Cited by 278Nutrition and Health in AgingMuscle Physiology and DisordersMuscle metabolism and nutrition

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Muscle quality in aging: a multi-dimensional approach to muscle functioning with applications for treatment.

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Fragala, Maren S., Kenny, Anne M., Kuchel, George A.·2015·Sports Medicine

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Abstract

Aging is often accompanied by declines in physical functioning which impedes older adults' quality of life, sense of independence, and ability to perform daily tasks. Age-related decreases in skeletal muscle quantity, termed sarcopenia, have traditionally been blamed for these physical decrements. However, recent evidence suggests that the quality of muscle tissue may be more functionally relevant than its quantity. 'Muscle quality' has been emerging as a means to elucidate and describe the intricate intramuscular changes associated with muscle performance in the context of aging and sarcopenia. While muscle quality has most commonly been defined in terms of muscle composition or relative strength, at the core, muscle quality really describes muscle's ability to function. Skeletal muscle displays a strong structure-function relationship by which several architectural characteristics factor into its functional capacity. This review describes the structural, physiological, and functional determinants of muscle quality at the tissue and cellular level, while also introducing other novel parameters such as sarcomere spacing and integrity, circulating biomarkers, and the muscle quality index. Muscle qualitative features are described from the perspective of how physical exercise may improve muscle quality in older adults. This broad, multidimensional perspective of muscle quality in the context of aging and sarcopenia offers comprehensive insights for consideration and integration in developing improved prognostic tools for research and clinical care, while also promoting translational approaches to the design of novel targeted intervention strategies designed to maintain function and mobility into late life.

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Authors: Fragala, M. S., Kenny, A. M., & Kuchel, G. A.
Affiliations: University of Central Florida (US)
University of Connecticut (US)
Corresponding author: Fragala, Maren S.
ORCID: Fragala, Maren S.
Kuchel, George A.
Venue: Sports Medicine
Publisher: Springer Science and Business Media LLC
Published: 2015-02-06
Volume: 45
Issue: 5
Pages: 641-658
ISSN: 0112-1642 (ISSN-L)
1179-2035
DOI: 10.1007/s40279-015-0305-z
OpenAlex: W1989017729
Cited by: 246
References: 275
Citations by year: 2026: 19 · 2025: 28 · 2024: 27 · 2023: 31 · 2022: 31 · 2021: 33 · 2020: 19 · 2019: 11 · 2018: 24 · 2017: 11 · 2016: 8 · 2015: 4
FWCI: 1.92
Type: journal article
Language: en
Open access: green
stars.library.ucf.edu
Licence: www.springer.com/tdm (tdm)
Locations: Sports Medicine (publishedVersion)
PubMed (publishedVersion)
Journal of International Crisis and Risk Communication Research (submittedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Keywords: muscle quality, aging, sarcopenia, skeletal muscle, muscle architecture, muscle quality index, circulating biomarkers, elderly exercise, muscle function, structure-function relationship
MeSH terms: Aging, Body Composition, Humans, Motor Activity, Gonadal Steroid Hormones, Ultrasonography, Biomarkers, Exercise, Muscle, Skeletal, Dietary Supplements, Muscle Strength, Sarcopenia

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Muscle quality in aging: a multi-dimensional approach to muscle functioning with applications for treatment.

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