The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Pharmacokinetics and Pharmacodynamics of Antibacterial Agents
Open accessAbstract
The pharmacodynamics of an antimicrobial drug relates its pharmacokinetics to the time course of the antimicrobial effects at the site of the infection. Knowledge of the drug's antimicrobial pharmacodynamic effects (eg, rate and extent of bactericidal action and postantibiotic effect) provides a more rational basis for determination of optimal dosing regimens in terms of the dose and the dosing interval than do the minimal inhibitory concentrations (MICs) and minimal bactericidal concentrations (MBCs) determined in vitro. This article reviews pharmacokinetics, antimicrobial pharmacodynamics, the effect of pharmacodynamics on the emergence of resistant bacterial subpopulations, and the development of pharmacodynamic breakpoints for use in the design of trials of these drugs and in the treatment of infected patients.
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Cites
Clinical Pharmacokinetics of Vancomycin
Matzke, G. R., Zhanel, G. G., & Guay, D. R. P. (1986) · Clinical Pharmacokinetics · doi:10.2165/00003088-198611040-00001 · Cited by 360
Brook, I. (1989) · Clinical Infectious Diseases · doi:10.1093/clinids/11.3.361 · Cited by 241
Intracellular pharmacodynamics of antibiotics
Carryn, S., Chanteux, H., Seral, C., Mingeot-Leclercq, M.-P., Van Bambeke, F., & Tulkens, P. M. (2003) · Infectious Disease Clinics of North America · doi:10.1016/s0891-5520(03)00066-7 · Cited by 201
Continuous infusion of β-lactam antibiotics in severe infections: a review of its role
Roberts, J. A., Paratz, J., Paratz, E., Krueger, W. A., & Lipman, J. (2007) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2007.02.002 · Cited by 150
Pharmacodynamics: Relation to Antimicrobial Resistance
Rybak, M. J. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.04.001 · Cited by 120 · cited 1×
“The likelihood that resistant subpopulations will emerge when using antimicrobial therapy will depend on the propensity for resistance within the population, that is, on the spontaneous mutation rate for antibiotic resistance, the ability of host defenses to control the growth of the resistant subpopulation, and the m…”
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Cited by
Rawson, T. M., Moore, L. S. P., Zhu, N., Ranganathan, N., Skolimowska, K., Gilchrist, M., Satta, G., Cooke, G., & Holmes, A. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa530 · Cited by 1,662
Nanoemulsion: Concepts, development and applications in drug delivery
Singh, Y., Meher, J. G., Raval, K., Khan, F. A., Chaurasia, M., Jain, N. K., & Chourasia, M. K. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.03.008 · Cited by 1,358
The intestinal microbiota: Antibiotics, colonization resistance, and enteric pathogens
Kim, S., Covington, A., & Pamer, E. G. (2017) · Immunological Reviews · doi:10.1111/imr.12563 · Cited by 741
A comprehensive insight on ocular pharmacokinetics
Agrahari, V., Mandal, A., Agrahari, V., Trinh, H. M., Joseph, M., Ray, A., Hadji, H., Mitra, R., Pal, D., & Mitra, A. K. (2016) · Drug Delivery and Translational Research · doi:10.1007/s13346-016-0339-2 · Cited by 462
Atassi, F., Pho Viet Ahn, D. L., & Lievin-Le Moal, V. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02900 · Cited by 71
Metadata
- Authors
- Levison, M. E., & Levison, J. H.
- Venue
- Infectious Disease Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 23
- Issue
- 4
- Pages
- 791-815
- ISSN
- 0891-5520 (ISSN-L)
- OpenAlex
- W2019799507
- Cited by
- 557
- References
- 5
- FWCI
- 2.56
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
