Phosphodiesterase-4 (PDE4) Molecular Pharmacology and Alzheimer's Disease

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404 · see citing works

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

Goate, A., Chartier-Harlin, M.-C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L., et al. (1991) · Nature · doi:10.1038/349704a0 · Cited by 4,659 · see citing works

Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B

Klunk, W. E., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D. P., Bergström, M., Savitcheva, I., Huang, G., Estrada, S., et al. (2004) · Annals of Neurology · doi:10.1002/ana.20009 · Cited by 4,496 · see citing works

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., et al. (1995) · Nature · doi:10.1038/375754a0 · Cited by 4,051 · see citing works

Hearing loss and cognitive decline in older adults

Lin, F. R., Yaffe, K., Xia, J., Xue, Q.-L., Harris, T. B., Purchase-Helzner, E., Satterfield, S., Ayonayon, H. N., Ferrucci, L., Simonsick, E. M., et al. (2013) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.1868 · Cited by 4,017 · see citing works

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., et al. (1999) · Science · doi:10.1126/science.286.5440.735 · Cited by 3,876 · see citing works

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., Bird, T. D., Hardy, J., Hutton, M., Kukull, W., et al. (1996) · Nature Medicine · doi:10.1038/nm0896-864 · Cited by 2,599 · see citing works

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

Salloway, S., Sperling, R., Fox, N. C., Blennow, K., Klunk, W., Raskind, M., Sabbagh, M., Honig, L. S., Porsteinsson, A. P., Ferris, S., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1304839 · Cited by 1,960 · see citing works

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

Jonsson, T., Atwal, J. K., Steinberg, S., Snaedal, J., Jonsson, P. V., Bjornsson, S., Stefansson, H., Sulem, P., Gudbjartsson, D., Maloney, J., et al. (2012) · Nature · doi:10.1038/nature11283 · Cited by 1,738 · see citing works

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

Doody, R. S., Thomas, R. G., Farlow, M., Iwatsubo, T., Vellas, B., Joffe, S., Kieburtz, K., Raman, R., Sun, X., Aisen, P. S., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1312889 · Cited by 1,668 · see citing works

Purification and cloning of amyloid precursor protein β-secretase from human brain

Sinha, S., Anderson, J. P., Barbour, R., Basi, G. S., Caccavello, R., Davis, D., Doan, M., Dovey, H. F., Frigon, N., Hong, J., et al. (1999) · Nature · doi:10.1038/990114 · Cited by 1,612 · see citing works

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid

Mullan, M., Crawford, F., Axelman, K., Houlden, H., Lilius, L., Winblad, B., & Lannfelt, L. (1992) · Nature Genetics · doi:10.1038/ng0892-345 · Cited by 1,513 · see citing works

Monetary Costs of Dementia in the United States

Hurd, M. D., Martorell, P., Delavande, A., Mullen, K. J., & Langa, K. M. (2013) · New England Journal of Medicine · doi:10.1056/nejmsa1204629 · Cited by 1,484 · see citing works

Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity

Yan, R., Bienkowski, M. J., Shuck, M. E., Miao, H., Tory, M. C., Pauley, A. M., Brashler, J. R., Stratman, N. C., Mathews, W. R., Buhl, A. E., et al. (1999) · Nature · doi:10.1038/990107 · Cited by 1,438 · see citing works

A mutation in the Amyloid Precursor Protein Associated with Hereditary Alzheimer's Disease

Murrell, J. R., Farlow, M. R., Ghetti, B. F., & Benson, M. D. (1991) · Science · doi:10.1126/science.1925564 · Cited by 1,122 · see citing works

Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor

Cai, X.-D., Golde, T. E., & Younkin, S. G. (1993) · Science · doi:10.1126/science.8424174 · Cited by 913 · see citing works

PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization

Houslay, M. D., & Adams, D. R. (2003) · Biochemical Journal · doi:10.1042/bj20021698 · Cited by 764 · see citing works

Toward a molecular definition of long-term memory storage

Bailey, C. H., Bartsch, D., & Kandel, E. R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13445 · Cited by 691 · see citing works

dunce, a mutant of Drosophila deficient in learning.

Dudai, Y., Jan, Y. N., Byers, D., Quinn, W. G., & Benzer, S. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.5.1684 · Cited by 619 · see citing works

Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides.

Robakis, N. K. R. K., Ramakrishna, N., Wolfe, G. C., & Wisniewski, H. M. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.12.4190 · Cited by 603 · see citing works

Amyloid β-peptide inhibition of the PKA/CREB pathway and long-term potentiation: Reversibility by drugs that enhance cAMP signaling

Vitolo, O. V., Sant'Angelo, A., Costanzo, V., Battaglia, F., Arancio, O., & Shelanski, M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172504199 · Cited by 534 · see citing works

Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases

Card, G. L., England, B. P., Suzuki, Y., Fong, D., Powell, B., Lee, B., Luu, C. A., Tabrizizad, M., Gillette, S., Ibrahim, P. N., et al. (2004) · Structure · doi:10.1016/j.str.2004.10.004 · Cited by 444 · see citing works

Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment

Gong, B., Vitolo, O. V., Trinchese, F., Liu, S., Shelanski, M., & Arancio, O. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22831 · Cited by 442 · see citing works

Defect in cyclic AMP phosphodiesterase due to the dunce mutation of learning in Drosophila melanogaster

Byers, D., Davis, R. L., & Kiger, J. A. (1981) · Nature · doi:10.1038/289079a0 · Cited by 440 · see citing works

Phosphorylation and Activation of a cAMP-specific Phosphodiesterase by the cAMP-dependent Protein Kinase

Sette, C., & Conti, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.28.16526 · Cited by 412 · see citing works

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

Burgin, A. B., Magnússon, Ó. Þ., Singh, J., Witte, P., Staker, B. L., Björnsson, J. M., Þorsteinsdóttir, M., Hrafnsdóttir, S., Hagen, T. J., Kiselyov, A. S., et al. (2009) · Nature Biotechnology · doi:10.1038/nbt.1598 · Cited by 396 · see citing works

Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-α responses

Jin, S.-L. C., & Conti, M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122041599 · Cited by 368 · see citing works

Regulation and organization of adenylyl cyclases and cAMP

COOPER, D. M. F. (2003) · Biochemical Journal · doi:10.1042/bj20031061 · Cited by 356 · see citing works

Targeting the CREB pathway for memory enhancers

Tully, T., Bourtchouladze, R., Scott, R., & Tallman, J. F. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1061 · Cited by 355 · see citing works

In vivo radioligand binding to translocator protein correlates with severity of Alzheimer’s disease

Kreisl, W. C., Lyoo, C. H., McGwier, M., Snow, J., Jenko, K. J., Kimura, N., Corona, W., Morse, C. L., Zoghbi, S. S., Pike, V. W., et al. (2013) · Brain · doi:10.1093/brain/awt145 · Cited by 350 · see citing works

cAMP-Specific Phosphodiesterase-4 Enzymes in the Cardiovascular System

Houslay, M. D., Baillie, G. S., & Maurice, D. H. (2007) · Circulation Research · doi:10.1161/01.res.0000261934.56938.38 · Cited by 318 · see citing works

A Family of Human Phosphodiesterases Homologous to the Dunce Learning and Memory Gene Product of Drosophila melanogaster are Potential Targets for Antidepressant Drugs

Bolger, G. B., Michaeli, T., Martins, T., John, T. S., Steiner, B., Rodgers, L., Riggs, M. G., Wigler, M. H., & Ferguson, K. M. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.10.6558-6571.1993 · Cited by 317 · see citing works

Selective phosphodiesterase inhibitors: a promising target for cognition enhancement

Reneerkens, O. A. H., Rutten, K., Steinbusch, H. W. M., Blokland, A., & Prickaerts, J. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1273-x · Cited by 268 · see citing works

Specific Role of Phosphodiesterase 4B in Lipopolysaccharide-Induced Signaling in Mouse Macrophages

Jin, S.-L. C., Lan, L., Zoudilova, M., & Conti, M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.3.1523 · Cited by 256 · see citing works

Molecular analysis of cDNA clones and the corresponding genomic coding sequences of the Drosophila dunce+ gene, the structural gene for cAMP phosphodiesterase.

Chen, C. N., Denome, S. A., & Davis, R. L. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.24.9313 · Cited by 244 · see citing works

Phosphodiesterase-4D Knock-Out and RNA Interference-Mediated Knock-Down Enhance Memory and Increase Hippocampal Neurogenesis via Increased cAMP Signaling

Li, Y., Cheng, Y., Huang, Y., Conti, M., Wilson, S. P., O’Donnell, J. M., & Zhang, H. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5236-10.2011 · Cited by 233 · see citing works

Phosphodiesterase type 4 isozymes expression in human brain examined by in situ hybridization histochemistry and [3H]rolipram binding autoradiography

Pérez-Torres, S., Miró, X., Palacios, J. M., Cortés, R., Puigdomènech, P., & Mengod, G. (2000) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(00)00097-1 · Cited by 231 · see citing works

PKA Dynamics in a Drosophila Learning Center: Coincidence Detection by Rutabaga Adenylyl Cyclase and Spatial Regulation by Dunce Phosphodiesterase

Gervasi, N., Tchénio, P., & Préat, T. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.014 · Cited by 230 · see citing works

Reversal of long-term dendritic spine alterations in Alzheimer disease models

Smith, D. L., Pozueta, J., Gong, B., Arancio, O., & Shelanski, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908706106 · Cited by 229 · see citing works

An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics

Willoughby, D., Wong, W., Schaack, J. B., Scott, J. D., & Cooper, D. M. F. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601113 · Cited by 185 · see citing works

PGE1 stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases

Terrin, A., Benedetto, G. D., Pertegato, V., Cheung, Y.-F., Baillie, G. S., Lynch, M. J., Elvassore, N., Prinz, A., Herberg, F. W., Houslay, M. D., et al. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200605050 · Cited by 184 · see citing works

Molecular cloning of rat homologues of the Drosophila melanogaster dunce cAMP phosphodiesterase: evidence for a family of genes.

Swinnen, J. V., JOSEPH, D. R., & Conti, M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.14.5325 · Cited by 173 · see citing works

cAMP-specific phosphodiesterase HSPDE4D3 mutants which mimic activation and changes in rolipram inhibition triggered by protein kinase A phosphorylation of Ser-54: generation of a molecular model

Hoffmann, R., Wilkinson, I., McCALLUM, J. F., ENGELS, P., & Houslay, M. D. (1998) · Biochemical Journal · doi:10.1042/bj3330139 · Cited by 165 · see citing works

Splice variants of the cyclic nucleotide phosphodiesterase PDE4D are differentially expressed and regulated in rat tissue

Richter, W., Jin, S.-L. C., & Conti, M. (2005) · Biochemical Journal · doi:10.1042/bj20050030 · Cited by 161 · see citing works

The phosphodiesterase-4 inhibitor rolipram reverses Aβ-induced cognitive impairment and neuroinflammatory and apoptotic responses in rats

Wang, C., Yang, X., Zhuo, Y., Zhou, H., Lin, H.-B., Cheng, Y., Xu, J., & Zhang, H. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000836 · Cited by 150 · see citing works

Cloning and characterization of mammalian homologs of the Drosophila dunce+ gene.

Davis, R., Takayasu, H., Eberwine, M., & Myres, J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.10.3604 · Cited by 146 · see citing works

GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses

Bruno, O., Fedele, E., Prickaerts, J., Parker, L. A., Canepa, E., Brullo, C., Cavallero, A., Gardella, E., Balbi, A., Domenicotti, C., et al. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01524.x · Cited by 138 · see citing works

Exome Sequencing Identifies PDE4D Mutations in Acrodysostosis

Lee, H., Graham, J. M., Rimoin, D. L., Lachman, R. S., Krejčı́, P., Tompson, S. W. J., Nelson, S. F., Krakow, D., & Cohn, D. H. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.03.004 · Cited by 136 · see citing works

Ameliorating effects of rolipram on experimentally induced impairments of learning and memory in rodents

Imanishi, T., Sawa, A., Ichimaru, Y., Miyashiro, M., Kato, S., Yamamoto, T., & Ueki, S. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(96)00969-7 · Cited by 130 · see citing works

Exome Sequencing Identifies PDE4D Mutations as Another Cause of Acrodysostosis

Michot, C., Goff, C. L., Goldenberg, A., Abhyankar, A., Klein, C., Kinning, E., Guerrot, A., Flahaut, P., Duncombe, A., Baujat, G., et al. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.03.003 · Cited by 128 · see citing works

Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors

Wang, H., Peng, M.-S., Chen, Y., Geng, J., Robinson, H. H., Houslay, M. D., Cai, J., & Ke, H. (2007) · Biochemical Journal · doi:10.1042/bj20070970 · Cited by 120 · see citing works

Beneficial effects of rolipram in the R6/2 mouse model of Huntington's disease

DeMarch, Z., Giampà, C., Patassini, S., Bernardi, G., & Fusco, F. R. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.02.010 · Cited by 117 · see citing works

PRKAR1A and PDE4D Mutations Cause Acrodysostosis but Two Distinct Syndromes with or without GPCR-Signaling Hormone Resistance

Linglart, A., Fryssira, H., Hiort, O., Holterhus, P., de Nanclares, G. P., Argente, J., Heinrichs, C., Kuechler, A., Mantovani, G., Leheup, B., et al. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2326 · Cited by 116 · see citing works

Crystal structure of phosphodiesterase 4D and inhibitor complex1

Lee, M. E., Markowitz, J., Lee, J., & Lee, H. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03396-3 · Cited by 114 · see citing works

Discovery of selective PDE4B inhibitors

Naganuma, K., Omura, A., Maekawara, N., Saitoh, M., Ohkawa, N., Kubota, T., Nagumo, H., Kodama, T., Takemura, M., Ohtsuka, Y., et al. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.04.121 · Cited by 111 · see citing works

Dimerization of the Type 4 cAMP-specific Phosphodiesterases Is Mediated by the Upstream Conserved Regions (UCRs)

Richter, W., & Conti, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203585200 · Cited by 110 · see citing works

Structural basis for the design of selective phosphodiesterase 4B inhibitors

Fox, D. N. A., Burgin, A. B., & Gurney, M. E. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.12.003 · Cited by 107 · see citing works

Inhibition of phosphodiesterase-4 reverses memory deficits produced by Aβ25–35 or Aβ1–40 peptide in rats

Cheng, Y., Wang, C., Lin, H.-B., Li, Y., Huang, Y., Xu, J., & Zhang, H. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1943-3 · Cited by 99 · see citing works

Proinflammatory cytokine regulation of cyclic AMP‐phosphodiesterase 4 signaling in microglia in vitro and following CNS injury

Ghosh, M., Garcia‐Castillo, D., Aguirre, V., Golshani, R., Atkins, C. M., Bramlett, H. M., Dietrich, W. D., & Pearse, D. D. (2012) · Glia · doi:10.1002/glia.22401 · Cited by 97 · see citing works

Structure of two rat genes coding for closely related rolipram-sensitive cAMP phosphodiesterases. Multiple mRNA variants originate from alternative splicing and multiple start sites.

Monaco, L., Vicini, E., & Conti, M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42355-6 · Cited by 93 · see citing works

The human area postrema and other nuclei related to the emetic reflex express cAMP phosphodiesterases 4B and 4D

Mori, F., Pérez-Torres, S., De, R., Porzionato, A., Macchi, V., Beleta, J., Gavaldà, A., Palacios, J. M., & Mengod, G. (2010) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2010.03.004 · Cited by 91 · see citing works

The Oligomerization State Determines Regulatory Properties and Inhibitor Sensitivity of Type 4 cAMP-specific Phosphodiesterases

Richter, W., & Conti, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312687200 · Cited by 90 · see citing works

Type 4 Phosphodiesterase Plays Different Integrating Roles in Different Cellular Domains in Pyramidal Cortical Neurons

Castro, L. R., Gervasi, N., Guiot, E., Cavellini, L., Nikolaev, V. O., Paupardin‐Tritsch, D., & Vincent, P. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5851-09.2010 · Cited by 79 · see citing works

cAMP microdomains and L‐type Ca2+ channel regulation in guinea‐pig ventricular myocytes

Warrier, S., Ramamurthy, G., Eckert, R. L., Nikolaev, V. O., Lohse, M. J., & Harvey, R. D. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2006.124891 · Cited by 65 · see citing works

Differential distribution of PDE4D splice variant mRNAs in rat brain suggests association with specific pathways and presynaptical localization

Miró, X., Pérez-Torres, S., Puigdomènech, P., Palacios, J. M., & Mengod, G. (2002) · Synapse · doi:10.1002/syn.10100 · Cited by 57 · see citing works

Identification of Novel Mutations ConfirmsPde4das a Major Gene Causing Acrodysostosis

Lynch, D. C., Dyment, D. A., Huang, L., Nikkel, S. M., Lacombe, D., Campeau, P. M., Lee, B., Bacino, C. A., Michaud, J. L., Bernier, F. P., et al. (2012) · Human Mutation · doi:10.1002/humu.22222 · Cited by 56 · see citing works

Disease modifying strategies for the treatment of Alzheimer's disease targeted at modulating levels of the β-amyloid peptide

Pangalos, M. N., Jacobsen, S. J., & Reinhart, P. H. (2005) · Biochemical Society Transactions · doi:10.1042/bst0330553 · Cited by 46 · see citing works

Development and organization of ocular dominance bands in primary visual cortex of the sable ferret

Ruthazer, E. S., Baker, G. E., & Stryker, M. P. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990503)407:2 · Cited by 46 · see citing works

The cAMP-specific phosphodiesterase 4B mediates Aβ-induced microglial activation

Sebastiani, G., Morissette, C., Lagacé, C., Boulé, M., Ouellette, M., McLaughlin, R. W., Lacombe, D., Gervais, F., & Tremblay, P. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.03.024 · Cited by 44 · see citing works

Identification of the fused bicyclic 4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors

Goto, T., Shiina, A., Yoshino, T., Mizukami, K., Hirahara, K., Suzuki, O., Sogawa, Y., Takahashi, T., Mikkaichi, T., Nakao, N., et al. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.03.104 · Cited by 40 · see citing works

Acrodysostosis: Report of a 13‐year‐old boy with review of literature and metacarphphalangeal pattern profile analysis

Butler, M. G., Rames, L. J., & Wadlington, W. B. (1988) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320300416 · Cited by 33 · see citing works

Efficacy of Selective PDE4D Negative Allosteric Modulators in the Object Retrieval Task in Female Cynomolgus Monkeys (Macaca fascicularis)

Sutcliffe, J. S., Beaumont, V., Watson, J. M., Chew, C. S., Beconi, M. G., Hutcheson, D. M., Dominguez, C., & Muñoz-Sanjuán, I. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102449 · Cited by 31 · see citing works

Phosphodiesterase Inhibition Rescues Chronic Cognitive Deficits Induced by Traumatic Brain Injury

Titus, D. J., Sakurai, A., Kang, Y., Furones, C., Jergova, S., Santos, R., Sick, T., & Atkins, C. M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5133-12.2013 · Cited by 29 · see citing works

Phosphodiesterase isoform‐specific expression induced by traumatic brain injury

Oliva, A. A., Kang, Y., Furones, C., Alonso, O. F., Bruno, O., Dietrich, W. D., & Atkins, C. M. (2012) · Journal of Neurochemistry · doi:10.1111/jnc.12049 · Cited by 29 · see citing works

Tau-targeting therapies for Alzheimer disease

Congdon, E. E., & Sigurdsson, E. M. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0013-z · Cited by 1,113 · see citing works

Increased miR‐124‐3p in microglial exosomes following traumatic brain injury inhibits neuronal inflammation and contributes to neurite outgrowth via their transfer into neurons

HUANG, S. H., Ge, X., Yu, J., Han, Z., Yin, Z., Li, Y., Chen, F., Wang, H., Zhang, J., & Lei, P. (2017) · The FASEB Journal · doi:10.1096/fj.201700673r · Cited by 422 · see citing works

Role of tau protein in Alzheimer’s disease: The prime pathological player

Muralidar, S., Ambi, S. V., Sekaran, S., Thirumalai, D., & Palaniappan, B. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.07.327 · Cited by 278 · see citing works

Pharmacological Modulation of Functional Phenotypes of Microglia in Neurodegenerative Diseases

Song, G. J., & Suk, K. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00139 · Cited by 199 · see citing works

Investigational phosphodiesterase inhibitors in phase I and phase II clinical trials for Alzheimer’s disease

Prickaerts, J., Heckman, P. R. A., & Blokland, A. (2017) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2017.1364360 · Cited by 172 · see citing works

Tumor Necrosis Factor (TNF) blocking agents are associated with lower risk for Alzheimer’s disease in patients with rheumatoid arthritis and psoriasis

Zhou, M., Xu, R., Kaelber, D. C., & Gurney, M. E. (2020) · PLOS ONE · doi:10.1371/journal.pone.0229819 · Cited by 157 · see citing works

Alzheimer's disease: Updated multi-targets therapeutics are in clinical and in progress

Sang, Z., Wang, K., Dong, J., & Tang, L. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114464 · Cited by 127 · see citing works

Advances in the Development of Phosphodiesterase-4 Inhibitors

Peng, T., Qi, B., He, J., Ke, H., & Shi, J. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b02170 · Cited by 119 · see citing works

The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses

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Phosphodiesterase-4 enzyme as a therapeutic target in neurological disorders

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