Role of matrix metalloproteinases and therapeutic benefits of their inhibition in spinal cord injury.

How Matrix Metalloproteinases Regulate Cell Behavior

Sternlicht, M. D., & Werb, Z. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.463 · Cited by 3,959

Regeneration beyond the glial scar

Silver, J., & Miller, J. H. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1326 · Cited by 3,151

Matrix metalloproteinases and the regulation of tissue remodelling

Page-McCaw, A., Ewald, A. J., & Werb, Z. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2125 · Cited by 2,630

Chondroitinase ABC promotes functional recovery after spinal cord injury

Bradbury, E. J., Moon, L. D. F., Popat, R. J., King, V. R., Bennett, G. S., Patel, P. N., Fawcett, J. W., & McMahon, S. B. (2002) · Nature · doi:10.1038/416636a · Cited by 2,357

Validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy

Overall, C. M., & Kleifeld, O. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1821 · Cited by 1,239

Metalloproteinases in biology and pathology of the nervous system

Yong, W. V., Power, C., Forsyth, P., & Edwards, D. (2001) · Nature Reviews Neuroscience · doi:10.1038/35081571 · Cited by 1,094

Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat

Yang, Y., Estrada, E. Y., Thompson, J. F., Liu, W., & Rosenberg, G. A. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600375 · Cited by 1,060

Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia

Asahi, M., Wang, X., Mori, T., Sumii, T., Jung, J.-C., Moskowitz, M. A., Fini, M. E., & Lo, E. H. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07724.2001 · Cited by 1,004

A longitudinal study of the prevalence and characteristics of pain in the first 5 years following spinal cord injury

Siddall, P. J., McClelland, J. M., Rutkowski, S. B., & Cousins, M. J. (2003) · Pain · doi:10.1016/s0304-3959(02)00452-9 · Cited by 968

Tetracyclines: Nonantibiotic properties and their clinical implications

Sapadin, A. N., & Fleischmajer, R. (2006) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2005.10.004 · Cited by 771

Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain

Kawasaki, Y., Xu, Z., Wang, X., Park, J. Y., Zhuang, Z., Tan, P.-H., Gao, Y., Roy, K., Corfas, G., Lo, E. H., et al. (2008) · Nature Medicine · doi:10.1038/nm1723 · Cited by 759

Metalloproteinases: Mediators of Pathology and Regeneration in the CNS

Yong, V. W. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1807 · Cited by 582

Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases.

Boissier, S., Ferreras, M., Peyruchaud, O., Magnetto, S., Ebetino, F. H., Colombel, M. C., Delmas, P. D., Delaissé, J., & Clézardin, P. (2000) · PubMed · Cited by 573

The Promise of Minocycline in Neurology

Yong, V. W., Wells, J., Giuliani, F., Casha, S., Power, C., & Metz, L. M. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00937-8 · Cited by 518

Matrix Metalloproteinases Limit Functional Recovery after Spinal Cord Injury by Modulation of Early Vascular Events

Noble‐Haeusslein, L. J., Donovan, F. M., Igarashi, T., Goussev, S., & Werb, Z. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-17-07526.2002 · Cited by 502

Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice.

Shipley, J. M., Wesselschmidt, R. L., Kobayashi, D. K., Ley, T. J., & Shapiro, S. D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.3942 · Cited by 502

NG2 Is a Major Chondroitin Sulfate Proteoglycan Produced after Spinal Cord Injury and Is Expressed by Macrophages and Oligodendrocyte Progenitors

Jones, L. L., Yamaguchi, Y., Stallcup, W. B., & Tuszynski, M. H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02792.2002 · Cited by 482

Minocycline and Neurodegenerative Diseases

Kim, H.-S., & Suh, Y.-H. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.09.040 · Cited by 447

A Highly Specific Inhibitor of Matrix Metalloproteinase-9 Rescues Laminin from Proteolysis and Neurons from Apoptosis in Transient Focal Cerebral Ischemia

Gu, Z., Cui, J., Brown, S., Fridman, R. A., Mobashery, S., Strongin, A. Y., & Lipton, S. A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1563-05.2005 · Cited by 420

Sodium Channels and Mechanisms of Neuropathic Pain

Devor, M. G. (2006) · Journal of Pain · doi:10.1016/j.jpain.2005.09.006 · Cited by 401

Matrix Metalloproteinase Inhibitor Development and the Remodeling of Drug Discovery

Peterson, J. T. (2004) · Heart Failure Reviews · doi:10.1023/b:hrev.0000011395.11179.af · Cited by 373

Macrophage-Derived Matrix Metalloproteinase-2 and -9 Promote the Progression of Cerebral Aneurysms in Rats

Aoki, T., Kataoka, H., Morimoto, M., Nozaki, K., & Hashimoto, N. (2006) · Stroke · doi:10.1161/01.str.0000252129.18605.c8 · Cited by 358

Vasogenic edema due to tight junction disruption by matrix metalloproteinases in cerebral ischemia

Rosenberg, G. A., & Yang, Y. R. (2007) · Neurosurgical FOCUS · doi:10.3171/foc.2007.22.5.5 · Cited by 358

Oxidative stress activates protein tyrosine kinase and matrix metalloproteinases leading to blood–brain barrier dysfunction

Haorah, J., Ramirez, S. H., Schall, K. A., Smith, D. L., Pandya, R., & Persidsky, Y. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04393.x · Cited by 334

To bind zinc or not to bind zinc: An examination of innovative approaches to improved metalloproteinase inhibition

Jacobsen, J. A., Jourden, J. L. M., Miller, M. T., & Cohen, S. M. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2009.08.006 · Cited by 327

Matrix metalloproteinases degrade myelin basic protein

Chandler, S., Coates, R. E., Gearing, A. J. H., Lury, J., Wells, G., & Bone, E. A. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12173-0 · Cited by 294

Blood‐spinal cord barrier after spinal cord injury: Relation to revascularization and wound healing

Whetstone, W. D., Hsu, J. C., Eisenberg, M., Werb, Z., & Noble‐Haeusslein, L. J. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10759 · Cited by 288

Matrix Metalloproteinase 7 (Matrilysin) from Human Rectal Carcinoma Cells

Imai, K., Yokohama, Y., Nakanishi, I., Ohuchi, E., Fujii, Y., Nakai, N., & Okada, Y. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.12.6691 · Cited by 286

Highly Selective and Orally Active Inhibitors of Type IV Collagenase (MMP-9 and MMP-2): N-Sulfonylamino Acid Derivatives

Tamura, Y., Watanabe, F., Nakatani, T., Yasui, K., Fuji, M., Komurasaki, T., Tsuzuki, H., Maekawa, R., Yoshioka, T., Kawada, K., et al. (1998) · Journal of Medicinal Chemistry · doi:10.1021/jm9707582 · Cited by 286

Remote activation of microglia and pro-inflammatory cytokines predict the onset and severity of below-level neuropathic pain after spinal cord injury in rats

Detloff, M. R., Fisher, L. C., McGaughy, V., Longbrake, E. E., Popovich, P. G., & Basso, D. M. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.04.009 · Cited by 278

Inhibition of human skin fibroblast collagenase, thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids

Grobelny, D. W., Poncz, L., & Galardy, R. E. (1992) · Biochemistry · doi:10.1021/bi00146a017 · Cited by 274

Matrix Metalloproteinase-2 Facilitates Wound Healing Events That Promote Functional Recovery after Spinal Cord Injury

Hsu, J.-Y. C., McKeon, R. J., Goussev, S., Werb, Z., Lee, J.-U., Trivedi, A. A., & Noble‐Haeusslein, L. J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1993-06.2006 · Cited by 238

MMPs in the central nervous system: Where the good guys go bad

AGRAWAL, S., LAU, L., & Yong, V. W. (2007) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2007.06.003 · Cited by 226

Effect of cytokines on neuronal excitability

Schäfers, M., & Sorkin, L. S. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.03.052 · Cited by 225

Overcoming Macrophage-Mediated Axonal Dieback Following CNS Injury

Busch, S. A., Horn, K. P., Silver, D. J., & Silver, J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1151-09.2009 · Cited by 217

Multiphasic roles for matrix metalloproteinases after stroke

ROSELL, A., & LO, E. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.12.001 · Cited by 215

Recent advances in MMP inhibitor design

Fisher, J. F., & Mobashery, S. (2006) · Cancer and Metastasis Reviews · doi:10.1007/s10555-006-7894-9 · Cited by 215

An Adverse Role for Matrix Metalloproteinase 12 after Spinal Cord Injury in Mice

Wells, J. E. A., Rice, T. K., Nuttall, R. K., Edwards, D. R., Zekki, H., Rivest, S., & Yong, V. W. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-31-10107.2003 · Cited by 203

MMP Inhibition and Downregulation by Bisphosphonates

Teronen, O. P., Heikkilä, P., Konttinen, Y. T., Laitinen, M., Salo, T. A., Hanemaaijer, R., TERONEN, A., Maisi, P. S., & Sorsa, T. A. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07702.x · Cited by 200

Potent and Selective Mechanism-Based Inhibition of Gelatinases

Brown, S., Bernardo, M. M., Li, Z., Kotra, L. P., Tanaka, Y., Fridman, R. A., & Mobashery, S. (2000) · Journal of the American Chemical Society · doi:10.1021/ja001461n · Cited by 198

Matrix Metalloproteinase Inhibitors

Dormán, G., Cseh, S., Hajdú, I., Barna, L., Konya, D., Kupai, K., Kovács, L., & Ferdinándy, P. (2010) · Drugs · doi:10.2165/11318390-000000000-00000 · Cited by 180

Extracellular matrix, junctional integrity and matrix metalloproteinase interactions in endothelial permeability regulation*

Alexander, J. S., & Elrod, J. W. (2002) · Journal of Anatomy · doi:10.1046/j.1469-7580.2002.00057.x · Cited by 179

Induction of matrix metalloproteinase activation cascades based on membrane-type 1 matrix metalloproteinase: associated activation of gelatinase A, gelatinase B and collagenase 3

Cowell, S., Knäuper, V., STEWART, M. L., d’Ortho, M., Stanton, H., Hembry, R. M., López-Otı́n, C., Reynolds, J. J., & Murphy, G. (1998) · Biochemical Journal · doi:10.1042/bj3310453 · Cited by 173

Inhibition of cell proliferation, invasion, tumor growth and metastasis by an oral non‐antimicrobial tetracycline analog (COL‐3) in a metastatic prostate cancer model

Lokeshwar, B. L., Selzer, M. G., Zhu, B., Block, N. L., & Golub, L. M. (2001) · International Journal of Cancer · doi:10.1002/ijc.10168 · Cited by 161

Dengue‐virus‐infected dendritic cells trigger vascular leakage through metalloproteinase overproduction

Luplerdlop, N., Missé, D., Bray, D. H., Deleuze, V., Gonzalez, J., Leardkamolkarn, V., Yssel, H., & Veas, F. (2006) · EMBO Reports · doi:10.1038/sj.embor.7400814 · Cited by 154

Anti-Invasive, Antitumoral, and Antiangiogenic Efficacy of a Pyrimidine-2,4,6-trione Derivative, an Orally Active and Selective Matrix Metalloproteinases Inhibitor

Maquoi, E., Sounni, N. E., Devy, L., Olivier, F., Frankenne, F., Krell, H., Grams, F., Foidart, J., & Noël, A. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0125 · Cited by 152

Matrix Metalloproteinase-9 Facilitates Glial Scar Formation in the Injured Spinal Cord

Hsu, J.-Y. C., Bourguignon, L., Adams, C. M., Peyrollier, K., Zhang, H. M., Fandel, T. M., Cun, C. L., Werb, Z., & Noble‐Haeusslein, L. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2287-08.2008 · Cited by 150

Cytokine regulation of MMP-9 in peripheral glia: Implications for pathological processes and pain in injured nerve

Chattopadhyay, S., Myers, R. R., Janes, J. R., & Shubayev, V. I. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.10.015 · Cited by 142

Diapedesis of monocytes is associated with MMP‐ mediated occludin disappearance in brain endothelial cells

Reijerkerk, A., Kooij, G., van der Pol, S. M. A., Khazen, S., Dijkstra, C. D., & de Vries, H. E. (2006) · The FASEB Journal · doi:10.1096/fj.06-6099fje · Cited by 140

Batimastat, a potent matrix mealloproteinase inhibitor, exhibits an unexpected mode of binding.

Botos, I., Scapozza, L., Zhang, D., Liotta, L. A., & Meyer, E. F. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.7.2749 · Cited by 138

Tissue Inhibitor of Metalloproteinase (TIMP)-2 Acts Synergistically with Synthetic Matrix Metalloproteinase (MMP) Inhibitors but Not with TIMP-4 to Enhance the (Membrane Type 1)-MMP-dependent Activation of Pro-MMP-2

Tóth, M., Bernardo, M. M., Gervasi, D. C., Soloway, P. D., Wang, Z., Bigg, H. F., Overall, C. M., DeClerck, Y. A., Tschesche, H., Cher, M. L., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006871200 · Cited by 134

Erratum To: Dengue‐virus‐infected dendritic cells trigger vascular leakage through metalloproteinase overproduction

Luplertlop, N., Missé, D., Bray, D. H., Deleuze, V., Gonzalez, J., Leardkamolkarn, V., Yssel, H., & Veas, F. (2006) · EMBO Reports · doi:10.1038/sj.embor.7400868 · Cited by 134

The TIMPs tango with MMPs and more in the central nervous system

Crocker, S. J., Pagenstecher, A., & Campbell, I. L. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10836 · Cited by 134

Induction of MMP-9 Expression and Endothelial Injury by Oxidative Stress after Spinal Cord Injury

Yu, F., Kamada, H., Niizuma, K., Endo, H., & Chan, P. H. (2008) · Journal of Neurotrauma · doi:10.1089/neu.2007.0438 · Cited by 133

Dopamine Receptor Modulation of Hypoxic—Ischemic Neuronal Injury in Striatum of Newborn Piglets

Yang, Z.-J., Torbey, M., Li, X., Bernardy, J., Golden, W. C., Martin, L. J., & Koehler, R. C. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600440 · Cited by 127

Cellular activation of proMMP‐13 by MT1‐MMP depends on the C‐terminal domain of MMP‐13

Knäuper, V., BAILEY, L., Worley, J. R., Soloway, P. D., Patterson, M. L., & Murphy, G. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03654-2 · Cited by 123

MMPs initiate Schwann cell-mediated MBP degradation and mechanical nociception after nerve damage

Kobayashi, H., Chattopadhyay, S., Kato, K., Dolkas, J., Kikuchi, S., Myers, R. R., & Shubayev, V. I. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.08.008 · Cited by 116

Overexpression of SOD1 protects vulnerable motor neurons after spinal cord injury by attenuating mitochondrial cytochrome c release

Sugawara, T., Lewén, A., Gasche, Y. G., Yu, F., & Chan, P. H. (2002) · The FASEB Journal · doi:10.1096/fj.02-0251fje · Cited by 116

Glucocorticoid Receptor-Mediated Suppression of Activator Protein-1 Activation and Matrix Metalloproteinase Expression after Spinal Cord Injury

Xu, J., Kim, G.-M., Ahmed, S. H., Xu, J., Yan, P., Xu, X., & Hsu, C. Y. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-01-00092.2001 · Cited by 113

Inhibition of angiogenesis and metastasis in two murine models by the matrix metalloproteinase inhibitor, BMS-275291.

Naglich, J. G., Jure‐Kunkel, M., Gupta, E., Fargnoli, J., Henderson, A. J., Lewin, A. C., Talbott, R. L., Baxter, A., Bird, J., Savopoulos, R., et al. (2001) · PubMed · Cited by 110

Bisphosphonates inhibit stromelysin-1 (MMP-3), matrix metalloelastase (MMP-12), collagenase-3 (MMP-13) and enamelysin (MMP-20), but not urokinase-type plasminogen activator, and diminish invasion and migration of human malignant and endothelial cell lines

Heikkilä, P., Teronen, O. P., Moilanen, M., Konttinen, Y. T., Hanemaaijer, R., Laitinen, M., Maisi, P. S., van der Pluijm, G., Bartlett, J. D., Salo, T. A., et al. (2002) · Anti-Cancer Drugs · doi:10.1097/00001813-200203000-00006 · Cited by 109

BAY 12-9566, a novel inhibitor of matrix metalloproteinases with antiangiogenic activity.

Gatto, C., Rieppi, M., Borsotti, P., Innocenti, S., Ceruti, R., Drudis, T., Scanziani, E., Casazza, A. M., Taraboletti, G., & Giavazzi, R. (1999) · PubMed · Cited by 107

Phenoxyphenyl Sulfone N -Formylhydroxylamines (Retrohydroxamates) as Potent, Selective, Orally Bioavailable Matrix Metalloproteinase Inhibitors

Wada, C. K., Holms, J. H., Curtin, M. L., Dai, Y., Florjancic, A. S., Garland, R. B., Guo, Y. P., Heyman, H. R., Stacey, J. R., Steinman, D. H., et al. (2001) · Journal of Medicinal Chemistry · doi:10.1021/jm0103920 · Cited by 106

Orally Active MMP-1 Sparing α-Tetrahydropyranyl and α-Piperidinyl Sulfone Matrix Metalloproteinase (MMP) Inhibitors with Efficacy in Cancer, Arthritis, and Cardiovascular Disease

Becker, D. P., Barta, T. E., Bedell, L. J., Boehm, T. L., Bond, B. R., Carroll, J. N., Carron, C. P., DeCrescenzo, G. A., Easton, A. M., Freskos, J. N., et al. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm100669j · Cited by 101

MMP-Related Gelatinase Activity Is Strongly Induced in Scar Tissue of Injured Adult Spinal Cord and Forms Pathways for Ingrowing Neurites

Duchossoy, Y., Horvat, J.-C., & Stettler, O. (2001) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2001.0986 · Cited by 99

Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13)

Kim, S., Pudzianowski, A. T., Leavitt, K. J., Barbosa, J., McDonnell, P. A., Metzler, W. J., Rankin, B. M., Liu, R., Vaccaro, W. D., & Pitts, W. J. (2005) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2004.12.016 · Cited by 96

Differential temporal expression of matrix metalloproteinases after spinal cord injury: relationship to revascularization and wound healing

Goussev, S., Hsu, J.-Y. C., Lin, Y., Tjoa, T., Maida, N., Werb, Z., & Noble‐Haeusslein, L. J. (2003) · Journal of Neurosurgery Spine · doi:10.3171/spi.2003.99.2.0188 · Cited by 91

Matrix Metalloproteinases and Neurotrauma: Evolving Roles in Injury and Reparative Processes

Zhang, H., Adwanikar, H., Werb, Z., & Noble-Haeusslein, L. J. (2010) · The Neuroscientist · doi:10.1177/1073858409355830 · Cited by 84

Ischemia injury alters endothelial cell properties of kidney cortex: Stimulation of MMP-9

Caron, A., Desrosiers, R. R., & Béliveau, R. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.07.004 · Cited by 76

Roles of Matrix Metalloproteinases in Flow-Induced Outward Vascular Remodeling

Ota, R., Kurihara, C., Tsou, T.-L., Young, W. L., Yeghiazarians, Y., Chang, M., Mobashery, S., Sakamoto, A., & Hashimoto, T. N. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.77 · Cited by 71

Matrix metalloproteinases and proteoglycans in axonal regeneration

Pizzi, M. A., & Crowe, M. J. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.12.012 · Cited by 71

Metalloproteinase increases in the injured rat spinal cord

de Castro, R., Burns, C. L., McAdoo, D. J., & Romanic, A. M. (2000) · Neuroreport · doi:10.1097/00001756-200011090-00029 · Cited by 70

Cardiac Uptake of Minocycline and Mechanisms for In Vivo Cardioprotection

Romero‐Perez, D., Fricovsky, E. S., Yamasaki, K. G., Griffin, M. O., Barraza-Hidalgo, M., DILLMANN, W. H., & Villarreal, F. J. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.06.028 · Cited by 69

Human umbilical cord blood stem cells upregulate matrix metalloproteinase-2 in rats after spinal cord injury

Veeravalli, K. K., Dasari, V. R., Tsung, A. J., Dinh, D. H., Gujrati, M., Fassett, D., & Rao, J. S. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.07.012 · Cited by 69

Evaluation of P1'-Diversified Phosphinic Peptides Leads to the Development of Highly Selective Inhibitors of MMP-11

Matziari, M., Beau, F., Cuniasse, P., Dive, V., & Yiotakis, A. (2003) · Journal of Medicinal Chemistry · doi:10.1021/jm0308491 · Cited by 67

Synthesis and Structure−Activity Relationship of α-Sulfonylhydroxamic Acids as Novel, Orally Active Matrix Metalloproteinase Inhibitors for the Treatment of Osteoarthritis

Aranapakam, V., Grosu, G. T., Davis, J. M., Hu, B., Ellingboe, J. W., Baker, J., Skotnicki, J. S., Zask, A., DiJoseph, J. F., Sung, A., et al. (2003) · Journal of Medicinal Chemistry · doi:10.1021/jm0205548 · Cited by 64

Targeting MMPs in Acute and Chronic Neurological Conditions

Yong, V. W., Agrawal, S. M., & Stirling, D. P. (2007) · Neurotherapeutics · doi:10.1016/j.nurt.2007.07.005 · Cited by 64

Prevention of progressive joint destruction in collagen‐induced arthritis in rats by a novel matrix metalloproteinase inhibitor, FR255031

Ishikawa, T., Nishigaki, F., Miyata, S., Hirayama, Y., Minoura, K., Imanishi, J., Neya, M., Mizutani, T., Imamura, Y., Naritomi, Y., et al. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706054 · Cited by 61

Synthesis of Chiral 2-(4-Phenoxyphenylsulfonylmethyl)thiiranes as Selective Gelatinase Inhibitors

Lee, M., Bernardo, M. M., Meroueh, S. O., Brown, S., Fridman, R. A., & Mobashery, S. (2005) · Organic Letters · doi:10.1021/ol0517269 · Cited by 59

Active Site Ring‐Opening of a Thiirane Moiety and Picomolar Inhibition of Gelatinases

Forbes, C. C., Shi, Q., Fisher, J. F., Lee, M., Hesek, D., Llarrull, L. I., Tóth, M., Gossing, M., Fridman, R. A., & Mobashery, S. (2009) · Chemical Biology & Drug Design · doi:10.1111/j.1747-0285.2009.00881.x · Cited by 59

Osler and the "medico-chirurgical neurologists": Horsley, Cushing, and Penfield.

Feindel, W. (2003) · Journal of Neurosurgery · doi:10.3171/jns.2003.99.1.0188 · Cited by 53

Matrix metalloproteinase-7 facilitates immune access to the CNS in experimental autoimmune encephalomyelitis

Buhler, L. A., Samara, R. F., Guzmán, E. A., Wilson, C. L., Krizanac-Bengez, L., Janigro, D., & Ethell, D. W. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-17 · Cited by 52

CMT-3, a Non-antimicrobial Tetracycline (TC), Inhibits MT1-MMP Activity: Relevance to Cancer

Lee, M. K., Golub, M., Cao, J. P., Teronen, O. P., Laitinen, M., Salo, T. A., Zucker, S., & Sorsa, T. A. (2001) · Current Medicinal Chemistry · doi:10.2174/0929867013373660 · Cited by 50

The discovery of anthranilic acid-based MMP inhibitors. Part 1: SAR of the 3-position

Levin, J. I., Du, M. T., DiJoseph, J. F., Killar, L. M., Sung, A., Walter, T., Sharr, M. A., Roth, C. E., Moy, F. J., Powers, R., et al. (2001) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(00)00642-9 · Cited by 45

Design, Synthesis, and Evaluation of a Mechanism-Based Inhibitor for Gelatinase A

Ikejiri, M., Bernardo, M. M., Meroueh, S. O., Brown, S., Chang, M., Fridman, R. A., & Mobashery, S. (2005) · The Journal of Organic Chemistry · doi:10.1021/jo050339+ · Cited by 41

Metabolism of a Highly Selective Gelatinase Inhibitor Generates Active Metabolite

Lee, M., Villegas‐Estrada, A., Celenza, G., Boggess, B., Tóth, M., Kreitinger, G., Forbes, C. C., Fridman, R. A., Mobashery, S., & Chang, M. (2007) · Chemical Biology & Drug Design · doi:10.1111/j.1747-0285.2007.00577.x · Cited by 41

Carbamoylphosphonate Matrix Metalloproteinase Inhibitors 6: cis-2-Aminocyclohexylcarbamoylphosphonic Acid, A Novel Orally Active Antimetastatic Matrix Metalloproteinase-2 Selective Inhibitor—Synthesis and Pharmacodynamic and Pharmacokinetic Analysis

Hoffman, A., Qadri, B., Frant, J., Katz, Y., Bhusare, S. R., Breuer, E., Hadar, R., & Reich, R. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm701087n · Cited by 41

Inhibition of MMP2/MMP9 After Spinal Cord Trauma Reduces Apoptosis

Dang, A. B. C., Tay, B. K.-B., Kim, H. T., Nauth, A., Alfonso-Jaume, M., & Lovett, D. H. (2008) · Spine · doi:10.1097/brs.0b013e31817ecc87 · Cited by 40

Sulfonate-Containing Thiiranes as Selective Gelatinase Inhibitors

Testero, S. A., Lee, M., Staran, R. T., Espahbodi, M., Llarrull, L. I., Tóth, M., Mobashery, S., & Chang, M. (2010) · ACS Medicinal Chemistry Letters · doi:10.1021/ml100254e · Cited by 38

A Potent Gelatinase Inhibitor with Anti‐Tumor‐Invasive Activity and its Metabolic Disposition

Lee, M., Celenza, G., Boggess, B., Blase, J. R., Shi, Q., Tóth, M., Bernardo, M. M., Wolter, W. R., Suckow, M. A., Hesek, D., et al. (2009) · Chemical Biology & Drug Design · doi:10.1111/j.1747-0285.2008.00750.x · Cited by 34

Phosphinic acid-based MMP-13 inhibitors that spare MMP-1 and MMP-3

Reiter, L. A., Mitchell, P. G., Martinelli, G. J., Lopresti‐Morrow, L., Yocum, S. A., & Eskra, J. D. (2003) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(03)00413-x · Cited by 34

Benzodiazepine inhibitors of the MMPs and TACE

Nelson, F. C., Santos, E. D., Levin, J. I., Chen, J., Skotnicki, J. S., DiJoseph, J. F., Sharr, M. A., Sung, A., Killar, L. M., Cowling, R. A., et al. (2002) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(02)00633-9 · Cited by 33

Design, synthesis and preliminary evaluation of new cinnamoyl pyrrolidine derivatives as potent gelatinase inhibitors

Zhang, L., Zhang, J., Fang, H., Wang, Q., & Xu, W. (2006) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2006.09.015 · Cited by 26

Design, synthesis and evaluation of novel sulfonyl pyrrolidine derivatives as matrix metalloproteinase inhibitors

Cheng, X., Wang, Q., Fang, H., Tang, W., & Xu, W. (2008) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2008.04.027 · Cited by 26

Orally bioavailable dual MMP-1/MMP-14 sparing, MMP-13 selective α-sulfone hydroxamates

Kolodziej, S. A., Hockerman, S. L., Boehm, T. L., Carroll, J. N., DeCrescenzo, G. A., McDonald, J. J., Mischke, D. A., Munie, G. E., Fletcher, T., Rico, J. G., et al. (2010) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2010.04.130 · Cited by 22

Effects of matrix metalloproteinase 9 inhibition on the blood brain barrier and inflammation in rats following cardiopulmonary resuscitation.

He, Z., Huang, Z., Chen, X.-T., & Zou, Z. (2009) · PubMed · Cited by 21

β-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: Part 2. Optimization of α-amino substituents

Yang, S., Scannevin, R. H., Wang, B., Burke, S. L., Huang, Z., Karnachi, P., Wilson, L. J., Rhodes, K. J., Lagu, B. R., & Murray, W. V. (2007) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2007.11.129 · Cited by 21

Heteroaryl and cycloalkyl sulfonamide hydroxamic acid inhibitors of matrix metalloproteinases

Levin, J. I., Gu, Y., Nelson, F. C., Zask, A., DiJoseph, J. F., Sharr, M. A., Sung, A., Jin, G., Cowling, R. A., Chanda, P. K., et al. (2001) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(00)00644-2 · Cited by 20

Discovery and characterization of the potent, selective and orally bioavailable MMP inhibitor ABT-770

Curtin, M. L., Florjancic, A. S., Heyman, H. R., Michaelides, M. R., Garland, R. B., Holms, J. H., Steinman, D. H., Dellaria, J. F., Gong, J., Wada, C. K., et al. (2001) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(01)00032-4 · Cited by 20

Synthesis, Kinetic Characterization and Metabolism of Diastereomeric 2‐(1‐(4‐Phenoxyphenylsulfonyl)ethyl)thiiranes as Potent Gelatinase and MT1‐MMP Inhibitors

Gooyit, M., Lee, M., Hesek, D., Boggess, B., Oliver, A. G., Fridman, R. A., Mobashery, S., & Chang, M. (2009) · Chemical Biology & Drug Design · doi:10.1111/j.1747-0285.2009.00898.x · Cited by 17

5-Carboxylate Substituted Piperazine-2-ones as Potent and Selective MMP-2 Inhibitors

Chung, Y.-J. (2008) · Bulletin of the Korean Chemical Society · doi:10.5012/bkcs.2008.29.6.1103 · Cited by 3

MMP ‐9 in translation: from molecule to brain physiology, pathology, and therapy

Vafadari, B., Salamian, A., & Kaczmarek, L. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13415 · Cited by 393

Restoring function after spinal cord injury: towards clinical translation of experimental strategies

Ramer, L. M., Ramer, M. S., & Bradbury, E. J. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70144-9 · Cited by 330

An injectable hydrogel enhances tissue repair after spinal cord injury by promoting extracellular matrix remodeling

Hong, L. T. A., Kim, Y., Park, H. H., Hwang, D. H., Cui, Y., Lee, E. M., Yahn, S. L., Lee, J. K., Song, S., & Kim, B. G. (2017) · Nature Communications · doi:10.1038/s41467-017-00583-8 · Cited by 254

Microglia and mast cells: two tracks on the road to neuroinflammation

Skaper, S. D., Giusti, P., & Facci, L. (2012) · The FASEB Journal · doi:10.1096/fj.11-197194 · Cited by 235

Acute complications of spinal cord injuries

Hagen, E. M. (2015) · World Journal of Orthopedics · doi:10.5312/wjo.v6.i1.17 · Cited by 228

Matrix Metalloproteinases: Potential Therapeutic Target in Spinal Cord Injury

Duchossoy, Y., Arnaud, S., & Feldblum, S. (2001) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2001.057 · Cited by 29

Differential temporal expression of matrix metalloproteinases after spinal cord injury: relationship to revascularization and wound healing

Goussev, S., Hsu, J.-Y. C., Lin, Y., Tjoa, T., Maida, N., Werb, Z., & Noble‐Haeusslein, L. J. (2003) · Journal of Neurosurgery Spine · doi:10.3171/spi.2003.99.2.0188 · Cited by 91

Inhibition of MMP2/MMP9 After Spinal Cord Trauma Reduces Apoptosis

Dang, A. B. C., Tay, B. K.-B., Kim, H. T., Nauth, A., Alfonso-Jaume, M., & Lovett, D. H. (2008) · Spine · doi:10.1097/brs.0b013e31817ecc87 · Cited by 40

Novel targets for Spinal Cord Injury related neuropathic pain

Ahmed, M. M., King, K. C., Pearce, S. M., Ramsey, M. A., Miranpuri, G. S., & Resnick, D. K. (2011) · Annals of Neurosciences · doi:10.5214/ans.0972.7531.1118413 · Cited by 23

Matrix metalloproteinases and their inhibitors in human traumatic spinal cord injury

Buss, A., Pech, K., Noth, J., & Brook, G. A. (2006) · Aktuelle Neurologie · doi:10.1055/s-2006-953073