The DOI matches its Crossref record; 142 of the 142 references it cites were found in a registry or an index.
Recent advances in the formulation of PLGA microparticles for controlled drug delivery
Open accessAbstract
Polymeric microparticles (MPs) are recognized as very popular carriers to increase the bioavailability and bio-distribution of both lipophilic and hydrophilic drugs. Among different kinds of polymers, poly-(lactic-co-glycolic acid) (PLGA) is one of the most accepted materials for this purpose, because of its biodegradability (due to the presence of ester linkages that are degraded by hydrolysis in aqueous environments) and safety (PLGA is a Food and Drug Administration (FDA)-approved compound). Moreover, its biodegradability depends on the number of glycolide units present in the structure, indeed, lower glycol content results in an increased degradation time and conversely a higher monomer unit number results in a decreased time. Due to this feature, it is possible to design and fabricate MPs with a programmable and time-controlled drug release. Many approaches and procedures can be used to prepare MPs. The chosen fabrication methodology influences size, stability, entrapment efficiency, and MPs release kinetics. For example, lipophilic drugs as chemotherapeutic agents (doxorubicin), anti-inflammatory non-steroidal (indomethacin), and nutraceuticals (curcumin) were successfully encapsulated in MPs prepared by single emulsion technique, while water-soluble compounds, such as aptamer, peptides and proteins, involved the use of double emulsion systems to provide a hydrophilic compartment and prevent molecular degradation. The purpose of this review is to provide an overview about the preparation and characterization of drug-loaded PLGA MPs obtained by single, double emulsion and microfluidic techniques, and their current applications in the pharmaceutical industry. Graphic abstract
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Cites
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Cited by
The blood–brain barrier: Structure, regulation and drug delivery
Wu, D., Chen, Q., Chen, X., Han, F., Chen, Z., & Wang, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01481-w · Cited by 1,906
“PLGA is a typical Food and Drug Administration (FDA)-approved polymer used for the formulation of delivery systems in biomedicine.(262) PLGA-based delivery system is qualified to encapsulate a wide range of therapeutic cargos including smallmolecule drugs, genes, proteins, vaccines, ensuring high bioavailability by pr…”
BackgroundVlachopoulos, A., Karlioti, G., Balla, E., Daniilidis, V., Kalamas, T., Stefanidou, M., Bikiaris, N. D., Christodoulou, E., Koumentakou, I., Karavas, E., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14020359 · Cited by 277
Del Amo, L., Cano, A., Ettcheto, M., Souto, E. B., Espina, M., Camins, A., García, M. L., & Sánchez-López, E. (2021) · Applied Sciences · doi:10.3390/app11094305 · Cited by 67
Metadata
- Authors
- Lagreca, E., Onesto, V., Di Natale, C., La Manna, S., Netti, P. A., & Vecchione, R.
- Venue
- Progress in Biomaterials
- Published
- 2020-10-15
- Volume
- 9
- Issue
- 4
- Pages
- 153-174
- ISSN
- 2194-0509 (ISSN-L)
- 2194-0517
- OpenAlex
- W3092755311
- Cited by
- 284
- References
- 142
- FWCI
- 9.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Lagreca, E., Onesto, V., Di Natale, C., La Manna, S., Netti, P. A., & Vecchione, R. (2020). Recent advances in the formulation of PLGA microparticles for controlled drug delivery. Progress in Biomaterials. https://doi.org/10.1007/s40204-020-00139-y
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