The DOI matches its Crossref record; 75 of the 76 references it cites were found in a registry or an index.
The Role of the Gut Microbiome in Multiple Sclerosis Risk and Progression : Towards Characterization of the “MS Microbiome.”
Open accessAbstract
Multiple sclerosis (MS) is the prototypic complex disease, in which both genes and the environment contribute to its pathogenesis. To date, > 200 independent loci across the genome have been associated with MS risk. However, these only explain a fraction of the total phenotypic variance, suggesting the possible presence of additional genetic factors, and, most likely, also environmental factors. New DNA sequencing technologies have enabled the sequencing of all kinds of microorganisms, including those living in and around humans (i.e., microbiomes). The study of bacterial populations inhabiting the gut is of particular interest in autoimmune diseases owing to their key role in shaping immune responses. In this review, we address the potential crosstalk between B cells and the gut microbiota, a relevant scenario in light of recently approved anti-B-cell therapies for MS. In addition, we review recent efforts to characterize the gut microbiome in patients with MS and discuss potential challenges and future opportunities. Finally, we describe the international MS microbiome study, a multicenter effort to study a large population of patients with MS and their healthy household partners to define the core MS microbiome, how it is shaped by disease-modifying therapies, and to explore potential therapeutic interventions.
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“Interestingly, even MS patients with active disease have an altered microbiota compared to patients in the remission phase, which in turn have a microbiota more similar to healthy controls (25, 134–138).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [138]
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Cites
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“Another major potential confounder for studies on the gut microbiome is diet, whose influence on the gut bacterial composition is arguably stronger than that of genetics [60].”
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
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Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment
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Wallin, M. T., Culpepper, W. J., Nichols, E., Bhutta, Z. A., Gebrehiwot, T. T., Hay, S. I., Khalil, I. A., Krohn, K. J., Liang, X., Naghavi, M., et al. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30443-5 · Cited by 1,134
The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology
Rutsch, A., Kantsjö, J. B., & Ronchi, F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.604179 · Cited by 821
Microbiota-Brain-Gut Axis and Neurodegenerative Diseases
Quigley, E. M. M. (2017) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-017-0802-6 · Cited by 804
Zhou, X., Baumann, R., Gao, X., Mendoza, M., Singh, S., Sand, I. K., Xia, Z., Cox, L. M., Chitnis, T., Yoon, H., et al. (2022) · Cell · doi:10.1016/j.cell.2022.08.021 · Cited by 326
Self-citationThe gut microbiota–brain axis in neurological disorder
Ullah, H., Arbab, S., Tian, Y., Liu, C., Chen, Y., Li, Q., Khan, M. I. U., Hassan, I. U., & Li, K. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1225875 · Cited by 292
Metadata
- Authors
- Pröbstel, A.-K., & Baranzini, S. E.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Baranzini, Sergio E.
- Venue
- Neurotherapeutics
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 15
- Issue
- 1
- Pages
- 126-134
- ISSN
- 1878-7479 (ISSN-L)
- PMC
- PMC5794700
- OpenAlex
- W2769299506
- Cited by
- 110
- References
- 76
- Citations by year
- 2026: 11 · 2025: 7 · 2024: 12 · 2023: 9 · 2022: 22 · 2021: 13 · 2020: 18 · 2019: 8 · 2018: 9
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neurotherapeutics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Multiple Sclerosis Society (US) (CA_1072-A)
- U.S. Department of Defense (US) (W81XWH-15-1-0652)
- Valhalla Charitable Foundation (N/A)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (CH) (P2SKP3_164938)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Keywords
- multiple sclerosis, gut microbiota, B cells, autoimmune disease, disease-modifying therapy, anti-B-cell therapy, disease progression, risk factors, core microbiome, therapeutic interventions
- MeSH terms
- Gastrointestinal Microbiome, Animals, B-Lymphocytes, Humans, Multiple Sclerosis, Risk Factors, Disease Progression, Dysbiosis
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