The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
The Effects of Arsenic Exposure on Neurological and Cognitive Dysfunction in Human and Rodent Studies: A Review
Open accessAbstract
Arsenic toxicity is a worldwide health concern as several millions of people are exposed to this toxicant via drinking water, and exposure affects almost every organ system in the body including the brain. Recent studies have shown that even low concentrations of arsenic impair neurological function, particularly in children. This review will focus on the current epidemiological evidence of arsenic neurotoxicity in children and adults, with emphasis on cognitive dysfunction, including learning and memory deficits and mood disorders. We provide a cohesive synthesis of the animal studies that have focused on neural mechanisms of dysfunction after arsenic exposure including altered epigenetics; hippocampal function; glucocorticoid and hypothalamus-pituitary-adrenal axis (HPA) pathway signaling; glutamatergic, cholinergic and monoaminergic signaling; adult neurogenesis; and increased Alzheimer's-associated pathologies. Finally, we briefly discuss new studies focusing on therapeutic strategies to combat arsenic toxicity including the use of selenium and zinc.
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Advances in metal-induced oxidative stress and human disease
Jomova, K., & Valko, M. (2011) · Toxicology · doi:10.1016/j.tox.2011.03.001 · Cited by 3,207
Naujokas, M. F., Anderson, B., Ahsan, H., Aposhian, H. V., Graziano, J. H., Thompson, C., & Suk, W. A. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1205875 · Cited by 1,372
Arsenic Exposure and Toxicology: A Historical Perspective
Hughes, M. F., Beck, B. D., Chen, Y., Lewis, A. S., & Thomas, D. J. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr184 · Cited by 1,312
Water Manganese Exposure and Children’s Intellectual Function in Araihazar, Bangladesh
Wasserman, G. A., Liu, X., Parvez, F., Ahsan, H., Levy, D., Factor-Litvak, P., Kline, J., van Geen, A., Slavkovich, V., LoIacono, N. J., et al. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.8030 · Cited by 1,071
Chelation in Metal Intoxication
Flora, S. J. S., & Pachauri, V. (2010) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph7072745 · Cited by 1,005
Water Arsenic Exposure and Children’s Intellectual Function in Araihazar, Bangladesh
Wasserman, G. A., Liu, X., Parvez, F., Ahsan, H., Factor-Litvak, P., van Geen, A., Slavkovich, V., Lolacono, N. J., Cheng, Z., Hussain, I., et al. (2004) · Environmental Health Perspectives · doi:10.1289/ehp.6964 · Cited by 611
Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications
Mufson, E. J., Counts, S. E., Perez, S. E., & Ginsberg, S. D. (2008) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.8.11.1703 · Cited by 587
Iron Deficiency Alters Brain Development and Functioning
Beard, J. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.5.1468s · Cited by 532
Exposure to Arsenic and Lead and Neuropsychological Development in Mexican Children
Calderón, J., Navarro, M. E., Jimenez-Capdeville, M. E., Santos-Diaz, M. A., Golden, A., Rodriguez-Leyva, I., Borja-Aburto, V., & Dı́az-Barriga, F. (2001) · Environmental Research · doi:10.1006/enrs.2000.4106 · Cited by 439
Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor
Anacker, C., Zunszain, P. A., Cattaneo, A., Carvalho, L. A., Garabedian, M. J., Thuret, S., Price, J., & Pariante, C. M. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.26 · Cited by 435
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Kuo, C.-C., Moon, K. A., Wang, S.-L., Silbergeld, E., & Navas-Acien, A. (2017) · Environmental Health Perspectives · doi:10.1289/ehp577 · Cited by 312
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Seo, E.-J., Fischer, N., & Efferth, T. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2017.11.030 · Cited by 265
Elucidating the links between endocrine disruptors and neurodevelopment
Schug, T. T., Blawas, A. M., Gray, K., Heindel, J. J., & Lawler, C. P. (2015) · Endocrinology · doi:10.1210/en.2014-1734 · Cited by 204
Emerging risk of environmental factors: insight mechanisms of Alzheimer’s diseases.
Rahman, M. A., Rahman, M. S., Uddin, M. J., Mamum-Or-Rashid, A. N. M., Pang, M.-G., & Rhim, H. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-020-08243-z · Cited by 115
Metadata
- Authors
- Tyler, C. R., & Allan, A. M.
- Venue
- Current Environmental Health Reports
- Published
- 2014-03-21
- Volume
- 1
- Issue
- 2
- Pages
- 132-147
- ISSN
- 2196-5412 (ISSN-L)
- OpenAlex
- W1984196841
- Cited by
- 537
- References
- 110
- FWCI
- 29.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
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