Anti-herpetic Medications and Reduced Risk of Dementia in Patients with Herpes Simplex Virus Infections—a Nationwide, Population-Based Cohort Study in Taiwan

A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation

Charlson, M. E., Pompei, P., Ales, K. L., & MacKenzie, C. R. (1987) · Journal of Chronic Diseases · doi:10.1016/0021-9681(87)90171-8 · Cited by 49,742

Validation of a combined comorbidity index

Charlson, M., Szatrowski, T. P., Peterson, J., & Gold, J. (1994) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(94)90129-5 · Cited by 6,587

How to measure comorbiditya critical review of available methods

DEGROOT, V, BECKERMAN, H., LANKHORST, G., & BOUTER, L. (2003) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(02)00585-1 · Cited by 1,757

Epidemiology of Alzheimer disease

Reitz, C., Brayne, C., & Mayeux, R. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.2 · Cited by 1,675

Epidemiology of Alzheimer DiseasePreprint

Mayeux, R. P., & Stern, Y. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006239 · Cited by 1,127

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

Soscia, S. J., Kirby, J. E., Washicosky, K. J., Tucker, S. M., Ingelsson, M., Hyman, B., Burton, M. A., Goldstein, L. E., Duong, S., Tanzi, R. E., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009505 · Cited by 1,060

Herpes simplex virus type 1 in brain and risk of Alzheimer's disease

Itzhaki, R. F., Lin, W., Shang, D., Wilcock, G. K., Faragher, B. E., & Jamieson, G. A. (1997) · The Lancet · doi:10.1016/s0140-6736(96)10149-5 · Cited by 671

Genital herpes

Gupta, R., Warren, T. J., & Wald, A. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61908-4 · Cited by 595

Microbes and Alzheimer’s Disease

Itzhaki, R. F., Lathe, R., Balin, B. J., Ball, M. J., Bearer, E. L., Braak, H., Bullido, M. J., Carter, C., Clerici, M., Cosby, S. L., et al. (2016) · Journal of Alzheimer’s Disease · doi:10.3233/jad-160152 · Cited by 532

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

Long, J. M., & Holtzman, D. M. (2019) · Cell · doi:10.1016/j.cell.2019.09.001 · Cited by 3,204

Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection

Eimer, W. A., Vijaya Kumar, D. K., Navalpur Shanmugam, N. K., Rodriguez, A. S., Mitchell, T., Washicosky, K. J., György, B., Breakefield, X. O., Tanzi, R. E., & Moir, R. D. (2018) · Neuron · doi:10.1016/j.neuron.2018.06.030 · Cited by 674

The antimicrobial protection hypothesis of Alzheimer’s disease

Moir, R. D., Lathe, R., & Tanzi, R. E. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.06.3040 · Cited by 456

Alzheimer’s disease: insights into pathology, molecular mechanisms, and therapy

Zheng, Q., & Wang, X. (2024) · Protein & Cell · doi:10.1093/procel/pwae026 · Cited by 483

The amyloid hypothesis on trial

Makin, S. (2018) · Nature · doi:10.1038/d41586-018-05719-4 · Cited by 360

Virus exposure and neurodegenerative disease risk across national biobanks

Levine, K. S., Leonard, H. L., Blauwendraat, C., Iwaki, H., Johnson, N., Bandres-Ciga, S., Ferrucci, L., Faghri, F., Singleton, A. B., & Nalls, M. A. (2023) · Neuron · doi:10.1016/j.neuron.2022.12.029 · Cited by 341

The Impact of Systemic Inflammation on Alzheimer’s Disease Pathology

Xie, J., Van Hoecke, L., & Vandenbroucke, R. E. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.796867 · Cited by 324

Herpes Simplex Virus-1 in the Brain: The Dark Side of a Sneaky Infection

Marcocci, M. E., Napoletani, G., Protto, V., Kolesova, O., Piacentini, R., Li Puma, D. D., Lomonte, P., Grassi, C., Palamara, A. T., & De Chiara, G. (2020) · Trends in Microbiology · doi:10.1016/j.tim.2020.03.003 · Cited by 303

Corroboration of a Major Role for Herpes Simplex Virus Type 1 in Alzheimer’s Disease

Itzhaki, R. F. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00324 · Cited by 256

CD8+ T-cells infiltrate Alzheimer’s disease brains and regulate neuronal- and synapse-related gene expression in APP-PS1 transgenic mice

Unger, M. S., Li, E., Scharnagl, L., Poupardin, R., Altendorfer, B., Mrowetz, H., Hutter-Paier, B., Weiger, T. M., Heneka, M. T., Attems, J., et al. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.05.070 · Cited by 248

Current understanding of the Alzheimer’s disease-associated microbiome and therapeutic strategies

Seo, D.-O., & Holtzman, D. M. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01146-2 · Cited by 259

Questions concerning the role of amyloid-β in the definition, aetiology and diagnosis of Alzheimer’s disease

Morris, G. P., Clark, I. A., & Vissel, B. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1918-8 · Cited by 212

The viral protein corona directs viral pathogenesis and amyloid aggregation

Ezzat, K., Pernemalm, M., Pålsson, S., Roberts, T. C., Järver, P., Dondalska, A., Bestas, B., Sobkowiak, M. J., Levänen, B., Sköld, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10192-2 · Cited by 209

Drug repositioning and repurposing for Alzheimer disease

Ballard, C., Aarsland, D., Cummings, J., O’Brien, J., Mills, R., Molinuevo, J. L., Fladby, T., Williams, G., Doherty, P., Corbett, A., et al. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0397-4 · Cited by 201

Hospital-treated infectious diseases and the risk of dementia: a large, multicohort, observational study with a replication cohort

Sipilä, P. N., Heikkilä, N., Lindbohm, J. V., Hakulinen, C., Vahtera, J., Elovainio, M., Suominen, S., Väänänen, A., Koskinen, A., Nyberg, S. T., et al. (2021) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(21)00144-4 · Cited by 197

Age-Associated Changes in the Immune System and Blood–Brain Barrier Functions

Erickson, M. A., & Banks, W. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071632 · Cited by 203

The role of microglia in viral encephalitis: a review

Chen, Z., Zhong, D., & Li, G. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1443-2 · Cited by 196

Do infections have a role in the pathogenesis of Alzheimer disease?

Itzhaki, R. F., Golde, T. E., Heneka, M. T., & Readhead, B. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0323-9 · Cited by 174

Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development

Wan, Q., Song, D., Li, H., & He, M. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00233-4 · Cited by 171

Time to test antibacterial therapy in Alzheimer’s disease

Panza, F., Lozupone, M., Solfrizzi, V., Watling, M., & Imbimbo, B. P. (2019) · Brain · doi:10.1093/brain/awz244 · Cited by 161

Periodontal disease as a possible cause for Alzheimer's disease

Kamer, A. R., Craig, R. G., Niederman, R., Fortea, J., & de Leon, M. J. (2020) · Periodontology 2000 · doi:10.1111/prd.12327 · Cited by 159

Multiple Neuroinvasive Pathways in COVID-19

Bougakov, D., Podell, K., & Goldberg, E. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02152-5 · Cited by 142

Human herpesvirus infections and dementia or mild cognitive impairment: a systematic review and meta-analysis

Warren-Gash, C., Forbes, H. J., Williamson, E., Breuer, J., Hayward, A. C., Mavrodaris, A., Ridha, B. H., Rossor, M. N., Thomas, S. L., & Smeeth, L. (2019) · Scientific Reports · doi:10.1038/s41598-019-41218-w · Cited by 125

Overwhelming Evidence for a Major Role for Herpes Simplex Virus Type 1 (HSV1) in Alzheimer’s Disease (AD); Underwhelming Evidence against

Itzhaki, R. F. (2021) · Vaccines · doi:10.3390/vaccines9060679 · Cited by 126

Potential Bidirectional Relationship Between Periodontitis and Alzheimer’s Disease

Liccardo, D., Marzano, F., Carraturo, F., Guida, M., Femminella, G. D., Bencivenga, L., Agrimi, J., Addonizio, A., Melino, I., Valletta, A., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00683 · Cited by 148

The role of the immune system in Alzheimer’s disease

Wu, K., Zhang, Y.-R., Huang, Y., Dong, Q., Tan, L., & Yu, J. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101409 · Cited by 119

Multi-pathogen infections and Alzheimer’s disease

Vigašová, D., Nemergut, M., Lišková, B., & Damborský, J. (2021) · Microbial Cell Factories · doi:10.1186/s12934-021-01520-7 · Cited by 117

Amyloid, tau, pathogen infection and antimicrobial protection in Alzheimer’s disease –conformist, nonconformist, and realistic prospects for AD pathogenesis

Li, H., Liu, C.-C., Zheng, H., & Huang, T. Y. (2018) · Translational Neurodegeneration · doi:10.1186/s40035-018-0139-3 · Cited by 103

Alzheimer’s Disease and Inflammaging

Kosyreva, A., Sentyabreva, A., Tsvetkov, I., & Makarova, O. (2022) · Brain Sciences · doi:10.3390/brainsci12091237 · Cited by 98

Cognitive decline following acute viral infections: literature review and projections for post-COVID-19

Damiano, R. F., Guedes, B. F., de Rocca, C. C., de Pádua Serafim, A., Castro, L. H. M., Munhoz, C. D., Nitrini, R., Filho, G. B., Miguel, E. C., Lucchetti, G., et al. (2022) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-021-01286-4 · Cited by 98

Association of herpes zoster with dementia and effect of antiviral therapy on dementia: a population-based cohort study

Bae, S., Yun, S.-C., Kim, M.-C., Yoon, W., Lim, J. S., Lee, S.-O., Choi, S.-H., Kim, Y. S., Woo, J. H., Kim, S. Y., et al. (2021) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-020-01157-4 · Cited by 94

Immunotherapies for Aging-Related Neurodegenerative Diseases—Emerging Perspectives and New Targets

Kwon, S., Iba, M., Kim, C., & Masliah, E. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00853-2 · Cited by 97

Infectious origin of Alzheimer’s disease: Amyloid beta as a component of brain antimicrobial immunity

Vojtechova, I., Machacek, T., Kristofikova, Z., Stuchlik, A., & Petrasek, T. (2022) · PLOS Pathogens · doi:10.1371/journal.ppat.1010929 · Cited by 92

Linking mechanisms of periodontitis to Alzheimer's disease

Sadrameli, M., Bathini, P., & Alberi, L. A. (2020) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000797 · Cited by 93

Infectious hypothesis of Alzheimer disease

Seaks, C. E., & Wilcock, D. M. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008596 · Cited by 93

Viral Involvement in Alzheimer’s Disease

Sait, A. M., Angeli, C., Doig, A. J., & Day, P. J. (2021) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00719 · Cited by 90

Helicobacter pylori infection in the stomach induces neuroinflammation: the potential roles of bacterial outer membrane vesicles in an animal model of Alzheimer’s disease

Park, A.-M., & Tsunoda, I. (2022) · Inflammation and Regeneration · doi:10.1186/s41232-022-00224-8 · Cited by 82

Herpesvirus infections, antiviral treatment, and the risk of dementia-a registry-based cohort study in Sweden

Lopatko Lindman, K., Hemmingsson, E., Weidung, B., Brännström, J., Josefsson, M., Olsson, J., Elgh, F., Nordström, P., & Lövheim, H. (2021) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1002/trc2.12119 · Cited by 99

Chronic effects of inflammation on tauopathies

Langworth-Green, C., Patel, S., Jaunmuktane, Z., Jabbari, E., Morris, H. R., Thom, M., Lees, A. J., Hardy, J., Zandi, M. S., & Duff, K. (2023) · The Lancet Neurology · doi:10.1016/s1474-4422(23)00038-8 · Cited by 85

Are infections seeding some cases of Alzheimer’s disease?

Abbott, A. (2020) · Nature · doi:10.1038/d41586-020-03084-9 · Cited by 82

Olfactory dysfunction in the pathophysiological continuum of dementia

Bathini, P., Brai, E., & Auber, L. A. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100956 · Cited by 77

Human Herpesviruses 6A and 6B in Brain Diseases: Association versus Causation

Komaroff, A. L., Pellett, P. E., & Jacobson, S. (2020) · Clinical Microbiology Reviews · doi:10.1128/cmr.00143-20 · Cited by 77

The intestinal microbiome and Alzheimer's disease: A review

Li, Z., Zhu, H., Zhang, L., & Qin, C. (2018) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12033 · Cited by 78

Dysfunction of the Blood-Brain Barrier—A Key Step in Neurodegeneration and Dementia

Noe, C. R., Noe-Letschnig, M., Handschuh, P. A., Noe, C. A., & Lanzenberger, R. R. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00185 · Cited by 76

The viral hypothesis: how herpesviruses may contribute to Alzheimer’s disease

Wainberg, M., Luquez, T., Koelle, D. M., Readhead, B., Johnston, C., Darvas, M., & Funk, C. C. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01138-6 · Cited by 74

Physical Exercise, a Potential Non-Pharmacological Intervention for Attenuating Neuroinflammation and Cognitive Decline in Alzheimer’s Disease Patients

Ribarič, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063245 · Cited by 77

Gut Microbiota is an Impact Factor based on the Brain-Gut Axis to Alzheimer’s Disease: A Systematic Review

Zou, B., Li, J., Ma, R., Cheng, X.-Y., Ma, R.-Y., Zhou, T.-Y., Wu, Z., Yao, Y., & Li, J. (2023) · Aging and Disease · doi:10.14336/ad.2022.1127 · Cited by 76

What could we learn from SARS when facing the mental health issues related to the COVID-19 outbreak? A nationwide cohort study in Taiwan

Tzeng, N.-S., Chung, C.-H., Chang, C.-C., Chang, H.-A., Kao, Y.-C., Chang, S.-Y., & Chien, W.-C. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01021-y · Cited by 63

Modulation of β-Amyloid Fibril Formation in Alzheimer’s Disease by Microglia and Infection

Brown, M. R., Radford, S. E., & Hewitt, E. W. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.609073 · Cited by 67

Herpes Viruses and Senile Dementia: First Population Evidence for a Causal Link

Itzhaki, R. F., & Lathe, R. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180266 · Cited by 63

Amyloid-β: A double agent in Alzheimer's disease?

Yu, H., & Wu, J. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111575 · Cited by 62

Role of HSV-1 in Alzheimer's disease pathogenesis: A challenge for novel preventive/therapeutic strategies

Protto, V., Marcocci, M. E., Miteva, M. T., Piacentini, R., Puma, D. D. L., Grassi, C., Palamara, A. T., & Chiara, G. D. (2022) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2022.102200 · Cited by 61

A genetic signature including apolipoprotein Eε4 potentiates the risk of herpes simplex–associated Alzheimer's disease

Lindman, K. L., Weidung, B., Olsson, J., Josefsson, M., Kok, E., Johansson, A. S., Eriksson, S., Hallmans, G., Elgh, F., & Lövheim, H. (2019) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2019.09.014 · Cited by 60

Apolipoprotein E and viral infection: Risks and Mechanisms

Chen, F., Ke, Q., Wei, W., Cui, L., & Wang, Y. (2023) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2023.07.031 · Cited by 60

Anti-herpetic tau preserves neurons via the cGAS-STING-TBK1 pathway in Alzheimer’s disease

Hyde, V. R., Zhou, C., y Fernández, J. R. M., Chatterjee, K., Ramakrishna, P., Lin, A., Fisher, G. W., Celiker, O. T., Caldwell, J., Bender, O., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2024.115109 · Cited by 61

Viruses in neurodegenerative diseases: More than just suspects in crimes

Leblanc, P., & Vorberg, I. M. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010670 · Cited by 58

Herpes simplex virus and Alzheimer’s disease: a Mendelian randomization study

Kwok, M. K., & Schooling, C. M. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.09.025 · Cited by 55

Herpes simplex virus type 1 and Alzheimer’s disease: link and potential impact on treatment

Mancuso, R., Sicurella, M., Agostini, S., Marconi, P., & Clerici, M. (2019) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2019.1656064 · Cited by 56

Comprehensive Management of Daily Living Activities, behavioral and Psychological Symptoms, and Cognitive Function in Patients with Alzheimer's Disease: A Chinese Consensus on the Comprehensive Management of Alzheimer's Disease

Jia, J., Xu, J. L., Liu, J., Wang, Y., Wang, Y., Cao, Y., Guo, Q., Qu, Q.-M., Wei, C., Wei, W., et al. (2021) · Neuroscience Bulletin · doi:10.1007/s12264-021-00701-z · Cited by 62

The association of herpes zoster and influenza vaccinations with the risk of developing dementia: a population-based cohort study within the UK Clinical Practice Research Datalink

Lophatananon, A., Carr, M., McMillan, B., Dobson, C. B., Itzhaki, R. F., Parisi, R., Ashcroft, D. M., & Muir, K. R. (2023) · BMC Public Health · doi:10.1186/s12889-023-16768-4 · Cited by 55

Persistent Infection with Herpes Simplex Virus 1 and Alzheimer’s Disease—A Call to Study How Variability in Both Virus and Host may Impact Disease

Mangold, C. A., & SZPARA, M. L. (2019) · Viruses · doi:10.3390/v11100966 · Cited by 53

Alzheimer Disease

McDade, E. (2022) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000001131 · Cited by 56

Antiherpetic medication and incident dementia: Observational cohort studies in four countries

Schnier, C., Janbek, J., Williams, L., Wilkinson, T., Laursen, T. M., Waldemar, G., Richter, H., Kostev, K., Lathe, R., & G Haas, J. (2021) · European Journal of Neurology · doi:10.1111/ene.14795 · Cited by 52

The associations of herpes simplex virus and varicella zoster virus infection with dementia: a nationwide retrospective cohort study

Shin, E., Ah, S., Chung, T., Kim, H. J., Kim, K., & Lim, D. H. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01418-7 · Cited by 49

Microglia in Alzheimer's Disease: a Key Player in the Transition Between Homeostasis and Pathogenesis

McFarland, K. N., & Chakrabarty, P. (2022) · Neurotherapeutics · doi:10.1007/s13311-021-01179-3 · Cited by 48

Mechanistic Insights for Drug Repurposing and the Design of Hybrid Drugs for Alzheimer’s Disease

Padhi, D., & Govindaraju, T. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00335 · Cited by 47

Herpes simplex virus 1 and the risk of dementia: a population-based study

Murphy, M. J., Fani, L., Ikram, M. K., Ghanbari, M., & Ikram, M. A. (2021) · Scientific Reports · doi:10.1038/s41598-021-87963-9 · Cited by 46

The Hippocampal Vulnerability to Herpes Simplex Virus Type I Infection: Relevance to Alzheimer’s Disease and Memory Impairment

Yong, S. J., Yong, M. H., Teoh, S. L., Soga, T., Parhar, I. S., Chew, J., & Lim, W. L. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.695738 · Cited by 47

Antimicrobial Peptides (AMPs) in the Pathogenesis of Alzheimer’s Disease: Implications for Diagnosis and Treatment

Bruno, F., Malvaso, A., Canterini, S., & Bruni, A. C. (2022) · Antibiotics · doi:10.3390/antibiotics11060726 · Cited by 44

Soluble Amyloid-β Consumption in Alzheimer’s Disease

Espay, A. J., Sturchio, A., Schneider, L. S., & Ezzat, K. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210415 · Cited by 46

Psychiatric disorders following traumatic brain injury: a nationwide population-based cohort study and the effects of rehabilitation therapies.

Yeh, T.-C., Chien, W.-C., Chung, C.-H., Liang, C.-S., Chang, H.-A., Kao, Y., Yeh, H.-W., Yang, Y.-J., & Tzeng, N.-S. (2020) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2019.12.005 · Cited by 42

Controversial role of herpesviruses in Alzheimer’s disease

Rizzo, R. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008575 · Cited by 45

Herpes Simplex Viral Infection Doubles the Risk of Dementia in a Contemporary Cohort of Older Adults: A Prospective Study

Vestin, E., Boström, G., Olsson, J., Elgh, F., Lind, L., Kilander, L., Lövheim, H., & Weidung, B. (2024) · Journal of Alzheimer’s Disease · doi:10.3233/jad-230718 · Cited by 44

Associations of infections and vaccines with Alzheimer's disease point to a role of compromised immunity rather than specific pathogen in AD

Ukraintseva, S. V., Yashkin, A. P., Akushevich, I. V., Arbeev, K. G., Duan, H., Gorbunova, G., Stallard, E., & Yashin, A. I. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112411 · Cited by 47

NLRP3 and Infections: β-Amyloid in Inflammasome beyond Neurodegeneration

Sita, G., Graziosi, A., Hrelia, P., & Morroni, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136984 · Cited by 43

Roles of HSV-1 infection-induced microglial immune responses in CNS diseases: friends or foes?

Wang, Y., Jia, J., Wang, Y., Li, F., Song, X., Qin, S., Wang, Z., Kitazato, K., & Wang, Y. (2019) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2019.1660615 · Cited by 40

Alzheimer’s Amyloid Hypothesis and Antibody Therapy: Melting Glaciers?

Høilund‐Carlsen, P. F., Alavi, A. A., Castellani, R. J., Neve, R. L., Perry, G. L., Revheim, M.-E. R., & Barrio, J. R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073892 · Cited by 44

The Potential Role of Herpes Simplex Virus Type 1 and Neuroinflammation in the Pathogenesis of Alzheimer's Disease

Laval, K., & Enquist, L. W. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.658695 · Cited by 43

VALZ‐Pilot: High‐dose valacyclovir treatment in patients with early‐stage Alzheimer's disease

Weidung, B., Hemmingsson, E., Olsson, J., Sundström, T., Blennow, K., Zetterberg, H., Ingelsson, M., Elgh, F., & Lövheim, H. (2022) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12264 · Cited by 40

Infectious diseases and cognition: do we have to worry?

Hernández‐Ruiz, V., Letenneur, L., Fülöp, T., Helmer, C., Baudron, C. R., Ávila‐Funes, J. A., & Amieva, H. (2022) · Neurological Sciences · doi:10.1007/s10072-022-06280-9 · Cited by 45

Herpes viruses and Alzheimer's disease: new evidence in the debate

Balin, B. J., & Hudson, A. P. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30316-8 · Cited by 38

Evolving therapeutic interventions for the management and treatment of Alzheimer’s disease

Ahmad, F., Karan, A., Sharma, R., Sharma, N. S., Sundar, V., Jayaraj, R. L., Mukherjee, S., & DeCoster, M. A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102229 · Cited by 40

Systemic inflammation as a central player in the initiation and development of Alzheimer’s disease

Bayraktaroğlu, I., Ortí-Casañ, N., Dam, D. V., Deyn, P. P. D., & Eisel, U. L. M. (2025) · Immunity & Ageing · doi:10.1186/s12979-025-00529-5 · Cited by 49

What is strain in neurodegenerative diseases?

Tian, Y., Meng, L., & Zhang, Z. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03298-9 · Cited by 37

Cerebral Organoids for Modeling of HSV-1-Induced-Amyloid β Associated Neuropathology and Phenotypic Rescue

Qiao, H., Zhao, W., Guo, M., Zhu, L., Chen, T., Wang, J., Xu, X., Zhang, Z., Wu, Y., & Chen, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23115981 · Cited by 43

Clinical evidence of human pathogens implicated in Alzheimer’s disease pathology and the therapeutic efficacy of antimicrobials: an overview

Catumbela, C. S. G., Giridharan, V. V., Barichello, T., & Morales, R. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00369-7 · Cited by 37

The lack of association between herpes simplex virus 1 or Toxoplasma gondii infection and cognitive decline in the general population: An 11-year follow-up study

Torniainen‐Holm, M., Suvisaari, J., Lindgren, M., Härkänen, T., Dickerson, F., & Yolken, R. H. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.11.016 · Cited by 37

Modeling Aβ42 Accumulation in Response to Herpes Simplex Virus 1 Infection: Two Dimensional or Three Dimensional?

Abrahamson, E. E., Zheng, W., Muralidaran, V., Ikonomović, M. D., Bloom, D. C., Nimgaonkar, V. L., & D’Aiuto, L. (2020) · Journal of Virology · doi:10.1128/jvi.02219-20 · Cited by 39

Can Infections Cause Alzheimer Disease?

Komaroff, A. L. (2020) · JAMA · doi:10.1001/jama.2020.4085 · Cited by 36

Selective Vulnerability of the Locus Coeruleus Noradrenergic System and its Role in Modulation of Neuroinflammation, Cognition, and Neurodegeneration

Evans, A. K., Defensor, E. B., & Shamloo, M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1030609 · Cited by 40

Sepsis exacerbates Alzheimer’s disease pathophysiology, modulates the gut microbiome, increases neuroinflammation and amyloid burden

Giridharan, V. V., Catumbela, C. S. G., Catalão, C. H. R., Lee, J., Ganesh, B. P., Petronilho, F. C., Dal‐Pizzol, F., Morales, R., & Barichello, T. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02172-2 · Cited by 38

KIR2DS2/KIR2DL2/HLA-C1 Haplotype Is Associated with Alzheimer’s Disease: Implication for the Role of Herpesvirus Infections

Rizzo, R., Bortolotti, D., Gentili, V., Rotola, A., Bolzani, S., Caselli, E., Tola, M. R., & Luca, D. D. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-180777 · Cited by 36

The Role of Genetic, Environmental, and Dietary Factors in Alzheimer’s Disease: A Narrative Review

Mertaş, B., & Boşgelmez, İ. İ. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031222 · Cited by 35

Immunosenescence as a convergence pathway in neurodegeneration

Mohapatra, L., Mishra, D. K., Tripathi, A. S., & Parida, S. K. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110521 · Cited by 38

Mechanisms and therapeutic potential of interactions between human amyloids and viruses

Michiels, E., Rousseau, F., & Schymkowitz, J. W. H. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03711-8 · Cited by 37

Alzheimer’s disease-associated β-amyloid does not protect against herpes simplex virus 1 infection in the mouse brain

Bocharova, O. V., Pandit, N. P., Molesworth, K., Fisher, A., Mychko, O., Makarava, N., & Baskakov, I. V. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100845 · Cited by 34

Microbes and Alzheimer’s Disease: New Findings Call for a Paradigm Change

Haas, J., & Lathe, R. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.07.001 · Cited by 34

Electroconvulsive Therapy and Risk of Dementia—A Nationwide Cohort Study in Taiwan

Chu, C., Chien, W., Chung, C., Chao, P.-C., Chang, H., Kao, Y., Chou, Y., & Tzeng, N. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00397 · Cited by 33

Targeting Infectious Agents as a Therapeutic Strategy in Alzheimer’s Disease

Fülöp, T., Munawara, U., Larbi, A., Desroches, M., Rodrigues, S., Catanzaro, M., Guidolin, A., Khalil, A., Bernier, F., Barron, A. E., et al. (2020) · CNS Drugs · doi:10.1007/s40263-020-00737-1 · Cited by 32

Herpes Zoster Does Not Increase the Risk of Neurodegenerative Dementia: A Case-Control Study

Choi, H. G., Park, B. J., Lim, J. S., Sim, S. Y., Jung, Y. J., & Lee, S. W. (2021) · American Journal of Alzheimer's Disease & Other Dementias® · doi:10.1177/15333175211006504 · Cited by 34

Symptomatic Herpes Simplex Virus Infection and Risk of Dementia in US Veterans: a Cohort Study

Young‐Xu, Y., Powell, E. I., Zwain, G., Yazdi, M. T., Gui, J., & Shiner, B. R. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01084-9 · Cited by 18

Anti-herpetic treatment reduces dementia risk: A systematic review and meta-analysis

Chang, S.-T., Wu, H., Chiu, Y., & Chuang, Y. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251409323 · Cited by 5

Association between anti‐herpetic medications and dementia risk: A systematic review and meta‐analysis

Chang, S., & Chuang, Y. F. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.085524

Herpes simplex diagnosis and treatment are not associated with incident dementia

Schmidt, M. A., Rawlings, A. M., Koppulo, P. D., Prado, Y. K., Rosales, A. G., & Weinmann, S. A. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.051898

Alzheimer's: Do Anti-Herpetics Reduce the Risk of Dementia and if so, Why?

Broxmeyer, L., & Perry, G. L. (2018) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.1493173