The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Questioning the use of PEGylation for drug delivery
Open accessAbstract
Polyethylene glycol (PEG) is widely utilized in drug delivery and nanotechnology due to its reported “stealth” properties and biocompatibility. It is generally thought that PEGylation allows particulate delivery systems and biomaterials to evade the immune system and thereby prolong circulation lifetimes. However, numerous studies over the past decade have demonstrated that PEGylation causes significant reductions in drug delivery, including enhanced serum protein binding, reduced uptake by target cells, and the elicitation of an immune response that facilitates clearance in vivo. This report reviews some of the extensive literature documenting the detrimental effects of PEGylation, and thereby questions the wisdom behind employing this strategy in drug development.
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Hossen, S., Hossain, M. K., Basher, M. K., Mia, M. N. H., Rahman, M. T., & Uddin, M. J. (2019) · Journal of Advanced Research · doi:10.1016/j.jare.2018.06.005 · Cited by 998
The Uniqueness of Albumin as a Carrier in Nanodrug Delivery
Spada, A., Emami, J., Tuszynski, J. A., & Lavasanifar, A. (2021) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.1c00046 · Cited by 591
Biointerfacing and Applications of Cell Membrane-Coated Nanoparticles
Kroll, A. V., Fang, R. H., & Zhang, L. (2017) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.6b00569 · Cited by 379
Immunological and Toxicological Considerations for the Design of Liposomes
Inglut, C. T., Sorrin, A. J., Kuruppu, T., Vig, S., Cicalo, J., Ahmad, H., & Huang, H.-C. (2020) · Nanomaterials · doi:10.3390/nano10020190 · Cited by 371
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Metadata
- Authors
- Verhoef, J. J. F., & Anchordoquy, T. J.
- Venue
- Drug Delivery and Translational Research
- Published
- 2013-09-25
- Volume
- 3
- Issue
- 6
- Pages
- 499-503
- ISSN
- 2190-393X (ISSN-L)
- 2190-3948
- OpenAlex
- W2085178300
- Cited by
- 342
- References
- 61
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- green
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- Verhoef, J. J. F., & Anchordoquy, T. J. (2013). Questioning the use of PEGylation for drug delivery. Drug Delivery and Translational Research. https://doi.org/10.1007/s13346-013-0176-5
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
