Risk of Diabetes Associated With Prescribed Glucocorticoids in a Large Population
Abstract
The burden of diabetes is increasing (1), as is the frequency of atopic disease (2), which is often treated with glucocorticoid drugs. Because of this, we asked, “What proportion of incident diabetic cases in a population is associated with prescribed glucocorticoid drugs?” A nested case-control study was implemented using The Health Improvement Network (3), which is a database containing electronic medical records from family practices in the U.K. (4). Data analyzed included medical diagnostic codes recorded for each consultation, as well as hospital referrals and discharges, and drug codes for all prescriptions issued by the practice. Primary care electronic records were subject to several validation studies (5). This study was approved by the South East Research Ethics Committee. The study population was drawn from 114 family practices with 644,495 registered patients aged ≤100 years. Diabetic case subjects were selected if the date of the first clinical diagnosis of diabetes was between 1 November 2003 and 31 October 2004 and if they were aged between 30 and 89 years at diagnosis and were never prescribed insulin or diagnosed with type 1 diabetes. Two control subjects were randomly selected for each case. The control subjects were matched for age, sex, and practice and were never diagnosed with diabetes or prescribed oral antidiabetic drugs or insulin. The entry date …
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In large retrospective case-control studies, low-dose GC treatment increased the risk of developing diabetes.
“and increased the risk of developing diabetes [15]”
From Low-dose glucocorticoid treatment affects multiple aspects of intermediary metabolism in healthy humans: a randomised controlled trial (2011) · cites this paper as [15]
Low-dose prednisolone-induced hepatic and adipose tissue insulin resistance provides supportive mechanisms for observations in large retrospective case-control studies that reported increased risk to develop diabetes and increased need to initiate blood-glucose lowering therapy during or following low-dose GC therapy.
“Our data, demonstrating clear low-dose prednisolone-induced hepatic and adipose tissue insulin resistance, provide supportive mechanisms for observations made in large retrospective case–control studies that reported increased risk to develop diabetes [15] and increased need to initiate blood-glucose lowering therapy [14] during or following low-dose GC therapy.”
From Low-dose glucocorticoid treatment affects multiple aspects of intermediary metabolism in healthy humans: a randomised controlled trial (2011) · cites this paper as [15]
Prominent hyperglycaemia is most often observed with high-dose glucocorticoids in persons with known diabetes, but may also occur at moderate and low doses in persons not previously known to be at risk.
“Prominent hyperglycaemia is most often observed when high dosages of GC are taken by persons with known diabetes, but may also occur at moderate and low doses in persons not previously known to be at risk.3,4”
From Twenty‐four‐hour profiles of plasma glucose, insulin, C‐peptide and free fatty acid in subjects with varying degrees of glucose tolerance following short‐term, medium‐dose prednisone (20 mg/day) treatment: evidence for differing effects on insulin secretion and action (2012) · cites this paper as [3]
Cites
Reducing Bias in Observational Studies Using Subclassification on the Propensity Score
Rosenbaum, P. R., & Rubin, D. B. (1984) · Journal of the American Statistical Association · doi:10.1080/01621459.1984.10478078 · Cited by 3,082 · see citing works
(1958) · Journal of the American Pharmaceutical Association (Scientific ed ) · doi:10.1002/jps.3030470133 · Cited by 2,491 · see citing works
The Global Burden of Chronic Diseases: Overcoming Impediments to Prevention and Control
Yach, D., Hawkes, C., Gould, C. L., & Hofman, K. J. (2004) · JAMA · doi:10.1001/jama.291.21.2616 · Cited by 1,369 · see citing works
PHARMACEUTICAL SOCIETY OF GREAT BRITAIN.
Hill, A. (1930) · The Lancet · doi:10.1016/s0140-6736(00)86391-6 · Cited by 376 · see citing works
Validation of the diagnosis of venous thromboembolism in general practice database studies
Lawrenson, R., Todd, J. ‐., Leydon, G. M., Williams, T. J., & Farmer, R. D. T. (2000) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2000.00199.x · Cited by 180 · see citing works
Changes in atopy over a quarter of a century, based on cross sectional data at three time periods
Law, M., Morris, J. K., Wald, N., Luczynska, C. M., & Burney, P. (2005) · BMJ · doi:10.1136/bmj.38435.582975.ae · Cited by 102 · see citing works
Increased Incidence of Carpal Tunnel Syndrome up to 10 Years Before Diagnosis of Diabetes
Gulliford, M. C., Latinovic, R., Charlton, J., & Hughes, R. A. (2006) · Diabetes Care · doi:10.2337/dc06-0939 · Cited by 62 · see citing works
Self-citationHubbard, R. (2005) · Thorax · doi:10.1136/thx.2005.041798 · Cited by 62 · see citing works
Current use of glucocorticoids in patients with rheumatoid arthritis in Germany
Thiele, K., Buttgereit, F., Huscher, D., & Zink, A. (2005) · Arthritis Care & Research · doi:10.1002/art.21467 · Cited by 61 · see citing works
Increased Utilization of Primary Care 5 Years Before Diagnosis of Type 2 Diabetes
Gulliford, M. C., Charlton, J., & Latinovic, R. (2005) · Diabetes Care · doi:10.2337/diacare.28.1.47 · Cited by 24 · see citing works
Self-citationEstimation of attributable risk for case‐control studies with multiple matching
Lui, K. (2005) · Statistics in Medicine · doi:10.1002/sim.2159 · Cited by 6 · see citing works
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Cited by
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Glucocorticoid-induced hyperglycemia
Clore, J. N., & Thurby-Hay, L. (2009) · Endocrine Practice · doi:10.4158/ep08331.rar · Cited by 508 · see citing works
Tamez-Pérez, H. E. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i8.1073 · Cited by 387 · see citing works
Dregan, A., Charlton, J., Chowienczyk, P., & Gulliford, M. C. (2014) · Circulation · doi:10.1161/circulationaha.114.009990 · Cited by 303 · see citing works
Self-citationMolecular Mechanisms of Glucocorticoid-Induced Insulin Resistance
Beaupere, C., Liboz, A., Fève, B., Blondeau, B., & Guillemain, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020623 · Cited by 271 · see citing works
van Raalte, D. H., Brands, M., van der Zijl, N. J., Muskiet, M. H., Pouwels, P. J. W., Ackermans, M. T., Sauerwein, H. P., Serlie, M. J., & Diamant, M. (2011) · Diabetologia · doi:10.1007/s00125-011-2174-9 · Cited by 109 · see citing works
A practical guide for the management of steroid induced hyperglycaemia in the hospital
Aberer, F., Hochfellner, D. A., Sourij, H., & Mader, J. K. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10102154 · Cited by 110 · see citing works
Steroid-induced hyperglycemia: An underdiagnosed problem or clinical inertia? A narrative review
Bonaventura, A., & Montecucco, F. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2018.03.006 · Cited by 108 · see citing works
β-cell adaptation in a mouse model of glucocorticoid-induced metabolic syndrome
Fransson, L., Franzén, S., Rosengren, V., Wolbert, P., Sjöholm, Å., & Ortsäter, H. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0189 · Cited by 59 · see citing works
Glucocorticoid-Induced Hyperglycemia: A Neglected Problem
Cho, J.-H., & Suh, S. (2024) · Endocrinology and Metabolism · doi:10.3803/enm.2024.1951 · Cited by 63 · see citing works
Yuen, K. C. J., McDaniel, P. A., & Riddle, M. C. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04242.x · Cited by 58 · see citing works
Practical Guide to Glucocorticoid Induced Hyperglycaemia and Diabetes
Barker, H. L., Morrison, D., Llano, A., Sainsbury, C. A. R., & Jones, G. C. (2023) · Diabetes Therapy · doi:10.1007/s13300-023-01393-6 · Cited by 58 · see citing works
Dhital, S. M., Shenker, Y., Meredith, M., & Davis, D. B. (2012) · Endocrine Practice · doi:10.4158/ep11371.or · Cited by 49 · see citing works
Management of steroid-induced hyperglycemia in hospitalized patients with cancer: a review
Brady, V. J., Grimes, D., Armstrong, T., & LoBiondo-Wood, G. (2014) · Oncology nursing forum · doi:10.1188/14.onf.e355-e365 · Cited by 31 · see citing works
Jain, A. B., & Lai, V. (2024) · Diabetes Therapy · doi:10.1007/s13300-024-01628-0 · Cited by 32 · see citing works
van Raalte, D. H., Diamant, M., Ouwens, D. M., Ijzerman, R. G., Linssen, M. M. L., Guigas, B., Eringa, E. C., & Serné, E. H. (2013) · Diabetologia · doi:10.1007/s00125-013-3016-8 · Cited by 33 · see citing works
- Authors
- Gulliford, M. C., Charlton, J., & Latinovic, R.
- Affiliations
- King's College London (GB)
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2006-12-01
- Volume
- 29
- Issue
- 12
- Pages
- 2728-2729
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2105803008
- Cited by
- 211
- References
- 11
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 12 · 2023: 19 · 2022: 14 · 2021: 9 · 2020: 16 · 2019: 19 · 2018: 14 · 2017: 12 · 2016: 10 · 2015: 8 · 2014: 13 · 2013: 13 · 2012: 10
- FWCI
- 1.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- glucocorticoids, diabetes risk, new-onset diabetes, atopic diseases, drug-induced diabetes, prescription drugs, primary care, Health Improvement Network, electronic health records
- MeSH terms
- Aged, Diabetes Mellitus, Female, Glucocorticoids, United Kingdom, Humans, Male, Medical Records, Middle Aged, Case-Control Studies
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