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Stem Cells Seeded on Multilayered Scaffolds Implanted into an Injured Bladder Rat Model Improves Bladder Function
Open accessAbstract
Background To investigate whether human adipose-derived stem cells (hADSCs) seeded on multilayered poly (l-lactide-co-ɛ-caprolactone) (PLCL) sheets improve bladder function in a rat model of detrusor smooth muscle-removed bladder.Methods Male rats were randomly divided into 4 groups: Normal, injury (detrusor smooth muscle-removed bladder), PLCL (detrusor smooth muscle-removed bladder implanted with PLCL sheets), and PLCL + ADSC (detrusor smooth muscle-removed bladder implanted with PLCL sheets seeded with hADSCs). Four weeks after the treatment, physiological, histological, immunohistochemical, and immunoblot analyses were performed.Results hADSCs were compatible with PLCL sheets. Further, the physiological study of PLCL + ADSC group showed significant improvement in compliance and contractility suggesting the functional improvement of the bladder. Histological, immunohistochemical and immunoblot analyses revealed the uniform distribution of hADSCs in between PLCL sheets as well as differentiation of hADSCs into smooth muscle cells (SMC) which is illustrated by the expression of SMC markers.Conclusion hADSCs seeded on the multilayered PLCL sheets has the potential to differentiate into SMC, thus facilitating the recovery of compliance and contractility of the injured bladder.
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PLCL can act as matrix carrier of cells to carry out local delivery of cells to injured area, thus promoting repair of urinary tissues and organs such as urethra and bladder.
“The above studies show that PLCL can act as a matrix carrier of cells to carry out local delivery of cells to the injured area, thus promoting the repair of urinary tissues and organs such as the urethra and bladder [213].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [213]
Section 2.7 describes hADSCs carried between PLCL sheets and placed over an injured rat bladder; the Introduction reports improved bladder function with these cell-seeded sheets. This supports local cell delivery for bladder repair, but the paper does not establish repair of the urethra or urinary organs generally. Page numbers are not available for these passages. (LLM, conf=0.86)
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Metadata
- Authors
- Shrestha, K. R., Jeon, S. H., Jung, A. R., Kim, I. G., Kim, G. E., Park, Y. H., Kim, S. H., & Lee, J. Y.
- Affiliations
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Korea Institute of Science and Technology (KR)
- Corresponding author
- Lee, Ji Youl
- ORCID
- Venue
- Tissue Engineering and Regenerative Medicine
- Published
- 2019-03-22
- Volume
- 16
- Issue
- 2
- Pages
- 201-212
- ISSN
- 1738-2696 (ISSN-L)
- 2212-5469
- PMC
- PMC6439074
- OpenAlex
- W2924001318
- Cited by
- 14
- References
- 35
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 1
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Tissue Engineering and Regenerative Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- This research was supported by the National Research Foundation of Korea grant funded by the Korea government (No. 2011-0030075)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Keywords
- bladder injury, adipose-derived stem cells, multilayered scaffolds, stem cell seeding, smooth muscle differentiation, bladder contractility, bladder compliance, bladder regeneration, rat model
- MeSH terms
- Calponins, Actins, Adipose Tissue, Animals, Urinary Bladder, Calcium-Binding Proteins, Cell Differentiation, Desmin, Humans, Male, Microfilament Proteins, Polyesters, Stem Cells, Transplantation, Heterologous, Biomarkers, Gene Expression, Treatment Outcome, Rats, Sprague-Dawley, Recovery of Function, Myocytes, Smooth Muscle, Stem Cell Transplantation, Rats, Tissue Scaffolds
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