Concurrent Use of Prescription Drugs and Herbal Medicinal Products in Older Adults: A Systematic Review
Open accessAbstract
BACKGROUND: The use of herbal medicinal products (HMPs) is common among older adults; however, little is known about concurrent use with prescription drugs, as well as potential interactions associated with such combinations. OBJECTIVE: The aim of this systematic review was to identify and evaluate the literature on concurrent prescription and HMP use among older adults to assess prevalence, patterns, potential interactions and factors associated with this use. METHODS: Systematic searches were conducted in the MEDLINE, PsycINFO, EMBASE, CINAHL, AMED, Web of Science and Cochrane databases from inception to May 2017 for studies reporting concurrent use of prescription medicines with HMPs in adults ≥ 65 years of age. Quality was assessed using the Joanna Briggs Institute checklists. And the Evidence for Policy and Practice Information and Co-ordinating Centre (EPPI-Centre) three-stage approach to mixed method research was used to synthesise data. RESULTS: Twenty-two studies were included. A definition of HMPs or what was considered an HMP was frequently missing. Prevalence of concurrent use by older adults varied widely between 5.3 and 88.3%. Prescription medicines most combined with HMPs were antihypertensive drugs, β-blockers, diuretics, antihyperlipidemic agents, anticoagulants, analgesics, antihistamines, antidiabetics, antidepressants and statins. The HMPs most frequently used were Ginkgo biloba, garlic, ginseng, St John's wort, Echinacea, saw palmetto, evening primrose oil and ginger. Potential risks of bleeding due to the use of Ginkgo biloba, garlic or ginseng with aspirin or warfarin was the most reported herb-drug interaction. Some data suggest being female, and having a lower household income and less than a high-school education were associated with concurrent use. CONCLUSION: The prevalence of concurrent prescription drugs and HMP use among older adults is substantial and potential interactions have been reported. Knowledge of the extent and manner in which older adults combine prescription drugs will aid healthcare professionals in appropriately identifying and managing patients at risk. Systematic Review Registration Number: PROSPERO 2014:CRD42014009091.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Concurrent, often undisclosed use of berberine with prescription drugs is common in older adults.
“Concurrent, often undisclosed use with prescription drugs is common in older adults, yet berberine is far from inert.”
From Berberine-Drug Interactions: Mechanisms, Clinical Relevance and Risk Stratification-A Narrative Review (2026) · cites this paper as [5]
The Discussion’s Implications for Practice section says that many older adults use herbal medicinal products alongside prescription drugs and that most do not disclose this to healthcare practitioners. The review does not establish that concurrent, undisclosed use of berberine specifically is common; its findings concern herbal products as a group. (LLM, conf=0.87)
Experimental — accuracy not yet measuredBetween 5% and over 80% of older adults combine supplements with prescription drugs, and a substantial proportion carry at least one potential interaction.
“Population studies report that between 5% and over 80% of older adults combine supplements with prescription drugs, and a substantial proportion carry at least one potential interaction [3,4,5,6,7].”
From Berberine-Drug Interactions: Mechanisms, Clinical Relevance and Risk Stratification-A Narrative Review (2026) · cites this paper as [5]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Shamseer, L., Moher, D., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., Stewart, L. A., & the PRISMA-P Group (2015) · BMJ · doi:10.1136/bmj.g7647 · Cited by 13,120 · see citing works
Munn, Z., Moola, S., Lisy, K., Riitano, D., & Tufanaru, C. (2015) · International Journal of Evidence-Based Healthcare · doi:10.1097/xeb.0000000000000054 · Cited by 3,131 · see citing works
Mangoni, A. A., & Jackson, S. H. (2003) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2003.02007.x · Cited by 1,887 · see citing works
Kaufman, D. W., Kelly, J. P., Rosenberg, L., Anderson, T. E., & Mitchell, A. A. (2002) · JAMA · doi:10.1001/jama.287.3.337 · Cited by 1,845 · see citing works
Fugh‐Berman, A. (2000) · The Lancet · doi:10.1016/s0140-6736(99)06457-0 · Cited by 1,194 · see citing works
Tsang, A., Von Korff, M., Lee, S., Alonso, J., Karam, E., Angermeyer, M. C., Borges, G. L. G., Bromet, E. J., de Girolamo, G., de Graaf, R., et al. (2008) · The Journal of Pain · doi:10.1016/j.jpain.2008.05.005 · Cited by 1,157 · see citing works
Synergy and other interactions in phytomedicines
WILLIAMSON, E. (2001) · Phytomedicine · doi:10.1078/0944-7113-00060 · Cited by 1,027 · see citing works
(2006) · CRC Press eBooks · doi:10.1201/9781420006452.ch4 · Cited by 909 · see citing works
Levine, M. E. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls233 · Cited by 897 · see citing works
Radimer, K. L. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh207 · Cited by 823 · see citing works
Interactions Between Herbal Medicines and Prescribed Drugs: An Updated Systematic Review
Izzo, A. A., & Ernst, E. (2009) · Drugs · doi:10.2165/11317010-000000000-00000 · Cited by 801 · see citing works
Adverse Drug Reactions in Hospital In-Patients: A Prospective Analysis of 3695 Patient-Episodes
Davies, E. C., Green, C. F., Taylor, S., Williamson, P. R., Mottram, D. R., & Pirmohamed, M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004439 · Cited by 692 · see citing works
Qato, D. M., Wilder, J. R., Schumm, L. P., Gillet, V. G., & Alexander, G. C. (2016) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2015.8581 · Cited by 658 · see citing works
Clinical and economic burden of adverse drug reactions
Sultana, J., Cutroneo, P. M., & Trifirò, G. (2013) · Journal of Pharmacology and Pharmacotherapeutics · doi:10.4103/0976-500x.120957 · Cited by 530 · see citing works
Interactions Between Herbal Medicines and Prescribed Drugs
Izzo, A., & Ernst, E. (2012) · Drugs · doi:10.2165/00003495-200161150-00002 · Cited by 464 · see citing works
Disclosure of CAM use to medical practitioners: a review of qualitative and quantitative studies
Robinson, A., & McGrail, M. R. (2004) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2004.09.006 · Cited by 409 · see citing works
The Effects of Polypharmacy in Older Adults
Hilmer, S. N., & Gnjidic, D. (2008) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2008.224 · Cited by 363 · see citing works
Defining "elderly" in clinical practice guidelines for pharmacotherapy
Singh, S., & Bajorek, B. V. (2014) · Pharmacy Practice · doi:10.4321/s1886-36552014000400007 · Cited by 324 · see citing works
Herb–drug interactions: an overview of systematic reviews
Posadzki, P., Watson, L. K., & Ernst, E. (2012) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04350.x · Cited by 309 · see citing works
Self-citationSt. John's Wort and Antidepressant Drug Interactions in the Elderly
Lantz, M., Buchalter, E. N., & Giambanco, V. (1999) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/089198879901200103 · Cited by 211 · see citing works
Cusack, L., Mar, C. D., Chalmers, I., & Hoffmann, T. (2016) · Systematic Reviews · doi:10.1186/s13643-016-0213-9 · Cited by 188 · see citing works
Herbal medicine: women's views, knowledge and interaction with doctors: a qualitative study
Vickers, K. A., Jolly, K. B., & Greenfield, S. (2006) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-6-40 · Cited by 172 · see citing works
Factors Associated With Dietary Supplement Use Among Prescription Medication Users
Gardiner, P. M. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.18.1968 · Cited by 171 · see citing works
Loya, A. M., González-Stuart, A., & Rivera, J. O. (2009) · Drugs & Aging · doi:10.2165/00002512-200926050-00006 · Cited by 149 · see citing works
Mehta, D. H., Gardiner, P. M., Phillips, R. S., & McCarthy, E. P. (2008) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2008.0290 · Cited by 140 · see citing works
Prevalence of Self-Medication and Associated Factors in an Elderly Population: A Systematic Review
Jerez‐Roig, J., Medeiros, L. F. B., Silva, V. A. B., Bezerra, C. L. P. A. M., Cavalcante, L. A. R., Piuvezam, G., & de Souza, D. L. B. (2014) · Drugs & Aging · doi:10.1007/s40266-014-0217-x · Cited by 140 · see citing works
Lynch, N., & Berry, D. C. (2006) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2006.06.007 · Cited by 131 · see citing works
Patient Disclosure about Herb and Supplement Use among Adults in the US
Kennedy, J. J., Wang, C., & Wu, C. (2007) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/ecam/nem045 · Cited by 127 · see citing works
Use of herbal remedies by Hispanic patients: do they inform their physician?
Howell, L. K., Kochhar, K., Saywell, R. M., Zollinger, T., Koehler, J. M., Mandzuk, C. A., Sutton, B. L., Sevilla-Martir, J., & Allen, D. H. (2006) · Journal of the American Board of Family Medicine · doi:10.3122/jabfm.19.6.566 · Cited by 127 · see citing works
Herbal Use among US Elderly: 2002 National Health Interview Survey
Bruno, J. J., & Ellis, J. J. (2005) · Annals of Pharmacotherapy · doi:10.1345/aph.1e460 · Cited by 123 · see citing works
Underprescription of Beneficial Medicines in Older People
Cherubini, A., Corsonello, A., & Lattanzio, F. (2012) · Drugs & Aging · doi:10.2165/11631750-000000000-00000 · Cited by 121 · see citing works
Dergal, J. M., Gold, J., Laxer, D. A., Lee, M. S. W., Binns, M. A., t, K. L. L., Freedman, M., & Rochon, P. A. (2002) · Drugs & Aging · doi:10.2165/00002512-200219110-00005 · Cited by 118 · see citing works
Marinac, J. S., Buchinger, C. L., Godfrey, L. A., Wooten, J. M., Sun, C., & Willsie, S. K. (2007) · PubMed · Cited by 117 · see citing works
Incidence and Severity of Potential Drug–Dietary Supplement Interactions in Primary Care Patients
Peng, C. C., Glassman, P. A., Trilli, L. E., Hayes-Hunter, J., & Good, C. B. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.6.630 · Cited by 102 · see citing works
Elmer, G. W., Lafferty, W. E., Tyree, P. T., & Lind, B. K. (2007) · Annals of Pharmacotherapy · doi:10.1345/aph.1k221 · Cited by 90 · see citing works
Herbal Supplement Use by Persons Aged Over 50 years in Britain
Canter, P. H., & Ernst, E. (2004) · Drugs & Aging · doi:10.2165/00002512-200421090-00004 · Cited by 89 · see citing works
Inappropriate prescribing for the elderly—a modern epidemic?
Nyborg, G. A., Straand, J., & Brekke, M. (2012) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-012-1223-8 · Cited by 88 · see citing works
Concomitant Use of Prescription Drugs and Dietary Supplements in Ambulatory Elderly People
Nahin, R. L., Pecha, M., Welmerink, D. B., Sink, K. M., DeKosky, S. T., Fitzpatrick, A. L., & for the Ginkgo Evaluation of Memory Study Investigators (2009) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2009.02329.x · Cited by 84 · see citing works
Use of herbal medicines by elderly patients: A systematic review
Silva, J. E. D. S., Souza, C. A. S., da Silva, T. B., Gomes, I. A., Brito, G. D. C., Araújo, A. A. D. S., de Lyra, D. P., da Silva, W. B., & da Silva, F. A. (2014) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2014.06.002 · Cited by 82 · see citing works
Djuv, A., Nilsen, O. G., & Steinsbekk, A. (2013) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-13-295 · Cited by 80 · see citing works
Leiss, W., Méan, M., Limacher, A., Righini, M., Jaeger, K. A., Beer, J. H., Osterwalder, J. J., Frauchiger, B., Matter, C. M., Kucher, N., et al. (2014) · Journal of General Internal Medicine · doi:10.1007/s11606-014-2993-8 · Cited by 78 · see citing works
The prevalence of herbs use in conjunction with conventional medicines in Jamaica
Delgoda, R., Younger, N. O. M., Barrett, C., Braithwaite, J., & Davis, D. (2010) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2010.01.002 · Cited by 72 · see citing works
Herbal products and conventional medicines used by community‐residing older women
Yoon, S. L., & Horne, C. H. (2001) · Journal of Advanced Nursing · doi:10.1046/j.1365-2648.2001.01637.x · Cited by 67 · see citing works
Herbal product use by older adults
González-Stuart, A. (2010) · Maturitas · doi:10.1016/j.maturitas.2010.09.006 · Cited by 49 · see citing works
Herbal, Prescribed, and Over-the-Counter Drug Use in Older Women: Prevalence of Drug Interactions
Yoon, S. L., & Schaffer, S. D. (2006) · Geriatric Nursing · doi:10.1016/j.gerinurse.2006.02.014 · Cited by 46 · see citing works
Automedicación y ancianos. La realidad de un botiquín casero
Rodilla, E. V., Dagà, I. C., Giralt, M. S., Algué, A. P., Comalada, M. C. P., & Corbera, M. B. (2009) · Atención Primaria · doi:10.1016/j.aprim.2008.09.018 · Cited by 41 · see citing works
Ethnic Differences in Herb and Vitamin/Mineral Use in the Elderly
Raji, M. A., Kuo, Y., Snih, S. A., Sharaf, B. M., & Loera, J. A. (2005) · Annals of Pharmacotherapy · doi:10.1345/aph.1e506 · Cited by 40 · see citing works
Mixed Methods Synthesis: A Worked Example
Kavanagh, J., Campbell, F., Harden, A., & Thomas, J. (2011) · Wiley eBooks · doi:10.1002/9781119959847.ch6 · Cited by 36 · see citing works
Stockley's Herbal Medicines Interactions
Williamson, E. M., Driver, S. R., & Baxter, K. (2009) · Cited by 34 · see citing works
Potential Interactions Between Pharmaceuticals and Natural Health Products in Canada
Singh, S. R., & Levine, M. A. H. (2007) · The Journal of Clinical Pharmacology · doi:10.1177/0091270006296421 · Cited by 32 · see citing works
Samuels, N., Zisk‐Rony, R. Y., Zevin, S., Becker, E. L., Yinnon, A. M., & Oberbaum, M. (2012) · Patient Education and Counseling · doi:10.1016/j.pec.2012.07.005 · Cited by 29 · see citing works
Use of dietary supplements and their interactions with prescription drugs in the elderly
Ly, J., Percy, L. A., & Dhanani, S. (2002) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/59.18.1759 · Cited by 28 · see citing works
Evaluation of herbal product use and possible herb–drug interactions in Turkish elderly
Türkmenoğlu, F. P., Kutsal, Y. G., Dolgun, A., Diker, N. Y., & Baydar, T. (2016) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2016.03.004 · Cited by 27 · see citing works
Zhang, X.-L., Chen, M., Zhu, L., & Zhou, Q. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/9296404 · Cited by 23 · see citing works
Peklar, J., Henman, M. C., Kos, M., Richardson, K., & Kenny, R. A. (2014) · Drugs & Aging · doi:10.1007/s40266-014-0180-6 · Cited by 21 · see citing works
Agbabiaka, T. B., Wider, B., Watson, L. K., & Goodman, C. M. (2016) · Systematic Reviews · doi:10.1186/s13643-016-0244-2 · Cited by 21 · see citing works
Self-citationFactors associated with potential medication-herb/natural product interactions in a rural community.
Blalock, S. J., Gregory, P. J., Patel, R. A., Norton, L. L., Callahan, L. F., & Jordan, J. M. (2009) · PubMed · Cited by 18 · see citing works
Interactions Between Complementary Therapies or Nutrition Supplements and Conventional Medications
Shane‐McWhorter, L., & Geil, P. (2002) · Diabetes Spectrum · doi:10.2337/diaspect.15.4.262 · Cited by 9 · see citing works
Yoon, S. L. (2001) · PubMed · Cited by 4 · see citing works
Batanero-Hernán, C., Guinea-López, M., García‐Jiménez, E., & Rodríguez-Chamorro, M. (2017) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 4 · see citing works
Polypharmacy, herbal therapies, and elders
Parkman, C. A. (2001) · The Case Manager · doi:10.1067/mcm.2001.117235 · Cited by 2 · see citing works
Flagged first, then by citations
1 of the 63 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Interventions to improve the appropriate use of polypharmacy for older people
Rankin, A., Cadogan, C. A., Patterson, S. M., Kerse, N. M., Cardwell, C. R., Bradley, M. C., Ryan, C. A., & Hughes, C. M. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008165.pub4 · Cited by 525 · see citing works
Trends in use, pharmacology, and clinical applications of emerging herbal nutraceuticals
Williamson, E. M., Liu, X., & Izzo, A. A. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14943 · Cited by 315 · see citing works
Bailey, R. L. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1524364 · Cited by 174 · see citing works
Interventions to improve the appropriate use of polypharmacy for older people
Cole, J. A., Gonçalves, D. C., Alqahtani, M., Barry, H. E., Cadogan, C. A., Rankin, A., Patterson, S. M., Kerse, N. M., Cardwell, C. R., Ryan, C. A., et al. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008165.pub5 · Cited by 168 · see citing works
Prevalence of drug-herb and drug-supplement interactions in older adults: A cross-sectional survey
Agbabiaka, T. B., Spencer, N. H., Khanom, S., & Goodman, C. (2018) · British Journal of General Practice · doi:10.3399/bjgp18x699101 · Cited by 115 · see citing works
Self-citationTamargo, J. L., Kjeldsen, K. P., Delpón, E., Semb, A. G., Cerbai, E., Dobrev, D., Savarese, G., Sulzgruber, P., Rosano, G. M. C., Borghi, C., et al. (2022) · European Heart Journal - Cardiovascular Pharmacotherapy · doi:10.1093/ehjcvp/pvac005 · Cited by 88 · see citing works
Michael, S., Ni, J., Duncan, E. S., Liu, Z., Li, S., Zhang, J., Guo, R., Gao, S., Gao, X., & Fan, G. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105481 · Cited by 87 · see citing works
Xie, Y., & Wang, C. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116156 · Cited by 74 · see citing works
Understanding and Managing Polypharmacy in the Aging Population
Csep, A. N., Voiţă-Mekereş, F., Tudoran, C., & Manole, F. (2024) · Annals of Pharmacy Practice and Pharmacotherapy · doi:10.51847/vdkr0egsln · Cited by 70 · see citing works
Caffeic acid, a dietary polyphenol, as a promising candidate for combination therapy
Maity, S., Kinra, M., Nampoothiri, M., Arora, D. S., Pai, K. S. R., & Mudgal, J. (2021) · Chemical Papers · doi:10.1007/s11696-021-01947-7 · Cited by 66 · see citing works
Interactions of ginseng with therapeutic drugs
Choi, M., & Song, I. (2019) · Archives of Pharmacal Research · doi:10.1007/s12272-019-01184-3 · Cited by 62 · see citing works
Herb–Drug Interaction in Inflammatory Diseases: Review of Phytomedicine and Herbal Supplements
Lippert, A., & Renner, B. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11061567 · Cited by 60 · see citing works
Brief Challenges on Medicinal Plants: An Eye‐Opening Look at Ageing‐Related Disorders
Bjørklund, G., Dadar, M., Martins, N. A., Chirumbolo, S., Goh, B. H., Smetanina, K., & Lysiuk, R. (2018) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12972 · Cited by 54 · see citing works
Phytochemical and Biological Screening of Oenothera biennis L. Hydroalcoholic Extract
Fecker, R., Buda, V. O., Alexa, E., Avram, Ș., Pavel, I. Z., Muntean, D., Cocan, I., Watz, C. G., Minda, D. I., Dehelean, C. A., et al. (2020) · Biomolecules · doi:10.3390/biom10060818 · Cited by 51 · see citing works
Azizah, N., Halimah, E., Puspitasari, I. M., & Hasanah, A. N. (2021) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s289156 · Cited by 51 · see citing works
Panax ginseng for Frailty-Related Disorders: A Review
Ogawa‐Ochiai, K., & Kawasaki, K. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00140 · Cited by 48 · see citing works
Mechanisms and interactions in concomitant use of herbs and warfarin therapy: An updated review
Leite, P. M., Martins, M. A. P., Ferriani, M. D. G. C., & Castilho, R. O. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112103 · Cited by 43 · see citing works
Developing a Knowledge Graph for Pharmacokinetic Natural Product-Drug Interactions
Taneja, S. B., Callahan, T. J., Paine, M. F., Kane‐Gill, S. L., Halil Kilicoglu, B., Joachimiak, M. P., & Boyce, R. D. (2023) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2023.104341 · Cited by 46 · see citing works
Mehrnoush, V., Darsareh, F., Roozbeh, N., & Ziraeie, A. (2021) · Journal of Menopausal Medicine · doi:10.6118/jmm.21022 · Cited by 41 · see citing works
An Update on Medication Use in Older Adults: a Narrative Review
Barry, H. E., & Hughes, C. M. (2021) · Current Epidemiology Reports · doi:10.1007/s40471-021-00274-5 · Cited by 38 · see citing works
Rosado-Pérez, J., Aguíñiga-Sánchez, I., Santiago‐Osorio, E., & Mendoza-Núñez, V. M. (2019) · Antioxidants · doi:10.3390/antiox8050146 · Cited by 35 · see citing works
Guzman Jennifer, R., Paterniti, D. A., Yihang, L., & Tarn, D. M. (2019) · Journal of Family Medicine and Disease Prevention · doi:10.23937/2469-5793/1510109 · Cited by 33 · see citing works
Chang, C. T., Ang, J.-Y., Islam, M. A., Chan, H., Cheah, W. K., & Gan, S. H. (2021) · Pharmaceuticals · doi:10.3390/ph14030187 · Cited by 33 · see citing works
Stanojević-Ristić, Z., Mrkić, I., Ćorac, A., Dejanović, M., Mitic, R., Vitković, L., Rašić, J., Valjarević, D., & Valjarević, A. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19074290 · Cited by 33 · see citing works
NUTRIVIGILANCE: A NEW ACTIVITY IN THE FIELD OF DIETARY SUPPLEMENTS
Morgovan, C. (2019) · FARMACIA · doi:10.31925/farmacia.2019.3.24 · Cited by 32 · see citing works
Roe, A. L., McMillan, D. A., & Mahony, C. (2018) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.1132 · Cited by 31 · see citing works
Nsibirwa, S. K., Anguzu, G., Kamukama, S., Ocama, P., & Nankya-Mutyoba, J. (2020) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-020-02959-8 · Cited by 28 · see citing works
Cardioprotection by ginseng: experimental and clinical evidence and underlying mechanisms
Gan, X. T., & Karmazyn, M. (2018) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2018-0192 · Cited by 26 · see citing works
Thangsuk, P., Pinyopornpanish, K., Jiraporncharoen, W., Buawangpong, N., & Angkurawaranon, C. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182412916 · Cited by 24 · see citing works
Zingiber officinale Roscoe: A comprehensive review of clinical properties
Bitari, A., Oualdi, I., Touzani, R., Elachouri, M., & Legssyer, A. (2022) · Materials Today Proceedings · doi:10.1016/j.matpr.2022.09.316 · Cited by 23 · see citing works
Kratom exposures among older adults reported to U.S. poison centers, 2014–2019
Graves, J. M., Dilley, J. A., Terpak, L., Brooks‐Russell, A., Whitehill, J. M., Klein, T., & Liebelt, E. L. (2021) · Journal of the American Geriatrics Society · doi:10.1111/jgs.17326 · Cited by 21 · see citing works
Voices of Polymedicated Older Patients: A Focus Group Approach
Plácido, A. I., Herdeiro, M. T., Simões, J. F. F. L., Amaral, O. P., Figueiras, A., & Roque, F. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17186443 · Cited by 19 · see citing works
Current update on herbal sources of antithrombotic activity—a comprehensive review
Subramani, B., & Sathiyarajeswaran, P. (2022) · The Egyptian Journal of Internal Medicine · doi:10.1186/s43162-021-00090-9 · Cited by 18 · see citing works
Sīle, I., Teterovska, R., Onževs, O., & Ardava, E. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20166551 · Cited by 18 · see citing works
Disclosure of Complementary and Alternative Medicine Use Among Older Adults: A Cross-Sectional Study
Golden, J., Kenyon‐Pesce, L., Robison, J. T., Grady, J. J., & Guerrera, M. P. (2023) · Gerontology and Geriatric Medicine · doi:10.1177/23337214231179839 · Cited by 17 · see citing works
Gbeasor‐Komlanvi, F. A., Zida-Compaore, W. I. C., Dare, I. H., Diallo, A., Darré, T., Potchoo, Y., Belo, M., & Ekouévi, D. K. (2020) · Current Gerontology and Geriatrics Research · doi:10.1155/2020/4346035 · Cited by 15 · see citing works
Sharif, S. N., & Darsareh, F. (2019) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000001434 · Cited by 14 · see citing works
Chi, D., Ding, D., Zhao, Q., Liang, X., Wu, W., Luo, J., & Wang, B. (2020) · Aging Clinical and Experimental Research · doi:10.1007/s40520-020-01489-0 · Cited by 14 · see citing works
Kwon, C., & Lee, B. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.713287 · Cited by 14 · see citing works
Halpin, S. N., Potapragada, N. R., Bergquist, S. H., & Jarrett, T. L. (2019) · Educational Gerontology · doi:10.1080/03601277.2019.1698184 · Cited by 14 · see citing works
The Use of Herbal Medicine in the Treatment of Vitiligo: An Updated Review
Castillo, E., González‐Rosende, M. E., & Martínez‐Solís, I. (2022) · Planta Medica · doi:10.1055/a-1855-1839 · Cited by 13 · see citing works
Cave, A. E., Chang, D., Münch, G. W., & Steiner, G. Z. (2023) · Systematic Reviews · doi:10.1186/s13643-023-02301-6 · Cited by 13 · see citing works
What Health Care Professionals Should Know about the Regulation and Safety of Dietary Supplements
STOHS, S. J., & Preuss, H. G. (2017) · Journal of the American College of Nutrition · doi:10.1080/07315724.2016.1275065 · Cited by 13 · see citing works
Capiau, A., Mehuys, E., Bolle, L. D., Tongelen, I. V., Backer, T. L. M. D., & Boussery, K. (2022) · International Journal of Clinical Pharmacy · doi:10.1007/s11096-022-01511-7 · Cited by 12 · see citing works
Antithrombotic potential of Lippia alba: A mechanistic approach
Leite, P. M., Miranda, A. P. N., Gomes, I. R. R., Rodrigues, M. L., Camargos, L. M., Amorim, J. M., Duarte, R. C. F., Faraco, A. A. G., Ferriani, M. D. G. C., & Castilho, R. O. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115744 · Cited by 12 · see citing works
Su, X., Shi, R., Hu, H., Hu, L., Wei, Q., Guan, Y., Jing-ling, C., & Li, C. (2022) · Molecules · doi:10.3390/molecules27217479 · Cited by 12 · see citing works
Kelly, D., Koay, A. C. C., Mineva, G., Volz, M., McCool, A., McLoughlin, E. C., Conluain, R. Ó., Sharma, M., Kerr, A., Franklin, B. D., et al. (2022) · Public Health · doi:10.1016/j.puhe.2022.10.026 · Cited by 10 · see citing works
Mhillaj, E., Cuomo, V., Trabace, L., & Mancuso, C. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01298 · Cited by 10 · see citing works
Nutraceutical Potential of Ginger
Srinivasan, K., Adhya, P., & Sharma, S. S. (2019) · Springer eBooks · doi:10.1007/978-3-030-04624-8_4 · Cited by 11 · see citing works
Interaction of Phytocompounds of Echinacea purpurea with ABCB1 and ABCG2 Efflux Transporters
Awortwe, C., Bruckmueller, H., Kaehler, M., & Cascorbi, I. (2021) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c01075 · Cited by 9 · see citing works
Severe Thrombocytopenia Associated With Black Seed Oil and Evening Primrose Oil
Wang, X., Jiang, A., & Batra, V. (2020) · Cureus · doi:10.7759/cureus.8390 · Cited by 9 · see citing works
Roe, A. L., Wilcox, R., Price, J. M., Li, L., Dai, H. J., Freeman, K., Friley, W. W., Herman, A. G., Black, C. B., Brouwer, K. R., et al. (2019) · Applied In Vitro Toxicology · doi:10.1089/aivt.2018.0023 · Cited by 9 · see citing works
Wang, Q., Liu, Z., Wang, R., Li, R., Lian, X., Yang, Y., Yan, J., Yin, Z., Wang, G., Sun, J., et al. (2023) · Food & Function · doi:10.1039/d2fo03238d · Cited by 8 · see citing works
Chen, Z., Zheng, R., Jiang, H., Zhang, X., Peng, M., Jiang, T., Zhang, X., & Shang, H. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156629 · Cited by 8 · see citing works
Herbal product use patterns and possible herb-drug interactions among older adults in Turkey
Taneri, P. E., Akış, N., & Karaalp, A. (2021) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2021.100487 · Cited by 8 · see citing works
Prevalence of Use of Herbal and Traditional Medicines
Lee, E. L., & Barnes, J. (2022) · Springer eBooks · doi:10.1007/978-3-031-07275-8_2 · Cited by 8 · see citing works
Huchel, S., Grumt, A., Keinki, C., Büntzel, J., Käsmann, L., & Hübner, J. (2024) · Integrative Cancer Therapies · doi:10.1177/15347354241293417 · Cited by 7 · see citing works
Wang, Z., Jones, G., Blizzard, L., Aitken, D. A., Zhou, Z., Wang, M., Balogun, S. A., Cicuttini, F., & Antony, B. (2023) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.14822 · Cited by 7 · see citing works
Effect of Water Extract of Mangosteen Pericarp on Donepezil Pharmacokinetics in Mice
Bae, M., Han, S. Y., Kim, E. S., You, B. H., Kim, Y., Cho, J., Chin, Y., & Choi, Y. H. (2021) · Molecules · doi:10.3390/molecules26175246 · Cited by 7 · see citing works
Huang, C.-Y., Wu, M., Chang, C., Liao, Y.-C., Chen, Y., Lin, W.-C., & Yen, H. (2021) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2021.102782 · Cited by 7 · see citing works
Gressenberger, P., Rief, P., Jud, P., Gütl, K., Muster, V., Ghanim, L., Brodmann, M., & Gary, T. (2019) · Europe PMC (PubMed Central) · Cited by 7 · see citing works
Evidence‐Based Clinical Assessment of Herbal Formulations: Traditional and Modern Insights
Banerjee, D., Banerjee, S., Shah, P., Singh, A., & Saharan, V. A. (2025) · doi:10.1002/9781119769484.ch25 · Cited by 7 · see citing works
Khawagi, W. Y., Alghamdi, M. M., Alfalqi, L. M., Alzahrani, A. A., Alotaibi, S. K., Alsuwat, J. J., Baali, F. H., Alruqayb, W. S., Alfian, S. D., & Alshehri, A. A. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1654337 · Cited by 6 · see citing works
Gavia-García, G., Hernández-Álvarez, D., Arista-Ugalde, T. L., Aguíñiga-Sánchez, I., Santiago‐Osorio, E., Mendoza-Núñez, V. M., & Rosado-Pérez, J. (2023) · Nutrients · doi:10.3390/nu15194106 · Cited by 6 · see citing works
Ng, J. Y., & Luong, M. (2020) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2020.101159 · Cited by 6 · see citing works
New Insights into the Future of Pharmacoepidemiology and Drug Safety
Herdeiro, M. T., Roque, F., Figueiras, A., & Silva, T. M. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.87642 · Cited by 6 · see citing works
Jarab, A. S., Al-Qerem, W. A., Alajlouni, H. Y., Alzoubi, K. H., Heshmeh, S. A., Mukattash, T. L., Naser, A. Y., & Hamarneh, Y. N. A. (2023) · International Journal of Environmental Health Research · doi:10.1080/09603123.2023.2286007 · Cited by 6 · see citing works
İDUĞ, T. (2023) · International Journal of Agriculture Environment and Food Sciences · doi:10.31015/jaefs.2023.4.9 · Cited by 5 · see citing works
Lee, E. L., Harrison, J., & Barnes, J. (2025) · Drugs - Real World Outcomes · doi:10.1007/s40801-025-00482-1 · Cited by 5 · see citing works
Wahab, M. S. A., Hamid, N. N. A., Yassen, A. O., Naim, M. J., Ahamad, J., Zulkifli, N. W., Ismail, F., Zulkifli, M. H., Goh, K. W., & Ming, L. C. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191911853 · Cited by 5 · see citing works
An evaluation of garlic products available in Australian pharmacies–From the label to the laboratory
Chan, W.-J. J., McLachlan, A. J., Wheate, N., & Harnett, J. (2018) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2018.09.004 · Cited by 5 · see citing works
Maghrabi, W. H., Badr, H., Alkhyat, A., Schlaeger, J. M., & Fritschi, C. (2025) · Journal of Integrative and Complementary Medicine · doi:10.1089/jicm.2024.0841 · Cited by 4 · see citing works
Tang, L., Zhao, C., Ren, Y., Liang, H., & Zhang, M. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-01840-9 · Cited by 4 · see citing works
Ccami‐Bernal, F., Rojas-Miliano, C., Soriano‐Moreno, D. R., Fernandez‐Guzman, D., Quispe‐Vicuña, C., Hernández-Bustamante, E. A., Zamora-Huaringa, E. G., & Nieto-Gutiérrez, W. (2024) · Revista Peruana de Medicina Experimental y Salud Pública · doi:10.17843/rpmesp.2024.411.13265 · Cited by 4 · see citing works
Food-Drug Interaction in Older Adults
Aðalbjörnsson, B. V., & Ramel, A. (2021) · Perspectives in nursing management and care for older adults · doi:10.1007/978-3-030-63892-4_20 · Cited by 4 · see citing works
Šadibolová, M., Zárybnický, T., Smutný, T., Pávek, P., Šubrt, Z., Matoušková, P., Skálová, L., & Boušová, I. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184562 · Cited by 4 · see citing works
Hyun, M. K. (2020) · Integrative Medicine Research · doi:10.1016/j.imr.2020.100485 · Cited by 4 · see citing works
Potential Cardiovascular Drug Interactions in Egypt: Incidence, Outcomes, Mechanism, and Management
Sobhy, K., Abdelmagged, O., Abdelaty, K., Khalil, D., & Abdelgaied, M. Y. (2021) · Kafrelsheikh Veterinary Medical Journal · doi:10.21608/kvmj.2021.97432.1025 · Cited by 4 · see citing works
Ventura, S., Rodrigues, M., Falcão, A. C., & Alves, G. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.08.069 · Cited by 4 · see citing works
Drug-Induced Delirium among Older People
Varallo, F. R., de Oliveira, A. M., Zanetti, A. C. B., Capucho, H. C., Pereira, L. R. L., Pereira, L. B., Zanetti, M. O. B., Oliveira, T. Z., & Lopes, V. D. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.95470 · Cited by 4 · see citing works
Spanakis, M., Pauw, A. D., Brumer, M., Symvoulakis, E. K., & Loof, H. D. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1767646 · Cited by 3 · see citing works
Siam, N. H., Nasrin, N., Saiyara, S., Saha, H., Deb, D. P., & Islam, J. (2026) · Scientifica · doi:10.1155/sci5/6124916 · Cited by 3 · see citing works
A Review of Polypharmacy in the Elderly and Its Management Strategies
Csep, A. N., Voiţă-Mekereş, F., Tudoran, C., & Manole, F. (2023) · Archives of Pharmacy Practice · doi:10.51847/ewhicm6ro1 · Cited by 3 · see citing works
Chaudhari, S. G., Zambad, S. P., & Ali, M. S. (2019) · Indian Journal of Pharmaceutical Education and Research · doi:10.5530/ijper.53.3s.97 · Cited by 3 · see citing works
CONTROVERSIAL ISSUES RELATED TO DRUG TREATMENT IN OLDER ADULTS
Kutsal, Y. G. (2022) · The Turkish Journal of Geriatrics · doi:10.31086/tjgeri.2022.257 · Cited by 3 · see citing works
Pharmacovigilance in Older Adults
Gomes, D., Gomes, E. R., Ribeiro‐Vaz, I., Herdeiro, M. T., & Roque, F. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.98665 · Cited by 3 · see citing works
Dumitru, C. N., Marcu, T., Dumitru, A. O., Tudor, S. S., Ferțu, I. D., Elisei, A.-M., & Goroftei, L. (2026) · Pharmaceuticals · doi:10.3390/ph19081313 · Cited by 2 · see citing works
(2023) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.joms.2023.06.024 · Cited by 2 · see citing works
Ahmad, R., Alsadah, H. H., Riaz, M., AlLehaibi, L. H., Alraya, R. A., Aljamea, A., & Zahoor, S. (2021) · Boletin Latinoamericano y del Caribe de plantas Medicinales y Aromaticas · doi:10.37360/blacpma.21.20.6.41 · Cited by 2 · see citing works
Shin, W.-Y., Kim, S., Kim, J., & Song, J. S. (2024) · 대한임상노인의학회지 · doi:10.15656/kjgg.2024.25.1.22 · Cited by 2 · see citing works
Lüthold, R. V., Rozsnyai, Z., Weir, K. R., Streit, S., & Jungo, K. T. (2024) · BMC Family Practice · doi:10.1186/s12875-024-02605-z · Cited by 2 · see citing works
Hu, X., Tang, M., Feng, J., Chen, W., Li, G., Ding, L., Cheng, M., Liu, M., Zhou, J., Liu, X., et al. (2024) · Medicine · doi:10.1097/md.0000000000040470 · Cited by 2 · see citing works
Aga, V. M., Shad, M. U., Zhu, H., & Salzman, C. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-800136-3.00023-5 · Cited by 2 · see citing works
Herbal preparations and their drug interactions in routine outpatient practice
Sychrová, A. (2021) · Medicína pro praxi · doi:10.36290/med.2021.045 · Cited by 2 · see citing works
Potentially Inappropriate Medications
Canterbury, D. (2017) · The American Pharmacists Association eBooks · doi:10.21019/pharmacotherapyfirst.meduse_overview · Cited by 2 · see citing works
Predicting Natural Product-Drug Interactions with Knowledge Graph Embeddings.
Taneja, S. B., Dilan-Pantojas, I. O., & Boyce, R. D. (2025) · Europe PMC (PubMed Central) · Cited by 1 · see citing works
Potential supplement-drug interactions and bleeding in patients with cancer: A UK Biobank study
Lam, C. S., Hua, R., Au-Doung, P. L. W., Wu, Y. K., Koon, H. K., Zhou, K. R., Loong, H. H.-F., Chung, V. C., Lee, R. T., Chan, A., et al. (2025) · Journal of Chinese Integrative Medicine · doi:10.1016/j.joim.2025.10.004 · Cited by 1 · see citing works
Humadi, S. S. (2026) · Natural Product Communications · doi:10.1177/1934578x261417131 · Cited by 1 · see citing works
Gavia-García, G., Hernández-Álvarez, D., Arista-Ugalde, T. L., Aguíñiga-Sánchez, I., Santiago‐Osorio, E., Cadena-Íñiguez, J., Rosado-Pérez, J., & Mendoza-Núñez, V. M. (2026) · Molecules · doi:10.3390/molecules31071182 · Cited by 1 · see citing works
Pharmacotherapeutic challenges for treating the baby boomer cohort
Pelok, S. D. (2023) · Special Care in Dentistry · doi:10.1111/scd.12839 · Cited by 1 · see citing works
- Authors
- Agbabiaka, T. B., Wider, B., Watson, L. K., & Goodman, C.
- Affiliations
- University of Hertfordshire (GB)
- University of Exeter (GB)
- Corresponding author
- Agbabiaka, Taofikat B.
- Venue
- Drugs & Aging
- Published
- 2017-12
- Volume
- 34
- Issue
- 12
- Pages
- 891-905
- ISSN
- 1170-229X (ISSN-L)
- 1179-1969
- PMC
- PMC5730633
- OpenAlex
- W2773883339
- Cited by
- 141
- References
- 63
- Citations by year
- 2026: 20 · 2025: 18 · 2024: 8 · 2023: 19 · 2022: 16 · 2021: 22 · 2020: 10 · 2019: 17 · 2018: 9 · 2017: 2
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Drugs & Aging (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- University of Hertfordshire Research Archive (University of Hertfordshire) (submittedVersion)
- Figshare (submittedVersion)
- Open Research Exeter (University of Exeter) (submittedVersion, cc-by-nc)
- University of Hertfordshire Research Archive (University of Hertfordshire) (submittedVersion, cc-by-nc)
- Funders
- National Institute for Health and Care Research (NF-SI-0515-10103)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry Medicinal Plant Applications
- Keywords
- herbal medicinal products, prescription drugs, polypharmacy, older adults, herb-drug interactions, anticoagulants, Ginkgo biloba, garlic, ginseng, Hypericum perforatum, saw palmetto, bleeding risk, warfarin, aspirin, socioeconomic factors
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Female, Humans, Male, Phytotherapy, Plant Preparations, Herb-Drug Interactions, Prescription Drugs
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
