Selenium, aging and aging-related diseases

Cellular senescence in aging and age-related disease: from mechanisms to therapy

Childs, B. G., Durik, M., Baker, D. J., & van Deursen, J. M. (2015) · Nature Medicine · doi:10.1038/nm.4000 · Cited by 2,363

The Cell Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

Durieux, J., Wolff, S., & Dillin, A. (2011) · Cell · doi:10.1016/j.cell.2010.12.016 · Cited by 1,059

Diversity of ageing across the tree of life

Jones, O. R., Scheuerlein, A., Salguero‐Gómez, R., Camarda, C. G., Schaible, R., Casper, B. B., Dahlgren, J. P., Ehrlén, J., Garcia, M. B., Menges, E. S., et al. (2013) · Nature · doi:10.1038/nature12789 · Cited by 1,046

Inflammatory Markers and Physical Performance in Older Persons: The InCHIANTI Study

Cesari, M., Penninx, B. W. J. H., Pahor, M., Lauretani, F., Corsi, A. M., Williams, G. R., Guralnik, J. M., & Ferrucci, L. (2004) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/59.3.m242 · Cited by 901

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

Zhang, G., Li, J., Purkayastha, S., Tang, Y., Zhang, H., Yin, Y., Li, B., Liu, G., & Cai, D. (2013) · Nature · doi:10.1038/nature12143 · Cited by 834

Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands

Broughton, S. J., Piper, M. D. W., Ikeya, T., Bass, T. M., Jacobson, J., Driege, Y., Martinez, P., Hafen, E., Withers, D. J., Leevers, S. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405775102 · Cited by 822

Reactive oxygen species and the free radical theory of aging

Liochev, S. I. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.02.011 · Cited by 768

Regulation of Selenium Metabolism and Transport

Burk, R. F., & Hill, K. E. (2015) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071714-034250 · Cited by 662

Chronic kidney disease of uncertain aetiology: prevalence and causative factors in a developing country

Jayatilake, N., Mendis, S., Maheepala, P., & Mehta, F. R. (2013) · BMC Nephrology · doi:10.1186/1471-2369-14-180 · Cited by 399

Oxidative stress in autoimmune rheumatic diseases

Smallwood, M. J., Nissim, A., Knight, A. R., Whiteman, M., Haigh, R. C., & Winyard, P. G. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.05.086 · Cited by 358

Valorisation of feather and wool for dietary applications and human nutrition: A step towards sustainable food production

Haththotuwa, T. N., Dias, G. J., & Bekhit, A. E. A. (2026) · Food Chemistry · doi:10.1016/j.foodchem.2026.148165 · Cited by 4

L-Se-methylselenocysteine alleviates iron deposit-induced anxiety- and depression-like behaviors in chronic renal failure rats receiving iron therapy via Nrf2/GPX4 activation

Li, F., Liu, S., Zhu, Y., Shi, L., Lv, J., Ma, S., Xiang, S., Hao, H., Zhang, M., & Gu, W. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.03.003 · Cited by 4

Selenium alleviates cadmium-induced biological aging acceleration and the potential mediating role of inflammation

Li, C., Xiang, Y., Liu, M., Wang, Z., Wu, Y., Yang, Q., & Huang, L. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.118361 · Cited by 4

Selenium in plant-based beverages: How can in vitro bioaccessibility contribute to an accurate daily intake?

Teixeira, J. L. D. P., Milani, R. F., & Morgano, M. A. (2024) · Journal of Trace Elements and Minerals · doi:10.1016/j.jtemin.2024.100124 · Cited by 4

Selenosalicylate; a little-studied heavy-element analogue of the versatile thiosalicylate ligand

Atiga, S., Saunders, G. C., & Henderson, W. (2024) · RSC Advances · doi:10.1039/d4ra00926f · Cited by 4

Uncovering the relationship between trace element exposure, cognitive function, and dietary inflammation index in elderly americans from the National Health and Nutrition Examination Survey 2011–2014

Tang, C., Shen, M., & Hong, H. (2024) · BMC Public Health · doi:10.1186/s12889-024-20060-4 · Cited by 5

Influence of age on biochemical serum parameters in female alpacas – A retrospective study

Wagener, M. G., Kornblum, M., Kiene, F., Ganter, M., & Teichmann, U. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e41097 · Cited by 4

Association of Blood Selenium Level with Estimated Glomerular Filtration Rate in the Aging Population: a Cross-sectional Study

Chen, D., Jiang, L., Ma, M., & Wan, X. H. (2022) · Biological Trace Element Research · doi:10.1007/s12011-022-03351-y · Cited by 4

Selenium and Human Health

Gelen, V., Kara, A., & Kükürt, A. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.105312 · Cited by 4

Effects of molecular interactions between the exposome and oxylipin metabolism on healthspan

Hinman, J., Alan, J. K., & Lee, K. S. S. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1584195 · Cited by 3

Selenium Dibromide Click Chemistry: The Efficient Synthesis of Novel Selenabicyclo[3.3.1]nonene-2 and -nonane Derivatives

Мусалов, М. В., Amosova, S. V., & Potapov, V. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417485 · Cited by 3

The Use of Dietary Supplements and Amino Acid Restriction Interventions to Reduce Frailty in Pre-Clinical Models

Bisset, E. S., & Howlett, S. E. (2022) · Nutrients · doi:10.3390/nu14142806 · Cited by 5

An Overview of the Antioxidant and Anti-Inflammatory Activity of Selenium

Başeğmez, M. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.111630 · Cited by 3

The association between dietary selenium intake and telomere length in hypertension

Liang, C., Zhao, R., Du, J., Zhao, G., & Zhang, Y. (2024) · Journal of Clinical Hypertension · doi:10.1111/jch.14861 · Cited by 2

Efeitos da suplementação de selênio sobre a defesa antioxidante na Doença Renal Crônica

Freitas, G. C. V., Lemos, R. D. C. A. S., França, A. C. B., dos Santos, L. C. C., Leão, S. M. L. M., & Nogueira, T. R. (2020) · Research Society and Development · doi:10.33448/rsd-v9i5.3247 · Cited by 3

Effects of selenium supplementation on the antioxidation response in the rotifer ( Brachionus plicatilis )

Sun, X. L., Liang, D., Luo, H., & Yang, Y. (2020) · Aquaculture Nutrition · doi:10.1111/anu.13108 · Cited by 3

Identification of FAM96B as a novel selenoprotein W binding partner in the brain

Chen, P., Wang, C., Liu, Q., Tian, J., & Liu, Q. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.02.139 · Cited by 3

Interaction effect between blood selenium levels and stroke history on all-cause mortality: a retrospective cohort study of NHANES

Li, Y., Liu, L., Yang, Z., & Xu, J. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1404570 · Cited by 2

Lifespan-Extending Natural Compounds

Ogidi, O. I., Ebong, C. U., & Ikimi, C. G. (2025) · IGI Global eBooks · doi:10.4018/979-8-3693-9730-5.ch010 · Cited by 2

Prospects for the sulfur-containing amino acids medicines usage for trimethylamine-N-oxide biosynthesis modulation in humans

Melnychuk, I. O., Sharayeva, M. L., Kramarova, V. N., & Vh, L. (2023) · Pathologia · doi:10.14739/2310-1237.2022.3.263564 · Cited by 2

Discovery of β-ionone derived chalcones as potent anti-aging agents

Wang, Y., Fan, X., Zhang, J., Ye, Y., Xing, S., Zhu, Q., Yang, H., Ni, Z., Wang, K., & Jiang, C. (2023) · Phytochemistry Letters · doi:10.1016/j.phytol.2023.01.001 · Cited by 2

Vitamins, minerals, and antiaging drugs in older adults

Cankurtaran, M., & Ceylan, S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-98804-9.00010-4 · Cited by 2

Effects of Selenium Ions on the Growth of Rice Seedlings

Li, F., Yao, Y., Guo, W., Wu, Z., Yang, S., & Liu, Y. (2024) · Journal of Physics Conference Series · doi:10.1088/1742-6596/2706/1/012090 · Cited by 1

Determination of Vitamin A and Mineral Levels (Zinc and Selenium) in Asam Kandis Fruit Peel Extract (Garcinia Cowa Roxb)

Minerva, P., Yuniarti, E., & Novelni, R. (2023) · Advances in biological sciences research/Advances in Biological Sciences Research · doi:10.2991/978-94-6463-166-1_67 · Cited by 1

Highlight the major clinical outcomes of vitamins and minerals in healthy aging: a systematic review

Ramos, J. J. P. (2023) · International Journal of Nutrology · doi:10.54448/ijn23402 · Cited by 1

Comprehensive Insights into the Health Effects of Selenium Exposure and Supplementation Among the Chinese Community Middle-Aged and Elderly: a Combined Retrospective Cohort Study and Intervention Study

Li, C., Peng, X., Zheng, J.-Y., Shi, K., Qin, L., Yang, Q., Wang, Z.-M., Liu, Y., & Huang, L. (2023) · Biological Trace Element Research · doi:10.1007/s12011-023-03963-y · Cited by 1

Unveiling the causal relationship between circulating levels of micronutrients and risk of facial aging: A Mendelian randomization study

Zhu, L., Cai, X., Cai, Y., Shi, W., & Jiang, Y. (2024) · Medicine · doi:10.1097/md.0000000000039118 · Cited by 1

Nano-Phytoremediation: A Sustainable Approach for Heavy Metal Removal Through Nanotechnology-Enhanced Plant-Based Remediation

Joshi, N., Jain, R., Gaur, A., Kumar, G., Jangid, H., Pant, G., Karnwal, A., & Malik, T. (2025) · Journal of Environmental Risk Impact and Claims · doi:10.1080/10406026.2025.2506657 · Cited by 1

Selen in der Anti-Aging-Medizin

Stoll, G. (2022) · Zeitschrift für Orthomolekulare Medizin · doi:10.1055/a-1973-1231 · Cited by 1

2,4-Dichlorophenoxyacetic Acid Promoted Selenium Biofortification and Nutritional Value of Pleurotus Ostreatus MyceliumPreprint

Guan, A., Wang, M., Gong, Y., Huang, T., Du, Y., & Zong, S. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4825392 · Cited by 1

Selenium supplementation in the prevention of coronavirus infections* (*In Memory of Laszlo G. Egyud)

Lipinski, B. (2022) · Annals of Antivirals and Antiretrovirals · doi:10.17352/aaa.000015

Voeding

Tieland, M., van den Helder, J., van der Spek, N., Benali, M., & Schoufour, J. D. (2022) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-368-2783-6_17

The Effect of Selenium on Pathogenicity and Mortality of COVID-19: Focusing on the Biological Role of Selenium

Vahdat, S. (2022) · Journal of Pharmaceutical Negative Results · doi:10.47750/pnr.2022.13.s03.038

Feeding selenium-rich fermented palm kernel cake to laying hens produces selenium-rich eggs, increases egg production and quality

Sundu, B., Hafsah, H., Pamulu, M., Adjis, A., Hatta, U., Kala’langi, E., Sapu, G., Arifuddin, S., Damry, D., & Putra, I. G. (2023) · Journal of the Indonesian Tropical Animal Agriculture · doi:10.14710/jitaa.48.1.37-46

Dietary iodine and selenium intake by participants older people at the University of the Third age

Vicentini, G. E., de Paula, M. B., Calixto, M. R. P., & Ferreto, L. E. D. (2023) · Disciplinarum Scientia. Série Ciências da Saúde · doi:10.37777/dscs.v24n1-003

Dietary intake of antioxidants in patients with myelodysplastic syndrome

Rodrigues, A. R. E. C., Sales, A. E. C., Pinheiro, H., Barros, G. A. B. D. R., Lopes, S. C., Alexandrino, R. K. C., Melo, P. T. H., Leite, L. T. E., de Sousa, V. B. G., & Mendonça, P. D. S. (2023) · Seven Editora eBooks · doi:10.56238/connexpemultidisdevolpfut-067

The Influence of Selenium on Telomere Length and DNA Damage as Indicators of Age-Related Changes: A Systematic Literature Review

Bohari, Mujahidah, F. F., Susilowati, E., Marhamah, M., & Rimbawan, R. (2023) · Poltekita Jurnal Ilmu Kesehatan · doi:10.33860/jik.v17i2.2269

Live Old Age with Serenity, in Good Health

Ferrara, L. (2020) · Research Journal of Food and Nutrition · doi:10.22259/2637-5583.0403003

Modulatory Effects of Nano-Selenium Supplementation along with High Intensity Interval Training on Dexamethasone-Induced Liver Metaflammation

Hamedchaman, N., Maleki, A. H., Kahe, Z., Hosseini, M., & Delpisheh, A. (2024) · Zahedan Journal of Research in Medical Sciences · doi:10.5812/zjrms-151558

THE EVALUATION OF ZINC, COPPER, AND SELENIUM TEST RESULTS IN GERIATRIC PATIENTS: THE FIVE-YEAR EXPERIENCE

Gök, G., & Erel, Ö. (2025) · The Turkish Journal of Geriatrics · doi:10.29400/tjgeri.2025.421

Toward the application of metallothionein inducers as a method of prevention of air pollutant-dependent lung injury

Tanaka, K. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2025.1652263

Selenium status markers and their relationship with anthropometric, glycemic, and inflammatory variables in institutionalized older adults

Padovam, J. C., Ferreira, R. L. U., Torres-Rêgo, M., Daniele-Silva, A., Sales, M. C., de Lima, K. C., Barbosa, F., Sena‐Evangelista, K. C. M., & Pedrosa, L. F. C. (2025) · BioMetals · doi:10.1007/s10534-025-00720-7

Nutritional interventions and telomere length in humans: a systematic review of evidence from randomized controlled trials

Soliman, F., Sultan, I. E., & Ahmed, Y. (2025) · The Egyptian Journal of Internal Medicine · doi:10.1186/s43162-025-00569-9

Additional file 1 of Uncovering the relationship between trace element exposure, cognitive function, and dietary inflammation index in elderly americans from the National Health and Nutrition Examination Survey 2011–2014

Tang, C., Shen, M., & Hong, H. (2024) · Figshare · doi:10.6084/m9.figshare.27042278

Construction and validation of a novel nutrient-based index for risk of aging using an interpretable machine learning framework: results from two population-based studies

Li, R. Q., Lu, T. Y., Wang, J., Zhang, W. S., Du, J., Jin, Y. L., Kan, J. T., Lam, T. H., Cheng, K. K., Huang, E. Y. Z., et al. (2025) · Nutrition Journal · doi:10.1186/s12937-025-01256-9

Amélioration de la régénération cellulaire et tissulaire au cours du vieillissement

Alle, Q. (2020) · theses.fr (ABES) · doi:10.70675/932e617bzcb45z4332z8badzfda37d5299a8

Integrative bibliometric and transcriptomic analyses identify selenium-associated molecular signatures in the aging brain

Liu, S., Yan, B., Gao, H., Zhang, L., Zhang, Z., Liu, Y., Chen, F., & Lei, P. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1791352

Mineral Bioaccessibility in Dishes from Community Senior Canteens: A Cluster-Based Evaluation with an Elderly-Adapted In Vitro Digestion ModelPreprint

Wang, L., Hu, Z., Tang, T., Tang, J., & Wang, X. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.7294114

Selenium in aging and longevity

Pierce, W. G., & Mackrill, J. J. (2026) · Biochimie · doi:10.1016/j.biochi.2026.09.002 · Cited by 1

Multifaceted role of selenium in mitigating ageing via epigenetic and antioxidative regulations

Kaushal, N., Sharma, T., & Garg, A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-33978-3.00003-4

Impact of Selenium on Biomarkers and Clinical Aspects Related to Ageing. A Review

Alehagen, U., Opstad, T. B., Alexander, J., Larsson, A., & Aaseth, J. (2021) · Biomolecules · doi:10.3390/biom11101478 · Cited by 69

Selenium: An Antioxidant with a Critical Role in Anti-Aging

Bjørklund, G., Shanaida, M., Lysiuk, R., Antonyak, H., Klishch, I. M., Shanaida, V., & Peana, M. (2022) · Molecules · doi:10.3390/molecules27196613 · Cited by 264

Selenium Status in Elderly People: Longevity and Age-Related Diseases

Robberecht, H. J., Bruyne, T. D., Davioud–Charvet, E., Mackrill, J. J., & Hermans, N. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190701144709 · Cited by 35

SELENIUM: A CLINICAL REVIEW OF AN ESSENTIAL ANTIOXIDANT TRACE ELEMENT IN THE ELDERLY

Okwara, E. (2026) · Pioneer Medical Journal · doi:10.83120/pmj.vol5no1.36

Role of selenium in aging: an overview

Yunice, A. A., & Hsu, J. M. (1987)