The TGF-β superfamily cytokine, MIC-1/GDF15: a pleotrophic cytokine with roles in inflammation, cancer and metabolism

High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin

Tanno, T., Bhanu, N. V., Oneal, P. A., Goh, S.-H., Staker, P., Lee, Y. T., Moroney, J. W., Reed, C. H., Luban, N. L., Wang, R.-H., et al. (2007) · Nature Medicine · doi:10.1038/nm1629 · Cited by 854 · see citing works

Substantial Genetic Influence on Cognitive Abilities in Twins 80 or More Years Old

McClearn, G. E., Johansson, B. E. A., Berg, S., Pedersen, N. L., Ahern, F. M., Petrill, S. A., & Plomin, R. J. (1997) · Science · doi:10.1126/science.276.5318.1560 · Cited by 727 · see citing works

Tumor-induced anorexia and weight loss are mediated by the TGF-β superfamily cytokine MIC-1

Johnen, H., Lin, S., Kuffner, T., Brown, D. A., Tsai, V. W.-W., Bauskin, A. R., Wu, L., Pankhurst, G., Jiang, L., Junankar, S., et al. (2007) · Nature Medicine · doi:10.1038/nm1677 · Cited by 612 · see citing works

GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice

Kempf, T., Zarbock, A., Widera, C., Butz, S., Stadtmann, A., Rossaint, J., Bolomini-Vittori, M., Korf-Klingebiel, M., Napp, L. C., Hansen, B., et al. (2011) · Nature Medicine · doi:10.1038/nm.2354 · Cited by 518 · see citing works

Large-Scale Delineation of Secreted Protein Biomarkers Overexpressed in Cancer Tissue and Serum

Welsh, J. B., Sapinoso, L. M., Kern, S. G., Brown, D. A., Liu, T., Bauskin, A. R., Ward, R. L., Hawkins, N. J., Quinn, D. I., Russell, P. J., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0530278100 · Cited by 503 · see citing works

Cyclooxygenase Inhibitors Regulate the Expression of a TGF-β Superfamily Member That Has Proapoptotic and Antitumorigenic Activities

Baek, S. J., Kim, K. S., Nixon, J. B., Wilson, L. C., & Eling, T. E. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.4.901 · Cited by 402 · see citing works

Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells

Tanno, T., Porayette, P., Sripichai, O., Noh, S.-J., Byrnes, C., Bhupatiraju, A., Lee, Y. T., Goodnough, J. B., Harandi, O., Ganz, T., et al. (2009) · Blood · doi:10.1182/blood-2008-12-195503 · Cited by 352 · see citing works

Macrophage inhibitory cytokine‐1 (MIC‐1/GDF15): a new marker of all‐cause mortality

Wiklund, F. E., Bennet, A. M., Magnusson, P. K. E., Eriksson, U. K., Lindmark, F., Wu, L., Yaghoutyfam, N., Marquis, C. P., Stattin, P. E., Pedersen, N. L., et al. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00629.x · Cited by 290 · see citing works

Circulating Concentrations of Growth-Differentiation Factor 15 in Apparently Healthy Elderly Individuals and Patients with Chronic Heart Failure as Assessed by a New Immunoradiometric Sandwich Assay

Kempf, T., Horn-Wichmann, R., Brabant, G. E., Peter, T., Allhoff, T., Klein, G. G., Drexler, H., Johnston, N., Wallentin, L. C., & Wollert, K. C. (2006) · Clinical Chemistry · doi:10.1373/clinchem.2006.076828 · Cited by 286 · see citing works

Serum Macrophage Inhibitory Cytokine 1 as a Marker of Pancreatic and Other Periampullary Cancers

Koopmann, J., Buckhaults, P., Brown, D. A., ZAHURAK, M. L., Sato, N., Fukushima, N., Sokoll, L. J., Chan, D. W., Yeo, C. J., Hruban, R. H., et al. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0165 · Cited by 274 · see citing works

MIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinoma.

Brown, D. A., Ward, R. L., Buckhaults, P., Liu, T., Romans, K. E., Hawkins, N. J., Bauskin, A. R., Kinzler, K. W., Vogelstein, B., & Breit, S. N. (2003) · PubMed · Cited by 265 · see citing works

Concentration in plasma of macrophage inhibitory cytokine-1 and risk of cardiovascular events in women: a nested case-control study

Brown, D. A., Breit, S. N., Buring, J. E., Fairlie, W. D., Bauskin, A. R., Liu, T., & Ridker, P. M. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09093-1 · Cited by 258 · see citing works

Placental Transforming Growth Factor-β Is a Downstream Mediator of the Growth Arrest and Apoptotic Response of Tumor Cells to DNA Damage and p53 Overexpression

Li, P.-X., Wong, J., Ayed, A., Ngo, D., Brade, A. M., Arrowsmith, C., Austin, R. C., & Klamut, H. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909580199 · Cited by 254 · see citing works

Role of macrophage inhibitory cytokine-1 in tumorigenesis and diagnosis of cancer

Bauskin, A. R., Brown, D. A., Kuffner, T., Johnen, H., Luo, X. W., Hunter, M., & Breit, S. N. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4067 · Cited by 251 · see citing works

Growth-Differentiation Factor-15 Is a Robust, Independent Predictor of 11-Year Mortality Risk in Community-Dwelling Older Adults

Daniels, L. B., Clopton, P., Laughlin, G. A., Maisel, A. S., & Barrett-Connor, E. L. (2011) · Circulation · doi:10.1161/circulationaha.110.979740 · Cited by 248 · see citing works

Growth-differentiation factor-15 is an independent marker of cardiovascular dysfunction and disease in the elderly: results from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) Study

Lind, L., Wallentin, L. C., Kempf, T., Tapken, H., Quint, A., Lindahl, B., Olofsson, S., Venge, P., Larsson, A. O., Hulthe, J., et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp261 · Cited by 244 · see citing works

Growth Differentiation Factor 15 for Risk Stratification and Selection of an Invasive Treatment Strategy in Non–ST-Elevation Acute Coronary Syndrome

Wollert, K. C., Kempf, T., Lagerqvist, B., Lindahl, B., Olofsson, S., Allhoff, T., Peter, T., Siegbahn, A., Venge, P., Drexler, H., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.697714 · Cited by 231 · see citing works

Growth-differentiation factor-15 improves risk stratification in ST-segment elevation myocardial infarction

Kempf, T., Björklund, E., Olofsson, S., Lindahl, B., Allhoff, T., Peter, T., Tongers, J., Wollert, K. C., & Wallentin, L. C. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm465 · Cited by 227 · see citing works

Growth differentiation factor 15 deficiency protects against atherosclerosis by attenuating CCR2-mediated macrophage chemotaxis

de Jager, S. C. A., Bermúdez, B., Bot, I., Koenen, R. R., Bot, M., Kavelaars, A., de Waard, V., Heijnen, C. J., Muriana, F. J. G., Weber, C., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20100370 · Cited by 222 · see citing works

Serum Markers in Patients with Resectable Pancreatic Adenocarcinoma: Macrophage Inhibitory Cytokine 1 versus CA19-9

Koopmann, J., Rosenzweig, C. N., Zhang, Z., Canto, M. I., Brown, D. A., Hunter, M. I., Yeo, C. J., Chan, D. W., Breit, S. N., & Goggins, M. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0564 · Cited by 212 · see citing works

Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53

Baek, S. J., Wilson, L. C., & Eling, T. E. (2002) · Carcinogenesis · doi:10.1093/carcin/23.3.425 · Cited by 194 · see citing works

Growth Differentiation Factor-15 for Prognostic Assessment of Patients with Acute Pulmonary Embolism

Lankeit, M., Kempf, T., Dellas, C., Cuny, M., Tapken, H., Peter, T., Olschewski, M., Konstantinides, S., & Wollert, K. C. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200712-1786oc · Cited by 188 · see citing works

Blockade of collagen-induced arthritis post-onset by antibody to granulocyte-macrophage colony-stimulating factor (GM-CSF): requirement for GM-CSF in the effector phase of disease

Cook, A. D., Braine, E. L., Campbell, I. K., Rich, M. J., & Hamilton, J. A. (2001) · Arthritis Research & Therapy · doi:10.1186/ar318 · Cited by 186 · see citing works

Increased serum concentrations of macrophage inhibitory cytokine-1 in patients with obesity and type 2 diabetes mellitus: the influence of very low calorie diet

Dostálová, I., Roubíček, T., Bártlová, M., Mráz, M., Lacinová, Z., Haluzíková, D., Kaválková, P., Matoulek, M., Kasalicky, M., & Haluzı́k, M. (2009) · European Journal of Endocrinology · doi:10.1530/eje-09-0417 · Cited by 183 · see citing works

The Transforming Growth Factor-β Superfamily Cytokine Macrophage Inhibitory Cytokine-1 Is Present in High Concentrations in the Serum of Pregnant Women1

Moore, A. G., Brown, D. A., Fairlie, W. D., Bauskin, A. R., Brown, P. K., Munier, M. L. C., Russell, P. K., Salamonsen, L. A., Wallace, E. M., & Breit, S. N. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.12.7007 · Cited by 181 · see citing works

Expression of a novel member of the TGF-β superfamily, growth/differentiation factor-15/macrophage-inhibiting cytokine-1 (GDF-15/MIC-1) in adult rat tissues

Bottner, M. B., Suter‐Crazzolara, C., Schober, A., & Unsicker, K. (1999) · Cell and Tissue Research · doi:10.1007/s004410051337 · Cited by 180 · see citing works

Nonsteroidal anti-inflammatory drug-activated gene-1 over expression in transgenic mice suppresses intestinal neoplasia

Baek, S. J., Okazaki, R., Lee, S.-H., Martinez, J., Kim, J.-S., Yamaguchi, K., Mishina, Y., Martin, D. W., Shoieb, A., Mcentee, M. F., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.09.015 · Cited by 175 · see citing works

Macrophage inhibitory cytokine 1 reduces cell adhesion and induces apoptosis in prostate cancer cells.

Liu, T., Bauskin, A. R., Zaunders, J. J., Brown, D. A., Pankhurst, S., Russell, P. J., Breit, S. N., & Panhurst, S. (2003) · PubMed · Cited by 174 · see citing works

Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1

Albertoni, M., Shaw, P., Nozaki, M., Godard, S., Tenan, M., Hamou, M., Fairlie, D. W., Breit, S., Paralkar, V., de Tribolet, N., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1205610 · Cited by 173 · see citing works

Growth Differentiation Factor-15 and Risk of Recurrent Events in Patients Stabilized After Acute Coronary Syndrome

Bonaca, M. P., Morrow, D. A., D, E. B. M., Cannon, C. P., Jiang, S., Breher, S., Sabatine, M. S., Kempf, T., Wallentin, L. C., & Wollert, K. C. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.213512 · Cited by 167 · see citing works

Cyclooxygenase Inhibitors Induce the Expression of the Tumor Suppressor Gene EGR-1, Which Results in the Up-Regulation of NAG-1, an Antitumorigenic Protein

Baek, S. J., Kim, J., Moore, S. M., Lee, S., Martinez, J. M., & Eling, T. E. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.005108 · Cited by 162 · see citing works

Macrophage inhibitory cytokine-1 induces the invasiveness of gastric cancer cells by up-regulating the urokinase-type plasminogen activator system.

Lee, D. H., Yang, Y. D., Lee, S. J., Kim, K. Y., Koo, T. H., Shin, S. M., Song, K. S., Lee, Y. H., Kim, Y. J., Lee, J. J., et al. (2003) · PubMed · Cited by 161 · see citing works

Genetic Classification of Benign and Malignant Thyroid Follicular Neoplasia Based on a Three-Gene Combination

Weber, F., Shen, L., Aldred, M. A., Morrison, C. D., Frilling, A., Saji, M., Schuppert, F., Broelsch, C. E., Ringel, M. D., & Eng, C. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2028 · Cited by 157 · see citing works

Macrophage inhibitory cytokine-1: a novel biomarker for p53 pathway activation.

Yang, H. S., Filipovic, Z., Brown, D. A., Breit, S. N., & Vassilev, L. T. (2003) · PubMed · Cited by 157 · see citing works

The Propeptide Mediates Formation of Stromal Stores of PROMIC-1: Role in Determining Prostate Cancer Outcome

Bauskin, A. R., Brown, D. A., Junankar, S. R., Rasiah, K., Eggleton, S. A., Hunter, M. I., Liu, T., Smith, D., Kuffner, T., Pankhurst, G. J., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3827 · Cited by 154 · see citing works

Macrophage Inhibitory Cytokine 1: A New Prognostic Marker in Prostate Cancer

Brown, D. A., Lindmark, F., Stattin, P. E., Bälter, K. A., Adami, H., Zheng, S. L., Xu, J., Isaacs, W. B., Grönberg, H., Breit, S. N., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-3126 · Cited by 152 · see citing works

Expression of growth differentiation factor‐15/ macrophage inhibitory cytokine‐1 (GDF‐15/MIC‐1) in the perinatal, adult, and injured rat brain

Schober, A., Bottner, M. B., Strelau, J., Kinscherf, R., Bonaterra, G. A., Barth, M., Schilling, L., Fairlie, W. D., Breit, S. N., & Unsicker, K. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1333 · Cited by 151 · see citing works

Growth Differentiation Factor-15 in Idiopathic Pulmonary Arterial Hypertension

Nickel, N. P., Kempf, T., Tapken, H., Tongers, J., Laenger, F., Lehmann, U., Golpon, H. A., Olsson, K. M., Wilkins, M. R., Gibbs, J. S. R., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200802-235oc · Cited by 150 · see citing works

Growth differentiation factor 15 in erythroid health and disease

Tanno, T., Noel, P., & Miller, J. L. (2010) · Current Opinion in Hematology · doi:10.1097/moh.0b013e328337b52f · Cited by 139 · see citing works

Elevated growth differentiation factor 15 expression in patients with congenital dyserythropoietic anemia type I

Tamary, H., Shalev, H., Perez-Avraham, G., Zoldan, M., Levi, I., Swinkels, D. W., Tanno, T., & Miller, J. L. (2008) · Blood · doi:10.1182/blood-2008-06-165738 · Cited by 135 · see citing works

Growth Differentiation Factor-15 Prevents Low Potassium-induced Cell Death of Cerebellar Granule Neurons by Differential Regulation of Akt and ERK Pathways

Subramaniam, S., Strelau, J., & Unsicker, K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210037200 · Cited by 134 · see citing works

The propeptide of macrophage inhibitory cytokine (MIC‐1), a TGF‐β superfamily member, acts as a quality control determinant for correctly folded MIC‐1

Bauskin, A. R., Zhang, H., Fairlie, W. D., He, X. Y., Russell, P. K., Moore, A. G., Brown, D. A., Stanley, K. K., & Breit, S. N. (2000) · The EMBO Journal · doi:10.1093/emboj/19.10.2212 · Cited by 133 · see citing works

Growth-Differentiation Factor-15 for Risk Stratification in Patients With Stable and Unstable Coronary Heart Disease

Kempf, T., Sinning, J., Guba‐Quint, A., Bickel, C., Sinning, C., Wild, P. S., Schnabel, R. B., Lubos, E., Rupprecht, H. J., Münzel, T. F., et al. (2009) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.108.824870 · Cited by 131 · see citing works

NSAID Activated Gene (NAG-1), a Modulator of Tumorigenesis

Eling, T. E., Baek, S. J., Shim, M., & Lee, C. H. (2006) · BMB Reports · doi:10.5483/bmbrep.2006.39.6.649 · Cited by 123 · see citing works

Overexpression of macrophage inhibitory cytokine-1 induces metastasis of human prostate cancer cells through the FAK–RhoA signaling pathway

Senapati, S., Rachagani, S., Chaudhary, K. R., Johansson, S. L., Singh, R. K., & Batra, S. K. (2009) · Oncogene · doi:10.1038/onc.2009.420 · Cited by 120 · see citing works

H6D Polymorphism in Macrophage-Inhibitory Cytokine-1 Gene Associated With Prostate Cancer

Lindmark, F., Zheng, S. L., Wiklund, F. E., Bensen, J. T., Bälter, K. A., Chang, B., Hedelin, M., Clark, J., Stattin, P., Meyers, D. A., et al. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh227 · Cited by 120 · see citing works

Indole-3-carbinol and 3,3′-diindolylmethane induce expression of NAG-1 in a p53-independent manner

Lee, S., Kim, J., Yamaguchi, K., Eling, T. E., & Baek, S. J. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.12.138 · Cited by 119 · see citing works

Gene Expression in Poorly Differentiated Papillary Thyroid Carcinomas

Fluge, Φ., Bruland, O., Akslen, L. A., Lillehaug, J. R., & Varhaug, J. E. (2006) · Thyroid · doi:10.1089/thy.2006.16.161 · Cited by 118 · see citing works

The K/BxN mouse: a model of human inflammatory arthritis

Ditzel, H. J. (2003) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2003.11.004 · Cited by 117 · see citing works

Growth differentiation factor-15 as a prognostic biomarker in ovarian cancer

Staff, A. C., Bock, A. J., Becker, C., Kempf, T., Wollert, K. C., & Davidson, B. (2010) · Gynecologic Oncology · doi:10.1016/j.ygyno.2010.05.032 · Cited by 115 · see citing works

Serum concentrations of macrophage inhibitory cytokine 1 (MIC 1) as a predictor of miscarriage

Tong, S. Y. C., Marjono, B., Brown, D. A., Mulvey, S., Breit, S. N., Manuelpillai, U., & Wallace, E. M. (2004) · The Lancet · doi:10.1016/s0140-6736(03)15265-8 · Cited by 112 · see citing works

Measurement of Serum Levels of Macrophage Inhibitory Cytokine 1 Combined with Prostate-Specific Antigen Improves Prostate Cancer Diagnosis

Brown, D. A., Stephan, C., Ward, R. L., Law, M. G., Hunter, M., Bauskin, A. R., Amin, J., Jung, K., Diamandis, E. P., Hampton, G. M., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1331 · Cited by 109 · see citing works

Macrophage Inhibitory Cytokine-1 Is Overexpressed in Malignant Melanoma and Is Associated with Tumorigenicity

Boyle, G. M., Pedley, J., Martyn, A. C., Banducci, K., Strutton, G., Brown, D. A., Breit, S. N., & Parsons, P. G. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.270 · Cited by 108 · see citing works

Identification of Candidate Biomarkers of Therapeutic Response to Docetaxel by Proteomic Profiling

Zhao, L., Lee, B. Y., Brown, D. A., Molloy, M. P., Marx, G. M., Pavlakis, N., Boyer, M. J., Stockler, M. R., Kaplan, W. H., Breit, S. N., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4901 · Cited by 104 · see citing works

Profile of gene expression regulated by induced p53: connection to the TGF‐β family

Kannan, K., Amariglio, N., Rechavi, G., & Givol, D. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01291-6 · Cited by 103 · see citing works

Elevated levels of MIC‐1/GDF15 in the cerebrospinal fluid of patients are associated with glioblastoma and worse outcome

Shnaper, S., Desbaillets, I., Brown, D. A., Murat, A., Migliavacca, E., Schluep, M., Ostermann, S., Hamou, M., Stupp, R., Breit, S. N., et al. (2009) · International Journal of Cancer · doi:10.1002/ijc.24639 · Cited by 100 · see citing works

Serum macrophage inhibitory cytokine 1 in rheumatoid arthritis: A potential marker of erosive joint destruction

Brown, D. A., Moore, J. J., Johnen, H., Smeets, T. J. M., Bauskin, A. R., Kuffner, T., Weedon, H., Milliken, S. T., Tak, P. P., Smith, M., et al. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22410 · Cited by 99 · see citing works

NSAID-activated gene-1 as a molecular target for capsaicin-induced apoptosis through a novel molecular mechanism involving GSK3 , C/EBP and ATF3

Lee, S. H., Krisanapun, C., & Baek, S. J. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq016 · Cited by 98 · see citing works

Analysis of differential gene expression in human melanocytic tumour lesions by custom made oligonucleotide arrays

de Wit, N. J. W., Rijntjes, J., Diepstra, J. H. S., Kuppevelt, T. H. V., Weidle, U. H., Ruiter, D. J., & van Muijen, G. N. P. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602612 · Cited by 97 · see citing works

Growth-Differentiation Factor-15 for Long-Term Risk Prediction in Patients Stabilized After an Episode of Non–ST-Segment–Elevation Acute Coronary Syndrome

Eggers, K. M., Kempf, T., Lagerqvist, B., Lindahl, B., Olofsson, S., Jantzen, F., Peter, T., Allhoff, T., Siegbahn, A. G., Venge, P., et al. (2009) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.109.877456 · Cited by 96 · see citing works

Protein Profiling of Microdissected Prostate Tissue Links Growth Differentiation Factor 15 to Prostate Carcinogenesis

Cheung, P. K., Woolcock, B. W., Adomat, H. H., Sutcliffe, M., Bainbridge, T. C., Jones, E. C., Webber, D. L., Κinahan, T. J., Sadar, M. D., Gleave, M. E., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1216 · Cited by 95 · see citing works

Macrophage Inhibitory Cytokine-1 in Gestational Tissues and Maternal Serum in Normal and Pre-eclamptic Pregnancy

Marjono, A. B., Brown, D. A., Horton, K. E., Wallace, E. M., Breit, S. N., & Manuelpillai, U. (2002) · Placenta · doi:10.1053/plac.2002.0881 · Cited by 93 · see citing works

Serum Macrophage Inhibitory Cytokine-1 Concentrations Correlate with the Presence of Prostate Cancer Bone Metastases

Selander, K. S., Brown, D. A., Sequeiros, G. B., Hunter, M. I., Desmond, R. A., Parpala, T. M., Risteli, J., Breit, S. N., & Jukkola‐Vuorinen, A. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-06-0841 · Cited by 93 · see citing works

A p53-type response element in the GDF15 promoter confers high specificity for p53 activation

Osada, M., Park, H. L., Park, M. J., Liu, J.-W., Wu, G., Trink, B., & Sidransky, D. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.01.089 · Cited by 90 · see citing works

Inflammatory arthritis can be reined in by CpG-induced DC–NK cell cross talk

Wu, H.-J. J., Sawaya, H., Binstadt, B. A., Brickelmaier, M., Blasius, A. L., Gorelik, L., Mahmood, U., Weissleder, R., Carulli, J. P., Benoist, C. O., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070285 · Cited by 90 · see citing works

Quantitative analysis of macrophage inhibitory cytokine-1 (MIC-1) gene expression in human prostatic tissues

Nakamura, T., Scorilas, A., Stephan, C., Yousef, G. M., Kristiansen, G., Jung, K., & Diamandis, E. P. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6600869 · Cited by 88 · see citing works

Protein Kinase C-dependent Regulation of NAG-1/Placental Bone Morphogenic Protein/MIC-1 Expression in LNCaP Prostate Carcinoma Cells

Shim, M., & Eling, T. E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414613200 · Cited by 80 · see citing works

Growth-differentiation factor-15 for early risk stratification in patients with acute chest pain

Eggers, K. M., Kempf, T., Allhoff, T., Lindahl, B., Wallentin, L. C., & Wollert, K. C. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn339 · Cited by 73 · see citing works

Macrophage inhibitory cytokine-1 is increased in individuals before type 2 diabetes diagnosis but is not an independent predictor of type 2 diabetes: the Whitehall II study

Carstensen, M., Herder, C., Brunner, E. J., Straßburger, K., Tabák, Á. G., Roden, M., & Witte, D. R. (2010) · European Journal of Endocrinology · doi:10.1530/eje-09-1066 · Cited by 72 · see citing works

Iron metabolism in heterozygotes for hemoglobin E (HbE), α-thalassemia 1, or β-thalassemia and in compound heterozygotes for HbE/β-thalassemia

Zimmermann, M. B., Fucharoen, S., Winichagoon, P., Sirankapracha, P., Zeder, C., Gowachirapant, S., Judprasong, K., Tanno, T., Miller, J. L., & Hurrell, R. F. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.4.1026 · Cited by 69 · see citing works

Growth Differentiation Factor-15: Induction in Liver Injury Through p53 and Tumor Necrosis Factor-Independent Mechanisms1

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Aberrant Neuropeptide Y and Macrophage Inhibitory Cytokine-1 Expression Are Early Events in Prostate Cancer Development and Are Associated with Poor Prognosis

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Growth Differentiation Factor 15 (GDF-15) Plasma Levels Increase during Bleomycin- and Cisplatin-Based Treatment of Testicular Cancer Patients and Relate to Endothelial Damage

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Multimarker Analysis of Serially Measured GDF-15, NT-proBNP, ST2, GAL-3, cTnI, Creatinine, and Prognosis in Acute Heart Failure

Gürgöze, M. T., van Vark, L. C., Baart, S. J., Kardys, I., Akkerhuis, K. M., Manintveld, O. C., Postmus, D., Hillege, H. L., Lesman‐Leegte, I., Asselbergs, F. W., et al. (2022) · Circulation Heart Failure · doi:10.1161/circheartfailure.122.009526 · Cited by 54 · see citing works

Association Between Plasma Levels of Macrophage Inhibitory Cytokine-1 Before Diagnosis of Colorectal Cancer and Mortality

Mehta, R. S., Chong, D. Q., Song, M., Meyerhardt, J. A., Ng, K., Nishihara, R., Qian, Z., Morikawa, T., Wu, K., Giovannucci, E. L., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.05.038 · Cited by 54 · see citing works

Growth differentiation factor 15 as a potential therapeutic for treating obesity

Hale, C., & Véniant, M. M. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101117 · Cited by 53 · see citing works

Mechanical Compression Regulates Brain Cancer Cell Migration Through MEK1/Erk1 Pathway Activation and GDF15 Expression

Kalli, M., Voutouri, C., Minia, A., Pliaka, V., Fotis, C., Alexopoulos, L. G., & Stylianopoulos, T. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00992 · Cited by 52 · see citing works

Growth differentiation factor 15 contributes to cancer-associated fibroblasts-mediated chemo-protection of AML cells

Zhai, Y., Zhang, J., Wang, H., Lu, W., Liu, S., Yu, Y., Weng, W., Ding, Z., Zhu, Q., & Shi, J. (2016) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-016-0405-0 · Cited by 51 · see citing works

Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche

Hao, S., Xiang, J., Wu, D.-C., Fraser, J. W., Ruan, B., Cai, J., Patterson, A. D., Lai, Z.-C., & Paulson, R. F. (2019) · Blood Advances · doi:10.1182/bloodadvances.2019000375 · Cited by 51 · see citing works

Growth differentiation factor 15 (GDF15) in cancer cell metastasis: from the cells to the patients

Spanopoulou, A., & Gkretsi, V. (2020) · Clinical & Experimental Metastasis · doi:10.1007/s10585-020-10041-3 · Cited by 50 · see citing works

Paralysis of the cytotoxic granule machinery is a new cancer immune evasion mechanism mediated by chitinase 3-like-1

Darwich, A., Silvestri, A., Benmebarek, M.-R., Mouriès, J., Cadilha, B. L., Melacarne, A., Morelli, L., Supino, D., Taleb, A., Obeck, H., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-003224 · Cited by 50 · see citing works

Inhibitory Effects of Salinomycin on Cell Survival, Colony Growth, Migration, and Invasion of Human Non-Small Cell Lung Cancer A549 and LNM35: Involvement of NAG-1

Arafat, K., Iratni, R., Takahashi, T., Parekh, K. A., Dhaheri, Y. A., Adrian, T. E., & Attoub, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066931 · Cited by 49 · see citing works

Anorexia‐cachexia syndrome in hepatoma tumour‐bearing rats requires the area postrema but not vagal afferents and is paralleled by increased MIC‐1/GDF15

Borner, T., Arnold, M., Ruud, J., Breit, S. N., Langhans, W., Lutz, T. A., Blomqvist, A. G., & Riediger, T. (2016) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12169 · Cited by 49 · see citing works

Growth differentiation factor 15 promotes blood vessel growth by stimulating cell cycle progression in repair of critical-sized calvarial defect

Wang, S., Li, M., Zhang, W., Hua, H., Wang, N., Zhao, J., Ge, J., Jiang, X., Zhang, Z., Ye, D., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-09210-4 · Cited by 49 · see citing works

Exploratory studies of the potential anti-cancer effects of creatine

Campos-Ferraz, P. L., Gualano, B., das Neves, W., Andrade, I. T., Hangai, I., Pereira, R. T. S., Bezerra, R. N., Deminice, R., Seelaender, M., & Lancha, A. H. (2016) · Amino Acids · doi:10.1007/s00726-016-2180-9 · Cited by 47 · see citing works

Association between GDF-15 levels and changes in vascular and physical function in older patients with hypertension

Barma, M., Khan, F., Price, R. J. G., Donnan, P. T., Messow, C. M., Ford, I., McConnachie, A., Struthers, A. D., McMurdo, M. E. T., & Witham, M. D. (2017) · Aging Clinical and Experimental Research · doi:10.1007/s40520-016-0636-0 · Cited by 47 · see citing works

GDF-15 in Pulmonary and Critical Care Medicine

Verhamme, F. M., Freeman, C. M., Brusselle, G., Bracke, K. R., & Curtis, J. L. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2018-0379tr · Cited by 47 · see citing works

Protective Effects of Silymarin Against D-Gal/LPS-Induced Organ Damage and Inflammation in Mice

Zhao, X., Wang, H., Yang, Y., Gou, Y., Wang, Z., Yang, D., & Li, C. V. (2021) · Drug Design Development and Therapy · doi:10.2147/dddt.s305033 · Cited by 47 · see citing works

Quercetin Induces Anticancer Activity by Upregulating Pro-NAG-1/GDF15 in Differentiated Thyroid Cancer Cells

Hong, Y., Lee, J., Moon, H., Ryu, C. H., Seok, J., Jung, Y., Ryu, J., & Baek, S. J. (2021) · Cancers · doi:10.3390/cancers13123022 · Cited by 45 · see citing works

Emerging targets to monitor and overcome docetaxel resistance in castration resistant prostate cancer (Review)

Magadoux, L., Isambert, N., Plenchette, S., Jeannin, J., & Laurens, V. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2517 · Cited by 45 · see citing works

Macrophage inhibitory factor 1 acts as a potential biomarker in patients with esophageal squamous cell carcinoma and is a target for antibody‐based therapy

Wang, X., Jiang, X., Yu, X., Wang, L., He, S., Feng, F., Guo, L., Jiang, W. B., & Lu, S. (2013) · Cancer Science · doi:10.1111/cas.12331 · Cited by 45 · see citing works

Growth differentiation factor 15 (GDF-15) in endocrinology

Iglesias, P., Silvestre, R. A., & Díez, J. J. (2023) · Endocrine · doi:10.1007/s12020-023-03377-9 · Cited by 44 · see citing works

Implications of Mitochondrial Unfolded Protein Response and Mitokines: A Perspective on Fatty Liver Diseases

Yi, H. (2019) · Endocrinology and Metabolism · doi:10.3803/enm.2019.34.1.39 · Cited by 44 · see citing works

Association of Growth Differentiation Factor 15 with Mortality in a Prospective Hemodialysis Cohort

You, A. S., Kalantar-Zadeh, K., Lerner, L., Nakata, T., Lopez, N., Lou, L., Veliz, M., Soohoo, M., Jing, J., Zaldivar, F., et al. (2017) · Cardiorenal Medicine · doi:10.1159/000455907 · Cited by 43 · see citing works

In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells

Cheah, N. P., Pennings, J. L. A., Vermeulen, J. P., van Schooten, F., & Opperhuizen, A. (2013) · Toxicology in Vitro · doi:10.1016/j.tiv.2013.02.003 · Cited by 43 · see citing works

Growth Differentiation Factor 15 May Predict Mortality of Peripheral and Coronary Artery Diseases and Correlate with Their Risk Factors

Hsu, L., Wu, S., Juang, J. J., Chiang, F., Teng, M., Lin, J.-F., Huang, H., & Ko, Y. (2017) · Mediators of Inflammation · doi:10.1155/2017/9398401 · Cited by 43 · see citing works

A Meta-Analysis of Genome-Wide Association Studies of Growth Differentiation Factor-15 Concentration in Blood

Jiang, J., Thalamuthu, A., Ho, J. E., Mahajan, A., Ek, W. E., Brown, D. A., Breit, S. N., Wang, T. J., Gyllensten, U. B., Chen, M., et al. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00097 · Cited by 42 · see citing works

Growth Differentiation Factor 15 and Its Role in Carcinogenesis: An Update

Modi, A., Dwivedi, S., Roy, D., Khokhar, M., Purohit, P., Vishnoi, J., Pareek, P., Sharma, S., Sharma, P., & Misra, S. (2019) · Growth Factors · doi:10.1080/08977194.2019.1685988 · Cited by 41 · see citing works

Growth differentiation factor 15 contributes to marrow adipocyte remodeling in response to the growth of leukemic cells

Lu, W., Wan, Y., Li, Z., Zhu, B., Yin, C., Liu, H., Yang, S., Zhai, Y., Yu, Y., Wei, Y., et al. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0738-y · Cited by 41 · see citing works

ASPirin Intervention for the REDuction of colorectal cancer risk (ASPIRED): a study protocol for a randomized controlled trial

Drew, D. A., Chin, S. M., Gilpin, K. K., Parziale, M., Pond, E. N., Schuck, M. M., Stewart, K. O., Flagg, M., Rawlings, C. A., Backman, V., et al. (2017) · Trials · doi:10.1186/s13063-016-1744-z · Cited by 40 · see citing works

Camptothecin effectively treats obesity in mice through GDF15 induction

Lu, J. F., Zhu, M., Xie, B., Shi, X., Liu, H., Zhang, R. X., Xia, B., & Wu, J. W. (2022) · PLoS Biology · doi:10.1371/journal.pbio.3001517 · Cited by 40 · see citing works

GDF15/MIC1 and MMP9 Cerebrospinal Fluid Levels in Parkinson’s Disease and Lewy Body Dementia

Maetzler, W., Deleersnijder, W., Hanssens, V., Bernard, A., Brockmann, K., Marquetand, J., Wurster, I., Rattay, T. W., Roncoroni, L., Schaeffer, E., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149349 · Cited by 36 · see citing works

The Clinical Value of GDF15 and Its Prospective Mechanism in Sepsis

Li, H., Tang, D., Chen, J., Hu, Y., Cai, X., & Zhang, P. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.710977 · Cited by 38 · see citing works

Inhibition of Activin A Ameliorates Skeletal Muscle Injury and Rescues Contractile Properties by Inducing Efficient Remodeling in Female Mice

Yaden, B. C., Wang, Y. X., Wilson, J. M., Culver, A. E., Milner, A., Datta‐Mannan, A., Shetler, P. K., Croy, J. E., Dai, G., & Krishnan, V. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.12.029 · Cited by 38 · see citing works

Twist promotes invasion and cisplatin resistance in pancreatic cancer cells through growth differentiation factor 15

Ji, H. L., Lü, H., Li, Y., LU, L., Wang, J., Zhang, Y., & SHANG, H. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3867 · Cited by 37 · see citing works

A novel biosensing platform for detection of glaucoma biomarker GDF15 via an integrated BLI-ELASA strategy

Gao, S., Li, Q., Zhang, S., Sun, X., Zhou, H., Wang, Z., & Wu, J. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.121997 · Cited by 37 · see citing works

Research on cachexia, sarcopenia and skeletal muscle in cardiology

Coats, A. J. S. (2012) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-012-0090-6 · Cited by 35 · see citing works

Increased serum levels of GDF-15 associated with mortality and subclinical atherosclerosis in patients on maintenance hemodialysis

Yilmaz, H., Çelik, H. T., Gurel, O. M., Bilgiç, M. A., Namuslu, M., Bozkurt, H., Ayyildiz, A., İnan, O., Bavbek, N., & Akçay, A. (2014) · Herz · doi:10.1007/s00059-014-4139-5 · Cited by 35 · see citing works

Combined Secretomics and Transcriptomics Revealed Cancer-Derived GDF15 is Involved in Diffuse-Type Gastric Cancer Progression and Fibroblast Activation

Ishige, T., Nishimura, M., Satoh, M., Fujimoto, M., Fukuyo, M., Semba, T., Kado, S., Tsuchida, S., Sawai, S., Matsushita, K., et al. (2016) · Scientific Reports · doi:10.1038/srep21681 · Cited by 34 · see citing works

Growth differentiation factor (GDF-15) concentration combined with Ca125 levels in serum is superior to commonly used cancer biomarkers in differentiation of pancreatic mass

Hogendorf, P., Durczyński, A., Skulimowski, A., Kumor, A., Poznańska, G., & Strzelczyk, J. (2017) · Cancer Biomarkers · doi:10.3233/cbm-170203 · Cited by 34 · see citing works

Associations Between Serum GDF15 Concentrations, Muscle Mass, and Strength Show Sex-Specific Differences in Older Hospital Patients

Herpich, C., Franz, K., Ost, M., Otten, L., Coleman, V., Klaus, S., Müller‐Werdan, U., & Norman, K. (2020) · Rejuvenation Research · doi:10.1089/rej.2020.2308 · Cited by 36 · see citing works

GDF-15 Is Associated with Cancer Incidence in Patients with Type 2 Diabetes

Pávó, N., Wurm, R., Neuhold, S., Adlbrecht, C., Vila, G., Strunk, G., Clodi, M., Resl, M., Brath, H., Prager, R., et al. (2016) · Clinical Chemistry · doi:10.1373/clinchem.2016.257212 · Cited by 33 · see citing works

Docetaxel enhances apoptosis and G2/M cell cycle arrest by suppressing mitogen-activated protein kinase signaling in human renal clear cell carcinoma

Han, T., Shang, D., & Tian, Y. (2016) · Genetics and Molecular Research · doi:10.4238/gmr.15017321 · Cited by 32 · see citing works

Growth differentiation factor-15 (GDF-15), novel biomarker for assessing atrial fibrosis in patients with atrial fibrillation and rheumatic heart disease.

Zhou, Y., Li, M., Zhou, Y., Ma, L.-L., & Yi, X. (2015) · PubMed Central · Cited by 32 · see citing works

Mechanically-induced GDF15 Secretion by Periodontal Ligament Fibroblasts Regulates Osteogenic Transcription

Symmank, J., Zimmermann, S., Goldschmitt, J., Schiegnitz, E., Wolf, M. F., Wehrbein, H., & Jacobs, C. (2019) · Scientific Reports · doi:10.1038/s41598-019-47639-x · Cited by 31 · see citing works

GDNF family receptor alpha-like (GFRAL) expression is restricted to the caudal brainstem

Hes, C., Gui, L., Bay, A., Alvarez, F., Katz, P., Paul, T., Bozadjieva-Kramer, N., Seeley, R. J., Piccirillo, C. A., & Sabatini, P. V. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.102070 · Cited by 30 · see citing works

Pathophysiological role of growth differentiation factor 15 (GDF15) in obesity, cancer, and cachexia

Siddiqui, J. A., Pothuraju, R., Κhan, P., Sharma, G., Muniyan, S., Seshacharyulu, P., Jain, M., Nasser, M. W., & Batra, S. K. (2021) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2021.11.002 · Cited by 182 · see citing works

Divergent molecular mechanisms underlying the pleiotropic functions of macrophage inhibitory cytokine‐1 in cancer

Mimeault, M., & Batra, S. K. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22196 · Cited by 208 · see citing works

TGF beta Superfamily Cytokine MIC-1/GDF15 in Health and Inflammatory Diseases

Breit, S. N., & Brown, D. A. (2016) · Compendium of Inflammatory Diseases · doi:10.1007/978-3-7643-8550-7_54 · Cited by 2 · see citing works

Anorexia/cachexia of chronic diseases: a role for the TGF‐β family cytokine MIC‐1/GDF15

Tsai, V. W.-W., Husaini, Y., Manandhar, R., Lee-Ng, K. K. M., Zhang, H. P., Harriott, K., Jiang, L., Lin, S., Sainsbury, A., Brown, D. A., et al. (2012) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-012-0082-6 · Cited by 81 · see citing works

TGF-b Superfamily Cytokine MIC-1/GDF15 in Health and Inflammatory Diseases

Breit, S. N., & Brown, D. A. (2014) · Encyclopedia of Inflammatory Diseases · doi:10.1007/978-3-0348-0620-6_54-1 · Cited by 1 · see citing works