Practical Guide to Glucocorticoid Induced Hyperglycaemia and Diabetes
Open accessAbstract
Glucocorticoids, also known as steroids, are a class of anti-inflammatory drugs utilised widely in clinical practice for a variety of conditions. They are associated with a range of side effects including abnormalities of glucose metabolism. Multiple guidelines have been published to illustrate best management of glucocorticoid-induced hyperglycaemia and diabetes in a variety of settings. This article discusses current best clinical practice including diagnosis, investigations and ongoing management of glucocorticoid-induced dysglycaemia in both in- and outpatient settings.
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Glucocorticoid-Induced Hyperglycemia: A Neglected Problem
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“3 – 7 GC-induced hyperglycaemia is mediated by several mechanisms, including increased hepatic gluconeogenesis, decreased peripheral glucose uptake, and reduced insulin sensitivity, all of which can complicate glycaemic management in susceptible populations, 8,9 such as in individuals with diabetes.”
- Authors
- Barker, H. L., Morrison, D., Llano, A., Sainsbury, C. A. R., & Jones, G. C.
- Affiliations
- Gartnavel General Hospital (GB)
- NHS Greater Glasgow and Clyde (GB)
- Corresponding author
- Barker, Hannah L.
- Morrison, Deborah
- Llano, Andrea
- Sainsbury, Christopher A. R.
- Jones, Gregory C.
- Venue
- Diabetes Therapy
- Published
- 2023-03-24
- Volume
- 14
- Issue
- 5
- Pages
- 937-945
- ISSN
- 1869-6953 (ISSN-L)
- 1869-6961
- PMC
- PMC10037401
- OpenAlex
- W4360816348
- Cited by
- 58
- References
- 20
- Citations by year
- 2026: 32 · 2025: 13 · 2024: 13
- FWCI
- 12.10
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Diabetes Therapy (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- glucocorticoids, glucocorticoid-induced diabetes, dysglycemia, glucose metabolism, anti-inflammatory agents, diabetes management, outpatient management
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