septic cardiomyopathy via inhibiting DRP1-related mitochondrial fission and normalizing the JNK-LATS2 signaling pathway

Tan, Y., Ouyang, H., Xiao, X., Zhong, J., & Dong, M. (2019) · Cell Stress and Chaperones · doi:10.1007/s12192-019-00992-2 · Cited by 72 · see citing works

Irisin reverses insulin resistance in C2C12 cells via the p38-MAPK-PGC-1α pathway

Ye, X., Shen, Y., Ni, C., Ye, J., Xin, Y., Zhang, W., & Ren, Y. (2019) · Peptides · doi:10.1016/j.peptides.2019.170120 · Cited by 72 · see citing works

Irisin prevents dexamethasone-induced atrophy in C2C12 myotubes

Chang, J. S., & Kong, I. D. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02367-4 · Cited by 72 · see citing works

The Emerging Role of Irisin in Cardiovascular Diseases

Fu, J., Li, F., Tang, Y., Cai, L., Zeng, C., Yang, Y., & Yang, J. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.121.022453 · Cited by 72 · see citing works

Irisin deficiency disturbs bone metabolism

Zhu, X., Li, X., Wang, X., Chen, T., Tao, F., Liu, C.-J., Tu, Q., Shen, G., & Chen, J. J. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29894 · Cited by 71 · see citing works

Irisin Exerts Inhibitory Effect on Adipogenesis Through Regulation of Wnt Signaling

Ma, E. B., Sahar, N.-E., Jeong, M., & Huh, J. Y. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01085 · Cited by 69 · see citing works

Irisin Correlates Positively With BMD in a Cohort of Older Adult Patients and Downregulates the Senescent Marker p21 in Osteoblasts

Colaianni, G., Errede, M., Sanesi, L., Notarnicola, A., Celi, M., Zerlotin, R., Storlino, G., Pignataro, P., Oranger, A., Pesce, V., et al. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4192 · Cited by 69 · see citing works

Irisin promotes osteogenic differentiation of bone marrow mesenchymal stem cells by activating autophagy via the Wnt//β-catenin signal pathway

Chen, X., Sun, K., Zhao, S., Geng, T., Fan, X., Sun, S., Zheng, M., & Jin, Q. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155292 · Cited by 68 · see citing works

10-Year Follow-Up After Revascularization in Elderly Patients With Complex Coronary Artery Disease

Ono, M., Serruys, P. W. J. C., Hara, H., Kawashima, H., Gao, C., Wang, R., Takahashi, K., O’Leary, N., Wykrzykowska, J. J., Sharif, F., et al. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.04.016 · Cited by 68 · see citing works

Decreased Concentration of Irisin Is Associated with Poor Functional Outcome in Ischemic Stroke

Tu, W., Qiu, H., Cao, J., Liu, Q., Zeng, X., & Zhao, J.-Z. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-0651-2 · Cited by 67 · see citing works

Exercise-Induced Irisin, the Fat Browning Myokine, as a Potential Anticancer Agent

Maalouf, G.-E., & Khoury, D. E. (2019) · Journal of Obesity · doi:10.1155/2019/6561726 · Cited by 67 · see citing works

Increased levels of irisin in people with long‐standing Type 1 diabetes

Espes, D., Lau, J., & Carlsson, P. (2015) · Diabetic Medicine · doi:10.1111/dme.12731 · Cited by 65 · see citing works

Irisin Ameliorates Glucolipotoxicity-Associated β-Cell Dysfunction and Apoptosis via AMPK Signaling and Anti-Inflammatory Actions

Zhang, D., Xie, T., & Leung, P. S. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000495395 · Cited by 65 · see citing works

Irisin ameliorates angiotensin II‐induced cardiomyocyte apoptosis through autophagy

Li, R., Wang, X., Wu, S., Yao, W., Chen, H., Xin, J., Li, H., Lan, J., Xue, K., Li, X., et al. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28382 · Cited by 64 · see citing works

Anti-diabetic activity of recombinant irisin in STZ-induced insulin-deficient diabetic mice

Duan, H., Ma, B., Ma, X., Wang, H., Ni, Z., Wang, B., Li, X., Jiang, P., Umar, M., & Li, M. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.12.049 · Cited by 62 · see citing works

FNDC5 attenuates obesity-induced cardiac hypertrophy by inactivating JAK2/STAT3-associated inflammation and oxidative stress

Geng, Z., Fan, W., Zhou, B. R., Ye, C., Tong, Y., Zhou, Y., & Xiong, X. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-1857-8 · Cited by 62 · see citing works

Irisin prevents microgravity‐induced impairment of osteoblast differentiation in vitro during the space flight CRS‐14 mission

Colucci, S. C., Colaianni, G., Brunetti, G., Ferranti, F., Mascetti, G., Mori, G., & Grano, M. (2020) · The FASEB Journal · doi:10.1096/fj.202000216r · Cited by 60 · see citing works

Association of irisin concentrations with the presence of diabetic nephropathy and retinopathy

Hu, W., Wang, R., Li, J., Zhang, J., & Wang, W. (2015) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/0004563215582072 · Cited by 59 · see citing works

Serum Irisin Level Can Predict the Severity of Coronary Artery Disease in Patients with Stable Angina

Efe, T. H., Açar, B., Ertem, A. G., Yayla, K. G., Algül, E., Yayla, Ç., Ünal, S., Bilgin, M., Çimen, T., Kırbaş, Ö., et al. (2016) · Korean Circulation Journal · doi:10.4070/kcj.2016.0079 · Cited by 58 · see citing works

Irisin promotes cardiac progenitor cell-induced myocardial repair and functional improvement in infarcted heart

Zhao, Y., Wang, J., Yano, N., Zhang, L. X., Wang, H., Zhang, S.-Y., Qin, G., Dubielecka, P., Zhuang, S., Liu, P., et al. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27037 · Cited by 57 · see citing works

Aquarobic exercises improve the serum blood irisin and brain-derived neurotrophic factor levels in elderly women

Kim, J.-H., & Kim, D. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.01.024 · Cited by 56 · see citing works

Serum irisin levels are associated with adverse cardiovascular outcomes in patients with acute myocardial infarction

Hsieh, C., Ho, M.-Y., Wen, M., Chen, C., Hsieh, M., Lin, C., Yeh, J., Tsai, M., Yang, C., Wu, V. C., et al. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.11.072 · Cited by 56 · see citing works

Serum Irisin Predicts Mortality Risk in Acute Heart Failure Patients

Shen, S., Gao, R., Bei, Y., Li, J., Zhang, H., Zhou, Y., Yao, W., Xu, D., Zhou, F., Jin, M., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000477867 · Cited by 55 · see citing works

Serum levels of irisin predict short-term outcomes in ischemic stroke

Wu, H., Guo, P., Jin, Z. Y., Li, X., Yang, X., Tang, C., Wang, Y., & Ke, J. (2018) · Cytokine · doi:10.1016/j.cyto.2018.02.017 · Cited by 55 · see citing works

Irisin serum levels are positively correlated with bone mineral status in a population of healthy children

Colaianni, G., Faienza, M. F., Sanesi, L., Brunetti, G., Pignataro, P., Lippo, L., Bortolotti, S., Storlino, G., Piacente, L., D’Amato, G., et al. (2019) · Pediatric Research · doi:10.1038/s41390-019-0278-y · Cited by 55 · see citing works

Irisin Levels are Not Affected by Physical Activity in Patients with Anorexia Nervosa

Hofmann, T., Elbelt, U., Ahnis, A., Kobelt, P., Rose, M., & Stengel, A. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00202 · Cited by 54 · see citing works

Irisin counteracts high glucose and fatty acid induced cytotoxicity by preserving AMPK-insulin receptor signaling axis in C2C12 myoblast.

Yano, N., Zhang, L. X., Wei, D., Dubielecka, P., Wei, L., Zhuang, S., Zhu, P., Qin, G., Liu, P., Chin, Y., et al. (2020) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00219.2019 · Cited by 53 · see citing works

Exercise-mimicking treatment fails to increase Fndc5 mRNA & irisin secretion in primary human myotubes

Kurdiová, T., Baláž, M., Mayer, A. E., Máderová, D., Belan, V., Wolfrum, C., Ukropec, J., & Ukropcová, B. (2014) · Peptides · doi:10.1016/j.peptides.2014.03.003 · Cited by 52 · see citing works

Low serum concentrations of Irisin are associated with increased risk of hip fracture in Chinese older women

Yan, J., Liu, H.-J., Guo, W., & Yang, J. (2017) · Joint Bone Spine · doi:10.1016/j.jbspin.2017.03.011 · Cited by 52 · see citing works

The Irisin Hormone Profile and Expression in Human Bone Tissue in the Bone Healing Process in Patients

Serbest, S., Tiftikçi, U., Tosun, H. B., & Kısa, Ü. (2017) · Medical Science Monitor · doi:10.12659/msm.906293 · Cited by 52 · see citing works

Serum irisin level in myocardial infarction patients with or without heart failure

El-Mottaleb, N. A. A., Galal, H. M., Maghraby, K., & Gadallah, A. I. (2019) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2018-0736 · Cited by 52 · see citing works

DSS-induced colitis produces inflammation-induced bone loss while irisin treatment mitigates the inflammatory state in both gut and bone

Metzger, C. E., Narayanan, S. A., Elizondo, J. P., Carter, A. M., Zawieja, D. C., Hogan, H. A., & Bloomfield, S. A. (2019) · Scientific Reports · doi:10.1038/s41598-019-51550-w · Cited by 52 · see citing works

The impact of high-intensity interval exercise training on NK-cell function and circulating myokines for breast cancer prevention among women at high risk for breast cancer

Coletta, A. M., Agha, N. H., Baker, F. L., Niemiro, G. M., Mylabathula, P. L., Brewster, A. M., Bevers, T. B., Fuentes‐Mattei, E., Basen-Engquist, K. M., Gilchrist, S. C., et al. (2021) · Breast Cancer Research and Treatment · doi:10.1007/s10549-021-06111-z · Cited by 51 · see citing works

Current Evidence of the Role of the Myokine Irisin in Cancer

Tsiani, E., Tsakiridis, N., Kouvelioti, R., Jaglanian, A., & Klentrou, P. (2021) · Cancers · doi:10.3390/cancers13112628 · Cited by 51 · see citing works

The relationship between circulating irisin levels and tissues AGE accumulation in type 2 diabetes patients

Zhu, L., Wang, G., Zhu, Y., Li, C.-G., Tang, Y., Jiang, Z., Yang, M. H., Ni, C., Chen, L., & Niu, W.-Y. (2017) · Bioscience Reports · doi:10.1042/bsr20170213 · Cited by 50 · see citing works

Aerobic exercise training-induced irisin secretion is associated with the reduction of arterial stiffness via nitric oxide production in adults with obesity

Inoue, K., Fujie, S. J., Hasegawa, N., Horii, N., Uchida, M., Iemitsu, K., Sanada, K., Hamaoka, T., & Iemitsu, M. (2019) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2019-0602 · Cited by 50 · see citing works

Glucocorticoid receptor positively regulates transcription of FNDC5 in the liver

Kim, H. K., Jeong, Y. J., Song, I.-S., Noh, Y. H., Seo, K. W., Kim, M., & Han, J. (2017) · Scientific Reports · doi:10.1038/srep43296 · Cited by 49 · see citing works

Lower irisin levels in coronary artery disease: a meta-analysis

Guo, W., Zhang, B., & Wang, X. (2020) · Minerva Endocrinology · doi:10.23736/s0391-1977.17.02663-3 · Cited by 49 · see citing works

Irisin ameliorates high glucose‐induced cardiomyocytes injury via AMPK/mTOR signal pathway

Deng, J., Zhang, N., Chen, F., Yang, C., Ning, H., Xiao, C. Y., Sun, K., Liu, Y., Yang, M., Hu, T., et al. (2020) · Cell Biology International · doi:10.1002/cbin.11441 · Cited by 48 · see citing works

The Neuroprotective Effect of Irisin in Ischemic Stroke

Liu, Y., Zhu, C., Guo, J., Chen, Y., & Meng, C. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.588958 · Cited by 48 · see citing works

Circulating levels of irisin in middle-aged first-degree relatives of type 2 diabetes mellitus — correlation with pancreatic β-cell function

Yang, M., Chen, P., Jin, H., Xie, X., Gao, T., Yang, L., & Yu, X. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-133 · Cited by 46 · see citing works

Study of Irisin Hormone Level in Type 2 Diabetic Patients and Patients with Diabetic Nephropathy

Shelbaya, S., Abushady, M. M., Nasr, M. S., Bekhet, M. M., Mageed, Y. A.-A., & Abbas, M. (2018) · Current Diabetes Reviews · doi:10.2174/1573399813666170829163442 · Cited by 46 · see citing works

Irisin Protects Brain against Ischemia/Reperfusion Injury through Suppressing TLR4/MyD88 Pathway

Yu, Q., Li, G., Ding, Q., Lei, T., Li, J., Sun, L., Sun, X., & Yang, Y. (2020) · Cerebrovascular Diseases · doi:10.1159/000505961 · Cited by 46 · see citing works

Irisin treatment improves healing of dystrophic skeletal muscle

Reza, M. M., Sim, C. M., Subramaniyam, N., Ge, X., Sharma, M., Kambadur, R., & McFarlane, C. (2017) · Oncotarget · doi:10.18632/oncotarget.21636 · Cited by 45 · see citing works

Fibronectin type III domain containing 5 attenuates NLRP3 inflammasome activation and phenotypic transformation of adventitial fibroblasts in spontaneously hypertensive rats

Ling, L., Chen, D., Tong, Y., Zang, Y.-H., Ren, X., Zhou, Y., Qi, X., Chen, Q., Li, Y., Kang, Y., et al. (2018) · Journal of Hypertension · doi:10.1097/hjh.0000000000001654 · Cited by 45 · see citing works

Expressions of irisin and urotensin II and their relationships with blood pressure in patients with preeclampsia

Zhang, L., Xie, Q., Tang, C., & Zhang, A. (2017) · Clinical and Experimental Hypertension · doi:10.1080/10641963.2016.1273945 · Cited by 44 · see citing works

Relationship of serum irisin levels to prevalence and progression of coronary artery calcification: A prospective, population-based study

Hisamatsu, T., Miura, K., Arima, H., Fujiyoshi, A., Kadota, A., Kadowaki, S., Zaid, M., Miyagawa, N., Satoh, A., Kunimura, A., et al. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.05.075 · Cited by 44 · see citing works

Effects of high-intensity interval training on mitochondrial supercomplex assembly and biogenesis, mitophagy, and the AMP-activated protein kinase pathway in the soleus muscle of aged female rats

Han, C., Lu, P., & Yan, S.-Z. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111648 · Cited by 44 · see citing works

Irisin, an exercise myokine, potently suppresses tumor proliferation, invasion, and growth in glioma

Huang, C., Chang, Y., Lee, H., Wu, J., Huang, J., Chung, Y., Hsu, S.-T., Chow, L., Wei, K., & Huang, F. (2020) · The FASEB Journal · doi:10.1096/fj.202000573rr · Cited by 42 · see citing works

Exercise‐Linked Irisin Prevents Mortality and Enhances Cognition in a Mice Model of Cerebral Ischemia by Regulating Klotho Expression

Jin, Z. Y., Zhang, Z., Ke, J., Wang, Y., & Wu, H. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/1697070 · Cited by 42 · see citing works

Excessive irisin increases oxidative stress and apoptosis in murine heart

Ho, M.-Y., Wen, M., Yeh, J., Hsieh, C., Chen, C., Hsieh, M., Tsai, M., Yang, C., Wu, V. C., Hung, K., et al. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.07.005 · Cited by 41 · see citing works

Irisin protects the substantia nigra dopaminergic neurons in the rat model of Parkinson's disease.

Zarbakhsh, S., Safari, M., Aldaghi, M. R., Sameni, H. R., Ghahari, L., Lagmouj, Y. K., Jaberi, K. R., & Parsaie, H. (2019) · PubMed Central · doi:10.22038/ijbms.2019.33444.7987 · Cited by 41 · see citing works

Irisin Is a Positive Regulator for Ferroptosis in Pancreatic Cancer

Yang, B. C., & Leung, P. S. (2020) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2020.08.002 · Cited by 41 · see citing works

Role of Regular Physical Activity in Neuroprotection against Acute Ischemia

Raimondo, D. D., Rizzo, G., Musiari, G., Tuttolomondo, A., & Pinto, A. V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239086 · Cited by 41 · see citing works

FNDC5 inhibits foam cell formation and monocyte adhesion in vascular smooth muscle cells via suppressing NFκB-mediated NLRP3 upregulation

Zang, Y.-H., Chen, D., Zhou, B. R., Chen, A., Wang, J., Gao, X.-Y., Chen, Q., Li, Y., Kang, Y., & Zhu, G. (2019) · Vascular Pharmacology · doi:10.1016/j.vph.2019.106579 · Cited by 40 · see citing works

Irisin treatment lowers levels of phosphorylated tau in the hippocampus of pre‐symptomatic female but not male htau mice

Bretland, K. A., Lin, L., Bretland, K. M., Smith, M. A., Fleming, S. M., & Crish, S. D. (2021) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12711 · Cited by 40 · see citing works

Systemic Administration of Recombinant Irisin Accelerates Fracture Healing in Mice

Colucci, S. C., Buccoliero, C., Sanesi, L., Errede, M., Colaianni, G., Annese, T., Khan, M. P., Zerlotin, R., Dicarlo, M., Schipani, E., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910863 · Cited by 40 · see citing works

Obese with higher FNDC5/Irisin levels have a better metabolic profile, lower lipopolysaccharide levels and type 2 diabetes risk

Bonfante, I. L. P., Chacon‐Mikahil, M. P. T., Brunelli, D. T., Gáspari, A. F., Duft, R. G., Oliveira, A. G., Araújo, T. G., Saad, M. J. A., & Cavaglieri, C. R. (2017) · Archives of Endocrinology and Metabolism · doi:10.1590/2359-3997000000305 · Cited by 39 · see citing works

The diagnostic value of FNDC5/Irisin in renal Cell Cancer

Altay, D. U., Keha, E. E., Karagüzel, E., Menteşe, A., Yaman, S. Ö., & Alver, A. (2018) · International braz j urol · doi:10.1590/s1677-5538.ibju.2017.0404 · Cited by 39 · see citing works

Irisin lowers blood pressure by activating the Nrf2 signaling pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats.

Huo, C.-J., Yu, X.-J., Sun, Y.-J., Li, H.-B., Su, Q., Bai, J., Li, Y., Liu, K.-L., Qi, J., Zhou, S., et al. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.114953 · Cited by 39 · see citing works

Irisin Contributes to Neuroprotection by Promoting Mitochondrial Biogenesis After Experimental Subarachnoid Hemorrhage

Tu, T., Yin, S., Pang, J., Zhang, X., Zhang, L., Zhang, Y., Xie, Y., Guo, K., Chen, L., Peng, J., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.640215 · Cited by 39 · see citing works

Irisin regulates thermogenesis and lipolysis in 3T3-L1 adipocytes

Vliora, M., Grillo, E., Corsini, M., Ravelli, C., Nintou, E., Karligiotou, E., Flouris, A. D., & Mitola, S. M. F. (2022) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2022.130085 · Cited by 39 · see citing works

Irisin functions to inhibit malignant growth of human pancreatic cancer cells via downregulation of the PI3K/AKT signaling pathway

Zhang, D., Zhang, P., Li, L., Tang, N., Huang, F., Kong, X., Tan, X., & Shi, G. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s214260 · Cited by 38 · see citing works

Irisin regulates cardiac physiology in zebrafish

Sundarrajan, L., Yeung, C., Hahn, L., Weber, L. P., & Unniappan, S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181461 · Cited by 35 · see citing works

Exercise training increases cardiac, hepatic and circulating levels of brain-derived neurotrophic factor and irisin in young and aged rats

Belviranlı, M., & Okudan, N. (2018) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2018-0053 · Cited by 35 · see citing works

Irisin levels are not associated to resistance training-induced alterations in body mass composition in older untrained women with and without obesity

Tibana, R. A., Nascimento, D. D. C., de Souza, N. M. F., de Souza, V. C., Neto, I. V. D. S., Voltarelli, F. A., Pereira, G. B., Navalta, J. W., & Prestes, J. (2016) · The journal of nutrition health & aging · doi:10.1007/s12603-016-0748-4 · Cited by 34 · see citing works

Association of Circulating Irisin Levels and the Characteristics and Prognosis of Coronary Artery Disease

Pan, J.-A., Zhang, H., Yu, Q., Zhang, J.-F., Wang, C.-Q., Gu, J., & Chen, K. (2021) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2021.02.020 · Cited by 34 · see citing works

Eight Weeks of High-Intensity Interval Static Strength Training Improves Skeletal Muscle Atrophy and Motor Function in Aged Rats via the PGC-1α/FNDC5/UCP1 Pathway

Liu, Y., Guo, C., Liu, S., Zhang, S., Mao, Y., & Fang, L. (2021) · Clinical Interventions in Aging · doi:10.2147/cia.s308893 · Cited by 32 · see citing works

The Effects of Valsartan and Amlodipine on the Levels of Irisin, Adropin, and Perilipin

Çelik, H. T., Akkaya, N., Erdamar, H., Gök, S., Kazancı, F. H., Demirçelik, B., Çakmak, M., & Yiǧitoǧlu, M. R. (2015) · Clinical Laboratory · doi:10.7754/clin.lab.2015.150420 · Cited by 31 · see citing works

Irisin increases the expression of anorexigenic and neurotrophic genes in mouse brain

Natalicchio, A., Marrano, N., Biondi, G., Dipaola, L., Spagnuolo, R., Cignarelli, A., Perrini, S., Laviola, L., & Giorgino, F. (2020) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3238 · Cited by 31 · see citing works

Association of Circulating Irisin Levels with Adiposity and Glucose Metabolic Profiles in a Middle-Aged Chinese Population: A Cross-Sectional Study

Zhang, R., Fu, T., Zhao, X., Qiu, Y., Hu, X., Shi, H., & Yin, X. L. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s275878 · Cited by 30 · see citing works

Irisin promotes C2C12 myoblast proliferation via ERK-dependent CCL7 upregulation

Lee, J., Park, J., Kim, Y. H., Lee, N. H., & Song, K. (2019) · PLoS ONE · doi:10.1371/journal.pone.0222559 · Cited by 29 · see citing works

Can the Irisin be a Biomarker for Prostate Cancer? A Case Control Study

Aslan, R., Hakan, H., Eryılmaz, R., Huyut, Z., Sevim, M., Araz, Ş., Ertaş, K., & Taken, K. (2020) · Asian Pacific Journal of Cancer Prevention · doi:10.31557/apjcp.2020.21.2.505 · Cited by 29 · see citing works

Association of Plasma Irisin with Bone Mineral Density in a Large Chinese Population Using an Extreme Sampling Design

Wu, L., Zhu, D., Tang, C.-H., Ge, B., Shi, J. F., Wang, B., Lu, Y., He, P., Wang, W., Lu, S., et al. (2018) · Calcified Tissue International · doi:10.1007/s00223-018-0415-3 · Cited by 28 · see citing works

Irisin injection mimics exercise effects on the brain proteome

Dehghan, F., Zamani, S., Barreiro, C., & Jami, M. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15493 · Cited by 28 · see citing works

The diagnostic and prognostic roles of serum irisin in bladder cancer

Esawy, M. M., & Abdel-Samd, K. M. (2019) · Current Problems in Cancer · doi:10.1016/j.currproblcancer.2019.100529 · Cited by 26 · see citing works

Effects of intra-dentate gyrus microinjection of myokine irisin on long-term potentiation in male rats

Mohammadi, S., Oryan, S., Komaki, A., Eidi, A., & Zarei, M. (2019) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x20190184 · Cited by 26 · see citing works

FNDC5 promotes paclitaxel sensitivity of non-small cell lung cancers via inhibiting MDR1

Fan, G.-H., Zhu, T.-Y., & Huang, J. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109665 · Cited by 26 · see citing works

Exercise-Induced Circulating Irisin Level Is Correlated with Improved Cardiac Function in Rats

Seo, D. Y., Bae, J. H., Kim, T. N., Kwak, H., Kha, P. T., & Han, J. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17113863 · Cited by 26 · see citing works

Irisin promotes cementoblast differentiation via p38 MAPK pathway

Zhu, J., Wang, Y., Cao, Z., Du, M., Hao, Y., Pan, J., & He, H. (2020) · Oral Diseases · doi:10.1111/odi.13307 · Cited by 24 · see citing works

Irisin induces white adipose tissue browning in mice as assessed by magnetic resonance imaging

Chen, Y., Ding, J., Zhao, Y., Ju, S., Mao, H. Z., & Peng, X. (2021) · Experimental Biology and Medicine · doi:10.1177/15353702211006049 · Cited by 24 · see citing works

Irisin reverses platelet derived growth factor-BB-induced vascular smooth muscle cells phenotype modulation through STAT3 signaling pathway

Song, H., Xu, J., Lv, N., Zhang, Y., Wu, F., Li, H., Shao, L., Mu, Q., Wang, F., Tang, D., et al. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.07.052 · Cited by 23 · see citing works

Effects of Irisin Compared with Exercise on Specific Metabolic and Obesity Parameters in Female Mice with Obesity

Yüksel, B., Demiral, İ., Zeybek, Ü., Çelik, F., Buyru, F., Yeh, J., & Baştu, E. (2020) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2019.0083 · Cited by 23 · see citing works

Irisin has no effect on lipolysis in 3T3-L1 adipocytes or fatty acid metabolism in HepG2 hepatocytes

Wang, C., Wang, L., Li, W., Yan, F., Tian, M., Wu, C., Qi, L., Wang, X., Song, J., Hou, X., et al. (2014) · Endocrine · doi:10.1007/s12020-014-0458-9 · Cited by 22 · see citing works

Serum Irisin Levels and Clinical Implication in Elderly Patients With Type 2 Diabetes Mellitus

Xuan, X., Lin, J., Zhang, Y., Zhou, L., Xu, L., Jia, J., Zhao, B., Lin, Z., Zhu, Q. N., Li, L., et al. (2020) · Journal of Clinical Medicine Research · doi:10.14740/jocmr4261 · Cited by 21 · see citing works

Exercise in the heat induces similar elevations in serum irisin in young and older men despite lower resting irisin concentrations in older adults

McCormick, J. J., King, K. E., Notley, S. R., Fujii, N., Boulay, P., Sigal, R. J., & Kenny, G. P. (2022) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2022.103189 · Cited by 21 · see citing works

Irisin and Visfatin Predicts Severity of Diabetic Nephropathy

Mageswari, R., Sridhar, M. G., Nandeesha, H., Parameswaran, S., & Vinod, K. V. (2018) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-018-0749-7 · Cited by 20 · see citing works

Interplay of skeletal muscle and adipose tissue: sarcopenic obesity.

Park, M., & Choi, K. M. (2023) · Metabolism: Clinical and Experimental · doi:10.1016/j.metabol.2023.155577 · Cited by 106 · see citing works

Bone and muscle crosstalk in ageing and disease

Kirk, B., Lombardi, G., & Duque, G. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-025-01088-x · Cited by 81 · see citing works

Metabolic reprogramming in ischemic stroke: when glycolytic overdrive meets lipid storm

Wang, Y., Ge, M., Wang, J., Xu, Y., Wang, N., & Xu, S. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08114-w · Cited by 75 · see citing works

Myokines: Metabolic regulation in obesity and type 2 diabetes

Chen, Z.-T., Weng, Z.-X., Lin, J. D., & Meng, Z.-X. (2024) · Life Metabolism · doi:10.1093/lifemeta/loae006 · Cited by 58 · see citing works

Irisin alleviates obesity-induced bone loss by inhibiting interleukin 6 expression via TLR4/MyD88/NF-κB axis in adipocytes

Zhang, Y.-S., He, X., Wang, K., Xue, Y., Hu, S.-H., Jin, Y.-S., Zhu, G., Rui, Y.-J., & Shi, Q. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.04.013 · Cited by 49 · see citing works

Endurance exercise preconditioning alleviates ferroptosis induced by doxorubicin-induced cardiotoxicity through mitochondrial superoxide-dependent AMPKα2 activation

Wang, L., Yang, Q., Yu, J., Wang, Q., Wu, X., Cao, Q., Zhang, Z., Feng, Z., & He, H. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103079 · Cited by 39 · see citing works

Exploring exercise-driven exerkines: unraveling the regulation of metabolism and inflammation

Zhou, N., Gong, L., Zhang, E., & Wang, X. (2024) · PeerJ · doi:10.7717/peerj.17267 · Cited by 34 · see citing works

Vitamin D and Sarcopenia in the Senior People: A Review of Mechanisms and Comprehensive Prevention and Treatment Strategies

Zhang, F., & Li, W. (2024) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s471191 · Cited by 35 · see citing works

Bridging neurotrophic factors and bioactive peptides to Alzheimer’s disease

Wei, M., Wu, T., & Chen, N. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102177 · Cited by 31 · see citing works

Control of muscle satellite cell function by specific exercise‐induced cytokines and their applications in muscle maintenance

Guo, Q., Luo, Q., & Song, G. (2024) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13440 · Cited by 32 · see citing works

Enhancing cardiometabolic health: unveiling the synergistic effects of high-intensity interval training with spirulina supplementation on selected adipokines, insulin resistance, and anthropometric indices in obese males

Delfan, M., Saeidi, A., Supriya, R., Escobar, K. A., Laher, I., Heinrich, K. M., Weiss, K., Knechtle, B., & Zouhal, H. (2024) · Nutrition & Metabolism · doi:10.1186/s12986-024-00785-0 · Cited by 31 · see citing works

Titanium implants with antiaging effect to repair senile osteoporosis fracture

Li, K., Tao, B., Tian, H., Wu, J., Huang, K., Yan, C., Chen, S., Guo, A., & Jiang, D. (2023) · Materials & Design · doi:10.1016/j.matdes.2023.112071 · Cited by 28 · see citing works

Relationship of irisin with disease severity and dopamine uptake in Parkinson's disease patients

Shi, X., Gu, Q., Fu, C., Ma, J., Li, D., Zheng, J., Chen, S., She, Z., Qi, X., Li, X., et al. (2023) · NeuroImage Clinical · doi:10.1016/j.nicl.2023.103555 · Cited by 24 · see citing works

A framework of biomarkers for skeletal muscle aging: a consensus statement by the Aging Biomarker Consortium

Huang, N., Ge, M., Liu, X., Tian, X., Yin, P., Bao, Z., Cao, F., Shyh‐Chang, N., Dong, B., Dai, L., et al. (2024) · Life Medicine · doi:10.1093/lifemedi/lnaf001 · Cited by 24 · see citing works

Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis

Wang, J., Jia, D., Zhang, Z., & Wang, D. (2025) · Metabolites · doi:10.3390/metabo15010059 · Cited by 23 · see citing works

Dietary Protein and Physical Exercise for the Treatment of Sarcopenia

Nasso, R., D’Errico, A., Motti, M. L., Masullo, M., & Arcone, R. (2024) · Clinics and Practice · doi:10.3390/clinpract14040117 · Cited by 22 · see citing works

Knockdown of SIRT3 perturbs protective effects of irisin against bone loss in diabetes and periodontitis

Li, G., Qin, H., Zhou, M., Zhang, T., Zhang, Y., Ding, H., Xu, L., & Song, J. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.02.023 · Cited by 20 · see citing works

A promising therapeutic peptide and preventive/diagnostic biomarker for age-related diseases: The Elabela/Apela/Toddler peptide

Monastero, R., Magro, D., Venezia, M., Pisano, C., & Balistreri, C. R. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102076 · Cited by 20 · see citing works

BMAL1/PGC1α4-FNDC5/irisin axis impacts distinct outcomes of time-of-day resistance exercise

Guo, M., Shen, F., Guo, X., Zhang, J., Ma, Y., Wu, X., Zuo, H., Yao, J., Hu, Y., Wang, D., et al. (2024) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2024.100968 · Cited by 19 · see citing works

New perspectives on molecular mechanisms underlying exercise-induced benefits in Parkinson’s disease

Chen, X., Zhang, G., Liu, M., He, J., & Zhang, Z. (2025) · npj Parkinson s Disease · doi:10.1038/s41531-025-01113-w · Cited by 18 · see citing works

Exercise in cold: Friend than foe to cardiovascular health

Feng, Z., Hu, Y., Yu, S., Bai, H., Sun, Y., Gao, W., Li, J., Qin, X., & Zhang, X. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121923 · Cited by 17 · see citing works

New insights into the roles of Irisin in diabetic cardiomyopathy and vascular diseases

Zhang, T., Qian, Y., Huang, W., Feng, J., & Liu, H. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116631 · Cited by 19 · see citing works

Exercise-Induced Biomarker Modulation in Sarcopenia: From Inflamm-Aging to Muscle Regeneration

Marmondi, F., Ferrando, V., Filipas, L., Codella, R., Ruggeri, P., Torre, A. L., Faelli, E. L., & Bonato, M. (2025) · Sports · doi:10.3390/sports13120444 · Cited by 16 · see citing works

Irisin, an Effective Treatment for Cardiovascular Diseases?

Liu, C., Wei, A., & Wang, T. (2022) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd9090305 · Cited by 16 · see citing works

Irisin alleviates hepatic steatosis by activating the autophagic SIRT3 pathway

Zhao, Y., Li, J., Ma, A., Wang, Z., Ni, Y., Wu, D., Zhou, Y., Zhang, N., Zhang, L., Chang, Y., et al. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003427 · Cited by 15 · see citing works

Gut microbiota and bone aging: Focusing on the gut-X axis modes

Zhang, Y.-W., Li, R.-Y., Wu, Y., Wang, P., Zhou, Q., & Su, J. (2026) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2026.101064 · Cited by 16 · see citing works

Move Your Body toward Healthy Aging: Potential Neuroprotective Mechanisms of Irisin in Alzheimer’s Disease

Bellettini‐Santos, T., Batista-Silva, H., Pereira, C. M., Castro, F. C. D. A. Q., Barcelos, R. M., Chiepe, K. C. M. B., Rossoni, J. V., Ambrósio, R. P., da Silva, B. S., Chiarelli-Neto, O., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512440 · Cited by 15 · see citing works

Effects of acute and chronic high-intensity interval training on serum irisin, BDNF and apelin levels in male soccer referees

Küçük, H., Söyler, M., Ceylan, T., Ceylan, L., & Şahin, F. N. (2024) · Journal of Men s Health · doi:10.22514/jomh.2024.027 · Cited by 15 · see citing works

The role and underlying mechanisms of irisin in exercise-mediated cardiovascular protection

Guo, W., Peng, J., Su, J., Xia, J., Deng, W., Li, P., Chen, Y., Liu, G., Wang, S., & Huang, J. (2024) · PeerJ · doi:10.7717/peerj.18413 · Cited by 15 · see citing works

The role of exercise in enhancing brain and cerebrovascular health via the bone–brain axis: implications for surgical and clinical interventions

Shi, H., Huang, L., Wang, Q., Zhang, N., Lv, C., Lin, C., Shao, L., Xia, D., Zhao, Z., Yang, G., et al. (2025) · International Journal of Surgery · doi:10.1097/js9.0000000000003030 · Cited by 15 · see citing works

Indoxyl sulfate mediates low handgrip strength and is predictive of high hospitalization rates in patients with end-stage renal disease

Hou, Y., Liu, Y.-M., Liao, M.-T., Zheng, C., Lu, C., Liu, W.-C., Hung, K.-C., Lin, S.-M., & Lu, K. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1023383 · Cited by 14 · see citing works

Unveiling the muscle-brain axis: A bidirectional mendelian randomization study investigating the causal relationship between sarcopenia-related traits and brain aging

Ze-fang, L., Wu, X., Yan, Z., Cui, Y., Liu, Y., Cui, S., Wang, Y., & Liu, T. (2024) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2024.105412 · Cited by 13 · see citing works

Deletion of FNDC5/irisin modifies murine osteocyte function in a sex-specific manner

Shimonty, A., Pin, F., Prideaux, M., Peng, G., Huot, J. R., Kim, H., Rosen, C. J., Spiegelman, B. M., & Bonewald, L. F. (2024) · eLife · doi:10.7554/elife.92263.3 · Cited by 13 · see citing works

Deletion of FNDC5/irisin modifies murine osteocyte function in a sex-specific manner

Shimonty, A., Pin, F., Prideaux, M., Peng, G., Huot, J. R., Kim, H., Rosen, C. J., Spiegelman, B. M., & Bonewald, L. F. (2023) · eLife · doi:10.7554/elife.92263 · Cited by 23 · see citing works

Cardioprotective Effects of Exercise: The Role of Irisin and Exosome

Wang, Y., Yang, Y., & Song, Y. (2024) · Current Vascular Pharmacology · doi:10.2174/0115701611285736240516101803 · Cited by 12 · see citing works

Resistance Training Reduces Blood Pressure: Putative Molecular Mechanisms

Mendes, B. F., Caria, A. C. I., Magalhães, C. O. D. E., Dias‐Peixoto, M. F., Cassilhas, R. C., de Oliveira, E. M., & Sousa, R. A. L. D. (2024) · Current Hypertension Reviews · doi:10.2174/0115734021277791240102041632 · Cited by 11 · see citing works

RNA-mediated epigenetic regulation in exercised heart: Mechanisms and opportunities for intervention

Wang, L., Wan, W., Zhang, S., Keswani, T., Li, G., & Xiao, J. (2024) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2024.101274 · Cited by 11 · see citing works

Effects of Different Intensities of Endurance Training on Neurotrophin Levels and Functional and Cognitive Outcomes in Post-Ischaemic Stroke Adults: A Randomised Clinical Trial

Górna, S., Podgórski, T., Kleka, P., & Domaszewska, K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062810 · Cited by 11 · see citing works

The emerging role of exercise preconditioning in preventing skeletal muscle atrophy

Zhou, X., Li, S., Wang, L., Wang, J., Zhang, P., & Chen, X. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1559594 · Cited by 10 · see citing works

Exercise attenuates the hallmarks of aging: Novel perspectives

Qiu, Y., Fernández‐Garcia, B., Lehmann, H. I., Li, G., Kroemer, G., López-Otı́n, C., & Xiao, J. (2025) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2025.101108 · Cited by 15 · see citing works

Irisin Ameliorates Renal Tubulointerstitial Fibrosis by Regulating the Smad4/β-Catenin Pathway in Diabetic Mice

Yang, Z., Wei, J., Wang, Y., Du, Y., Song, S., Li, J., Su, Z., Shi, Y., & Wu, H. (2023) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s407734 · Cited by 9 · see citing works

The emerging roles of irisin in vascular calcification

Wang, S., Hu, S., & Pan, Y. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1337995 · Cited by 8 · see citing works

The association between circulating irisin levels and osteoporosis in women: a systematic review and meta-analysis of observational studies

Shen, X., Chen, Y., Zhang, J., Yang, M., Huang, L. H., Luo, J., & Xu, L. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1388717 · Cited by 8 · see citing works

Irisin improves ROS‑induced mitohormesis imbalance in H9c2 cells

Wang, B., Xu, H., Shang, S., Liu, L., Sun, C., & Du, W. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13364 · Cited by 7 · see citing works

Improving effect of physical exercise on heart failure: Reducing oxidative stress-induced inflammation by restoring Ca2+ homeostasis

Yuan, S., Kuai, Z., Zhao, F., Xu, D., & Wu, W. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-05124-8 · Cited by 7 · see citing works

Exercise Mimetic Exosomes Re‐establish the Extracellular Matrix Metabolic Balance and Alleviate the Inflammatory Macrophage Infiltration in Intervertebral Disc Degeneration

Zhao, K., Cui, Y., Du, Y., Zheng, L., Liang, Y., Liu, C., Hecker, P., Moroz, O., Zhu, L., & Zhan, J. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202500219 · Cited by 6 · see citing works

Irisin Increases Sirtuin 1 to Improve Glucocorticoid-Induced Sarcopenia and Mitochondrial Dysfunction

Shi, H., Sun, W., Cao, X., Fan, X., Xie, W., Hao, X., Wang, S., Lu, J., Yan, Y., Luo, X., et al. (2025) · Cells · doi:10.3390/cells14211675 · Cited by 6 · see citing works

Exercise mimetics: molecular mechanisms, biological and therapeutic effects

Zhang, J., Shao, Q., 程腾, Lin, J., Tang, Y., Lu, H., Zhang, Y., Yu, Z., & Cao, L. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00483-8 · Cited by 8 · see citing works

Rejuvenation of the Aging Heart: Molecular Determinants and Applications

Alibhai, F. J., & Li, R. (2024) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2024.03.004 · Cited by 7 · see citing works

Engineered long-acting Irisin-albumin binding domain fusion protein for enhanced anti-inflammatory efficacy in lipopolysaccharide-induced systemic inflammation

Zhu, J., Zhang, Y., Wang, X., Peng, L., Ma, X., Qiu, Z., Kang, Z., Zheng, F., Zhang, X., Song, M., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-09000-z · Cited by 5 · see citing works

Decorin Deficiency Promotes D‐Galactose–Induced Skeletal Muscle Atrophy and Fibrosis by Regulating ITGB1/Akt/mTOR Signalling Pathway

Luo, X., Zhang, M., Chen, L.-L., Wang, R., Lian, J., Yang, Z., Iozzo, R. V., Wang, J., Zhang, Y., & Bi, X. (2025) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.70144 · Cited by 6 · see citing works

Irisin-mediated hepatic autophagy remodels nutritional metabolism to prevent cognitive dysfunction

Zhang, X., Yang, Y., Song, H., Hu, X., Wang, X., & Yu, Y. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102936 · Cited by 4 · see citing works

Irisin targets the HK1–glycolysis–NLRP3 pyroptosis axis to prevent chronic kidney disease-associated vascular calcification

Xu, W., Wang, P., Zhu, X., Zhang, Z., Dong, X., An, R., Pang, Q., & Zhang, A. (2025) · Renal Failure · doi:10.1080/0886022x.2025.2610545 · Cited by 4 · see citing works

Myokines as molecular mediators of the muscle–brain axis: Mechanisms linking sarcopenia to cognitive decline and implications for preventive strategies in ageing — A narrative review

Dharmansyah, D., Rahayuwati, L., Defi, I. R., Pramukti, I., & Mutyara, K. (2026) · Experimental Gerontology · doi:10.1016/j.exger.2026.113247 · Cited by 3 · see citing works

A 21-Day Individual Rehabilitation Exercise Training Program Changes Irisin, Chemerin, and BDNF Levels in Patients after Hip or Knee Replacement Surgery

Skrzep-Poloczek, B., Idzik, M., Michalczyk, K., Chełmecka, E., Kukla, M., Zalejska–Fiolka, J., Poloczek, J., Bogielski, B., Jochem, J., Nowak, D., et al. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12154881 · Cited by 3 · see citing works

Causal Effects of Sarcopenia-related Traits on Ischemic Stroke: A Two-sample Mendelian Randomization Study

Chen, Y., Wu, J., Yang, Y., Xiong, M., Yu, X., & Lei, S. (2024) · Clinical and Molecular Epidemiology · doi:10.53964/cme.2024009 · Cited by 3 · see citing works

Exploring the Anti-Aging Mechanisms of Queen Bee Acid Based on Network Pharmacology and Molecular Docking

Feng, Y., Tian, Y., & Huang, A. (2025) · Applied Sciences · doi:10.3390/app15063192 · Cited by 2 · see citing works

Exploring the Role of Exercise and the Lysosomal Cathepsin Family in the Regulation of Vascular–Musculoskeletal Degenerative Diseases

Fan, K., Li, X., & Wang, Z. (2025) · The FASEB Journal · doi:10.1096/fj.202501901r · Cited by 2 · see citing works

Irisin Research Landscape (2012–2024): A Bibliometric and Visual Analysis of Evolving Hotspots and Future Trends

Gao, L., Sun, W., Shi, H., Zhu, W., Wang, H., & Wang, J. (2025) · Biologics · doi:10.2147/btt.s536800 · Cited by 2 · see citing works

Protective effects of irisin in sarcopenia: a promising treatment

Chen, Y., Li, G., Gao, F., Li, R., Yang, M., Ge, Y., & Wu, X. (2026) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2026.101090 · Cited by 2 · see citing works

Parkinson and Sexuality

Graziottin, A., & Bertolasi, L. (2024) · Trends in andrology and sexual medicine · doi:10.1007/978-3-031-55080-5_29 · Cited by 2 · see citing works

High-intensity interval training and moderate-intensity continuous training alleviate vascular dysfunction in spontaneously hypertensive rats through the inhibition of pyroptosis

Li, Y., Luo, M., Chang, Q., Cao, S., Wang, Y., Chen, Z., Yang, J., & Liu, G. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e39505 · Cited by 2 · see citing works

Serum Irisin Levels are Inversely Correlated with Acute Ischaemic Stroke Incidence: Implications for Early Diagnosis in Southern China

Ouyang, F., Chen, S., Li, S., Liu, L., Guan, S., Yan, Z., Shumin, W., Zeng, Y., Liu, J., & Zhong, J. (2024) · International Journal of General Medicine · doi:10.2147/ijgm.s483793 · Cited by 2 · see citing works

Periodontal Ligament Stem Cell Aging in Age‐Related Orthodontic Changes: Mechanisms and Rescue Strategies

Tang, J., & Yang, K. (2025) · The FASEB Journal · doi:10.1096/fj.202501731r · Cited by 2 · see citing works

Exerkines in diabetic retinopathy: from mechanisms to therapeutic prospects

Zhu, J. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1762255 · Cited by 1 · see citing works

Sex specific effects of irisin on the skeleton

Shimonty, A., & Bonewald, L. F. (2026) · Bone Research · doi:10.1038/s41413-026-00542-4 · Cited by 1 · see citing works

The irisin-PINK1/Parkin axis plays an essential role in mediating microglial mitophagy: A crucial mechanism for exercise-induced neuroprotection against Parkinson's disease

Wang, B., Liu, X., Tian, X., Lin, J., Li, Q., Wu, Y., & Zhao, R. (2026) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2026.168335 · Cited by 1 · see citing works

The relationship of cognitive functions with brain damage markers, myokines and neurotrophic factors in amateur soccer players

IPEKTEN, E., Belviranlı, M., & Okudan, N. (2024) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765202420231132 · Cited by 1 · see citing works

Deletion of FNDC5/Irisin modifies murine osteocyte function in a sex-specific mannerPreprint

Shimonty, A., Pin, F., Prideaux, M., Peng, G., Huot, J. R., Kim, H., Rosen, C. J., Spiegelman, B. M., & Bonewald, L. F. (2024) · eLife · doi:10.7554/elife.92263.2 · Cited by 1 · see citing works

Can we target insulin signalling for cognition therapeutics?

Macrı̀, S., & Giovanni Laviola, A. (2024) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2024.2407821 · Cited by 1 · see citing works

Deletion of FNDC5/Irisin modifies murine osteocyte function in a sex-specific mannerPreprint

Shimonty, A., Pin, F., Prideaux, M., Peng, G., Huot, J. R., Kim, H., Rosen, C. J., Spiegelman, B. M., & Bonewald, L. F. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.06.565774

Changes in the Level of Irisin in the Blood of Women with Obesity Under Different Fitness Programs

Panchenko, Y., & Drozdovska, S. (2023) · CHERKASY UNIVERSITY BULLETIN BIOLOGICAL SCIENCES SERIES · doi:10.31651/2076-5835-2018-1-2023-2-89-94

Deletion of FNDC5/Irisin modifies murine osteocyte function in a sex-specific mannerPreprint

Shimonty, A., Pin, F., Prideaux, M., Peng, G., Huot, J. R., Kim, H., Rosen, C. J., Spiegelman, B. M., & Bonewald, L. F. (2023) · eLife · doi:10.7554/elife.92263.1

Parkinson’s Disease

Cremascoli, R. (2024) · Springer eBooks · doi:10.1007/978-3-031-18545-8_13

Gut microbiota and skeletal muscle axis in sports performance through nutrological activation of irisin and microRNAs: a systematic review

Lopes, H. M., Nogueira, M. A., Alves, M. C., Carvalho, R. D. O., Cano, A. C. S., Soares, V. C., Izidorio, F. T., Pereira, J. D. S., Salvá, M. D. A., & Alves, T. V. (2024) · International Journal of Nutrology · doi:10.54448/ijn24303

Decreased Expression and Secretion of the Myokine Fndc5/Irisin by Cisplatin Treatment in Mouse Skeletal Muscle

Miyauchi, Y., Soga, S., Nanri, H., Yonamine, S., Ogiwara, T., Kiyama, M., Kon, R., Ikarashi, N., Chiba, Y., Hosoe, T., et al. (2025) · Calcified Tissue International · doi:10.1007/s00223-025-01406-5

Circulating irisin and rehabilitation: expanding cutting edge research of muscle-derivate endocrine profile to the physical activity/therapy in various ailments

Suveică, L., Loghin-Oprea, N., Schipor, S. V., Cumpătă, V., Carşote, M., Gheorghe, A.-M., Sima, O.-C., Costăchescu, M., Petrova, E., Trandafir, A.-I., et al. (2025) · Balneo and PRM Research Journal · doi:10.12680/balneo.2025.884

Irisin and exercise activate renal anti-aging pathways and enhance survival in young mice: a translational insight into muscle-kidney crosstalk

Aghili, Z. S., Homayoun, M., Rezazadeh, H., & Zamani, S. (2025) · European Journal of Translational Myology · doi:10.4081/ejtm.2025.14214

Circulating Irisin as a Possible Marker of Glucose and Bone Metabolism: Evidence from the IRI-OP-OB Pilot Study

Cumpătă, V., Gheorghe, A.-M., Suveică, L., Sima, O.-C., Loghin-Oprea, N., Costăchescu, M., Petrova, E., Trandafir, A.-I., Popescu, A., Manda, D. A., et al. (2026) · Diabetology · doi:10.3390/diabetology7020023

Overexpression of irisin reduces embryonic and diet-induced hepatic lipid accumulation in chickens

Liu, J., Wang, J., Xiao, N., Lu, H., Han, R., Tao, B., Yan, P., Wu, Z., Wang, X., & Tang, X. (2026) · Poultry Science · doi:10.1016/j.psj.2026.106831

Relación entre resistina e irisina y la placa de ateroma evaluada mediante tomografía de coherencia óptica en pacientes con enfermedad coronaria

Álvarez, C. B., Esteban, M. R., González, N. T., Hernández-Afonso, J. S., González, D. A., & de León, A. C. (2026) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2026.500942

Exercise hormone irisin alleviates rheumatoid arthritis by removing dysfunctional mitochondria

Wu, Y., Fu, T., Teng, Y., Pan, Y., Li, L., Feng, Y., & Lin, J. (2026) · Autophagy · doi:10.1080/15548627.2026.2680560

Predictive Factors for Changes in Serum Irisin Concentrations after Different Exercise Interventions

Chen, T., Gu, Z.-Z., & He, Z. (2026) · International Journal of Sports Medicine · doi:10.1055/a-2912-9831

Circulating biomarkers of the brain–muscle–metabolic axis in primary sarcopenia: neudesin, nesfatin-1, and irisin

Avcı, G. U., Bilgin, S., Avcı, Y., Can, G., Bolayırlı, M., Erdinçler, D. S., & Döventaş, A. (2026) · European Geriatric Medicine · doi:10.1007/s41999-026-01582-z

Relationship between resistin and irisin and atherosclerotic plaque characteristics assessed by optical coherence tomography in patients with coronary artery disease

Álvarez, C. B., Esteban, M. R., González, N. T., Afonso, J. S. H., González, D. A., & de León, A. C. (2026) · Clínica e Investigación en Arteriosclerosis (English Edition) · doi:10.1016/j.artere.2026.500942

Cinnamaldehyde combined with 18β-glycyrrhetinic acid promotes the differentiation of C3H10T1/2 MSCs into thermogenic adipocytes through PGC1α/FNDC5/UCP1 pathway

Lai, T., Lin, Y., Ding, F., Shi, Z., Jun, Z., Yan, Y., Gu, S., Zhong, K., Liu, J., Liang, W., et al. (2026) · Adipocyte · doi:10.1080/21623945.2026.2719272

Correlation Between Cognitive Function and Serum Irisin Levels in Parkinson's Disease Patients

Gui, M., Qin, L., Lv, L., Huang, J., Hu, S., Chen, K., Wang, X., Zhou, Y., Tang, B., 张海南, et al. (2026) · Brain and Behavior · doi:10.1002/brb3.71848

Irisin enhances longevity by boosting SIRT1, AMPK, autophagy and telomerase

Sánchez, B., Muñoz-Pinto, M. F., & Cano, M. (2023) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2022.41 · Cited by 38 · see citing works

Irisin: An anti-inflammatory exerkine in aging and redox-mediated comorbidities

Trettel, C. D. S., Pelozin, B. R. D. A., Barros, M. P., Bachi, A. L. L., Braga, P. G. S., Momesso, C. M., Furtado, G. E., Valente, P. A., de Oliveira, E. M., Hogervorst, E., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1106529 · Cited by 55 · see citing works

Irisin, a mediator of muscle crosstalk with other organs: from metabolism regulation to protective and regenerative effects

Momenzadeh, S., Jami, M., Jalalvand, A., Esfarjani, F., Shahabi, S., & Zamani, S. (2022) · Current Protein and Peptide Science · doi:10.2174/1389203723666220217141918 · Cited by 13 · see citing works

Irisin and Autophagy: First Update

Pesce, M., Ballerini, P., Paolucci, T., Puca, I., Farzaei, M. H., & Patruno, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207587 · Cited by 59 · see citing works

Irisin, an exercise‐induced myokine as a metabolic regulator: an updated narrative review

Chen, N., Li, Q., Liu, J., & Jia, S. (2015) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2660 · Cited by 164 · see citing works