The DOI matches its Crossref record; 64 of the 67 references it cites were found in a registry or an index.
Anti-herpetic Medications and Reduced Risk of Dementia in Patients with Herpes Simplex Virus Infections—a Nationwide, Population-Based Cohort Study in Taiwan
Open accessAbstract
This retrospective cohort study is to investigate the association between herpes simplex virus (HSV) infections and dementia, and the effects of anti-herpetic medications on the risk involved, using Taiwan's National Health Insurance Research Database (NHIRD). We enrolled a total of 33,448 subjects, and identified 8362 with newly diagnosed HSV infections and 25,086 randomly selected sex- and age-matched controls without HSV infections in a ratio of 1:3, selected from January 1, to December 31, 2000. A multivariable Cox proportional hazards regression model was used to evaluate the risk of developing dementia in the HSV cohort. This analysis revealed an adjusted hazard ratio of 2.564 (95% CI: 2.351-2.795, P < 0.001) for the development of dementia in the HSV-infected cohort relative to the non-HSV cohort. Thus, patients with HSV infections may have a 2.56-fold increased risk of developing dementia. A risk reduction of dementia development in patients affected by HSV infections was found upon treatment with anti-herpetic medications (adjusted HR = 0.092 [95% CI 0.079-0.108], P < 0.001). The usage of anti-herpetic medications in the treatment of HSV infections was associated with a decreased risk of dementia. These findings could be a signal to clinicians caring for patients with HSV infections. Further research is, therefore, necessary to explore the underlying mechanism(s) of these associations.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“HSV-2 seropositivity has also been associated with decreased memory performance, but appeared to be unrelated to global cognition and other cognitive domains, or the risk of all-cause dementia, AD, vascular dementia and other dementias [27,28].”
From What would it take to prove that a chronic infection is a causal agent in Alzheimer’s disease? (2025) · cites this paper as [28]
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredIn the citing paper
“This risk was nearly eliminated in patients that received antiherpetic treatment (Tzeng et al., 2018).”
From Alzheimer Disease: An Update on Pathobiology and Treatment Strategies (2019) · cites this paper as Tzeng et al., 2018
In the citing paper
“One study demonstrated a significantly increased risk of developing all-cause dementia (~3-fold increase) in patients greater than 50 years of age following a new HSV infection.”
From Alzheimer Disease: An Update on Pathobiology and Treatment Strategies (2019) · cites this paper as Tzeng et al., 2018
In the citing paper
“The advent of acyclovir, in the late 1980s, considerably modified the prognosis of HSV-1 encephalitis [54–56].”
From Cognitive decline following acute viral infections: literature review and projections for post-COVID-19 (2022) · cites this paper as [56]
In the citing paper
“Previous research has found that the development of anti-herpes medications had a positive impact, reducing the incidence of AD [56].”
From Cognitive decline following acute viral infections: literature review and projections for post-COVID-19 (2022) · cites this paper as [56]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Daulatzai, M. A. (2016) · Europe PMC (PubMed Central) · Cited by 60
RetractedCharlson, M. E., Pompei, P., Ales, K. L., & MacKenzie, C. R. (1987) · Journal of Chronic Diseases · doi:10.1016/0021-9681(87)90171-8 · Cited by 49,742
Validation of a combined comorbidity index
Charlson, M., Szatrowski, T. P., Peterson, J., & Gold, J. (1994) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(94)90129-5 · Cited by 6,587
How to measure comorbiditya critical review of available methods
DEGROOT, V, BECKERMAN, H., LANKHORST, G., & BOUTER, L. (2003) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(02)00585-1 · Cited by 1,757
Epidemiology of Alzheimer disease
Reitz, C., Brayne, C., & Mayeux, R. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.2 · Cited by 1,675
Epidemiology of Alzheimer DiseasePreprint
Mayeux, R. P., & Stern, Y. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006239 · Cited by 1,127
The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide
Soscia, S. J., Kirby, J. E., Washicosky, K. J., Tucker, S. M., Ingelsson, M., Hyman, B., Burton, M. A., Goldstein, L. E., Duong, S., Tanzi, R. E., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009505 · Cited by 1,060
Herpes simplex virus type 1 in brain and risk of Alzheimer's disease
Itzhaki, R. F., Lin, W., Shang, D., Wilcock, G. K., Faragher, B. E., & Jamieson, G. A. (1997) · The Lancet · doi:10.1016/s0140-6736(96)10149-5 · Cited by 671
Gupta, R., Warren, T. J., & Wald, A. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61908-4 · Cited by 595
Microbes and Alzheimer’s Disease
Itzhaki, R. F., Lathe, R., Balin, B. J., Ball, M. J., Bearer, E. L., Braak, H., Bullido, M. J., Carter, C., Clerici, M., Cosby, S. L., et al. (2016) · Journal of Alzheimer’s Disease · doi:10.3233/jad-160152 · Cited by 532
Research works printed but not linked: 3
- Tzeng, 2017, The Impact of Pharmacological Treatments on Cognitive Function and Severity of Behavioral Symptoms in Geriatric Elder Patients with Dementia: Pharmacological Treatments on in Elder Patients with Dementia, Taiwanese J Psychiatry., 311, 69
- Daulatzai, 2016, Fundamental Role of Pan-Inflammation and Oxidative-Nitrosative Pathways in Neuropathogenesis of Alzheimer's Disease, Am J Neurodegener Dis., 51, 1
- Kamboh, 1995, Polymorphism and Susceptibility to Alzheimer's Disease, Hum Biol., 672, 195
Cited by
Sorted by citations
Items 201–300 of 368
Herpes Simplex Virus Neurovirulence Across the Human Lifespan
Dutton, A. J., Hayes, C. K., Leib, D. A., & Akhtar, L. N. (2025) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaf275 · Cited by 10
Matrix metalloproteinase 14 regulates HSV-1 infection in neuroblastoma cells
Llorente, P., Mejías, V., Sastre, I., Recuero, M., Aldudo, J., & Bullido, M. J. (2021) · Antiviral Research · doi:10.1016/j.antiviral.2021.105116 · Cited by 10
Wang, Y.-H., Chien, W., Chung, C., Her, Y., Yao, C.-Y., Lee, B.-L., Li, F., Wan, F.-J., & Tzeng, N. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20042868 · Cited by 10
Self-citationBalasubramaniam, M., Ganne, A., Mainali, N., Pahal, S., Ayyadevara, S., & Reis, R. J. S. (2023) · iScience · doi:10.1016/j.isci.2023.108745 · Cited by 9
Cross-Linked Amyloid β-Protein Oligomers: A Missing Link in Alzheimer’s Disease Pathology?
Urbanc, B. (2021) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.0c07716 · Cited by 11
Yang, C.-C., Chien, W., Chung, C., Lai, C., & Tzeng, N. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.811494 · Cited by 9
Self-citationLongitudinal Effects of Herpesviruses on Multiple Cognitive Outcomes in Healthy Elderly Adults
Weidung, B., Josefsson, M., Lyttkens, P., Olsson, J., Elgh, F., Lind, L., Kilander, L., & Lövheim, H. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221116 · Cited by 9
Analysis of the Association Between Pathogen Exposure and the Risk of Dementia
Fu, J., Wei, Q., Chen, X., Lai, X., & Shang, H. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-240073 · Cited by 9
Krakowiak, P. A., Flores, M., Cuddy, S. R., Whitford, A. L., Dochnal, S. A., Babnis, A. W., Miyake, T., Tigano, M., Engel, D. A., & Cliffe, A. R. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2413965122 · Cited by 9
Borase, H. P., Patil, C. D., Vályi-Nagy, T., & Shukla, D. (2025) · mBio · doi:10.1128/mbio.03765-24 · Cited by 9
Trunfio, M., Girolamo, L. D., Ponzetta, L., Russo, M., Burdino, E., Imperiale, D., Atzori, C., Perri, G. D., & Calcagno, A. (2022) · Journal of NeuroVirology · doi:10.1007/s13365-022-01105-z · Cited by 9
Herpes Infections and Dementia: Rebutting Alternative Fact
Lathe, R., Tzeng, N., & Itzhaki, R. F. (2019) · Neurotherapeutics · doi:10.1007/s13311-018-00700-5 · Cited by 11
Self-citationViruses as ‘Truffle Hounds’: Molecular Tools for Untangling Brain Cellular Pathology
Müller‐Schiffmann, A., Trossbach, S. V., Lingappa, V. R., & Korth, C. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.11.004 · Cited by 8
Platelet Behavior Contributes to Neuropathologies: A Focus on Alzheimer's and Parkinson's Disease
Page, M. J., & Pretorius, E. (2021) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0041-1733960 · Cited by 11
Does antiherpetic antiviral therapy reduce the risk of dementia?
Itzhaki, R. F. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00596-4 · Cited by 9
What is the role of microbial infection in Alzheimer’s disease?
Barichello, T., Giridharan, V. V., Comim, C. M., & Morales, R. (2021) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2021-0037 · Cited by 9
Altered Synaptic Plasticity: Plausible Mechanisms Associated With Viral Infections
Saini, V., Rani, A., Kumar, A., Jha, K., Karnati, S., & Jha, H. C. (2023) · Future Virology · doi:10.2217/fvl-2023-0105 · Cited by 7
Olson, M. N., Dawes, P., Murray, L. F., Barton, N., Sundstrom, J., Orszulak, A. R., Chigas, S. M., Tran, K., Aylward, A. J., Caliandro, M. F., et al. (2026) · npj Dementia · doi:10.1038/s44400-026-00066-y · Cited by 7
Huang, C., Liu, W., Ren, X., Lv, Y., Wang, L., Huang, J., Zhu, F., Wu, D., Zhou, L., Huang, X., et al. (2022) · Aging Clinical and Experimental Research · doi:10.1007/s40520-022-02170-4 · Cited by 8
Viruses - a major cause of amyloid deposition in the brain
Fülöp, T., Ramassamy, C., Lévesque, S., Frost, E. H., Laurent, B., Lacombe, G., Khalil, A., Larbi, A., Hirokawa, K., Desroches, M., et al. (2023) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2023.2244162 · Cited by 8
Herpes Simplex Virus 1 Infection Does Not Increase Amyloid-β Pathology in APP/PS1 Mice
Lapeyre, L., Piret, J., Rhéaume, C., Pons, V., Uyar, O., Préfontaine, P., Rivest, S., & Boivin, G. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230746 · Cited by 10
Chauhan, P., Begum, M. Y., Narapureddy, B. R., Gupta, S., Wadhwa, K., Singh, G., Kumawat, R., Sharma, N., Ballal, S., Jha, S. K., et al. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04535-4 · Cited by 9
Screening neuroprotective compounds in herpes-induced Alzheimer's disease cell and 3D tissue models
Silveira, I. A., Mullis, A. S., Cairns, D. M., Shevzov-Zebrun, A., Whalen, J., Galuppo, A., Walsh, K. G., & Kaplan, D. L. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.05.002 · Cited by 9
D’Aiuto, L., Caldwell, J. K., Edwards, T. G., Zhou, C., McDonald, M. L., Maio, R. D., Joel, W., Hyde, V. R., Wallace, C. T., Watkins, S. C., et al. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.106804 · Cited by 7
Wang, T.-M., Chou, C.-H., Lee, Y., Chung, C., Huang, Y.-C., Lai, X.-C., Sun, C., Kang, C.-Y., Wu, G., & Chien, W. (2022) · International Journal of Women s Health · doi:10.2147/ijwh.s376244 · Cited by 7
Self-citationHuang, C.-Y., Wu, M., Wang, H.-C., Liao, Y.-C., Tou, S.-I., & Yen, H. (2021) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2020.0494 · Cited by 7
Polansky, H., & Goral, B. (2021) · Journal of NeuroVirology · doi:10.1007/s13365-021-01012-9 · Cited by 9
Pathogens accelerate features of human aging: A review of molecular mechanisms
Proal, A. D., & VanElzakker, M. B. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102865 · Cited by 7
Ayyubova, G., Bablu, F. E., Rahimli, N., Aghayeva, L., Springer, E. M., Alghenaim, F., & Suzuki, Y. J. (2026) · Antioxidants · doi:10.3390/antiox15010066 · Cited by 8
Mood Alterations in the Prodromal Phase of Sporadic Creutzfeldt-Jakob Disease
Wurm, R., Klotz, S., Erber, A. C., Gruber, F., Leitner, S., Reichardt, B., Stögmann, E., Schernhammer, E. S., Gelpí, E., & Çetin, H. (2024) · JAMA Neurology · doi:10.1001/jamaneurol.2024.4447 · Cited by 6
Kordi, R., Andrews, T. J., & Hicar, M. D. (2025) · Virology · doi:10.1016/j.virol.2025.110523 · Cited by 6
Maple, P. A. C., & Hosseini, A. A. (2025) · Vaccines · doi:10.3390/vaccines13060572 · Cited by 6
Goldstein, M. R., & Cheslock, M. (2021) · Medical Hypotheses · doi:10.1016/j.mehy.2021.110645 · Cited by 8
Long-term time trends in reactivated herpes simplex infections and treatment in Sweden
Lindman, K. L., Lockman-Lundgren, J., Weidung, B., Olsson, J., Elgh, F., & Lövheim, H. (2022) · BMC Infectious Diseases · doi:10.1186/s12879-022-07525-w · Cited by 6
Sun, J. Y., Yan, C., Niu, J., Pan, M., Luo, Z., Duan, W., Li, W., Wu, Y., Sun, W., Huang, F., et al. (2022) · Acta Materia Medica · doi:10.15212/amm-2022-0043 · Cited by 7
Self-citationUntersteiner, H., Wurm, R., Reichardt, B., Goeschl, S., Berger–Sieczkowski, E., König, T., Parvizi, T., Silvaieh, S., & Stögmann, E. (2024) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2024.92 · Cited by 5
Melatonin regulation of phase separation in Neuro-PASC: out-maneuvering Janus-faced amyloids
Loh, D., & Reiter, R. J. (2025) · Exploration of neuroscience · doi:10.37349/en.2025.100678 · Cited by 6
Anti-herpetic treatment reduces dementia risk: A systematic review and meta-analysis
Chang, S.-T., Wu, H., Chiu, Y., & Chuang, Y. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251409323 · Cited by 5
Yang, J., & Jiang, J. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877251411573 · Cited by 6
Litvinenko, I., & Lobzin, V. Y. (2022) · Advances in Gerontology · doi:10.1134/s2079057022040117 · Cited by 5
Chen, P.-J., Chung, C., Chien, W., & Chen, H. (2019) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000001323 · Cited by 5
Self-citationChen, C.-W., Hsueh, C., Chung, C., Wang, H.-S., Chang, H., & Chien, W. (2020) · Brain and Development · doi:10.1016/j.braindev.2020.01.002 · Cited by 5
Self-citationChung, C., Chien, W., Yeh, H., & Tzeng, N. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.09.013 · Cited by 5
Self-citationTyler, K. L. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01112-8 · Cited by 5
Wang, E., Huang, X., Ye, Y., Zou, S., Chen, G., Yang, L., Fraser, N. W., Bao, F., Zhou, J., & Cao, X. (2022) · Virologica Sinica · doi:10.1016/j.virs.2022.11.008 · Cited by 6
Salgado, B., Sastre, I., Bullido, M. J., & Aldudo, J. (2023) · Microorganisms · doi:10.3390/microorganisms11051205 · Cited by 6
A Turning Point in Alzheimer’s Disease: Microbes Matter
Itzhaki, R. F. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-191171 · Cited by 5
Nath, A. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-0625-4 · Cited by 5
Further evidence of increased human Herpesvirus in Alzheimer’s diseasePreprint
Readhead, B., Haure‐Mirande, J., Ehrlich, M. E., Gandy, S., & Dudley, J. T. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/858050 · Cited by 5
Immunogenetic profiles of 9 human herpes virus envelope glycoproteins
Georgopoulos, A., & James, L. (2024) · Scientific Reports · doi:10.1038/s41598-024-71558-1 · Cited by 2
Yan, X., Wang, E., Zhao, M. L., Ma, G., Xu, X.-X., Zhao, J.-B., Li, X., Zeng, J., & Ma, X. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.03.019 · Cited by 5
Tripathi, P., & Shah, J. (2026) · Molecular Neurobiology · doi:10.1007/s12035-025-05652-4 · Cited by 7
Israel, A., Weizman, A., Israel, S., Ashkenazi, S., Vinker, S., Magen, E., & Merzon, E. (2026) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2026.106473 · Cited by 4
Wright, L. R., Wright, D. L., & Weller, S. K. (2022) · Viruses · doi:10.3390/v14071557 · Cited by 4
Pathogen infection in Alzheimer’s disease: pathophysiology and therapeutic strategies
Xiong, M., Yu, H., Tian, Y., Meng, L., & Zhang, Z. (2023) · Ageing and Neurodegenerative Diseases · doi:10.20517/and.2022.32 · Cited by 4
Stone, J., Mitrofanis, J., Johnstone, D. M., & Robinson, S. R. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231202 · Cited by 4
Infectious hypothesis of neurodegenerative diseases. What waits us after the COVID-19 pandemic?
Litvinenko, I., Lobzin, V. Y., Pushkarev, V. A., & Skripchenko, N. V. (2022) · Russian neurological Journal · doi:10.30629/2658-7947-2022-27-3-64-73 · Cited by 5
Wang, Y., Tang, Y., Liu, T., Shao, L., Li, C., Wang, Y., & Tan, P. (2024) · Molecular Neurobiology · doi:10.1007/s12035-023-03903-w · Cited by 4
Gurjar, P., Khan, A. A., Alanazi, A. M., Vasil’ev, V. G., Zouganelis, G. D., & Alexiou, A. T. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231083 · Cited by 4
What would it take to prove that a chronic infection is a causal agent in Alzheimer’s disease?
Brutkiewicz, R. R., Cao, W., Morgan, D., Reis, R. S. D., Suryadevara, V., Willette, A. A., Willette, S. A., Wyatt-Johnson, S. K., & Duggan, M. R. (2025) · Trends in Neurosciences · doi:10.1016/j.tins.2025.05.009 · Cited by 3
Sheikh, M. A., Moon, M. P., Wright, C. B., Gutierrez, J., Liu, M., Rundek, T., Cheung, K., Hornig, M., & Elkind, M. S. V. (2024) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2024.100937 · Cited by 3
Laadraoui, J., Kabdy, H., Oufquir, S., Aitlarradia, M., Agouram, F., Aitbaba, A., Oubella, K., & El‐Mansoury, B. (2025) · IGI Global eBooks · doi:10.4018/979-8-3693-9112-9.ch005 · Cited by 3
Tick bite induced α‐gal syndrome highlights anticancer effect of allergy
Apari, P., & Földvári, G. (2021) · BioEssays · doi:10.1002/bies.202100142 · Cited by 3
Liu, H., Wang, J., Yuan, Y., Gu, J., & Yan, Y. (2023) · Medical Science Monitor · doi:10.12659/msm.939670 · Cited by 3
"Epilepsy; An Insight into Epileptogenic Potential of Infections and Antibiotics"
Khan, S. (2023) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2023.53.008376 · Cited by 3
Multiple Causes of Dementia as Engineered Senescence
Garrett, M. D. (2020) · European Journal of Medical and Health Sciences · doi:10.24018/ejmed.2020.2.2.227 · Cited by 3
Herpes Viruses, Alzheimer's Disease, and Related Dementias: Unifying or Confusing Hypothesis?
Nath, A. (2019) · Neurotherapeutics · doi:10.1007/s13311-018-00701-4 · Cited by 3
Goldschmidt‐Clermont, P. J., Volinsky, F. G., LaRosa, S. P., Gilbert, J. R., & Pericak‐Vance, M. A. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz150 · Cited by 3
Risk of Dementia in Patients with Leptospirosis: A Nationwide Cohort Analysis
Chiu, C.-H., Chen, P.-C., Wang, Y.-C., Lin, C., Lee, F.-Y., Wu, C., & Chang, K. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16173168 · Cited by 3
Alzheimer’s Disease: Causes, Mechanisms, and Steps Toward Prevention
Choi, S. H., & Tanzi, R. E. (2020) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190069162.013.18 · Cited by 3
Bioactive Constituents and Pharmacological Activities
Azeem, U., Hakeem, K. R., & Ali, S. (2020) · Springer eBooks · doi:10.1007/978-3-030-58756-7_7 · Cited by 3
Multi-pathogen Infections and Alzheimer’s DiseasePreprint
Damborský, J., Vigašová, D., Nemergut, M., & Lišková, B. (2021) · Preprints.org · doi:10.20944/preprints202101.0184.v1 · Cited by 4
Oxidized MIF is an Alzheimer’s Disease drug target relaying external risk factors to tau pathologyPreprint
Müller‐Schiffmann, A., Torres, F., Kitaygorodskyy, A., Ramani, A., Alatza, A., Tschirner, S. K., Prikulis, I., Yu, S., Dey, D., Mallesh, S., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.11.459903 · Cited by 3
Slama, P. S., Macbale, A. R., & Jedynak, B. (2026) · medRxiv · doi:10.64898/2026.02.13.26346282 · Cited by 3
Andalibi, M. S. S., Hastie, E., Barone, M. E., Tavasoli, A., Ellis, R., Letendre, S. L., & Trunfio, M. (2025) · Future Virology · doi:10.1080/17460794.2025.2595851 · Cited by 2
Hossain, M. M., Shammi, S. S., Sarwar, G., Ahmed, S., Fardous, J., Morshed, M. M., SARKER, M. A., & Asaduzzaman, M. (2026) · Journal of Genetic Engineering and Biotechnology · doi:10.1016/j.jgeb.2026.100728 · Cited by 2
Osborne, L., Dunai, C., Huang, Y., Egbe, F. N., Turtle, L., Michael, B. D., & Ellul, M. A. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1751672 · Cited by 2
Wu, C., Peng, C., Chung, C.-H., Chien, W., & Tzeng, N. (2022) · Psychiatry Investigation · doi:10.30773/pi.2021.0277 · Cited by 2
Self-citationRizvi, S. T., Shah, J., Shaaya, S., & Mollayeva, T. (2023) · Medicine · doi:10.1097/md.0000000000034151 · Cited by 2
Tan, S., Kelty, E. A., Page, A. T., Etherton‐Beer, C., Sanfilippo, F. M., & Almeida, O. P. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-240391 · Cited by 2
Infection, Neuroinflammation and Interventions for Healthy Brain and Longevity
Fülöp, T., Ramassamy, C., Lacombe, G., Frost, E. H., Cohen, A. A., Rodrigues, S., Desroches, M., Hirokawa, K., Laurent, B., & Witkowski, J. M. (2024) · Healthy ageing and longevity · doi:10.1007/978-3-031-68513-2_12 · Cited by 2
Hansen, N., Buschatzky, V., Bastin, A. K., Rentzsch, K., Teegen, B., Luedecke, D., Skripuletz, T., Maier, H. B., Bleich, S., Gallinat, J., et al. (2025) · Journal of Neural Transmission · doi:10.1007/s00702-025-02943-x · Cited by 2
A lipid-raft theory of Alzheimer's disease
Rappoport, A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-44-345008-2.00017-5 · Cited by 2
Dementias Caused by Persistent Pathogens and the Protective Role of HLA Against them
James, L. M., & Georgopoulos, A. P. (2020) · Journal of Neurology and Neuromedicine · doi:10.29245/2572.942x/2019/1.1260 · Cited by 2
Discovery and Development of Brincidofovir
Lanier, E. R., Foster, S., & Andrei, G. (2025) · Wiley eBooks · doi:10.1002/9783527845088.ch15 · Cited by 2
Sung, C., Chung, C., Sun, C., Tsao, C., Ng, D. Y., Weng, T., Fann, L.-Y., Lin, F., & Chien, W. (2025) · Medicine · doi:10.1097/md.0000000000044953 · Cited by 1
Self-citationBoopathi, S., Garduño‐Juárez, R., & Gromiha, M. M. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00866 · Cited by 2
Oxidized MIF is an Alzheimer’s disease drug target relaying external risk factors to tau pathology
Müller-Schiffmann, A., Torres, F., Kitaygorodskyy, A., Ramani, A., Alatza, A., Tschirner, S. K., Orts, J., Haltrich, A., Prikulis, I., Yu, S., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102520 · Cited by 4
Lee, C. K., Woodward, M., Hohenberg, M. I., & Tang, J. W.-T. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1701760 · Cited by 3
Unmasking the hidden catalyst: How infections trigger Alzheimer's disease
Fülöp, T., Cohen, A. A., Frost, E. H., Lévesque, S., Khalil, A., Rodrigues, S., Desroches, M., Alami, M., Berrougui, H., Ramassamy, C., et al. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877251415571 · Cited by 2
Herpes simplex virus 2 and dementia risk: a systematic review and meta-analysis
Hunt, C. J., Zabriskie, B. N., Coulter, E. J., McClellan, M. C., Templeton, G., Erbstoesser, R., MacLean, S., Miller, C. H., Moss, J., Carter, C., et al. (2026) · Frontiers in Dementia · doi:10.3389/frdem.2026.1737068 · Cited by 1
Majdič, G. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1815976 · Cited by 1
Alghamdi, A., Balafas, S. E., Bos, J., Munster, B. C. V., Rafie, K., Dolga, A. M., & Hak, E. (2026) · BMJ Open · doi:10.1136/bmjopen-2025-114033 · Cited by 1
Israel, A., & Israel, S. (2026) · Microorganisms · doi:10.3390/microorganisms14081757 · Cited by 1
Herpes simplex virus infection and Alzheimer’s disease
Hur, J. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1858017 · Cited by 1
The Association Between Herpes Simplex Virus Type 1 Reactivation and Alzheimer’s Disease
Allee, A. M. (2019) · Blue Tiger Commons (Lincoln University - Missouri) · Cited by 1
Yao, C.-Y., Chung, C., Chien, W., Li, S.-T., Lee, S., Huang, C.-C., Yang, C.-C., & Tzeng, N. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1410685 · Cited by 1
Self-citationHerpes Zoster Cerebral Vasculopathy in a Case of Cognitive Decline
Mizoguchi, R. (2019) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2019.20.003390 · Cited by 1
Ostrovskа, S. S., Шаторна, В. Ф., & Liholetov, E. О. (2021) · Medicni perspektivi · doi:10.26641/2307-0404.2021.1.227729 · Cited by 1
Ansart, M., Epelbaum, S., Houot, M., Nédelec, T., Lekens, B., Gantzer, L., Dormont, D., & Durrleman, S. (2021) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12210
Metadata
- Authors
- Tzeng, N.-S., Chung, C.-H., Lin, F.-H., Chiang, C.-P., Yeh, C.-B., Huang, S.-Y., Lu, R.-B., Chang, H.-A., Kao, Y.-C., Yeh, H.-W., Chiang, W.-S., Chou, Y.-C., Tsao, C.-H., Wu, Y.-F., & Chien, W.-C.
- Affiliations
- Tri-Service General Hospital (TW)
- National Defense Medical Center (TW)
- Tamkang University (TW)
- Corresponding author
- Chien, Wu-Chien
- ORCID
- Venue
- Neurotherapeutics
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 15
- Issue
- 2
- Pages
- 417-429
- ISSN
- 1878-7479 (ISSN-L)
- PMC
- PMC5935641
- OpenAlex
- W2790037954
- Cited by
- 356
- References
- 67
- Citations by year
- 2026: 34 · 2025: 35 · 2024: 41 · 2023: 40 · 2022: 49 · 2021: 59 · 2020: 48 · 2019: 29 · 2018: 21
- FWCI
- 30.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neurotherapeutics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Tri-Service General Hospital Research Foundation (TSGH-C105-130, TSGH-C106-002, TSGH-C107-004)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- herpes simplex, dementia risk, antiviral therapy, neurodegeneration, Taiwan
- MeSH terms
- Aged, Antiviral Agents, Dementia, Female, Herpes Simplex, Humans, Male, Middle Aged, Retrospective Studies, Risk Factors, Taiwan, Proportional Hazards Models
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
