Catechol-functionalized chitosan/pluronic hydrogels for tissue adhesives and hemostatic materials
Abstract
Bioinspired from adhesion behaviors of mussels, injectable and thermosensitive chitosan/Pluronic composite hydrogels were synthesized for tissue adhesives and hemostatic materials. Chitosan conjugated with multiple catechol groups in the backbone was cross-linked with terminally thiolated Pluronic F-127 triblock copolymer to produce temperature-sensitive and adhesive sol-gel transition hydrogels. A blend mixture of the catechol-conjugated chitosan and the thiolated Pluronic F-127 was a viscous solution state at room temperature but became a cross-linked gel state with instantaneous solidification at the body temperature and physiological pH. The adhesive chitosan/Pluronic injectable hydrogels with remnant catechol groups showed strong adhesiveness to soft tissues and mucous layers and also demonstrated superior hemostatic properties. These chitosan/Pluronic hydrogels are expected to be usefully exploited for injectable drug delivery depots, tissue engineering hydrogels, tissue adhesives, and antibleeding materials.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Many mussel-inspired injectable hydrogels have been developed for hemorrhage control.
“During recent decades, many mussel-inspired injectable hydrogels have been developed for hemorrhage control [120,121].”
From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [121]
Cites
Independent Control of Rigidity and Toughness of Polymeric Hydrogels
Kong, H. J., Wong, E., & Mooney, D. J. (2003) · Macromolecules · doi:10.1021/ma034137w · Cited by 224 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Recent progress in biomedical applications of pluronic (PF127): Pharmaceutical perspectives
Akash, M. S. H., & Rehman, K. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.04.032 · Cited by 394 · see citing works
Recent progress in synthesis and application of mussel-inspired adhesives
Guo, Q., Chen, J., Wang, J., Zeng, H., & Yu, J. (2020) · Nanoscale · doi:10.1039/c9nr09780e · Cited by 370 · see citing works
Huang, W., Cheng, S., Wang, X., Zhang, Y., Chen, L., & Zhang, L. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202009189 · Cited by 272 · see citing works
Liu, Y., Zhu, Z., Pei, X., Zhang, X., Cheng, X., Hu, S., Gao, X., Wang, J., Chen, J., & Wan, Q. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c12090 · Cited by 259 · see citing works
Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications
Dou, W., Zeng, X., Zhu, S., Zhu, Y., Liu, H., & Li, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25169100 · Cited by 52 · see citing works
“During recent decades, many mussel-inspired injectable hydrogels have been developed for hemorrhage control [120,121].”
BackgroundDopa-empowered schiff base forming alginate hydrogel glue for rapid hemostatic control
Song, C. K., Kim, M.-K., Lee, J., Davaa, E., Baskaran, R., & Yang, S.-G. (2019) · Macromolecular Research · doi:10.1007/s13233-019-7026-3 · Cited by 46 · see citing works
Enzymatically cross-linked poly(γ-glutamic acid) hydrogel with enhanced tissue adhesive property
Kim, M. H., Lee, J. N., Lee, J., Lee, H., & Park, W. H. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c00411 · Cited by 45 · see citing works
Self-citationWei, C., Shi, W., Zhao, C., Yang, S., Zheng, J., Zhong, J., Zhao, T., Kong, S., Gong, X., & Liu, M. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202201799 · Cited by 38 · see citing works
- Authors
- Ryu, J. H., Lee, Y., Kong, W. H., Kim, T. G., Park, T. G., & Lee, H.
- Affiliations
- Korea Advanced Institute of Science and Technology (KR)
- Corresponding author
- Park, Tae Gwan
- Lee, Haeshin
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-06-07
- Volume
- 12
- Issue
- 7
- Pages
- 2653-2659
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2035332297
- Cited by
- 677
- References
- 1
- Citations by year
- 2026: 24 · 2025: 39 · 2024: 46 · 2023: 36 · 2022: 52 · 2021: 76 · 2020: 76 · 2019: 62 · 2018: 62 · 2017: 52 · 2016: 34 · 2015: 30 · 2014: 36 · 2013: 28 · 2012: 22
- FWCI
- 12.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomacromolecules (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Keywords
- Pluronic F127, injectable hydrogel, thermosensitive hydrogel, tissue adhesives, hemostatic materials, mussel-inspired adhesion, sol-gel transition, soft tissue adhesion, mucoadhesion, injectable drug delivery
- MeSH terms
- Animals, Biocompatible Materials, Catechols, Cross-Linking Reagents, Hemostatics, Hydrogen-Ion Concentration, Injections, Subcutaneous, Mice, Inbred BALB C, Temperature, Tissue Adhesives, Molecular Structure, Rats, Sprague-Dawley, Hydrogels, Poloxamer, Models, Animal, Chitosan, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
