Rapid and effective virucidal activity of povidone-iodine products against middle east respiratory syndrome coronavirus (MERS-CoV) and modified vaccinia virus ankara (MVA).

Eggers, Maren; Eickmann, Markus; Zorn, Juergen

doi:10.1007/s40121-015-0091-9

Cited by 229Antimicrobial agents and applicationsInfection Control in HealthcareInfection Control and Ventilation

Rapid and effective virucidal activity of povidone-iodine products against middle east respiratory syndrome coronavirus (MERS-CoV) and modified vaccinia virus ankara (MVA).

Open access

Eggers, Maren, Eickmann, Markus, Zorn, Juergen·2015·Infectious Diseases and Therapy

DOI 10.1007/s40121-015-0091-9PMC PMC4675768

Open this paper in CoChat — free account Open PDF

Abstract

INTRODUCTION: Since the first case of Middle East Respiratory Syndrome coronavirus (MERS-CoV) infection was reported in 2012, the virus has infected more than 1300 individuals in 26 countries, and caused more than 480 deaths. Human-to-human transmission requires close contact, and has typically occurred in the healthcare setting. Improved global awareness, together with improved hygiene practices in healthcare facilities, has been highlighted as key strategies in controlling the spread of MERS-CoV. This study tested the in vitro efficacy of three formulations of povidone iodine (PVP-I: 4% PVP-I skin cleanser, 7.5% PVP-I surgical scrub, and 1% PVP-I gargle/mouthwash) against a reference virus (Modified vaccinia virus Ankara, MVA) and MERS-CoV. METHODS: According to EN14476, a standard suspension test was used to assess virucidal activity against MVA and large volume plating was used for MERS-CoV. All products were tested under clean (0.3 g/L bovine serum albumin, BSA) and dirty conditions (3.0 g/L BSA + 3.0 mL/L erythrocytes), with application times of 15, 30, and 60 s for MVA, and 15 s for MERS-CoV. The products were tested undiluted, 1:10 and 1:100 diluted against MVA, and undiluted against MERS-CoV. RESULTS: A reduction in virus titer of ≥4 log10 (corresponding to an inactivation of ≥99.99%) was regarded as evidence of virucidal activity. This was achieved versus MVA and MERS-CoV, under both clean and dirty conditions, within 15 s of application of each undiluted PVP-I product. CONCLUSION: These data indicate that PVP-I-based hand wash products for potentially contaminated skin, and PVP-I gargle/mouthwash for reduction of viral load in the oral cavity and the oropharynx, may help to support hygiene measures to prevent transmission of MERS-CoV. FUNDING: Mundipharma Research GmbH & Co.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s40121-015-0091-9

Cites

20 of 20 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz
(2013) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/103.1437-1588 · Cited by 11,769 · see citing works
Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
Zaki, A. M., van Boheemen, S., Bestebroer, T. M., Osterhaus, A. D. M. E., & Fouchier, R. A. M. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1211721 · Cited by 5,677 · see citing works
Beitrag zur kollektiven Behandlung pharmakologischer Reihenversuche
Kärber, G. (1931) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf01863914 · Cited by 3,074 · see citing works
Biosafety in microbiological and biomedical laboratories
Richmond, J. Y., & McKinney, R. W. (1999) · U.S. G.P.O. , For sale by the Supt. of Docs., U.S. G.P.O. eBooks · Cited by 1,494 · see citing works
THE METHOD OF ‘RIGHT AND WRONG CASES’ (‘CONSTANT STIMULI’) WITHOUT GAUSS'S FORMULAE
Spearman, C. (1908) · British Journal of Psychology 1904-1920 · doi:10.1111/j.2044-8295.1908.tb00176.x · Cited by 745 · see citing works
Inactivation of SARS coronavirus by means of povidone-iodine, physical conditions and chemical reagents.
Kariwa, H., Fujii, N., & Takashima, I. (2006) · Dermatology · doi:10.1159/000089211 · Cited by 458 · see citing works
State of Knowledge and Data Gaps of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Humans
(2013) · PLoS Currents · doi:10.1371/currents.outbreaks.0bf719e352e7478f8ad85fa30127ddb8 · Cited by 308 · see citing works
Safety of modified vaccinia virus Ankara (MVA) in immune-suppressed macaques
Stittelaar, K. J., Kuiken, T., de Swart, R. L., van Amerongen, G., Vos, H. W., Niesters, H. G. M., van Schalkwijk, P., van der Kwast, T., Wyatt, L. S., Moss, B., et al. (2001) · Vaccine · doi:10.1016/s0264-410x(01)00075-5 · Cited by 187 · see citing works
Frequently Asked Questions about Color
Poynton, C. A. (1997) · Cited by 178 · see citing works
Identification of New Respiratory Viruses in the New Millennium
Berry, M. J., Gamieldien, J., & Fielding, B. C. (2015) · Viruses · doi:10.3390/v7030996 · Cited by 163 · see citing works
Respiratory virus RNA is detectable in airborne and droplet particles
Gralton, J., Tovey, E. R., McLaws, M., & Rawlinson, W. D. (2013) · Journal of Medical Virology · doi:10.1002/jmv.23698 · Cited by 128 · see citing works
In-vivo efficacy of hand sanitisers against feline calicivirus: a surrogate for norovirus
Lages, S. L. S., Ramakrishnan, M. A., & Goyal, S. M. (2008) · Journal of Hospital Infection · doi:10.1016/j.jhin.2007.11.018 · Cited by 81 · see citing works
Povidone-iodine hand wash and hand rub products demonstrated excellent in vitro virucidal efficacy against Ebola virus and modified vaccinia virus Ankara, the new European test virus for enveloped viruses
Eggers, M., Eickmann, M., Kowalski, K., Zorn, J., & Reimer, K. (2015) · BMC Infectious Diseases · doi:10.1186/s12879-015-1111-9 · Cited by 75 · see citing works
Self-citation
Comparison of virucidal activity of alcohol-based hand sanitizers versus antimicrobial hand soaps in vitro and in vivo
Steinmann, J., Paulmann, D., Becker, B., Bischoff, B., Steinmann, E., & Steinmann, J. (2012) · Journal of Hospital Infection · doi:10.1016/j.jhin.2012.08.005 · Cited by 68 · see citing works
Leitlinie der Deutschen Vereinigung zur Bekämpfung der Viruskrankheiten (DVV) e. V. und des Robert Koch-Instituts (RKI) zur Prüfung von chemischen Desinfektionsmitteln auf Wirksamkeit gegen Viren in der Humanmedizin
Rabenau, H. F., Schwebke, I., Blümel, J., Eggers, M., Glebe, D., Rapp, I., Sauerbrei, A., Steinmann, E., Steinmann, J., Willkommen, H., et al. (2015) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-015-2131-8 · Cited by 43 · see citing works
Self-citation
Log10 Reduction Factors in Viral Clearance Studies
Ruppach, H. (2014) · BioProcessing Journal · doi:10.12665/j124.ruppach · Cited by 24 · see citing works
The use of povidone–iodine and hydrogen peroxide mixture as an adjunct to non-surgical treatment of slight to moderate chronic periodontitis
Al-Saeed, M. Y., & Babay, N. (2009) · The Saudi Dental Journal · doi:10.1016/j.sdentj.2009.10.004 · Cited by 17 · see citing works
The effect of residual moisture in lyophilized smallpox vaccine on its stability at different temperatures.
Sparkes, J. D., & Fenje, P. (1972) · PubMed · Cited by 15 · see citing works
Comparing hand-hygiene measures in a neonatal ICU: A randomized cross-over trial
Sharma, V. S., Dutta, S., Taneja, N., & Narang, A. P. S. (2013) · Indian Pediatrics · doi:10.1007/s13312-013-0261-3 · Cited by 15 · see citing works
Mitteilung der Deutschen Vereinigung zur Bekämpfung der Viruskrankheiten e. V. (DVV) und des Robert Koch-Instituts (RKI) zur Veröffentlichung der aktualisierten Fassung der Leitlinie zur Prüfung von chemischen Desinfektionsmitteln auf Wirksamkeit gegen Viren in der Humanmedizin (Suspensionstest) – Fassung vom 1. Dezember 2014
Schwebke, I., Blümel, J., Eggers, M., Glebe, D., Rapp, I., Rheinbaben, F. V., Sauerbrei, A., Steinmann, E., Steinmann, J., Willkommen, H., et al. (2015) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-015-2130-9 · Cited by 9 · see citing works
Self-citation

Flagged first, then by citations

1 of the 21 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

[22]Yung D, Tang M. Press release: 10 years after SARS—improper hand washing in the majority of HK people coupled with a 25% drop in cold & flu sick leave for reducing risk of spreading of germs doctor urges to regain strict personal hygiene habits. 2013. http://hkupop.hku.hk/english/report/postSARS/content/resources/pr.pdf. Accessed July 2015.

Sorted by citations

Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents.
Kampf, G., Todt, D., Pfaender, S., & Steinmann, E. (2020) · Journal of Hospital Infection · doi:10.1016/j.jhin.2020.01.022 · Cited by 3,796 · see citing works
Pharmaceutical assessment of polyvinylpyrrolidone (PVP): As excipient from conventional to controlled delivery systems with a spotlight on COVID-19 inhibition
Kurakula, M., & Rao, G. K. (2020) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2020.102046 · Cited by 543 · see citing works
In vitro bactericidal and virucidal efficacy of povidone-iodine gargle/mouthwash against respiratory and oral tract pathogens.
Eggers, M., Koburger-Janssen, T., Eickmann, M., & Zorn, J. (2018) · Infectious Diseases and Therapy · doi:10.1007/s40121-018-0200-7 · Cited by 386 · see citing works
Self-citation
MERS-CoV: Understanding the Latest Human Coronavirus Threat
Chafekar, A., & Fielding, B. C. (2018) · Viruses · doi:10.3390/v10020093 · Cited by 276 · see citing works
Can Nanotechnology and Materials Science Help the Fight against SARS-CoV-2?
Sportelli, M. C., Izzi, M., Kukushkina, E. A., Hossain, S. I., Picca, R. A., Ditaranto, N., & Cioffi, N. (2020) · Nanomaterials · doi:10.3390/nano10040802 · Cited by 244 · see citing works
Is the oral cavity relevant in SARS-CoV-2 pandemic?
Herrera, D., Serrano, J., Roldán, S., & Sanz, M. (2020) · Clinical Oral Investigations · doi:10.1007/s00784-020-03413-2 · Cited by 222 · see citing works
Oral Microbiome and SARS-CoV-2: Beware of Lung Co-infection
Bao, L., Zhang, C., Dong, J., Zhao, L., Li, Y., & Sun, J. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01840 · Cited by 207 · see citing works
Povidone-Iodine Demonstrates Rapid In Vitro Virucidal Activity Against SARS-CoV-2, The Virus Causing COVID-19 Disease
Anderson, D. E., Sivalingam, V., Kang, A. E. Z., Ananthanarayanan, A., Arumugam, H., Jenkins, T. M., Hadjiat, Y., & Eggers, M. (2020) · Infectious Diseases and Therapy · doi:10.1007/s40121-020-00316-3 · Cited by 177 · see citing works
Self-citation
A systematic review of emerging human coronavirus (SARS-CoV-2) outbreak: focus on disinfection methods, environmental survival, and control and prevention strategies
Noorimotlagh, Z., Mirzaee, S. A., Jaafarzadeh, N., Maleki, M., Kalvandi, G., & Karami, C. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-020-11060-z · Cited by 176 · see citing works
Fomite Transmission, Physicochemical Origin of Virus–Surface Interactions, and Disinfection Strategies for Enveloped Viruses with Applications to SARS-CoV-2
Castaño, N., Cordts, S. C., Jalil, M. K., Zhang, K. S., Koppaka, S., Bick, A., Paul, R., & Tang, S. K. Y. (2021) · ACS Omega · doi:10.1021/acsomega.0c06335 · Cited by 148 · see citing works
Prevalence of SARS-CoV-2 in human post-mortem ocular tissues
Sawant, O. B., Singh, S., Wright, R. E., Jones, K. M., Titus, M. S., Dennis, E., Hicks, E., Majmudar, P. A., Kumar, A., & Mian, S. I. (2020) · The Ocular Surface · doi:10.1016/j.jtos.2020.11.002 · Cited by 118 · see citing works
Update on the role of antiseptics in the management of chronic wounds with critical colonisation and/or biofilm
Alves, P. J. P., Barreto, R. T., Barrois, B., Gryson, L., Meaume, S., & Monstrey, S. (2020) · International Wound Journal · doi:10.1111/iwj.13537 · Cited by 118 · see citing works
Chemical disinfectants of COVID-19: an overview
Al-Sayah, M. H. (2020) · Journal of Water and Health · doi:10.2166/wh.2020.108 · Cited by 108 · see citing works
Biocides and Novel Antimicrobial Agents for the Mitigation of Coronaviruses
Kumar, G. D., Mishra, A., Dunn, L. L., Townsend, A. M., Oguadinma, I. C., Bright, K. R., & Gerba, C. P. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01351 · Cited by 106 · see citing works
The Use of Povidone Iodine Nasal Spray and Mouthwash During the Current COVID-19 Pandemic May Protect Healthcare Workers and Reduce Cross Infection.Preprint
Kirk-Bayley, J., Challacombe, S., Sunkaraneni, V., & Combes, J. (2020) · SSRN Electronic Journal · doi:10.2139/ssrn.3563092 · Cited by 102 · see citing works
Povidone-Iodine Use in Sinonasal and Oral Cavities: A Review of Safety in the COVID-19 Era
Frank, S., Capriotti, J. A., Brown, S. M., & Tessema, B. (2020) · Ear Nose & Throat Journal · doi:10.1177/0145561320932318 · Cited by 97 · see citing works
Efficacy of Povidone-Iodine Nasal and Oral Antiseptic Preparations Against Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2)
Pelletier, J. S., Tessema, B., Westover, J., Frank, S., Brown, S. M., & Capriotti, J. A. (2020) · Ear Nose & Throat Journal · doi:10.1177/0145561320957237 · Cited by 94 · see citing works
Disinfection methods against SARS-CoV-2: a systematic review
Martins, C. P. V., Xavier, C. S. F., & Cobrado, L. (2021) · Journal of Hospital Infection · doi:10.1016/j.jhin.2021.07.014 · Cited by 90 · see citing works
In vivo evaluation of the virucidal efficacy of chlorhexidine and povidone-iodine mouthwashes against salivary SARS-CoV-2. A randomized-controlled clinical trial
Elzein, R., Abdel‐Sater, F., Fakhreddine, S., Hanna, P. A., Feghali, R., Hamad, H., & Ayoub, F. (2021) · Journal of Evidence Based Dental Practice · doi:10.1016/j.jebdp.2021.101584 · Cited by 88 · see citing works
All India difficult airway association (AIDAA) consensus guidelines for airway management in the operating room during the COVID-19 pandemic
Garg, R. K., Patwa, A., Shah, A., Divatia, J. V., Kundra, P., Doctor, J., Shetty, S. R., Ahmed, S. M., Das, S., & Myatra, S. N. (2020) · Indian Journal of Anaesthesia · doi:10.4103/ija.ija_498_20 · Cited by 79 · see citing works
Bactericidal and virucidal activity of ethanol and povidone‐iodine
Sauerbrei, A. (2020) · MicrobiologyOpen · doi:10.1002/mbo3.1097 · Cited by 79 · see citing works
Lowering the transmission and spread of human coronavirus
Meyers, C., Robison, R. A., Milici, J., Alam, S., Quillen, D. A., Goldenberg, D. M., & Kass, R. B. (2020) · Journal of Medical Virology · doi:10.1002/jmv.26514 · Cited by 71 · see citing works
Topical preparations to reduce SARS‐CoV ‐2 aerosolization in head and neck mucosal surgery
Parhar, H. S., Tasche, K. K., Brody, R. M., Weinstein, G. S., O'Malley, B. W., Shanti, R. M., & Newman, J. G. (2020) · Head & Neck · doi:10.1002/hed.26200 · Cited by 69 · see citing works
Bactericidal and Virucidal Activity of Povidone-Iodine and Chlorhexidine Gluconate Cleansers in an In Vivo Hand Hygiene Clinical Simulation Study
Eggers, M., Koburger‐Janssen, T., Ward, L., Newby, C. S., & Müller, S. (2018) · Infectious Diseases and Therapy · doi:10.1007/s40121-018-0202-5 · Cited by 68 · see citing works
Self-citation
Antimicrobial mouthwashes (gargling) and nasal sprays administered to patients with suspected or confirmed COVID-19 infection to improve patient outcomes and to protect healthcare workers treating them
Burton, M. J., Clarkson, J., Goulão, B., Glenny, A., McBain, A. J., Schilder, A. G., Webster, K. E., & Worthington, H. V. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013627.pub2 · Cited by 68 · see citing works
Oral antiseptics against coronavirus: in-vitro and clinical evidence
Mateos‐Moreno, M., Mira, Á., Ausina-Márquez, V., & Ferrer, M. D. (2021) · Journal of Hospital Infection · doi:10.1016/j.jhin.2021.04.004 · Cited by 68 · see citing works
Environmental and decontamination issues for human coronaviruses and their potential surrogates
Cimolai, N. (2020) · Journal of Medical Virology · doi:10.1002/jmv.26170 · Cited by 65 · see citing works
Clinical evaluation of antiseptic mouth rinses to reduce salivary load of SARS-CoV-2
Ferrer, M. D., Barrueco, Á. S., Beneyto, Y. M., Mateos‐Moreno, M., Ausina-Márquez, V., García‐Vázquez, E., Torres, M. P., Giner, M. J. F., González, A. C., Coello, J. M. S., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-03461-y · Cited by 65 · see citing works
A Systematic Review of Surface Contamination, Stability, and Disinfection Data on SARS-CoV‑2 (Through July 10, 2020)
Bedrosian, N., Mitchell, E., Rohm, E., Rothe, M., Kelly, C., String, G. M., & Lantagne, D. (2020) · Environmental Science & Technology · doi:10.1021/acs.est.0c05651 · Cited by 63 · see citing works
Antiviral mouthwashes: possible benefit for COVID-19 with evidence-based approach
Moosavi, M., Aminishakib, P., & Ansari, M. (2020) · Journal of Oral Microbiology · doi:10.1080/20002297.2020.1794363 · Cited by 61 · see citing works
In vitro virucidal activity of povidone iodine gargle and mouthwash against SARS-CoV-2: implications for dental practice
Hassandarvish, P., Tiong, V., Mohamed, N. A., Arumugam, H., Ananthanarayanan, A., Qasuri, M., Hadjiat, Y., & AbuBakar, S. (2020) · BDJ · doi:10.1038/s41415-020-2402-0 · Cited by 61 · see citing works
Coronavirus in water media: Analysis, fate, disinfection and epidemiological applications
Buonerba, A., Corpuz, M. V. A., Ballesteros, F., Choo, K., Hasan, S. W., Korshin, G. V., Belgiorno, V., Barceló, ‪., & Naddeo, V. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.125580 · Cited by 61 · see citing works
Ethanol and isopropanol inactivation of human coronavirus on hard surfaces
Meyers, C., Kass, R. B., Goldenberg, D., Milici, J., Alam, S., & Robison, R. A. (2020) · Journal of Hospital Infection · doi:10.1016/j.jhin.2020.09.026 · Cited by 60 · see citing works
Management of Adenoviral Keratoconjunctivitis: Challenges and Solutions
Labib, B. A., Minhas, B. K., & Chigbu, D. I. (2020) · Clinical ophthalmology · doi:10.2147/opth.s207976 · Cited by 58 · see citing works
Repurposing 0.5% povidone iodine solution in otorhinolaryngology practice in Covid 19 pandemic
Khan, M. M., Parab, S. R., & Paranjape, M. (2020) · American Journal of Otolaryngology · doi:10.1016/j.amjoto.2020.102618 · Cited by 57 · see citing works
Disinfectants against SARS-CoV-2: A Review
Xiao, S., Yuan, Z., & Huang, Y. P. (2022) · Viruses · doi:10.3390/v14081721 · Cited by 54 · see citing works
Biosafety Concerns During the Collection, Transportation, and Processing of COVID-19 Samples for Diagnosis
Karthik, K., Aravindhbabu, R. P., Dhama, K., Chitra, M., Kalaiselvi, G., Senthilkumar, T. M. A., & Raj, G. (2020) · Archives of Medical Research · doi:10.1016/j.arcmed.2020.08.007 · Cited by 51 · see citing works
Measures and suggestions for the prevention and control of the novel coronavirus in dental institutions
Zhang, W., & Jiang, X. (2020) · Frontiers of Oral and Maxillofacial Medicine · doi:10.21037/fomm.2020.02.01 · Cited by 52 · see citing works
Strategies for daily operating room management of ambulatory surgery centers following resolution of the acute phase of the COVID-19 pandemic
Dexter, F., Elhakim, M., Loftus, R. W., Seering, M. S., & Epstein, R. H. (2020) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2020.109854 · Cited by 52 · see citing works
Use of antimicrobial mouthwashes (gargling) and nasal sprays by healthcare workers to protect them when treating patients with suspected or confirmed COVID-19 infection
Burton, M. J., Clarkson, J., Goulão, B., Glenny, A., McBain, A. J., Schilder, A. G., Webster, K. E., & Worthington, H. V. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013626.pub2 · Cited by 48 · see citing works
Do hydrogen peroxide mouthwashes have a virucidal effect? A systematic review
Ortega, K. L., Rech, B. D. O., Haje, G. L. C. E., Gallo, C. D. B., Pérez‐Sayáns, M., & Braz‐Silva, P. H. (2020) · Journal of Hospital Infection · doi:10.1016/j.jhin.2020.10.003 · Cited by 46 · see citing works
Is there scientific evidence of the mouthwashes effectiveness in reducing viral load in Covid-19? A systematic review
Cavalcante-Leão, B. L., de Araújo, C. M., Basso, I. B., Schröder, Â. G. D., Filho, O. G., Ravazzi, G. C., Gonçalves, F. D. S., Zeigelboim, B. S., Santos, R. S., & Stechman‐Neto, J. (2021) · Journal of Clinical and Experimental Dentistry · doi:10.4317/jced.57406 · Cited by 46 · see citing works
Situations Leading to Reduced Effectiveness of Current Hand Hygiene against Infectious Mucus from Influenza Virus-Infected Patients
Hirose, R., Nakaya, T., Naito, Y., Daidoji, T., Bandou, R., Inoue, K., Dohi, O., Yoshida, N., Konishi, H., & Itoh, Y. (2019) · mSphere · doi:10.1128/msphere.00474-19 · Cited by 45 · see citing works
Seven recommendations to rescue the patients and reduce the mortality from COVID-19 infection: An immunological point of view
Kronbichler, A., Effenberger, M., Eisenhut, M., Lee, K. H., & Shin, J. I. (2020) · Autoimmunity Reviews · doi:10.1016/j.autrev.2020.102570 · Cited by 45 · see citing works
Surface interactions and viability of coronaviruses
Aydoğdu, M. O., Altun, E., Chung, E., Ren, G., Homer‐Vanniasinkam, S., Chen, B., & Edirisinghe, M. J. (2021) · Journal of The Royal Society Interface · doi:10.1098/rsif.2020.0798 · Cited by 44 · see citing works
Rethinking Elective Cataract Surgery Diagnostics, Assessments, and Tools after the COVID-19 Pandemic Experience and Beyond: Insights from the EUROCOVCAT Group
Tognetto, D., Brézin, A. P., Cummings, A. B., Malyugin, B. E., Kemer, Ö. E., Prieto, I., Ręjdak, R., Teus, M. A., Törnblom, R., Toro, M. D., et al. (2020) · Diagnostics · doi:10.3390/diagnostics10121035 · Cited by 43 · see citing works
The European tiered approach for virucidal efficacy testing – rationale for rapidly selecting disinfectants against emerging and re-emerging viral diseases
Eggers, M., Schwebke, I., Suchomel, M., Fotheringham, V. J., Gebel, J., Meyer, B., Morace, G., Roedger, H. J., Roques, C. G., Visa, P., et al. (2021) · Eurosurveillance · doi:10.2807/1560-7917.es.2021.26.3.2000708 · Cited by 43 · see citing works
Self-citation
A Guide to Facial Trauma Triage and Precautions in the COVID-19 Pandemic
Hsieh, T., Dedhia, R. D., Chiao, W., Dresner, H. S., Barta, R. J., Lyford-Pike, S., Hamlar, D. D., Stephan, S. J., Schubert, W., & Hilger, P. A. (2020) · Facial Plastic Surgery & Aesthetic Medicine · doi:10.1089/fpsam.2020.0185 · Cited by 41 · see citing works
Total Knee Replacement: The Inpatient-Only List and the Two Midnight Rule, Patient Impact, Length of Stay, Compliance Solutions, Audits, and Economic Consequences
Iorio, R. R., Barnes, C. L., Vitale, M. P., Huddleston, J. I., & Haas, D. A. (2020) · The Journal of Arthroplasty · doi:10.1016/j.arth.2020.01.007 · Cited by 40 · see citing works
Considerations for Oral and Maxillofacial Surgeons in COVID-19 Era: Can We Sustain the Solutions to Keep Our Patients and Healthcare Personnel Safe?
Chigurupati, R., Panchal, N. H., Henry, A. M., Batal, H., Sethi, A., D’Innocenzo, R., Mehra, P., Krishnan, D. G., & Roser, S. M. (2020) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.joms.2020.05.027 · Cited by 42 · see citing works
Infection control in dentistry during COVID – 19 pandemic: what has changed?
Patel, M. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e05402 · Cited by 39 · see citing works
EARLY VIRAL CLEARANCE AMONG COVID-19 PATIENTS WHEN GARGLING WITH POVIDONE-IODINE AND ESSENTIAL OILS – A CLINICAL TRIALPreprint
Mohamed, N. A., Baharom, N., Sulaiman, W. S. W., Rashid, Z. Z., Wong, K. K., Ali, U. K., Othman, S. N., Samat, M. N. A., Kori, N., Periyasamy, P. R., et al. (2020) · medRxiv · doi:10.1101/2020.09.07.20180448 · Cited by 38 · see citing works
Efficacy of biocidal agents and disinfectants against the monkeypox virus and other orthopoxviruses
Kampf, G. (2022) · Journal of Hospital Infection · doi:10.1016/j.jhin.2022.06.012 · Cited by 34 · see citing works
Antiviral adsorption activity of porous silicon nanoparticles against different pathogenic human viruses
Osminkina, L. A., Agafilushkina, S. N., Kropotkina, E. A., Saushkin, N. Y., Bozhev, I. V., Abramchuk, S. S., Samsonova, J. V., & Gambaryan, A. S. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.06.001 · Cited by 32 · see citing works
Operative team checklist for aerosol generating procedures to minimise exposure of healthcare workers to SARS-CoV-2
Soma, M. A., Jacobson, I., Brewer, J., Blondin, A., Davidson, G., & Singham, S. (2020) · International Journal of Pediatric Otorhinolaryngology · doi:10.1016/j.ijporl.2020.110075 · Cited by 31 · see citing works
Evolving consensus on managing vitreo-retina and uvea practice in post-COVID-19 pandemic era
Gupta, V., Rajendran, A., Narayanan, R., Chawla, S., Kumar, A., Palanivelu, M., Muralidhar, N. S., Jayadev, C., Pappuru, R. R., Khatri, M., et al. (2020) · Indian Journal of Ophthalmology · doi:10.4103/ijo.ijo_1404_20 · Cited by 31 · see citing works
Rapid initiation of nasal saline irrigation to reduce severity in high-risk COVID+ outpatients
Baxter, A. L., Schwartz, K., Johnson, R. W., Kuchinski, A.-M., Swartout, K. M., Rao, A. S. R. S., Gibson, R. W., Cherian, E., Giller, T., Boomer, H., et al. (2022) · Ear Nose & Throat Journal · doi:10.1177/01455613221123737 · Cited by 29 · see citing works
A review of current effective COVID-19 testing methods and quality control
Cheng, L., Lan, L., Ramalingam, M., He, J., Yang, Y., Gao, M., & Shi, Z. (2023) · Archives of Microbiology · doi:10.1007/s00203-023-03579-9 · Cited by 29 · see citing works
Safety and Tolerability of an Eye Drop Based on 0.6% Povidone–Iodine Nanoemulsion in Dry Eye Patients
Oliverio, G. W., Spinella, R., Postorino, E. I., Inferrera, L., Aragona, E., & Aragona, P. (2020) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2020.0085 · Cited by 29 · see citing works
Cationic Antiseptics Facilitate Pore Formation in Model Bacterial Membranes
Георгиевна, Х. Е., Kovalenko, I. B., Bozdaganyan, M. E., Strakhovskaya, M. G., & Orekhov, P. S. (2020) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.0c07212 · Cited by 28 · see citing works
Viral Inactivation with Emphasis on SARS-CoV-2 Using Physical and Chemical Disinfectants
Fadaei, A. (2021) · The Scientific World JOURNAL · doi:10.1155/2021/9342748 · Cited by 28 · see citing works
Antimicrobial mouthwashes (gargling) and nasal sprays to protect healthcare workers when undertaking aerosol-generating procedures (AGPs) on patients without suspected or confirmed COVID-19 infection
Burton, M. J., Clarkson, J., Goulão, B., Glenny, A., McBain, A. J., Schilder, A. G., Webster, K. E., & Worthington, H. V. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013628.pub2 · Cited by 27 · see citing works
Povidone-iodine solution as SARS-CoV-2 prophylaxis for procedures of the upper aerodigestive tract a theoretical framework
Naqvi, S. H. S., Citardi, M. J., Cattano, D., Ostrosky‐Zeichner, L., Knackstedt, M. I., & Karni, R. J. (2020) · Journal of Otolaryngology - Head and Neck Surgery · doi:10.1186/s40463-020-00474-x · Cited by 28 · see citing works
Protective Measures against COVID-19: Dental Practice and Infection Control
Induri, S. N. R., Chun, Y. C., Chun, J. C., Fleisher, K. E., Glickman, R. S., Xu, F., Ioannidou, E., Li, X., & Saxena, D. B. (2021) · Healthcare · doi:10.3390/healthcare9060679 · Cited by 28 · see citing works
Povidone-iodine loaded bigels: Characterization and effect as a hand antiseptic agent
Vergara, D., Loza-Rodríguez, N., Acevedo, F., Bustamante, M., & Serrano, O. L. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103427 · Cited by 27 · see citing works
Viricidal treatments for prevention of coronavirus infection
Khokhar, M., Roy, D., Purohit, P., Goyal, M., & Setia, P. (2020) · Pathogens and Global Health · doi:10.1080/20477724.2020.1807177 · Cited by 25 · see citing works
Mouth rinses efficacy on salivary SARS‐CoV‐2 viral load: A randomized clinical trial
Alzahrani, M. M., Bamashmous, S., Alkharobi, H. E., Alghamdi, A. A., Alharbi, R. H., Hassan, A. M., Darwish, M., Bukhari, A. I., Mahmoud, A. B., Alfaleh, M. A., et al. (2022) · Journal of Medical Virology · doi:10.1002/jmv.28412 · Cited by 26 · see citing works
Virucidal benefits of povidone-iodine use on the ocular surface: a review
Edington, M., Ramaesh, K., & Lockington, D. (2020) · BMJ Open Ophthalmology · doi:10.1136/bmjophth-2020-000509 · Cited by 25 · see citing works
Eyes on coronavirus
Li, Y.-P., Ma, Y., Wang, N., & Jin, Z. (2021) · Stem Cell Research · doi:10.1016/j.scr.2021.102200 · Cited by 24 · see citing works
In-Vivo Toxicity Studies and In-Vitro Inactivation of SARS-CoV-2 by Povidone-iodine In-situ Gel Forming FormulationsPreprint
Liang, B., Yuan, X., Wei, G., Wang, W., Zhang, M., Peng, H., Javer, A. R., Mendenhall, M., Julander, J. G., Huang, S., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.18.103184 · Cited by 24 · see citing works
Repurposing povidone-iodine to reduce the risk of SARS-CoV-2 infection and transmission: a narrative review
Lim, N.-A., Teng, O., Ng, C. Y. H., Bao, L. X. Y., Tambyah, P. A., Quek, A. M. L., & Seet, R. C. S. (2022) · Annals of Medicine · doi:10.1080/07853890.2022.2076902 · Cited by 23 · see citing works
Preprocedural Use of Povidone-Iodine Mouthwash during Dental Procedures in the COVID-19 Pandemic
Imran, E., Khurshid, Z., Al-Qadhi, A. A. M., Al-Quraini, A. A. A., & Tariq, K. (2020) · European Journal of Dentistry · doi:10.1055/s-0040-1717001 · Cited by 21 · see citing works
Antiviral effect of multipurpose contact lens disinfecting solutions against coronavirus
Yasir, M., Vijay, A. K., & Willcox, M. D. P. (2021) · Contact Lens and Anterior Eye · doi:10.1016/j.clae.2021.101513 · Cited by 21 · see citing works
In vitro studies evaluating the efficacy of mouth rinses on Sars-Cov-2: A systematic review
Tadakamadla, J., Boccalari, E., Rathore, V., Dolci, C., Tartaglia, G. M., & Tadakamadla, S. K. (2021) · Journal of Infection and Public Health · doi:10.1016/j.jiph.2021.07.020 · Cited by 21 · see citing works
Persistence of Coronavirus on Surface Materials and Its Control Measures Using Nonthermal Plasma and Other Agents
Ashokkumar, S., Kaushik, N. K., Han, I., Uhm, H. S., Park, J. S., Cho, G. S., Oh, Y., Shin, Y. O., & Choi, E. H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814106 · Cited by 21 · see citing works
Tolerability and effectiveness of povidone-iodine or mupirocin versus saline sinus irrigations for chronic rhinosinusitis
Lee, V. S., Pottinger, P. S., & Davis, G. E. (2020) · American Journal of Otolaryngology · doi:10.1016/j.amjoto.2020.102604 · Cited by 20 · see citing works
Sample sizes for surveillance of S. aureus transmission to monitor effectiveness and provide feedback on intraoperative infection control including for COVID-19
Dexter, F., Ledolter, J., Wall, R. T., Datta, S., & Loftus, R. W. (2020) · Perioperative Care and Operating Room Management · doi:10.1016/j.pcorm.2020.100115 · Cited by 20 · see citing works
Possible prophylactic or preventive role of topical povidone iodine during accidental ocular exposure to 2019-nCoV
Sarma, P., Kaur, H., Medhi, B., & Bhattacharyya, A. (2020) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-020-04752-2 · Cited by 19 · see citing works
COVID‐19 Pandemic and Periodontal Practice: The Immunological, Clinical, and Economic Points of View
Darestani, M. N., Akbari, A. A., Yaghobee, S., Taheri, M., & Akbari, S. (2022) · BioMed Research International · doi:10.1155/2022/3918980 · Cited by 18 · see citing works
Middle East respiratory syndrome coronavirus on inanimate surfaces: A risk for health care transmission
Khan, R., Al‐Dorzi, H. M., Johani, S. A., Balkhy, H. H., Alenazi, T. H., Baharoon, S. A., & Arabi, Y. M. (2016) · American Journal of Infection Control · doi:10.1016/j.ajic.2016.05.006 · Cited by 18 · see citing works
In vitro efficacy of a copper iodine complex PPE disinfectant for SARS-CoV-2 inactivation
Mantlo, E., Rhodes, T., Boutros, J., Patterson-Fortin, L. M., Evans, A., & Paessler, S. (2020) · F1000Research · doi:10.12688/f1000research.24651.1 · Cited by 17 · see citing works
Hospital Dentistry and Dental Care for Patients with Special Needs: Dental approach during COVID-19 Pandemic.
Franco, J. B., Ribas, P. F., Soares, L. A. V., Matias, D. T., Varotto, B. L. R., Hamza, C. R., Araújo, J. F., & Peres, M. P. S. D. M. (2020) · Brazilian Dental Science · doi:10.14295/bds.2020.v23i2.2243 · Cited by 17 · see citing works
Effect of 1% Povidone Iodine Mouthwash/Gargle, Nasal and Eye Drop in COVID-19 patient
Choudhury, M. I. M., Shabnam, N., Ahsan, T., Kabir, M. S., Khan, R. M., & Ahsan, S. A. (2021) · Bioresearch Communications · doi:10.3329/brc.v7i1.54245 · Cited by 17 · see citing works
Disinfectants Used in Stomatology and SARS-CoV-2 Infection
Stawarz-Janeczek, M., Kryczyk‐Poprawa, A., Muszyńska, B., Opoka, W., & Pytko-Polończyk, J. (2021) · European Journal of Dentistry · doi:10.1055/s-0041-1724154 · Cited by 17 · see citing works
In Response: "Perioperative COVID-19 Defense: An Evidence-Based Approach for Optimization of Infection Control and Operating Room Management"
Loftus, R. W., Dexter, F., Parra, M. C., & Brown, J. R. (2020) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000004854 · Cited by 17 · see citing works
Viscosity is an important factor of resistance to alcohol-based disinfectants by pathogens present in mucus
Hirose, R., Nakaya, T., Naito, Y., Daidoji, T., Watanabe, Y., Yasuda, H., Konishi, H., & Itoh, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-13732-2 · Cited by 16 · see citing works
Fomite transmission and disinfection strategies for SARS-CoV-2 and related virusesPreprint
Castaño, N., Cordts, S. C., Jalil, M. K., Zhang, K. S., Koppaka, S., Bick, A., Paul, R., & Tang, S. K. Y. (2020) · arXiv (Cornell University) · doi:10.48550/arxiv.2005.11443 · Cited by 16 · see citing works
Ocular oncology practice guidelines during COVID-19 pandemic-An expert consensus
Manjandavida, F. P., Honavar, S. G., Kim, U. R., Singh, U., Menon, V., Das, S., Kaliki, S., Palanivelu, M. S., Khetan, V., Shah, P. K., et al. (2020) · Indian Journal of Ophthalmology · doi:10.4103/ijo.ijo_1669_20 · Cited by 15 · see citing works
Considerations for povidone-iodine antisepsis in pediatric nasal and pharyngeal surgery during the COVID-19 pandemic
Chorney, S. R., Rizzi, M. D., & Dedhia, K. K. (2020) · American Journal of Otolaryngology · doi:10.1016/j.amjoto.2020.102737 · Cited by 15 · see citing works
Antimicrobial mouthwashes (gargling) and nasal sprays administered to patients with suspected or confirmed COVID-19 infection to improve patient outcomes and to protect healthcare workers treating them
Burton, M. J., Clarkson, J., Goulão, B., Glenny, A., McBain, A. J., Schilder, A. G., Webster, K. E., & Worthington, H. V. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013627 · Cited by 15 · see citing works
Topical Preparations to Reduce SARS-CoV-2 Aerosolization in Head and Neck Mucosal SurgeryPreprint
Parhar, H. S. (2020) · doi:10.22541/au.158636956.63067038 · Cited by 15 · see citing works
Use of antimicrobial mouthwashes (gargling) and nasal sprays by healthcare workers to protect them when treating patients with suspected or confirmed COVID-19 infection
Burton, M. J., Clarkson, J., Goulão, B., Glenny, A., McBain, A. J., Schilder, A. G., Webster, K. E., & Worthington, H. V. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013626 · Cited by 13 · see citing works
In vitro inactivation of SARS-CoV-2 using a povidone-iodine oral rinse
Shet, M. S., Westover, J. B., Hong, R., Igo, D. H., Cataldo, M., & Bhaskar, S. (2022) · BMC Oral Health · doi:10.1186/s12903-022-02082-9 · Cited by 14 · see citing works
COVID-19 and Oral Surgery: A narrative review of preoperative mouth rinses
Testori, T., Wang, H., Basso, M., Bordini, G., Dian, A., Vitelli, C. A., Miletić, I., & FABBRO, M. D. (2020) · Acta Stomatologica Croatica · doi:10.15644/asc54/4/10 · Cited by 14 · see citing works
Tolerability and usability of 0.5% PVP-I gargles and nasal drops in 6692 patients: Observational study
Khan, M. M., & Parab, S. R. (2021) · American Journal of Otolaryngology · doi:10.1016/j.amjoto.2020.102880 · Cited by 14 · see citing works
Environmental detection and spreading of mpox in healthcare settings: a narrative review
Taha, A. M., Katamesh, B. E., Hassan, A. R., Abdelwahab, O. A., Rustagi, S., Nguyen, D. H., Silva-Cajaleón, K., Rodriguez-Morales, A. J., Mohanty, A., Bonilla‐Aldana, D. K., et al. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1272498 · Cited by 13 · see citing works
Prevention of Infection and Disruption of the Pathogen Transfer Chain in Elective Surgery
Chisari, E., Krueger, C. A., Barnes, C. L., Onsem, S. V., Walter, W. L., & Parvizi, J. (2020) · The Journal of Arthroplasty · doi:10.1016/j.arth.2020.04.049 · Cited by 13 · see citing works
0.5% povidone iodine irrigation in otorhinolaryngology surgical practice during COVID 19 pandemic
Khan, M. M., & Parab, S. R. (2020) · American Journal of Otolaryngology · doi:10.1016/j.amjoto.2020.102687 · Cited by 12 · see citing works
How to improve the chemical disinfection of contaminated surfaces by viruses, bacteria and fungus?
Leclercq, L., & Nardello‐Rataj, V. (2020) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2020.105559 · Cited by 12 · see citing works
Sample times for surveillance of S. aureus transmission to monitor effectiveness and provide feedback on intraoperative infection control
Datta, S., Dexter, F., Ledolter, J., Wall, R. T., & Loftus, R. W. (2020) · Perioperative Care and Operating Room Management · doi:10.1016/j.pcorm.2020.100137 · Cited by 12 · see citing works

BRIEF REPORT Rapid and Effective Virucidal Activity of Povidone- Iodine Products Against Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and Modified
Eggers, M., Eickmann, M., & Zorn, J. (2015)
Self-citation
In vitro bactericidal and virucidal efficacy of povidone-iodine gargle/mouthwash against respiratory and oral tract pathogens.
Eggers, M., Koburger-Janssen, T., Eickmann, M., & Zorn, J. (2018) · Infectious Diseases and Therapy · doi:10.1007/s40121-018-0200-7 · Cited by 386 · see citing works
Self-citation
Povidone-iodine demonstrates rapid in vitro virucidal activity against SARS-CoV-2, the virus causing COVID-19 disease
Anderson, D. E., Sivalingam, V., Kang, A. E. Z., Ananthanarayanan, A., Arumugam, H., Jenkins, T. M., Hadjiat, Y., & Eggers, M. (2020) · Medic ro · doi:10.26416/med.136.4.2020.3668 · Cited by 9 · see citing works
Self-citation
Iod povidona demonstrează activitate virucidă in vitro rapid instalată împotriva SARS-CoV-2, virusul responsabil de apariţia COVID-19
Anderson, D. E., Sivalingam, V., Kang, A. E. Z., Ananthanarayanan, A., Arumugam, H., Jenkins, T. M., Hadjiat, Y., & Eggers, M. (2020) · Farmacist ro
Self-citation
In Vitro Evaluation of the Virucidal Activity of Different Povidone–Iodine Formulations Against Murine and Human Coronaviruses
Shet, M. S., Hong, R., Igo, D. H., Cataldo, M., & Bhaskar, S. (2021) · Infectious Diseases and Therapy · doi:10.1007/s40121-021-00536-1 · Cited by 8 · see citing works

Authors: Eggers, M., Eickmann, M., & Zorn, J.
Affiliations: Philipps University of Marburg (DE)
Mundipharma (Germany) (DE)
Corresponding author: Zorn, Juergen
ORCID: Eggers, Maren
Venue: Infectious Diseases and Therapy
Publisher: Springer Science and Business Media LLC
Published: 2015-09-28
Volume: 4
Issue: 4
Pages: 491-501
ISSN: 2193-6382 (ISSN-L)
2193-8229
DOI: 10.1007/s40121-015-0091-9
PMC: PMC4675768
OpenAlex: W2106483552
Cited by: 229
References: 21
Citations by year: 2026: 2 · 2025: 3 · 2024: 8 · 2023: 17 · 2022: 29 · 2021: 54 · 2020: 108 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 1
FWCI: 0.91
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc
Locations: Infectious Diseases and Therapy (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Funders: Philipps-Universität Marburg
Topics: Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Infection Control and Ventilation
Keywords: povidone-iodine, MERS-CoV, modified vaccinia Ankara, virucidal activity, hand hygiene, surgical scrubbing, mouthwash, skin disinfection, viral load reduction, nosocomial transmission

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Rapid and effective virucidal activity of povidone-iodine products against middle east respiratory syndrome coronavirus (MERS-CoV) and modified vaccinia virus ankara (MVA).

Abstract

Integrity signals

Claims the paper makes

Self-check

Cites

Cited by

Related

Record

About these checks