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The Role of the Gut Microbiome in Multiple Sclerosis Risk and Progression : Towards Characterization of the “MS Microbiome.”
Open accessAbstract
Multiple sclerosis (MS) is the prototypic complex disease, in which both genes and the environment contribute to its pathogenesis. To date, > 200 independent loci across the genome have been associated with MS risk. However, these only explain a fraction of the total phenotypic variance, suggesting the possible presence of additional genetic factors, and, most likely, also environmental factors. New DNA sequencing technologies have enabled the sequencing of all kinds of microorganisms, including those living in and around humans (i.e., microbiomes). The study of bacterial populations inhabiting the gut is of particular interest in autoimmune diseases owing to their key role in shaping immune responses. In this review, we address the potential crosstalk between B cells and the gut microbiota, a relevant scenario in light of recently approved anti-B-cell therapies for MS. In addition, we review recent efforts to characterize the gut microbiome in patients with MS and discuss potential challenges and future opportunities. Finally, we describe the international MS microbiome study, a multicenter effort to study a large population of patients with MS and their healthy household partners to define the core MS microbiome, how it is shaped by disease-modifying therapies, and to explore potential therapeutic interventions.
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“Interestingly, even MS patients with active disease have an altered microbiota compared to patients in the remission phase, which in turn have a microbiota more similar to healthy controls (25, 134–138).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [138]
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Metadata
- Authors
- Pröbstel, A.-K., & Baranzini, S. E.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Baranzini, Sergio E.
- Venue
- Neurotherapeutics
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 15
- Issue
- 1
- Pages
- 126-134
- ISSN
- 1878-7479 (ISSN-L)
- PMC
- PMC5794700
- OpenAlex
- W2769299506
- Cited by
- 110
- References
- 76
- Citations by year
- 2026: 11 · 2025: 7 · 2024: 12 · 2023: 9 · 2022: 22 · 2021: 13 · 2020: 18 · 2019: 8 · 2018: 9
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neurotherapeutics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Multiple Sclerosis Society (US) (CA_1072-A)
- U.S. Department of Defense (US) (W81XWH-15-1-0652)
- Valhalla Charitable Foundation (N/A)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (CH) (P2SKP3_164938)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Keywords
- multiple sclerosis, gut microbiota, B cells, autoimmune disease, disease-modifying therapy, anti-B-cell therapy, disease progression, risk factors, core microbiome, therapeutic interventions
- MeSH terms
- Gastrointestinal Microbiome, Animals, B-Lymphocytes, Humans, Multiple Sclerosis, Risk Factors, Disease Progression, Dysbiosis
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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