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The Gut Microbiome as Therapeutic Target in Central Nervous System Diseases: Implications for Stroke
Open accessAbstract
Research on commensal microbiota and its contribution to health and disease is a new and very dynamically developing field of biology and medicine. Recent experimental and clinical investigations underscore the importance of gut microbiota in the pathogenesis and course of stroke. Importantly, microbiota may influence the outcome of cerebral ischemia by modulating central nervous system antigen-specific immune responses. In this review we summarize studies linking gut microbiota with physiological function and disorders of the central nervous system. Based on these insights we speculate about targeting the gut microbiome in order to treat stroke.
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“Several different microbiome-targeted approaches, including prebiotic, probiotic, and FMT strategies, have shown promising results for a variety of GI conditions in preclinical and clinical models and could be extended to pathologies involving microglia in the near future (Fond et al., 2015; Winek et al., 2016).”
From Microbiome–microglia connections via the gut–brain axis (2019) · cites this paper as Winek et al., 2016
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“compared with specific-pathogen-free (SPF) mice, germ-free (GF) mice show social communication disorders and increased anxiety behaviors, and these abnormal social behaviors are corrected after the mice are colonized with normal microbiota”
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Research works printed but not linked: 1
- Dickson, 2016, The premature invocation of a ‘gut-lung axis' may obscure the direct effects of respiratory microbiota on pneumonia susceptibility, Gut
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Brain-gut communication and potential applications of microecological treatments in stroke
Gao, M., Zhou, Y., Zhang, K., Ye, Y., Han, Z., Chen, Q., Shi, W., & Lu, X. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1799890
Guan, J., Kizil, B., Kalakoti, G., Kummerfeld, D.-M., Doroshenko, O., Pelcastre-Neri, V., Frigger, N. C., Cirri, E., Pömpner, N., Goyal, M., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.25.727504
Self-citation
Metadata
- Authors
- Winek, K., Dirnagl, U., & Meisel, A.
- Affiliations
- Center for Stroke Research Berlin (DE)
- German Center for Neurodegenerative Diseases (DE)
- Corresponding author
- Meisel, Andreas
- Venue
- Neurotherapeutics
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 13
- Issue
- 4
- Pages
- 762-774
- ISSN
- 1878-7479 (ISSN-L)
- PMC
- PMC5081128
- OpenAlex
- W2528944013
- Cited by
- 108
- References
- 141
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 7 · 2023: 8 · 2022: 12 · 2021: 15 · 2020: 17 · 2019: 16 · 2018: 9 · 2017: 9 · 2016: 1
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neurotherapeutics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DZNE Pub (submittedVersion, other-oa)
- Funders
- Deutsche Forschungsgemeinschaft (NeuroCure Cluster of Excellence, Exc 257, Collaborative Research Centres SFB-TRR 84)
- Center for Stroke Research Berlin (01 EO 08 01)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- gut microbiota, stroke, cerebral ischemia, central nervous system disorders, commensal microbiota, immune response, microbiome-targeted therapy, neuroinflammation
- MeSH terms
- Gastrointestinal Microbiome, Animals, Brain, Central Nervous System Diseases, Humans, Microbiota
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