The Effect of Silver Nanoparticles on Antioxidant/Pro-Oxidant Balance in a Murine Model
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This study aimed to evaluate the subacute effect of two types of Ag-NPs(EG-AgNPs and PVP-EG-AgNPs) on antioxidant/pro-oxidant balance in rats. Seventy Wistar rats (35 males and 35 females) were divided in 7 groups and intraperitoneally exposed for 28 days to 0, 1, 2 and 4 mg/kg bw/day EG-Ag-NPs and 1, 2 and 4 mg/kg bw/day PVP- EG-Ag-NPs. After 28 days, the blood was collected, and the total antioxidant capacity (TAC), thiobarbituric reactive species (TBARS),protein carbonyl (PROTC) levels, reduced glutathione (GSH) levels and catalase (CAT) activity were determined. EG-Ag-NPs determined protective antioxidant effects in a dose-dependent manner. The exposure to the 4 mg/kg bw/day EG-Ag-NPs determines both in males and females a significant increase in TAC and CAT and a significant decrease in TBARS and PROTC only in females. The PVP-EG-AgNPs showed a different trend compared to EG-AgNPs. At 4 mg/kg bw/day the PVP-EG-AgNPs induce increased PROTC levels and decreased GSH (males and females) and TAC levels (males). The different mechanisms of EG-AgNPs and PVP-EG-AgNPs on antioxidant-/pro-oxidant balance can be explained by the influence of coating agent used for the preparation of the nanoparticles in the formation and composition of protein corona that influence their pathophysiology in the organism.
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Phytochemicals rarely fit the ideal drug-like profile due to their scarce bioavailability; therefore, their manipulation also aims to ameliorate their pharmacokinetics.
“However, phytochemicals rarely fit in the ideal drug-like profile due to their scarce bioavailability; therefore, their manipulation also aims to ameliorate their pharmacokinetics [210,211].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [211]
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- Authors
- Docea, A. O., Calina, D., Buga, A. M., Zlatian, O., Paoliello, M. M. B., Mogosanu, G. D., Streba, C. T., Popescu, E. L., Stoica, A. E., Bîrcă, A. C., Vasile, B. Ș., Grumezescu, A. M., & Mogoanta, L.
- Affiliations
- University of Medicine and Pharmacy of Craiova (RO)
- Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
- Department of Biochemistry, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
- Universidade Estadual de Londrina (BR)
- Department of Pharmacognosy and Phytotherapy, Faculty of Pharmacy University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
- Universitatea Națională de Știință și Tehnologie Politehnica București (RO)
- Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 011061 Bucharest, Romania
- Department of Histology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
- Corresponding author
- Docea, Anca Oana
- ORCID
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2020-02-12
- Volume
- 21
- Issue
- 4
- Pages
- 1233
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC7072874
- OpenAlex
- W3006274881
- Cited by
- 111
- References
- 64
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 19 · 2023: 21 · 2022: 25 · 2021: 21 · 2020: 7
- FWCI
- 7.19
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Romanian National Authority for Scientific Research (45PCCDI/2018)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- silver nanoparticles, polyvinylpyrrolidone coating, protein corona, oxidative stress, lipid peroxidation, protein carbonylation, glutathione, catalase, total antioxidant capacity, subacute toxicity, sex differences
- MeSH terms
- Animals, Antioxidants, Disease Models, Animal, Female, Glutathione, Male, Particle Size, Silver, Rats, Wistar, Reactive Oxygen Species, Oxidative Stress, Rats, Metal Nanoparticles, Toxicity Tests, Subacute
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Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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