The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
A comprehensive insight on ocular pharmacokinetics
Open accessAbstract
The eye is a distinctive organ with protective anatomy and physiology. Several pharmacokinetics compartment models of ocular drug delivery have been developed for describing the absorption, distribution, and elimination of ocular drugs in the eye. Determining pharmacokinetics parameters in ocular tissues is a major challenge because of the complex anatomy and dynamic physiological barrier of the eye. In this review, pharmacokinetics of these compartments exploring different drugs, delivery systems, and routes of administration is discussed including factors affecting intraocular bioavailability. Factors such as precorneal fluid drainage, drug binding to tear proteins, systemic drug absorption, corneal factors, melanin binding, and drug metabolism render ocular delivery challenging and are elaborated in this manuscript. Several compartment models are discussed; these are developed in ocular drug delivery to study the pharmacokinetics parameters. There are several transporters present in both anterior and posterior segments of the eye which play a significant role in ocular pharmacokinetics and are summarized briefly. Moreover, several ocular pharmacokinetics animal models and relevant studies are reviewed and discussed in addition to the pharmacokinetics of various ocular formulations.
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Cites
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Self-citationChallenges and obstacles of ocular pharmacokinetics and drug delivery
Urtti, A. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.07.027 · Cited by 1,003
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Recent Perspectives in Ocular Drug Delivery
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Self-citationPharmacokinetics and Pharmacodynamics of Antibacterial Agents
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Pharmacokinetics of Intravitreal Ranibizumab (Lucentis)
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Human Corneal Anatomy Redefined
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Cited by
Principles of pharmacology in the eye
Awwad, S., Mohamed Ahmed, A. H. A., Sharma, G., Heng, J. S., Khaw, P. T., Brocchini, S., & Lockwood, A. (2017) · British Journal of Pharmacology · doi:10.1111/bph.14024 · Cited by 224
Zhao, X., Seah, I., Xue, K., Wong, W., Tan, Q. S. W., Ma, X., Lin, Q., Lim, J. Y. C., Liu, Z., Parikh, B. H., et al. (2022) · Advanced Materials · doi:10.1002/adma.202108360 · Cited by 84
An insight on ophthalmic drug delivery systems: focus on polymeric biomaterials-based carriers
Shafiq, M., Rafique, M., Cui, Y., Pan, L., Do, C.-W., & Ho, E. A. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.08.041 · Cited by 67
Lohia, A., Sahel, D. K., Salman, M., Singh, V., Mariappan, I., Mittal, A., & Chitkara, D. (2022) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2022.02.001 · Cited by 33
Dahmana, N., Kowalczuk, L., Gabriel, D., Behar-Cohen, F., Gurny, R., & Kalia, Y. N. (2020) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.9b00707 · Cited by 7
Metadata
- Authors
- Agrahari, V., Mandal, A., Agrahari, V., Trinh, H. M., Joseph, M., Ray, A., Hadji, H., Mitra, R., Pal, D., & Mitra, A. K.
- Venue
- Drug Delivery and Translational Research
- Published
- 2016-10-31
- Volume
- 6
- Issue
- 6
- Pages
- 735-754
- ISSN
- 2190-393X (ISSN-L)
- 2190-3948
- OpenAlex
- W2539812081
- Cited by
- 462
- References
- 70
- FWCI
- 7.38
- Type
- journal article
- Language
- en
- Open access
- green
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- Agrahari, V., Mandal, A., Agrahari, V., Trinh, H. M., Joseph, M., Ray, A., Hadji, H., Mitra, R., Pal, D., & Mitra, A. K. (2016). A comprehensive insight on ocular pharmacokinetics. Drug Delivery and Translational Research. https://doi.org/10.1007/s13346-016-0339-2
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