Klinische Evidenz zu Probiotika in der Prävention einer Antibiotika-assoziierten Diarrhö: Systematischer Review
Abstract
Background Antibiotic-associated diarrhoea (AAD) is the most common intestinal side effect of an antibiotic therapy. Various probiotics or probiotic combinations are often used preventively while taking antibiotics for the prevention of AAD.Method This review is based on a systematic literature research in MEDLINE and EMBASE. 7 probiotics are presented with regard to their effectiveness and evidence in the prevention of AAD. Only preparations classified by the World Gastroenerology Organization (WGO) with evidence levels 1-3 for the prevention of AAD were taken into account. 37 clinical studies, including 33 RCTs, were evaluated.Results Saccharomyces (S.) boulardii CNCM I-745 is the most extensively studied probiotic regarding the prevention of AAD. It has shown evidence-based efficacy in all patient groups (outpatients and hospitalized children and adults). Lactobacillus rhamnosus GG also has a good evidence regarding the prevention of AAD in children and outpatient adults. The other probiotics and probiotic combinations evaluated in the present study only show efficacy in hospitalized patients or only show very limited evidence regarding their efficacy in the prevention of AAD due to the underlying study design or the small number of patients.Conclusion The effect of probiotics is strain-specific, no general statement can be made about the efficacy of probiotics in the prevention of AAD. In principle, it is advisable to select a probiotic with an evidence-based effect such as S. boulardii CNCM I-745 or Lactobacillus rhamnosus GG to prevent AAD.
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S. boulardii and L. rhamnosus GG have been shown to reduce the risk of Antibiotic-Associated Diarrhea (AAD) and are effective in preventing AAD and/or Clostridium difficile diarrhea.
“Also, S. boulardii and L. rhamnosus GG have been shown to reduce the risk of Antibiotic-Associated Diarrhea (AAD). Both probiotic strains have been shown to be effective in preventing AAD [109,110,111] and/or Clostridium difficile diarrhea [112,113].”
From The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties (2024) · cites this paper as [111]
Higher doses of probiotics are the most effective in preventing AAD and/or C. difficile diarrhea.
“The researchers in these studies reported that higher doses are the most effective in these conditions.”
From The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties (2024) · cites this paper as [111]
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The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties
Maftei, N.-M., Raileanu, C. R., Balta, A. A., Ambrose, L., Boev, M., Marin, D. B., & Lisa, E. L. (2024) · Microorganisms · doi:10.3390/microorganisms12020234 · Cited by 381 · see citing works
- Authors
- Storr, M., & Stengel, A.
- Affiliations
- Starnberg Hospital (DE)
- Universitätsklinikum Tübingen (DE)
- Venue
- MMW - Fortschritte der Medizin
- Published
- 2021-04
- Volume
- 163
- Issue
- S4
- Pages
- 19-26
- ISSN
- 1438-3276 (ISSN-L)
- 1613-3560
- OpenAlex
- W3157238283
- Cited by
- 12
- References
- 47
- Citations by year
- 2026: 4 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 1
- FWCI
- 0.18
- Type
- journal article
- Language
- de
- Open access
- closed
- Locations
- MMW - Fortschritte der Medizin (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- probiotics, antibiotic-associated diarrhea, diarrhea prevention, gut microbiota, clinical evidence
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