Cited by 92Curcumin's Biomedical ApplicationsNatural Antidiabetic Agents StudiesNigella sativa pharmacological applications

Therapeutic Applications of Curcumin in Diabetes: A Review and Perspective

Open access
Quispe, Cristina, Herrera-Bravo, Jesús, Javed, Zeeshan, Khan, Khushbukhat, Raza, Shahid, Gulsunoglu-Konuskan, Zehra, Daştan, Sevgi Durna, Sytar, Oksana +3 more·2022·BioMed Research International

Abstract

Diabetes is a metabolic disease with multifactorial causes which requires lifelong drug therapy as well as lifestyle changes. There is now growing scientific evidence to support the effectiveness of the use of herbal supplements in the prevention and control of diabetes. Curcumin is one of the most studied bioactive components of traditional medicine, but its physicochemical characteristics are represented by low solubility, poor absorption, and low efficacy. Nanotechnology-based pharmaceutical formulations can help overcome the problems of reduced bioavailability of curcumin and increase its antidiabetic effects. The objectives of this review were to review the effects of nanocurcumin on DM and to search for databases such as PubMed/MEDLINE and ScienceDirect. The results showed that the antidiabetic activity of nanocurcumin is due to complex pharmacological mechanisms by reducing the characteristic hyperglycemia of DM. In light of these results, nanocurcumin may be considered as potential agent in the pharmacotherapeutic management of patients with diabetes.

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Crossref · 10.1155/2022/1375892

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  • Micro and nanospheres, polymeric micelles, nanocapsules and nanoparticulate systems improve specific targeting of bioactive compounds, decrease systemic toxicity, improve therapeutic efficiency, and protect active substances against biochemical degradation.

    “In the last decade, micro and nanospheres, polymeric micelles, nanocapsules and, in general, nanoparticulate systems have been shown to have an effect in improving the specific targeting of bioactive compounds, decreasing their systemic toxicity, improving the therapeutic efficiency rate and protecting active substances against biochemical degradation [217,218].”

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Research works printed but not linked: 1

  1. [33]Price G. Patel D. A. Drug bioavailability StatPearls 2021 Treasure Island FL StatPearls Publishing 32496732

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Authors
Quispe, C., Herrera-Bravo, J., Javed, Z., Khan, K., Raza, S., Gulsunoglu-Konuskan, Z., Daştan, S. D., Sytar, O., Martorell, M., Sharifi-Rad, J., & Calina, D.
Affiliations
  • Arturo Prat University (CL)
  • Lahore Garrison University (PK)
  • National University of Sciences and Technology (PK)
  • Sivas Cumhuriyet Üniversitesi (TR)
  • Slovak University of Agriculture in Nitra (SK)
  • University of Concepción (CL)
Corresponding author
Martorell, Miquel
Venue
BioMed Research International
Publisher
Wiley
Published
2022-01
Volume
2022
Issue
1
Pages
1375892-1375892
ISSN
  • 1110-7243 (ISSN-L)
  • 2314-6133
  • 2314-6141
OpenAlex
W4210785929
Cited by
92
References
122
Citations by year
2026: 13 · 2025: 22 · 2024: 14 · 2023: 26 · 2022: 17
FWCI
1.46
Type
journal article
Language
en
Open access
Locations
  • BioMed Research International (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Omeka S (Universidad de La Frontera) (submittedVersion, cc-by-nc-nd)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Health Sciences › Medicine › Complementary and alternative medicine › Nigella sativa pharmacological applications
Keywords
curcumin, nanocurcumin, diabetes mellitus, antidiabetic activity, herbal supplements, bioavailability, nanotechnology-based drug delivery, hyperglycemia, traditional medicine
MeSH terms
Biological Availability, Curcumin, Diabetes Mellitus, Humans, Nanotechnology

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