Association between GDF-15 levels and changes in vascular and physical function in older patients with hypertension
Open accessAbstract
Growth differentiation factor-15 (GDF-15) may be a biomarker of disease, protective response and/or prognosis, in older people with hypertension. To correlate baseline GDF-15 levels with physical and vascular health data in this population. Baseline blood samples were analysed using a GDF-15 ELISA assay kit. Correlations with baseline and 12-month outcome data, including measures of physical and vascular function, were performed. A total of 147 individuals, mean age 76.8 ± 4.7 years, were included. 77 (52 %) were male. Baseline log 10 GDF-15 showed significant correlations with age ( r = 0.37, p < 0.001), total cholesterol ( r = −0.33, p < 0.001) and 6-min walking distance ( r = −0.37, p < 0.001). Age remained significantly associated with log 10 GDF-15 in multivariable analysis (beta = −0.29, p = 0.001). Baseline log 10 GDF-15 was significantly associated with decline in 6-min walk distance over 12 months (beta = −0.27, p = 0.01) in multivariable models. No significant correlations were seen with changes in vascular function over 12 months. Baseline GDF-15 predicts declining physical, but not vascular, function in our population.
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GDF15 is a predictor of physical decline in old subjects.
“GDF15 has been shown to be a predictor of physical decline in old subjects (50)”
From Human Aging and Longevity Are Characterized by High Levels of Mitokines (2019) · cites this paper as [50]
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Fried, L. P., Ferrucci, L., Darer, J., Williamson, J. D., & Anderson, G. (2004) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/59.3.m255 · Cited by 4,032 · see citing works
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
Franceschi, C., & Campisi, J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu057 · Cited by 3,891 · see citing works
MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-β superfamily
Bootcov, M. R., Bauskin, A. R., Valenzuela, S. M., Moore, A. G., Bansal, M., He, X. Y., Zhang, H. P., Donnellan, M., Mahler, S. M., Pryor, K., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11514 · Cited by 1,180 · see citing works
Macrophage inhibitory cytokine‐1 (MIC‐1/GDF15): a new marker of all‐cause mortality
Wiklund, F. E., Bennet, A. M., Magnusson, P. K. E., Eriksson, U. K., Lindmark, F., Wu, L., Yaghoutyfam, N., Marquis, C. P., Stattin, P. E., Pedersen, N. L., et al. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00629.x · Cited by 290 · see citing works
Unsicker, K., Spittau, B., & KRIEGLSTEIN, K. G. (2013) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2013.05.003 · Cited by 274 · see citing works
Daniels, L. B., Clopton, P., Laughlin, G. A., Maisel, A. S., & Barrett-Connor, E. L. (2011) · Circulation · doi:10.1161/circulationaha.110.979740 · Cited by 248 · see citing works
Breit, S. N., Johnen, H., Cook, A. D., Tsai, V. W. W., Mohammad, M. G., Kuffner, T., Zhang, H. P., Marquis, C. P., Jiang, L., Lockwood, G., et al. (2011) · Growth Factors · doi:10.3109/08977194.2011.607137 · Cited by 247 · see citing works
Lind, L., Wallentin, L. C., Kempf, T., Tapken, H., Quint, A., Lindahl, B., Olofsson, S., Venge, P., Larsson, A. O., Hulthe, J., et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp261 · Cited by 244 · see citing works
Concise Review: Growth Differentiation Factor 15 in Pathology: A Clinical Role?
Corre, J., Hébraud, B., & Bourin, P. (2013) · Stem Cells Translational Medicine · doi:10.5966/sctm.2013-0055 · Cited by 209 · see citing works
Schober, A., Bottner, M. B., Strelau, J., Kinscherf, R., Bonaterra, G. A., Barth, M., Schilling, L., Fairlie, W. D., Breit, S. N., & Unsicker, K. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1333 · Cited by 151 · see citing works
Witham, M. D., Price, R. J. G., Struthers, A. D., Donnan, P. T., Messow, C., Ford, I., & McMurdo, M. E. T. (2013) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.9043 · Cited by 146 · see citing works
GDF-15 for Prognostication of Cardiovascular and Cancer Morbidity and Mortality in Men
Wallentin, L. C., Zethelius, B., Berglund, L., Eggers, K. M., Lind, L., Lindahl, B., Wollert, K. C., & Siegbahn, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078797 · Cited by 132 · see citing works
hNAG-1 increases lifespan by regulating energy metabolism and insulin/IGF-1/mTOR signaling
Wang, X., Chrysovergis, K., Kosak, J., Kissling, G., Streicker, M., Moser, G., Li, R., & Eling, T. E. (2014) · Aging · doi:10.18632/aging.100687 · Cited by 106 · see citing works
Anorexia/cachexia of chronic diseases: a role for the TGF‐β family cytokine MIC‐1/GDF15
Tsai, V. W.-W., Husaini, Y., Manandhar, R., Lee-Ng, K. K. M., Zhang, H. P., Harriott, K., Jiang, L., Lin, S., Sainsbury, A., Brown, D. A., et al. (2012) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-012-0082-6 · Cited by 81 · see citing works
Wu, J., Wang, Y., Zhang, M., Tang, Y., Wang, B., He, P., Lv, Y.-C., Ouyang, X.-P., Yao, F., Tan, Y.-L., et al. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.01.048 · Cited by 23 · see citing works
Biological resilience in older people – a step beyond frailty?
Witham, M. D., & Sayer, A. A. (2015) · European Geriatric Medicine · doi:10.1016/j.eurger.2014.12.008 · Cited by 12 · see citing works
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Cardoso, A. L., Fernandes, A. M. A., Aguilar‐Pimentel, J. A., de Angelis, M. H., Guedes, J. R., Brito, M. A., Ortolano, S., Pani, G., Athanasopoulou, S., Gonos, E. S., et al. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.07.004 · Cited by 471 · see citing works
Human Aging and Longevity Are Characterized by High Levels of Mitokines
Conte, M., Ostan, R., Fabbri, C., Santoro, A., Guidarelli, G., Vitale, G., Mari, D., Sevini, F., Capri, M., Sandri, M., et al. (2019) · The Journals of Gerontology: Series A · doi:10.1093/gerona/gly153 · Cited by 219 · see citing works
Kim-Muller, J. Y., Song, L., Paulhus, B. L., Pashos, E. E., Li, X., Rinaldi, A., Joaquim, S., Stansfield, J. C., Zhang, J., Robertson, A. W., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2022.111947 · Cited by 114 · see citing works
Alcázar, J., Frandsen, U., Prokhorova, T. A., Kamper, R. S., Haddock, B., Aagaard, P., & Suetta, C. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12823 · Cited by 67 · see citing works
Rothenbacher, D., Dallmeier, D., Christow, H., Köenig, W., Denkinger, M. D., Klenk, J., & the ActiFE study group (2019) · Age and Ageing · doi:10.1093/ageing/afz022 · Cited by 46 · see citing works
Tavenier, J., Rasmussen, L. J. H., Andersen, A. L., Houlind, M. B., Langkilde, A., Andersen, O., Petersen, J., & Nehlin, J. O. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab011 · Cited by 45 · see citing works
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Sarkar, S., Legere, S. A., Haidl, I. D., Marshall, J. S., MacLeod, J. B., Aguiar, C., Lutchmedial, S. R., Hassan, A., Brunt, K. R., Kienesberger, P. C., et al. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00103 · Cited by 36 · see citing works
Lu, X., Duan, J., Cheng, Q., & Lu, J. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.09.037 · Cited by 35 · see citing works
Herpich, C., Franz, K., Ost, M., Otten, L., Coleman, V., Klaus, S., Müller‐Werdan, U., & Norman, K. (2020) · Rejuvenation Research · doi:10.1089/rej.2020.2308 · Cited by 36 · see citing works
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Zhao, J., Li, M., Chen, Y., Zhang, S., Ying, H., Song, Z., Lü, Y., Li, X., Xiong, X., & Jiang, J. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00793 · Cited by 28 · see citing works
Role and Mechanism of Growth Differentiation Factor 15 in Chronic Kidney Disease
Tang, Y., Liu, T., Sun, S., Peng, Y.-B., Huang, X., Wang, S., & Zhou, Z. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s451398 · Cited by 25 · see citing works
The effect of metformin on influenza vaccine responses in nondiabetic older adults: a pilot trial
Martin, D. E., Cadar, A. N., Panier, H. A., Torrance, B. L., Kuchel, G. A., & Bartley, J. M. (2023) · Immunity & Ageing · doi:10.1186/s12979-023-00343-x · Cited by 24 · see citing works
Gopčević, K., Gkaliagkousi, Ε., Nemcsik, J., Acet, Ö., Bernal-López, M. R., Bruno, R. M., Climie, R. E., Fountoulakis, N., Fraenkel, E., Lazaridis, A. A., et al. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.789690 · Cited by 25 · see citing works
GDF-15 Is Associated with Poor Physical Function in Prefrail Older Adults with Diabetes
Merchant, R. A., Chan, Y. H., & Duque, G. (2023) · Journal of Diabetes Research · doi:10.1155/2023/2519128 · Cited by 20 · see citing works
Mallardo, M., Daniele, A., Musumeci, G., & Nigro, E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25074089 · Cited by 20 · see citing works
Fabiani, I., Santoni, T., Angelillis, M., Petricciuolo, S., Colli, A., Pellegrini, G., Mazzei, D., Pugliese, N. R., Petronio, A. S., & Caterina, R. D. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9092998 · Cited by 17 · see citing works
Rubio‐Tomás, T., Aguado, D. M., Blaya, D., Ariño, S., Aguilar‐Bravo, B., de la Torre, R. A. M. G., Miravet-Marti, M., Ferrer‐Lorente, R., Zanatto, L., Xu, Z., et al. (2025) · JHEP Reports · doi:10.1016/j.jhepr.2025.101478 · Cited by 15 · see citing works
Papa, M. V., Ceolin, C., Boschele, F., Pagliuca, R., Sergi, G., & RUI, M. D. (2025) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2025.112117 · Cited by 12 · see citing works
Relationship of Growth Differentiation Factor-15 with Aortic Stiffness in Essential Hypertension
Sökmen, E., Uçar, C., Sivri, S., Çelık, M., & Güçlü, K. (2019) · Future Science OA · doi:10.2144/fsoa-2019-0029 · Cited by 12 · see citing works
Chuang, W., Chu, C.-H., Yao, C.-S., Wei, M.-C., Hsieh, I.-L., & Liao, C.-M. (2025) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-025-01588-w · Cited by 11 · see citing works
Ho, L., Wu, H., Hung, H., Chou, H., Cheng, K., Lin, C., Wang, C., & Ou, H. (2022) · BioFactors · doi:10.1002/biof.1871 · Cited by 9 · see citing works
de Campos, K. F., García‐Esquinas, E., Soto, A. B., Sotos‐Prieto, M., Carballo‐Casla, A., Rodríguez-Artalejo, F., & Ortolá, R. (2025) · GeroScience · doi:10.1007/s11357-025-01779-3 · Cited by 8 · see citing works
Beydoun, M. A., Beydoun, H. A., Ashe, J. J., Georgescu, M. F., Horvath, S., Lu, A. T.-H., Zannas, A. S., Shadyab, A. H., Jung, S. Y., Wassertheil-Smoller, S. W., et al. (2024) · Aging · doi:10.18632/aging.205868 · Cited by 8 · see citing works
Yue, T., Lu, H., Yao, X., Du, X., Wang, L., Guo, D., & Liu, Y. (2020) · World Journal of Clinical Cases · doi:10.12998/wjcc.v8.i12.2473 · Cited by 7 · see citing works
Lee, A. R. Y. B., Vidhya, S. N., Hong, A., Amanda, T. W., Yau, C. E., Low, C. E., & Merchant, R. A. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103085 · Cited by 6 · see citing works
Ayaz, E. Y., Mesçi, B., Üner, Ö. E., Kaya, F. N., Dinçer, B., İşman, F. K., & Oğuz, A. (2025) · Journal of Diabetes Investigation · doi:10.1111/jdi.14404 · Cited by 6 · see citing works
Moghadam, B. H., Johne, M., Golestani, F., Lorenz, K., Asad, M., Maculewicz, E., & Mastalerz, А. (2023) · Biology of Sport · doi:10.5114/biolsport.2023.123894 · Cited by 5 · see citing works
Witham, M. D., Adamson, S., Avenell, A., Band, M. M., Bashir, T., Donnan, P. T., Casella, G., Hapca, A., Hume, C., Kemp, P. R., et al. (2022) · Efficacy and Mechanism Evaluation · doi:10.3310/llbx6901 · Cited by 5 · see citing works
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Afzal, O., Afzal, M., Khan, N. H., Altharawi, A., Alamri, M. A., Alossaimi, M. A., Altamimi, A. S., & Goud, P. (2026) · Clinica Chimica Acta · doi:10.1016/j.cca.2026.120839 · Cited by 4 · see citing works
Bathina, S., Lopez, V. F., Prado, M., Ballato, E., Colleluori, G., Tetlay, M., Villareal, D. T., Mediwala, S. N., Chen, R., Qualls, C., et al. (2024) · Physiological Reports · doi:10.14814/phy2.70124 · Cited by 3 · see citing works
Huntula, S., Lalert, L., & Punsawad, C. (2022) · Scientifica · doi:10.1155/2022/3619362 · Cited by 4 · see citing works
Gburi, R. H. A., Hashim, R. D., Kadhim, H. A., Adam, Ş., & Almashhadani, H. A. (2022) · Research Journal of Pharmacy and Technology · doi:10.52711/0974-360x.2022.00580 · Cited by 4 · see citing works
Vicent, L., Martínez-Sellés, H., Ariza‐Solé, A., Lucía, A., Emanuele, E., Bayés‐Genís, A., Fernández‐Avilés, F., & Martínez‐Sellés, M. (2018) · Maturitas · doi:10.1016/j.maturitas.2018.07.011 · Cited by 2 · see citing works
Magen, E. (2018) · MOJ Gerontology & Geriatrics · doi:10.15406/mojgg.2018.03.00089 · Cited by 2 · see citing works
Vastrad, B. M., & Vastrad, C. M. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.29.489994 · Cited by 2 · see citing works
Daloii, A. A., Hoteit, M., Sadek, Z., Rand, M. K., Ramezani, A., Pashaei, Z., Afshar, M., Escobar, K. A., Supriya, R., Saeidi, A., et al. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1513681 · Cited by 1 · see citing works
Growth Differentiation Factor 15 and Physical Function Impairment in the SardiNIA Study
Profili, N. I., Fiorillo, E., Orrù, V., Benelli, M., Cucca, F., & Delitala, A. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15072612 · Cited by 1 · see citing works
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Zhu, H., Han, G., & Li, S. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.88649
Vastrad, B. M., Pattanashetti, S., & Vastrad, C. M. (2025) · Advances in Biomarker Sciences and Technology · doi:10.1016/j.abst.2025.08.004
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- Authors
- Barma, M., Khan, F., Price, R. J. G., Donnan, P. T., Messow, C. M., Ford, I., McConnachie, A., Struthers, A. D., McMurdo, M. E. T., & Witham, M. D.
- Affiliations
- University of Dundee (GB)
- University of Glasgow (GB)
- Corresponding author
- Barma, Maryam
- ORCID
- Venue
- Aging Clinical and Experimental Research
- Published
- 2016-10-12
- Volume
- 29
- Issue
- 5
- Pages
- 1055-1059
- ISSN
- 1594-0667 (ISSN-L)
- 1720-8319
- PMC
- PMC5589783
- OpenAlex
- W2531220660
- Cited by
- 47
- References
- 16
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 4 · 2023: 12 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 4
- FWCI
- 3.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Aging Clinical and Experimental Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
- Discovery Research Portal (University of Dundee) (submittedVersion, cc-by)
- Funders
- Chief Scientist Office (CZH/4/1100)
- Topics
- Health Sciences › Medicine › Rheumatology › GDF15 and Related Biomarkers
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Keywords
- growth differentiation factor 15, GDF15, hypertension, older adults, physical function, vascular function, biomarkers, 6-minute walk distance, functional decline, aging
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Aging, Enzyme-Linked Immunosorbent Assay, Female, Humans, Hypertension, Male, Biomarkers, Multivariate Analysis, Walking, Growth Differentiation Factor 15
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