Kuchel, George A.

Sexual-dimorphism in human immune system aging

Márquez, E. J., Chung, C.-H., Marches, R., Rossi, R. J., Nehar-Belaid, D., Eroglu, A., Mellert, D. J., Kuchel, G. A., Banchereau, J., & Ucar, D. (2020) · Nature Communications

Genetics, Aging, and Longevity in Model OrganismsT-cell and B-cell Immunology

Cited by 584

Strategies for targeting senescent cells in human disease

Gasek, N. S., Kuchel, G. A., Kirkland, J. L., & Xu, M. (2021) · Nature Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 501

SenNet recommendations for detecting senescent cells in different tissues

Suryadevara, V., Hudgins, A. D., Rajesh, A., Pappalardo, A., Karpova, A., Dey, A. K., Hertzel, A., Agudelo, A., Rocha, A., Soygur, B., et al. (2024) · Nature Reviews Molecular Cell Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 408

APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort

Kuo, C.-L., Pilling, L. C., Atkins, J. L., Masoli, J. A. H., Delgado, J., Kuchel, G. A., & Melzer, D. (2020) · The Journals of Gerontology: Series A

COVID-19 Clinical Research StudiesGenetic Associations and Epidemiology

Cited by 388

A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup

Justice, J. N., Ferrucci, L., Newman, A. B., Aroda, V. R., Bahnson, J. L., Divers, J., Espeland, M. A., Marcovina, S., Pollak, M. N., Kritchevsky, S. B., et al. (2018) · GeroScience

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 359

The heterogeneity of cellular senescence: insights at the single-cell level

Cohn, R. L., Gasek, N. S., Kuchel, G. A., & Xu, M. (2023) · Trends in Cell Biology

Telomeres, Telomerase, and SenescenceSingle-cell and spatial transcriptomics

Cited by 294

Muscle quality in aging: a multi-dimensional approach to muscle functioning with applications for treatment.

Fragala, M. S., Kenny, A. M., & Kuchel, G. A. (2015) · Sports Medicine

Nutrition and Health in AgingMuscle Physiology and Disorders

Cited by 246

Human longevity: 25 genetic loci associated in 389,166 UK biobank participants

Pilling, L. C., Kuo, C.-L., Sicinski, K., Tamosauskaite, J., Kuchel, G. A., Harries, L. W., Herd, P., Wallace, R., Ferrucci, L., & Melzer, D. (2017) · Aging

Genetic Associations and EpidemiologyGenetics, Aging, and Longevity in Model Organisms

Cited by 211

The chromatin accessibility signature of human immune aging stems from CD8+ T cells

Ucar, D., Márquez, E. J., Chung, C.-H., Marches, R., Rossi, R. J., Uyar, A., Wu, T.-C., George, J., Stitzel, M. L., Palucka, A. K., et al. (2017) · Journal of Experimental Medicine

Genomics and Chromatin DynamicsT-cell and B-cell Immunology

Cited by 200

Common conditions associated with hereditary haemochromatosis genetic variants: cohort study in UK Biobank

Pilling, L. C., Tamosauskaite, J., Jones, G., Wood, A. R., Jones, L., Kuo, C.-L., Kuchel, G. A., Ferrucci, L., & Melzer, D. (2019) · BMJ

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 198

Report: NIA Workshop on Measures of Physiologic Resiliencies in Human Aging

Hadley, E. C., Kuchel, G. A., Newman, A. B., Allore, H. G., Bartley, J. M., Bergeman, C. S., Blinov, M. L., Colon-Emeric, C. S., Dabhar, F. S., Dugan, L. L., et al. (2017) · The Journals of Gerontology: Series A

Resilience and Mental HealthGenetics, Aging, and Longevity in Model Organisms

Cited by 173

Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity

Wang, L., Wang, B., Gasek, N. S., Zhou, Y., Cohn, R. L., Martin, D. E., Zuo, W., Flynn, W. F., Guo, C., Jellison, E. R., et al. (2022) · Cell Metabolism

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 163

An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo

Wang, B., Wang, L., Gasek, N. S., Zhou, Y., Kim, T., Guo, C., Jellison, E. R., Haynes, L., Yadav, S., Tchkonia, T., et al. (2021) · Nature Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 145

Central adiposity and the overweight risk paradox in aging: follow-up of 130,473 UK Biobank participants

Bowman, K., Atkins, J. L., Delgado, J., Kos, K., Kuchel, G. A., Ble, A., Ferrucci, L., & Melzer, D. (2017) · The American Journal of Clinical Nutrition

Obesity, Physical Activity, DietDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 100

Impact of age, caloric restriction, and influenza infection on mouse gut microbiome: an exploratory study of the role of age-related microbiome changes on influenza responses

Bartley, J. M., Zhou, X., Kuchel, G. A., Weinstock, G. M., & Haynes, L. (2017) · Frontiers in Immunology

Gut microbiota and healthAnimal Nutrition and Physiology

Cited by 87

Development of clinical trials to extend healthy lifespan

Justice, J. N., Niedernhofer, L., Robbins, P. D., Aroda, V. R., Espeland, M. A., Kritchevsky, S. B., Kuchel, G. A., & Barzilai, N. (2018) · Cardiovascular Endocrinology & Metabolism

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 84

Transplanting cells from old but not young donors causes physical dysfunction in older recipients

Wang, B., Liu, Z., Chen, V. P., Wang, L., Inman, C. L., Zhou, Y., Guo, C., Tchkonia, T., Rowe, D. W., Kuchel, G. A., et al. (2020) · Aging Cell

Mesenchymal stem cell researchTelomeres, Telomerase, and Senescence

Cited by 76

Impact of Aging and Cytomegalovirus on Immunological Response to Influenza Vaccination and Infection

Merani, S., Pawelec, G., Kuchel, G. A., & McElhaney, J. E. (2017) · Frontiers in Immunology

Influenza Virus Research StudiesCytomegalovirus and herpesvirus research

Cited by 74

Associations of adverse childhood experiences with past-year DSM-5 psychiatric and substance use disorders in older adults

Rhee, T. G., Barry, L. C., Kuchel, G. A., Steffens, D. C., & Wilkinson, S. T. (2019) · Journal of the American Geriatrics Society

Child Abuse and TraumaPosttraumatic Stress Disorder Research

Cited by 70

International drive to illuminate delirium: a developing public health blueprint for action

Khachaturian, A. S., Hayden, K. M., Devlin, J. W., Fleisher, L. A., Lock, S. L., Cunningham, C., Oh, E. S., Fong, T. G., Fick, D. M., Marcantonio, E. R., et al. (2020) · Alzheimer's & Dementia

Intensive Care Unit Cognitive DisordersDementia and Cognitive Impairment Research

Cited by 60

Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function

Wang, B., Wang, L., Gasek, N. S., Kuo, C.-L., Nie, J., Kim, T., Yan, P., Zhu, J., Torrance, B. L., Zhou, Y., et al. (2024) · Cell Metabolism

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 59

ApoE e2 and aging-related outcomes in 379,000 UK Biobank participants

Kuo, C.-L., Pilling, L. C., Atkins, J. L., Kuchel, G. A., & Melzer, D. (2020) · Aging

Lipoproteins and Cardiovascular HealthGenetic Associations and Epidemiology

Cited by 55

Mid‐life leukocyte telomere length and dementia risk: An observational and mendelian randomization study of 435,046 UK Biobank participants

Liu, R., Xiang, M., Pilling, L. C., Melzer, D., Wang, L., Manning, K. J., Steffens, D. C., Bowden, J., Fortinsky, R. H., Kuchel, G. A., et al. (2023) · Aging Cell

Dementia and Cognitive Impairment ResearchTelomeres, Telomerase, and Senescence

Cited by 33

p21-senescent cells drive pancreatic islet dysfunction through targetable paracrine signaling in type 2 diabetes

Iwasaki, K., Carapeto, P., Abarca, C., Hela, F., Sanjines, S., Pena, S., Le, S., Pan, H., Jackson, M., Cahill, C., et al. (2026) · JCI Insight

Pancreatic function and diabetesTelomeres, Telomerase, and Senescence

Cited by 4