The Gut Microbiome as Therapeutic Target in Central Nervous System Diseases: Implications for Stroke

The “Golden Age” of Probiotics: A Systematic Review and Meta-Analysis of Randomized and Observational Studies in Preterm Infants

Dermyshi, E., Wang, Y., Yan, C., Hong, W., Qiu, G., Gong, X., & Zhang, T. (2017) · Neonatology · doi:10.1159/000454668 · Cited by 24,586

A core gut microbiome in obese and lean twins

Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823

The gut microbiota as an environmental factor that regulates fat storage

Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature · doi:10.1038/nature09922 · Cited by 5,597

EVOLUTION AND MEASUREMENT OF SPECIES DIVERSITY

WHITTAKER, R. H. (1972) · Taxon · doi:10.2307/1218190 · Cited by 5,398

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

Koeth, R. A., Wang, Z., Levison, B. S., Buffa, J. A., Org, E., Sheehy, B. T., Britt, E. B., Fu, X., Wu, Y., Li, L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3145 · Cited by 4,386

Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy

Sivan, A., Corrales, L., Hubert, N., Williams, J. B., Aquino-Michaels, K., Earley, Z. M., Benyamin, F. W., Man Lei, Y., Jabri, B., Alegre, M.-L., et al. (2015) · Science · doi:10.1126/science.aac4255 · Cited by 3,888 · cited 1×

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888

Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile

van Nood, E., Vrieze, A., Nieuwdorp, M., Fuentes, S., Zoetendal, E. G., de Vos, W. M., Visser, C. E., Kuijper, E. J., Bartelsman, J. F. W. M., Tijssen, J. G. P., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1205037 · Cited by 3,708

The Microbiota-Gut-Brain Axis

Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286

A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders

Sorboni, S. G., Moghaddam, H. S., Esfehani, R. J., & Soleimanpour, S. (2022) · Clinical Microbiology Reviews · doi:10.1128/cmr.00338-20 · Cited by 586

Tryptophan metabolism and gut-brain homeostasis

Roth, W., Zadeh, K., Vekariya, R., Ge, Y., & Mohamadzadeh, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062973 · Cited by 519

Microbiome–microglia connections via the gut–brain axis

Abdel-Haq, R., Schlachetzki, J. C. M., Glass, C. K., & Mazmanian, S. K. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20180794 · Cited by 471

The progress of gut microbiome research related to brain disorders

Zhu, S., Jiang, Y., Xu, K., Cui, M., Ye, W., Zhao, G., Jin, L., & Chen, X. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-1705-z · Cited by 419

Transplantation of fecal microbiota rich in short chain fatty acids and butyric acid treat cerebral ischemic stroke by regulating gut microbiota

Chen, R., Xu, Y., Wu, P., Zhou, H., Lasanajak, Y., Fang, Y., Tang, L. Y., Ye, L., Li, X., Cai, Z., et al. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104403 · Cited by 374

Brain–gut–microbiota axis — mood, metabolism and behaviour

Dinan, T. G., & Cryan, J. F. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.200 · Cited by 361

Lipopolysaccharide Associates with Amyloid Plaques, Neurons and Oligodendrocytes in Alzheimer’s Disease Brain: A Review

Zhan, X., Stamova, B. S., & Sharp, F. R. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00042 · Cited by 361

Gut reactions: Breaking down xenobiotic–microbiome interactions

Clarke, G., Sandhu, K. V., Griffin, B. T., Dinan, T. G., Cryan, J. F., & Hyland, N. P. (2019) · Pharmacological Reviews · doi:10.1124/pr.118.015768 · Cited by 319

Dysbiosis of Gut Microbiota and Short‐Chain Fatty Acids in Acute Ischemic Stroke and the Subsequent Risk for Poor Functional Outcomes

Tan, C., Wu, Q., Wang, H., Gao, X., Xu, R., Cui, Z., Zhu, J., Zeng, X., Zhou, H., He, Y., et al. (2020) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1861 · Cited by 233

Stroke Dysbiosis Index (SDI) in Gut Microbiome Are Associated With Brain Injury and Prognosis of Stroke

Xia, G., You, C., Gao, X., Zeng, X., Zhu, J., Xu, K., Tan, C., Xu, R., Wu, Q., Zhou, H., et al. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00397 · Cited by 226

Steroids, stress and the gut microbiome-brain axis

Tetel, M. J., de Vries, G. J., Melcangi, R. C., Panzica, G., & O'Mahony, S. M. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12548 · Cited by 187

Brain–gut axis after stroke

Hu, B., & Arya, A. K. (2018) · Brain Circulation · doi:10.4103/bc.bc_32_18 · Cited by 170

Secretome of Intestinal Bacilli: A Natural Guard against Pathologies

Ilinskaya, O. N., Владимировна, У. В., Рашидовна, Я. Д., & Гатауллин, И. Г. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01666 · Cited by 149

Fecal Microbiome Transplantation from Children with Autism Spectrum Disorder Modulates Tryptophan and Serotonergic Synapse Metabolism and Induces Altered Behaviors in Germ-Free Mice

Xiao, L., Yan, J., Yang, T., Zhu, J., Li, T., Wei, H., & Chen, J. (2021) · mSystems · doi:10.1128/msystems.01343-20 · Cited by 141

The gut microbiota as a key regulator of visceral pain

O’Mahony, S. M., Dinan, T. G., & Cryan, J. F. (2016) · Pain · doi:10.1097/j.pain.0000000000000779 · Cited by 104

Baicalin ameliorates neuropathology in repeated cerebral ischemia-reperfusion injury model mice by remodeling the gut microbiota

Liu, J., Zhang, T., Wang, Y., Si, C., Wang, X., Wang, R., & Lv, Z. (2020) · Aging · doi:10.18632/aging.102846 · Cited by 90

Gut microbiota dysbiosis enhances migraine-like pain via TNFα upregulation

Tang, Y., Liu, S., Shu, H., Yanagisawa, L., & Tao, F. (2020) · Molecular Neurobiology · doi:10.1007/s12035-019-01721-7 · Cited by 88

The influence of gut microbiota alteration on age-related neuroinflammation and cognitive decline

Shah, Z., & Alsegiani, A. S. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.335837 · Cited by 89

Administration of Bifidobacterium breve Improves the Brain Function of Aβ1-42-Treated Mice via the Modulation of the Gut Microbiome

Zhu, G., Zhao, J., Zhang, H., Chen, W., & Wang, G. (2021) · Nutrients · doi:10.3390/nu13051602 · Cited by 89

Irritable Bowel Syndrome and Stress-Related Psychiatric Co-morbidities: Focus on Early Life Stress

O’Mahony, S. M., Clarke, G. A., Dinan, T. G., & Cryan, J. F. (2017) · Handbook of experimental pharmacology · doi:10.1007/164_2016_128 · Cited by 82

Exploring the microbiome in health and disease

Scotti, E., Boué, S., Sasso, G. L., Zanetti, F., Belcastro, V., Poussin, C., Sierro, N., Battey, J. N. D., Gimalac, A., Ivanov, N. V., et al. (2017) · Toxicology Research and Application · doi:10.1177/2397847317741884 · Cited by 56

Protective Effect of Tong-Qiao-Huo-Xue Decoction on Inflammatory Injury Caused by Intestinal Microbial Disorders in Stroke Rats

Zhang, F., Zhai, M., Wu, Q., Jia, X., Wang, Y., & Wang, N. (2020) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b19-00847 · Cited by 53

Dynamic Changes in the Gut Microbiome at the Acute Stage of Ischemic Stroke in a Pig Model

Jeon, J. H., Lourenco, J. M., Kaiser, E. E., Waters, E. S., Scheulin, K. M., Fang, X., Kinder, H. A., Platt, S. R., Rothrock, M. J., Callaway, T. R., et al. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.587986 · Cited by 55

Gut Microbiota‐Related Effects of Tanhuo Decoction in Acute Ischemic Stroke

Guo, Q., Jiang, X., Ni, C., Li, L., Chen, L., Wang, Y., Li, M., Wang, C., Gao, L. Q., Zhu, H., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5596924 · Cited by 54

Mechanisms of inflammation after ischemic stroke in brain-peripheral crosstalk

Xie, L., He, M., Ying, C., & Chu, H. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1400808 · Cited by 54

The gut-brain axis in ischemic stroke: its relevance in pathology and as a therapeutic target

Benakis, C., & Liesz, A. (2022) · Neurological Research and Practice · doi:10.1186/s42466-022-00222-8 · Cited by 52

Bacterial lipopolysaccharide is associated with stroke

Hakoupian, M., Ferino, E., Jickling, G. C., Amini, H., Stamova, B. S., Ander, B. P., Alomar, N., Sharp, F. R., & Zhan, X. (2021) · Scientific Reports · doi:10.1038/s41598-021-86083-8 · Cited by 46

In vivo imaging biomarkers of neuroinflammation in the development and assessment of stroke therapies - towards clinical translation

Zinnhardt, B., Wiesmann, M., Honold, L., Barca, C., Schäfers, M. A., Kiliaan, A. J., & Jacobs, A. H. (2018) · Theranostics · doi:10.7150/thno.24128 · Cited by 44

Orally Administered Crocin Protects Against Cerebral Ischemia/Reperfusion Injury Through the Metabolic Transformation of Crocetin by Gut Microbiota

Zhang, Y., Geng, J., Hong, Y., Li, J., Li, S., Sun, R., Xie, Y., Yan, C., Aa, J., & Wang, G. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00440 · Cited by 43

Complex interplay of multiple biological systems that contribute to post-stroke infections

Shim, R., & Wong, C. H. Y. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.03.019 · Cited by 40

The role of cofilin in age-related neuroinflammation

Alsegiani, A. S., & Shah, Z. A. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.274330 · Cited by 40

Poststroke Lung Infection by Opportunistic Commensal Bacteria Is Not Mediated by Their Expansion in the Gut Microbiota

Díaz-Marugán, L., Gallizioli, M., Márquez‐Kisinousky, L., Arboleya, S., Mastrangelo, A., Ruíz-Jaén, F., Pedragosa, J., Casals, C., Morales, F. J., Ramos‐Romero, S., et al. (2023) · Stroke · doi:10.1161/strokeaha.123.042755 · Cited by 38

Translational Block in Stroke: A Constructive and “Out-of-the-Box” Reappraisal

Lourbopoulos, A. I., Mourouzis, I. S., Xinaris, C., Zerva, N., Filippakis, K., Pavlopoulos, A., & Pantos, C. I. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.652403 · Cited by 40

The transformative possibilities of the microbiota and mycobiota for health, disease, aging, and technological innovation

Jones, L., Kumar, J., Mistry, A., Sankar Chittoor Mana, T., Perry, G., Reddy, V. P., & Obrenovich, M. (2019) · Biomedicines · doi:10.3390/biomedicines7020024 · Cited by 34

Pharmacological Effects and Regulatory Mechanisms of Tobacco Smoking Effects on Food Intake and Weight Control

Hu, T., Yang, Z., & Li, M. D. (2018) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-018-9800-y · Cited by 34

Chungkookjang, a soy food, fermented with Bacillus amyloliquefaciens protects gerbils against ishcmeic stroke injury, and post-stroke hyperglycemia

Jeong, D., Jeong, S.-Y., Zhang, T., Wu, X., Qiu, J. Y., & Park, S. (2019) · Food Research International · doi:10.1016/j.foodres.2019.108769 · Cited by 34

Are There Potential Applications of Fecal Microbiota Transplantation beyond Intestinal Disorders?

Zhou, Y., Xu, H., Huang, H., Li, Y., Chen, H., He, J., Du, Y., Chen, Y., Zhou, Y., & Nie, Y. (2019) · BioMed Research International · doi:10.1155/2019/3469754 · Cited by 32

Influence of the gut microbiome on inflammatory and immune response after stroke

Huang, Q., & Xia, J. (2021) · Neurological Sciences · doi:10.1007/s10072-021-05603-6 · Cited by 31

Protection against Neurological Symptoms by Consuming Corn Silk Water Extract in Artery-Occluded Gerbils with Reducing Oxidative Stress, Inflammation, and Post-Stroke Hyperglycemia through the Gut-Brain Axis

Ryuk, J. A., Ko, B., Moon, N. R., & Park, S. (2022) · Antioxidants · doi:10.3390/antiox11010168 · Cited by 30

Biotransformation of natural hydroxycinnamic acids by gut microbiota from normal and cerebral ischemia-reperfusion injured rats: a comparative study

Shen, H., Tong, X., Yang, J., Yu, L., Zhou, H., Wang, Y., He, Y. T., Wan, H., & Li, C. (2020) · Food & Function · doi:10.1039/d0fo00775g · Cited by 32

Migraine as a Disease Associated with Dysbiosis and Possible Therapy with Fecal Microbiota Transplantation

Kappéter, Á., Sipos, D., Varga, A., Vigvári, S., Halda-Kiss, B., & Péterfi, Z. (2023) · Microorganisms · doi:10.3390/microorganisms11082083 · Cited by 30

Crosstalk between gut microbiome and immunology in the management of ischemic brain injury

Rahman, Z., & Dandekar, M. P. (2021) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2021.577498 · Cited by 28

Ischemic Stroke Impacts the Gut Microbiome, Ileal Epithelial and Immune Homeostasis

Ge, Y., Zadeh, M., Yang, C., Candelario‐Jalil, E., & Mohamadzadeh, M. (2022) · iScience · doi:10.1016/j.isci.2022.105437 · Cited by 26

Old Dog New Tricks; Revisiting How Stroke Modulates the Systemic Immune Landscape

Krishnan, S., & Lawrence, C. B. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00718 · Cited by 24

Microbiota Gut–Brain Axis in Ischemic Stroke: A Narrative Review with a Focus about the Relationship with Inflammatory Bowel Disease

Sinagra, E., Pellegatta, G., Guarnotta, V., Maida, M. F., Rossi, F., Conoscenti, G., Pallio, S., Alloro, R., Raimondo, D., Pace, F., et al. (2021) · Life · doi:10.3390/life11070715 · Cited by 23

Inflammation-relevant microbiome signature of the stroke brain, gut, spleen, and thymus and the impact of exercise

Kingsbury, C., Shear, A., Heyck, M., Sadanandan, N., Zhang, H., Gonzales-Portillo, B., Cozene, B., Sheyner, M., Navarro-Torres, L., García-Sánchez, J., et al. (2021) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x211039598 · Cited by 23

Intersecting Pathways: The Role of Metabolic Dysregulation, Gastrointestinal Microbiome, and Inflammation in Acute Ischemic Stroke Pathogenesis and Outcomes

Nuszkiewicz, J., Kukulska-Pawluczuk, B., Piec, K., Jarek, D. J., Motolko, K., Szewczyk‐Golec, K., & Woźniak, A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13144258 · Cited by 24

Effects of Dioscorea polystachya 'yam gruel' on the cognitive function of diabetic rats with focal cerebral ischemia-reperfusion injury via the gut-brain axis

Pang, S., Luo, Z., Wang, C. C., Hong, X., Zhou, J., Chen, F., Ge, L., Li, X., Dai, Y., Wu, Y., et al. (2020) · Journal of Integrative Neuroscience · doi:10.31083/j.jin.2020.02.69 · Cited by 23

The Brain-gut Axis-where are we now and how can we Modulate these Connections?

Dąbrowski, W., Siwicka-Gieroba, D., Kotfis, K., Zaid, S., Terpiłowska, S., Robba, C., & Siwicki, A. K. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666201119155535 · Cited by 21

The Gut Brain-Axis in Neurological Diseases

Barbosa, P., & Barbosa, E. R. (2020) · International Journal of Cardiovascular Sciences · doi:10.36660/ijcs.20200039 · Cited by 20

Microecologics and Exercise: Targeting the Microbiota–Gut–Brain Axis for Central Nervous System Disease Intervention

Peng, Z., Hou, T., Yang, K., Zhang, J., Mao, Y.-H., & Hou, X. (2025) · Nutrients · doi:10.3390/nu17111769 · Cited by 21

Evaluation of improvement of cognitive impairment in older adults with probiotic supplementation: A systematic review and meta-analysis

Kou, J., Kang, H., Hu, L., Wang, D., Wang, S., Wang, Q., & Yang, Z. (2023) · Geriatric Nursing · doi:10.1016/j.gerinurse.2023.09.009 · Cited by 21

Imbalance in the force: the dark side of the microbiota on stroke risk and progression

Kumar, K. P., & Wong, C. H. Y. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.10.002 · Cited by 18

Could the Gut Microbiota Serve as a Therapeutic Target in Ischemic Stroke?

Zhang, J., Tang, Q., & Zhu, L. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/1391384 · Cited by 17

Development of an Index Score for Intestinal Inflammation-Associated Dysbiosis Using Real-World Stool Test Results

Chen, L., Reynolds, C. A., David, R. M., & Brewer, A. P. (2019) · Digestive Diseases and Sciences · doi:10.1007/s10620-019-05828-8 · Cited by 16

The gut microbiota in post-stroke depression: A systematic review of microbial mechanisms and therapeutic targeting of neuroinflammation

Zhang, Q., Zhang, S., Cao, X., Zhi, Y., & Guo, Y. C. (2025) · Microbiological Research · doi:10.1016/j.micres.2025.128391 · Cited by 17

Mapping trends and hotspot regarding gastrointestinal microbiome and neuroscience: A bibliometric analysis of global research (2002–2022)

Yang, J., Deng, Y., Cai, Y., Liu, Y., Peng, L., Luo, Z., & Li, D. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1048565 · Cited by 16

Therapeutic potential of nutraceuticals to protect brain after stroke

Chelluboina, B., & Vemuganti, R. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104908 · Cited by 14

Effect of gut microbiota on host whole metabolome

Moriya, T., Satomi, Y., Murata, S., Sawada, H., & Kobayashi, H. (2017) · Metabolomics · doi:10.1007/s11306-017-1240-9 · Cited by 15

Anti-Inflammatory Effects of Hydrogen Sulfide in Axes Between Gut and Other Organs

Lu, W., & Wen, J. (2024) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0531 · Cited by 14

The current novel therapeutic regimens forClostridium difficileinfection (CDI) and the potentials of Traditional Chinese Medicine in treatment of CDI

Gao, Y., Li, H., Yang, H., Su, J., & Huang, L. (2019) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2019.1700905 · Cited by 11

Impaired tissue barriers as potential therapeutic targets for Parkinson’s disease and amyotrophic lateral sclerosis

Fang, X. (2018) · Metabolic Brain Disease · doi:10.1007/s11011-018-0239-x · Cited by 11

Untargeted metabonomic analysis of a cerebral stroke model in rats: a study based on UPLC–MS/MS

Huang, D., Yang, Y., Song, W., Jiang, C., Zhang, Y., Zhang, A., Lin, Z., & Ke, X. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1084813 · Cited by 11

Precision neurology

Small, S. L. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102632 · Cited by 10

Role of the Gut Microbiota in Ischemic Stroke

Winek, K., Dirnagl, U., & Meisel, A. (2017) · Neurology International Open · doi:10.1055/s-0043-107843 · Cited by 10

Gastrointestinal Hemorrhage is Associated with Mortality after Acute Ischemic Stroke

Zhou, Y., Xu, W., Wang, W., Yao, S., Xiao, B., Wang, Y., & Chen, B. (2019) · Current Neurovascular Research · doi:10.2174/1567202616666190412160451 · Cited by 9

Ischaemic stroke patients present sex differences in gut microbiota

Lledós, M., Prats‐Sánchez, L., Llucià‐Carol, L., Cárcel‐Márquez, J., Muiño, E., Cullell, N., Gallego-Fábrega, C., Martín-Campos, J. M., Aguilera‐Simón, A., Guasch‐Jiménez, M., et al. (2023) · European Journal of Neurology · doi:10.1111/ene.15931 · Cited by 8

Crosstalk between the gut microbiota and brain network topology in poststroke aphasia patients: perspectives from neuroimaging findings

Cao, Y., Huang, J., Zhang, D., Ji, J., Lei, X., Tan, Z., & Chang, J. (2025) · Therapeutic Advances in Neurological Disorders · doi:10.1177/17562864251319870 · Cited by 8

Effects of Intestinal Flora on Irritable Bowel Syndrome and Therapeutic Significance of Polysaccharides

Ye, Y., Liu, Y., Cheng, K., Wu, Z., Zhang, P., & Zhang, X. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.810453 · Cited by 8

Experimental Stroke Induces Chronic Gut Dysbiosis and Neuroinflammation in Male MicePreprint

Brichacek, A. L., Nwafor, D. C., Benkovic, S. A., Chakraborty, S., Kenney, S. M., Mace, M. E., Jun, S., Gambill, C. A., Wang, W., Hu, H., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.29.069575 · Cited by 7

Insights of acupuncture in modulating gut microbiota in stroke treatment

Xing, H., Lin, W.-J., Hu, W.-L., Cao, J.-S., Cui, Y., Lyu, W., Zhu, H.-K., Wu, A.-J., Xu, Q., Zhao, Y., et al. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1579585 · Cited by 6

Investigating causal associations of gut microbiota and blood metabolites on stroke and its subtypes: A Mendelian randomization study

Zhang, R., Han, L., Pu, L., Jiang, G., Guan, Q., Fan, W., & Liu, H. (2025) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2025.108233 · Cited by 8

Gastrointestinal Dysfunction and Dysbiosis in Ischemic Stroke: Opportunities for Therapeutic Intervention

Macom, R. V., & Brown, C. M. (2025) · Pharmaceuticals · doi:10.3390/ph18030320 · Cited by 7

Importance of fiber in human diet: Contribution of microbiota in human health

Farooqui, A. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821039-0.00010-1 · Cited by 4

Gut Microbiota:Metabolic Programmers as a Lead for Deciphering Ayurvedic Pharmacokinetics

Ranade, A. V., Gayakwad, S., Chougule, S., Shirolkar, A. R., Gaidhani, S. N., & Pawar, S. D. (2020) · Current Science · doi:10.18520/cs/v119/i3/451-461 · Cited by 2

Gut microbiome and serum metabolome as biomarkers of clinical severity and prognosis in patients with traumatic brain injury

Li, P., Xie, L., Ma, Q., Liu, B., Cheng, H., & Mao, X. (2024) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003310 · Cited by 3

Microbial Signature Present in Thrombotic Material of Acute Ischemic Stroke Patients Retrieved by Mechanical Thrombectomy

Yadav, L. B., Tiwari, S., Vajpeyee, M., & Vajpeyee, A. (2023) · Neurochemical Journal · doi:10.1134/s1819712423030194 · Cited by 3

Gut Remediation: Back to the Future

Ling, Z., Jiang, Y., & Li, X. (2020) · Springer eBooks · doi:10.1007/978-981-15-4759-1_7 · Cited by 3

Gut Microbiome in Stress-related Disorders: The New Approaches to Neuroinflamation syndrome

Халтурина, Е. О., Klyueva, L. A., Boshiyan, R. E., Zembatov, G. M., & Alimova, A. M. (2022) · Экспериментальная и клиническая гастроэнтерология · doi:10.31146/1682-8658-ecg-196-12-74-82 · Cited by 2

Gut Microbiome Differentiates Levels of Consciousness in Patients with Prolonged Disorders of Consciousness after Brain Injury

You, W., Lin, Y., Wei, A., Cai, J., Wen, L., Lin, Y., Yang, X., & Wu, Z. (2025) · Journal of Neurotrauma · doi:10.1177/08977151251360256 · Cited by 2

Microbiota–Drug Interaction and Its Influence on Drug Metabolism and Toxicity

Pal, R., Bhowmick, P., Mahanty, J., Halder, P., & Bhowmick, M. (2025) · Interdisciplinary biotechnological advances · doi:10.1007/978-981-95-2104-3_3 · Cited by 2

Robot-assisted gait training alleviates the symptoms of acute ischemic stroke via regulating gut microbiota composition and function

Liu, H., Han, B., Yao, H., Wang, J., Xv, F., Xv, Y., Zhang, M., Lin, M., Li, Z., Wang, S., et al. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2026.1810501 · Cited by 2

Human Gut Microbiome as an Indicator of Human Health

Ivanova, A., Yalovenko, O., & Dugan, A. (2021) · Innovative Biosystems and Bioengineering · doi:10.20535/ibb.2021.5.4.244375 · Cited by 2

Non-concussive head impacts sustained during American football correlate with changes in gut microbiome diversity and composition

Pelland, Z. J., Zafar, A., Ay, A. A., & Belanger, K. D. (2026) · PLoS ONE · doi:10.1371/journal.pone.0345651 · Cited by 1

Insulin resistance and stroke

Farooqui, A. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819603-8.00005-5 · Cited by 1

Gut Microbiota Regulation of Cerebral Stroke

Kumar, K., Hema, K., & Tripathi, A. K. (2022) · Nutritional neurosciences · doi:10.1007/978-981-19-4530-4_4 · Cited by 1

Insulin resistance and Alzheimer’s disease

Farooqui, A. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819603-8.00006-7 · Cited by 1

The contribution of microbiota, cerebral blood flow, and sleep deprivation in the pathogenesis of Alzheimer’s disease

Farooqui, A. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821039-0.00001-0 · Cited by 1

PREBIOTICS FOR ACUTE ISCHEMIC STROKE

Renamastika, S. N., Wahyuningrum, D. R., PUTRI, V. A., & Aisy, R. (2021) · International Journal of Pharmacy and Pharmaceutical Sciences · doi:10.22159/ijpps.2021v13i5.41110 · Cited by 1

The Bacterial Blood Microbiota/Microbiome

Burd, E. M., & Westblade, L. F. (2017) · doi:10.1128/9781555819811.ch13 · Cited by 1

Die Bedeutung des intestinalen Mikrobioms beim ischämischen Schlaganfall

Winek, K., Dirnagl, U., & Meisel, A. (2017) · Aktuelle Neurologie · doi:10.1055/s-0043-108060

Gastrointestinal Growth and Development: From Embryo to Adult. The Aging Gut

Welcome, M. O. (2018) · Springer eBooks · doi:10.1007/978-3-319-91056-7_6

Computational psychiatry 2.0 and implications for stress researchPreprint

Pashkov, A. A., & Беребин, М. А. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/483164

Nutrition and the Neurologic Patient

Badjatia, N., Patel, N., & Tavarez, T. (2019) · Textbook of Neuroanesthesia and Neurocritical Care · doi:10.1007/978-981-13-3390-3_17

Linking homocysteine, B vitamins, and choline to ischemic stroke risk

Moftah, M., Emmerson, J. T., & Jadavji, N. M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-811907-5.00010-5

Effect of diet on neurological disorders and regenerative processes in the brain

Farooqui, A. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-821711-5.00002-4

Histamine Regulates BDNF Catabolism By Specific Gut MicrobesPreprint

Luo, Q., Shi, R., Liu, Y., Huang, L., Chen, W., & Wang, C. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4047089

Gut microbiome as a target organ in diagnosis and treatment of neuropsychiatric disorders and diseases (a literature review)

Мінухін, В. В., Knysh, O. V., Ждамарова, Л. А., Bolshakova, H., & Voyda, Y. V. (2022) · Zaporozhye Medical Journal · doi:10.14739/2310-1210.2022.1.236932

Upregulation of CXCL1 and FCGR1A is Associated With the ischemic stroke and Crohn’s DiseasePreprint

Zhang, W., Li, Y., Xu, H., Li, C., Zhang, Y., & Han, B. (2023) · Research Square · doi:10.21203/rs.3.rs-2676536/v1

Role of the Gut Microbiota in Ischemic Stroke

Winek, K., Dirnagl, U., & Meisel, A. (2017) · Neurology International Open · doi:10.1055/s-0043-107843 · Cited by 10

Bidirectional Microbiota-Gut-Brain Axis after Stroke and Its Implications for Treating Ischemic Stroke

Lei, C., Liu, C., Chen, E.-Y., Lin, L.-D., Liu, T., & Liu, Z. (2022) · Exploratory Research and Hypothesis in Medicine · doi:10.14218/erhm.2022.00040 · Cited by 1

The specifics of the intestinal microflora and the relevance of improving the intestinal microbiota in stroke patients

Gulmurotova, D., Muminov, K., & Tursunaliev, S. (2025) · Eurasian Journal of Medical and Natural Sciences · doi:10.70413/ejmns-v05-i11-s46768

Searching for new therapy options – the microbiome in the spotlight of stroke research

Meisel, A., & Winek, K. (2017) · The Biochemist · doi:10.1042/bio03902018

The Role of the Gut Microbiota in the Development of Ischemic Stroke

Wang, J., Zhang, H., He, J., & Xiong, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.845243 · Cited by 56