Cited by 368Herpesvirus Infections and TreatmentsCytomegalovirus and herpesvirus researchDementia and Cognitive Impairment Research

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Anti-herpetic Medications and Reduced Risk of Dementia in Patients with Herpes Simplex Virus Infections—a Nationwide, Population-Based Cohort Study in Taiwan

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Tzeng, Nian-Sheng, Chung, Chi-Hsiang, Lin, Fu-Huang, Chiang, Chien-Ping, Yeh, Chin-Bin, Huang, San-Yuan, Lu, Ru-Band, Chang, Hsin-An, Kao, Yu-Chen, Yeh, Hui-Wen, Chiang, Wei-Shan, Chou, Yu-Ching, Tsao, Chang-Huei, Wu, Yung-Fu, Chien, Wu-Chien·2018·Neurotherapeutics

DOI 10.1007/s13311-018-0611-xPMC PMC5935641

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Abstract

This retrospective cohort study is to investigate the association between herpes simplex virus (HSV) infections and dementia, and the effects of anti-herpetic medications on the risk involved, using Taiwan's National Health Insurance Research Database (NHIRD). We enrolled a total of 33,448 subjects, and identified 8362 with newly diagnosed HSV infections and 25,086 randomly selected sex- and age-matched controls without HSV infections in a ratio of 1:3, selected from January 1, to December 31, 2000. A multivariable Cox proportional hazards regression model was used to evaluate the risk of developing dementia in the HSV cohort. This analysis revealed an adjusted hazard ratio of 2.564 (95% CI: 2.351-2.795, P < 0.001) for the development of dementia in the HSV-infected cohort relative to the non-HSV cohort. Thus, patients with HSV infections may have a 2.56-fold increased risk of developing dementia. A risk reduction of dementia development in patients affected by HSV infections was found upon treatment with anti-herpetic medications (adjusted HR = 0.092 [95% CI 0.079-0.108], P < 0.001). The usage of anti-herpetic medications in the treatment of HSV infections was associated with a decreased risk of dementia. These findings could be a signal to clinicians caring for patients with HSV infections. Further research is, therefore, necessary to explore the underlying mechanism(s) of these associations.

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Authors: Tzeng, N.-S., Chung, C.-H., Lin, F.-H., Chiang, C.-P., Yeh, C.-B., Huang, S.-Y., Lu, R.-B., Chang, H.-A., Kao, Y.-C., Yeh, H.-W., Chiang, W.-S., Chou, Y.-C., Tsao, C.-H., Wu, Y.-F., & Chien, W.-C.
Affiliations: Tri-Service General Hospital (TW)
National Defense Medical Center (TW)
Tamkang University (TW)
Corresponding author: Chien, Wu-Chien
ORCID: Tzeng, Nian-Sheng
Chung, Chi-Hsiang
Lin, Fu-Huang
Chiang, Chien-Ping
Yeh, Chin-Bin
Huang, San-Yuan
Lu, Ru-Band
Chang, Hsin-An
Chou, Yu-Ching
Tsao, Chang-Huei
Wu, Yung-Fu
Chien, Wu-Chien
Venue: Neurotherapeutics
Publisher: Elsevier BV
Published: 2018-04
Volume: 15
Issue: 2
Pages: 417-429
ISSN: 1878-7479 (ISSN-L)
DOI: 10.1007/s13311-018-0611-x
PMC: PMC5935641
OpenAlex: W2790037954
Cited by: 356
References: 67
Citations by year: 2026: 34 · 2025: 35 · 2024: 41 · 2023: 40 · 2022: 49 · 2021: 59 · 2020: 48 · 2019: 29 · 2018: 21
FWCI: 30.72
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1970 d)
Locations: Neurotherapeutics (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Tri-Service General Hospital Research Foundation (TSGH-C105-130, TSGH-C106-002, TSGH-C107-004)
Topics: Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: herpes simplex, dementia risk, antiviral therapy, neurodegeneration, Taiwan
MeSH terms: Aged, Antiviral Agents, Dementia, Female, Herpes Simplex, Humans, Male, Middle Aged, Retrospective Studies, Risk Factors, Taiwan, Proportional Hazards Models

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Anti-herpetic Medications and Reduced Risk of Dementia in Patients with Herpes Simplex Virus Infections—a Nationwide, Population-Based Cohort Study in Taiwan

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