The DOI matches its Crossref record; 163 of the 163 references it cites were found in a registry or an index.
Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion
Open accessAbstract
Transdermal microneedle (MN) patches are a promising tool used to transport a wide variety of active compounds into the skin. To serve as a substitute for common hypodermic needles, MNs must pierce the human stratum corneum (~ 10 to 20 µm), without rupturing or bending during penetration. This ensures that the cargo is released at the predetermined place and time. Therefore, the ability of MN patches to sufficiently pierce the skin is a crucial requirement. In the current review, the pain signal and its management during application of MNs and typical hypodermic needles are presented and compared. This is followed by a discussion on mechanical analysis and skin models used for insertion tests before application to clinical practice. Factors that affect insertion (e.g., geometry, material composition and cross-linking of MNs), along with recent advancements in developed strategies (e.g., insertion responsive patches and 3D printed biomimetic MNs using two-photon lithography) to improve the skin penetration are highlighted to provide a backdrop for future research.
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1 retracted
Permana, A. D., Mir, M., Utomo, E., & Donnelly, R. F. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119220 · Cited by 57
Self-citationRetractedMolecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
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Biomechanics. Mechanical Properties of Living Tissues
Fung, Y. C., & Skalak, R. (1982) · Journal of Applied Mechanics · doi:10.1115/1.3162171 · Cited by 6,025
Cellular and Molecular Mechanisms of Pain
Basbaum, A. I., Bautista, D. M., Scherrer, G., & Julius, D. (2009) · Cell · doi:10.1016/j.cell.2009.09.028 · Cited by 4,344
Collagen Structure and Stability
Shoulders, M. D., & Raines, R. T. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.032207.120833 · Cited by 3,923
Biomechanics: Mechanical Properties of Living Tissues
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Lee, H., Choi, T. K., Lee, Y. B., Cho, H. R., Ghaffari, R., Wang, L., Choi, H. J., Chung, T. D., Lu, N., Hyeon, T., et al. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2016.38 · Cited by 1,802
Microneedles for drug and vaccine delivery
Kim, Y.-C., Park, J.-H., & Prausnitz, M. R. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.04.005 · Cited by 1,760
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Cited by
End-to-end design of wearable sensors
Ates, H. C., Nguyen, P. Q., Gonzalez-Macia, L., Morales-Narváez, E., Güder, F., Collins, J. J., & Dincer, C. (2022) · Nature Reviews Materials · doi:10.1038/s41578-022-00460-x · Cited by 1,306
Chitosan-based microneedle arrays for dermal delivery of Centella asiatica
Ryall, C., Chen, S., Duarah, S., & Wen, J. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.122221 · Cited by 65
Shin, J. Y., Han, D., Yoon, K. Y., Jeong, D. H., & Park, Y. I. (2024) · Annals of Dermatology · doi:10.5021/ad.23.136 · Cited by 19
Metadata
- Authors
- Makvandi, P., Kirkby, M., Hutton, A. R. J., Shabani, M., Yiu, C. K. Y., Baghbantaraghdari, Z., Jamaledin, R., Carlotti, M., Mazzolai, B., Mattoli, V., & Donnelly, R. F.
- Venue
- Nano-Micro Letters
- Published
- 2021-03-16
- Volume
- 13
- Issue
- 1
- Pages
- 93-93
- ISSN
- 2150-5551 (ISSN-L)
- 2311-6706
- OpenAlex
- W3152604448
- Cited by
- 455
- References
- 163
- FWCI
- 21.10
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion. https://app.cochat.ai/papers/10.1007/s40820-021-00611-9
- The paper
- Makvandi, P., Kirkby, M., Hutton, A. R. J., Shabani, M., Yiu, C. K. Y., Baghbantaraghdari, Z., Jamaledin, R., Carlotti, M., Mazzolai, B., Mattoli, V., & Donnelly, R. F. (2021). Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion. Nano-Micro Letters. https://doi.org/10.1007/s40820-021-00611-9
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
