Cited by 211Nanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryPhotodynamic Therapy Research Studies

Phototheranostics: Active Targeting of Orthotopic Glioma Using Biomimetic Proteolipid Nanoparticles

Jia, Yali, Wang, Xiaobing, Hu, Dehong, Wang, Pan, Liu, Quanhong, Zhang, Xuanjun, Jiang, Jingying, Liu, Xin +3 more·2019·ACS Nano

Abstract

Advances in phototheranostics revolutionized glioma intraoperative fluorescence imaging and phototherapy. However, the lack of desired active targeting agents for crossing the blood–brain barrier (BBB) significantly compromises the theranostic efficacy. In this study, biomimetic proteolipid nanoparticles (NPs) with U.S. Food and Drug Administration (FDA)-approved indocyanine green (ICG) were constructed to allow fluorescence imaging, tumor margin detection, and phototherapy of orthotopic glioma in mice. By embedding glioma cell membrane proteins into NPs, the obtained biomimetic ICG-loaded liposome (BLIPO-ICG) NPs could cross BBB and actively reach glioma at the early stage thanks to their specific binding to glioma cells due to their excellent homotypic targeting and immune escaping characteristics. High accumulation in the brain tumor with a signal to background ratio of 8.4 was obtained at 12 h post-injection. At this time point, the glioma and its margin were clearly visualized by near-infrared fluorescence imaging. Under the imaging guidance, the glioma tissue could be completely removed as a proof of concept. In addition, after NIR laser irradiation (1 W/cm 2, 5 min), the photothermal effect exerted by BLIPO-ICG NPs efficiently suppressed glioma cell proliferation with a 94.2% tumor growth inhibition. No photothermal damages of normal brain tissue and treatment-induced side effects were observed. These results suggest that the biomimetic proteolipid NP is a promising phototheranostic nanoplatform for brain-tumor-specific imaging and therapy.

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Crossref · 10.1021/acsnano.8b06556

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  • Membrane-camouflaged nanoparticles were proved to be soft and their active proteins were easy to be inserted.

    “these membrane-camouflaged nanoparticles were proved to be “soft” and the active proteins were easy to be inserted.”

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Authors
Jia, Y., Wang, X., Hu, D., Wang, P., Liu, Q., Zhang, X., Jiang, J., Liu, X., Sheng, Z., Liu, B., & Zheng, H.
Affiliations
  • Chinese Academy of Sciences (CN)
  • Shaanxi Normal University (CN)
  • University of Macau (MO)
  • National University of Singapore (SG)
Corresponding author
  • Sheng, Zonghai
  • Liu, Bin
  • Zheng, Hairong
Venue
ACS Nano
Published
2018-12-21
Volume
13
Issue
1
Pages
386-398
ISSN
  • 1936-0851 (ISSN-L)
  • 1936-086X
OpenAlex
W2905610837
Cited by
211
References
61
Citations by year
2026: 8 · 2025: 18 · 2024: 27 · 2023: 39 · 2022: 43 · 2021: 29 · 2020: 34 · 2019: 13
FWCI
7.60
Type
journal article
Language
en
Open access
closed
Locations
  • ACS Nano (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ministry of Education of the People's Republic of China (2015CB755500, 2016TS059, GK201802002)
  • National Research Foundation Singapore (R279-000-483-281)
  • National Natural Science Foundation of China (81472846, 81527901, 81327801, 81827807)
  • Shaanxi Normal University (16QNGG012)
  • Shenzhen Key Laboratory of Ultrasound Imaging and Therapy
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
Keywords
phototheranostics, glioma, biomimetic nanoparticles, indocyanine green, blood-brain barrier penetration, tumor margin detection, near-infrared fluorescence imaging, photothermal therapy, active targeting, orthotopic glioma
MeSH terms
Theranostic Nanomedicine, Animals, Blood-Brain Barrier, Brain Neoplasms, Female, Glioma, Humans, Indocyanine Green, Mice, Inbred BALB C, Mice, Nude, Proteolipids, Surgery, Computer-Assisted, Biomimetic Materials, Mice, Nanoparticles, Hep G2 Cells, MCF-7 Cells

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