CoChat
Sign Up
Cited by 29

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

The use of Ursolit for gallstone prophylaxis following bariatric surgery: a randomized-controlled trial

Sakran, Nasser, Dar, Ron, Assalia, Ahmad, Neeman, Ziv, Farraj, Moaad, Sherf-Dagan, Shiri, Gralnek, Ian M., Hazzan, Rawi, Mokary, Shams Eldin, Nevo-Aboody, Hadar, Dola, Tamar, Kaplan, Uri, Hershko, Dan·2020·Updates in Surgery
DOI 10.1007/s13304-020-00850-2
Open this paper in CoChat — free account

Abstract

Background Although bariatric surgery (BS) predisposes patients to development of gallstone formation, a preventive strategy is still in debate. Aim To compare the incidence of gallstone formation between patients treated with ursodeoxycholic acid (UDCA) vs. placebo for a duration of 6 months following BS. Methods This multicenter randomized, double-blind controlled trial entails treatment with UDCA vs. an identical-looking placebo. The primary outcome was gallstone formation, as measured by abdominal ultrasound. Results The data of 209 subjects were enrolled in the study, and 92 subjects completed the study and were analyzed (n = 46 for each study group). The high dropout rate was mainly due to difficulties in adding more medications and swallowing the pill. Among the subjects who completed the study, 77.2% were women, and their mean age and pre-surgery BMI were 42.2 ± 10.2 years and 44.4 ± 6.1 kg/m 2 , respectively. Gallstone formation was recorded in 45.7% (n = 21) vs. 23.9% (n = 11) of subjects among placebo vs. UDCA groups, respectively, p = 0.029. Subgroup-analysis, according to surgery type, found that the results were significant only for SG subjects (p = 0.041), although the same trend was observed for OAGB/RYGB. Excess Weight Loss percent (%EWL) at 6 months post-surgery was 66.0 ± 17.1% vs. 71.8 ± 19.5% for the placebo and UDCA groups, respectively; p = 0.136. A trend towards a reduction in prescribed comorbidity medications was noted within-groups during the follow…

Overview

Integrity signals

Registry

Crossref · 10.1007/s13304-020-00850-2

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 26

  1. Angrisani L, Santonicola A, Iovino P et al (2018) IFSO worldwide survey 2016: primary, endoluminal, and revisional procedures. Obes Surg 28:3783–3794 · DOI · Paper page
  2. Busetto L, Dicker D, Azran C et al (2017) Practical recommendations of the obesity management task force of the european association for the study of obesity for the post-bariatric surgery medical management. Obesity facts 10:597–632 · DOI
  3. Lim R, Beekley A, Johnson DC et al (2018) Early and late complications of bariatric operation. Trauma Surg Acute Care Open 3:e000219 · DOI · Paper page
  4. Jonas E, Marsk R, Rasmussen F et al (2010) Incidence of postoperative gallstone disease after antiobesity surgery: population-based study from Sweden. Surg Obesity Relat Dis Off J Am Soc Bariat Surg 6:54–58 · DOI
  5. Dakour-Aridi HN, El-Rayess HM, Abou-Abbass H et al (2017) Safety of concomitant cholecystectomy at the time of laparoscopic sleeve gastrectomy: analysis of the American College of Surgeons National Surgical Quality Improvement Program database. Surg Obes Relat Dis Off J Am Soc Bariat Surg 13:934–941 · DOI
  6. Della Penna A, Lange J, Hilbert J et al (2019) Ursodeoxycholic acid for 6 months after bariatric surgery is impacting gallstone associated morbidity in patients with preoperative asymptomatic gallstones. Obes Surg 29:1216–1221 · DOI
  7. Moon RC, Teixeira AF, DuCoin C et al (2014) Comparison of cholecystectomy cases after Roux-en-Y gastric bypass, sleeve gastrectomy, and gastric banding. Surg Obes Relat Dis Off J Am Soc Bariat Surg 10:64–68 · DOI
  8. Wudel LJ Jr, Wright JK, Debelak JP et al (2002) Prevention of gallstone formation in morbidly obese patients undergoing rapid weight loss: results of a randomized controlled pilot study. J Surg Res 102:50–56 · DOI · Paper page
  9. Melmer A, Sturm W, Kuhnert B et al (2015) Incidence of gallstone formation and cholecystectomy 10 years after bariatric surgery. Obes Surg 25:1171–1176 · DOI
  10. Adams LB, Chang C, Pope J et al (2016) Randomized, prospective comparison of ursodeoxycholic acid for the prevention of gallstones after sleeve gastrectomy. Obes Surg 26:990–994 · DOI · Paper page
  11. Boerlage TCC, Haal S, Maurits de Brauw L et al (2017) Ursodeoxycholic acid for the prevention of symptomatic gallstone disease after bariatric surgery: study protocol for a randomized controlled trial (UPGRADE trial). BMC Gastroenterol 17:164 · DOI · Paper page
  12. Coupaye M, Castel B, Sami O et al (2015) Comparison of the incidence of cholelithiasis after sleeve gastrectomy and Roux-en-Y gastric bypass in obese patients: a prospective study. Surg Obes Relat Dis Off J Am Soc Bariat Surg 11:779–784 · DOI · Paper page
  13. Uy MC, Talingdan-Te MC, Espinosa WZ et al (2008) Ursodeoxycholic acid in the prevention of gallstone formation after bariatric surgery: a meta-analysis. Obes Surg 18:1532–1538 · DOI · Paper page
  14. Guarino MP, Cocca S, Altomare A et al (2013) Ursodeoxycholic acid therapy in gallbladder disease, a story not yet completed. World J Gastroenterol WJG 19:5029–5034 · DOI
  15. Mechanick JI, Youdim A, Jones DB et al (2013) Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient–2013 update: cosponsored by American Association of Clinical Endocrinologists, The Obesity Society, and American Society for Metabolic and Bariatric Surgery. Obesity (Silver Spring Md) 21(Suppl 1):S1–27 · DOI · Paper page
  16. Benarroch-Gampel J, Lairson DR, Boyd CA et al (2012) Cost-effectiveness analysis of cholecystectomy during Roux-en-Y gastric bypass for morbid obesity. Surgery 152:363–375 · DOI
  17. Yardimci S, Coskun M, Demircioglu S et al (2018) Is concomitant cholecystectomy necessary for asymptomatic cholelithiasis during laparoscopic sleeve gastrectomy? Obes Surg 28:469–473 · DOI
  18. Brandao I, de Oliveira C, Adami Chaim E, da Silva BB (2003) Impact of rapid weight reduction on risk of cholelithiasis after bariatric surgery. Obes Surg 13:625–628 · DOI
  19. Sugerman HJ, Brewer WH, Shiffman ML et al (1995) A multicenter, placebo-controlled, randomized, double-blind, prospective trial of prophylactic ursodiol for the prevention of gallstone formation following gastric-bypass-induced rapid weight loss. Am J Surg 169:91–96 (discussion 96-7) · DOI · Paper page
  20. Machado FHF, Castro Filho HF, Babadopulos R et al (2019) Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass1. Acta Cirurgica Brasileira 34:e20190010000009 · DOI
  21. Nabil TM, Khalil AH, Gamal K (2019) Effect of oral ursodeoxycholic acid on cholelithiasis following laparoscopic sleeve gastrectomy for morbid obesity. Surg Obes Relat Dis Off J Am Soc Bariat Surg 15:827–831 · DOI · Paper page
  22. Brethauer SA, Kim J, el Chaar M et al (2015) Standardized outcomes reporting in metabolic and bariatric surgery. Surg Obes Relat Dis Off J Am Soc Bariat Surg 11:489–506 · DOI
  23. Coupaye M, Calabrese D, Sami O et al (2017) Evaluation of incidence of cholelithiasis after bariatric surgery in subjects treated or not treated with ursodeoxycholic acid. Surg Obes Relat Dis 13:681–685 · DOI · Paper page
  24. Liu J, Lin H, Zhang C et al (2014) Nonalcoholic fatty liver disease associated with gallstones in females rather than males: a longitudinal cohort study in Chinese urban population. BMC Gastroenterol 14:213 · DOI
  25. Arrese M, Cortes V, Barrera F et al (2018) Nonalcoholic fatty liver disease, cholesterol gallstones, and cholecystectomy: new insights on a complex relationship. Curr Opin Gastroenterol 34:90–96 · DOI
  26. Somasekar K, Chan DSY, Sreekumar NS et al (2018) Choledocholithiasis after bariatric surgery-more than a stone's throw to reach? J Gastrointest Surg Off J Soc Surg Aliment Tract 22:529–537 · DOI

Cited by

Sorted by citations

Metadata

Authors
Sakran, N., Dar, R., Assalia, A., Neeman, Z., Farraj, M., Sherf-Dagan, S., Gralnek, I. M., Hazzan, R., Mokary, S. E., Nevo-Aboody, H., Dola, T., Kaplan, U., & Hershko, D.
ORCID
Sakran, Nasser
Venue
Updates in Surgery
Publisher
Springer Science and Business Media LLC
Published
2020-07-14
Volume
72
Issue
4
Pages
1125-1133
ISSN
  • 2038-131X
  • 2038-3312
DOI
10.1007/s13304-020-00850-2
Cited by
29
References
4
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review