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Cited by 26Curcumin's Biomedical ApplicationsCystic Fibrosis Research AdvancesNigella sativa pharmacological applications

Therapeutic applications of curcumin nanomedicine formulations in cystic fibrosis

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Quispe, Cristina, Herrera-Bravo, Jesús, Khan, Khushbukhat, Javed, Zeeshan, Semwal, Prabhakar, Painuli, Sakshi, Kamiloglu, Senem, Martorell, Miquel +2 more·2022·Progress in Biomaterials
DOI 10.1007/s40204-022-00198-3PMC PMC9626725
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Abstract

Medicinal applications of turmeric-derived curcumin have been known to mankind for long ages. Its potential in managing "cystic fibrosis" has also been evaluated. This autosomal recessive genetic disease is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) which involves an impaired secretion of chloride ions and leads to hypersecretion of thick and sticky mucus and serious complications including airway obstruction, chronic lung infection, and inflammatory reactions. This narrative review aims to highlight the available evidence for the efficacy of curcumin nanoformulations in its potential treatment of cystic fibrosis. Recent research has shown that curcumin acts on the localized mutant CFTR ion channel at the plasma membrane. Preclinical studies have also shown that curcumin nanoformulations have promising effects in the treatment of cystic fibrosis. In this context, the purpose of this narrative review is to highlight the general bioactivity of curcumin, the types of formulations and related studies, thus opening new therapeutic perspectives for CF.

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Authors
Quispe, C., Herrera-Bravo, J., Khan, K., Javed, Z., Semwal, P., Painuli, S., Kamiloglu, S., Martorell, M., Calina, D., & Sharifi-Rad, J.
Affiliations
  • Arturo Prat University (CL)
  • National University of Sciences and Technology (PK)
  • University of the Punjab (PK)
  • Uttarakhand State Council for Science and Technology (IN)
  • Graphic Era University (IN)
  • University of Concepción (CL)
Corresponding author
Martorell, Miquel
ORCID
Venue
Progress in Biomaterials
Publisher
Springer Science and Business Media LLC
Published
2022-07-29
Volume
11
Issue
4
Pages
321-329
ISSN
  • 2194-0509 (ISSN-L)
  • 2194-0517
DOI
10.1007/s40204-022-00198-3
PMC
PMC9626725
OpenAlex
W4288514214
Cited by
26
References
68
Citations by year
2025: 3 · 2024: 5 · 2023: 9 · 2022: 9
FWCI
0.48
Type
journal article
Language
en
Open access
Licence
Locations
  • Progress in Biomaterials (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Omeka S (Universidad de La Frontera) (submittedVersion, cc-by-nc-nd)
  • Bursa Uludag University - AVESIS (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
  • Health Sciences › Medicine › Complementary and alternative medicine › Nigella sativa pharmacological applications
Keywords
curcumin, cystic fibrosis, nanomedicine, nanoformulations, CFTR, chloride transport, mucus hypersecretion, airway obstruction, pulmonary infection, turmeric, drug delivery

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