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Cited by 70Blood Pressure and Hypertension StudiesCardiovascular Function and Risk FactorsHormonal Regulation and Hypertension

Influence of the arterial blood pressure and nonhemodynamic factors on left ventricular hypertrophy in moderate essential hypertension

Bauwens, Frank R., Duprez, Daniel A., De Buyzere, Marc L., De Backer, Tine L., Kaufman, Jean M., Van Hoecke, José, Vermeulen, Alex, Clement, Denis L.·1991·The American Journal of Cardiology
DOI 10.1016/0002-9149(91)90410-m
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Abstract

In a group of 36 untreated patients with mild to moderate essential hypertension (office systolic and diastolic blood pressures (BPs) 160 +/- 3.4 and 102 +/- 1.5 mm Hg, respectively), a 24-hour ambulatory BP monitoring and determination of left ventricular (LV) mass index according to the formula of Devereux were performed. After an overnight fast, blood samples were taken for the determination of serum aldosterone, plasma renin activity and serum parathyroid hormone. Urinary catecholamines were sampled for 24 hours. LV mass index (143.7 +/- 8 g/m2) did not correlate significantly either with office systolic or diastolic BP. The correlation of LV mass index with mean 24-hour systolic BP (145 +/- 3 mm Hg) was statistically significant: r = 0.395, p = 0.026. However, the best correlation was obtained with mean 24-hour diastolic BP (90 +/- 3 mm Hg) with r = 0.500 (p = 0.004). Urinary catecholamines were not correlated with LV mass index. LV mass index correlated significantly with plasma renin activity (r = 0.346, p = 0.050), and aldosterone (r = 0.559, p = 0.001). There was a very significant correlation between LV mass index and parathyroid hormone (r = 0.719, p = 0.00001) even after adjustment for mean 24-hour systolic and diastolic BPs. These results clearly demonstrate that ambulatory BP determinants but not office BP parameters are well correlated with LV hypertrophy in essential hypertension. Nonhemodynamic factors are important determinants of LV mass as well. Besides the renin-angiotensin-aldosterone system, parathyroid hormone appears to play an important role in cardiac hypertrophy.

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Crossref · 10.1016/0002-9149(91)90410-m

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  • The development of LVH has been attributed to many factors, including raised arterial pressure levels and growth-promoting substances such as angiotensin II, insulin-like growth factor-1 and circulating catecholamines.

    “The development of LVH has been attributed to many factors, including raised arterial pressure levels (resulting in increased myocardial workload) and growth-promoting substances such as angiotensin II, insulin-like growth factor-1 and circulating catecholamines (5–10).”

    From Hypertensive left ventricular hypertrophy: relation to peripheral sympathetic drive (2001) · cites this paper as [6]

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Authors
Bauwens, F. R., Duprez, D. A., De Buyzere, M. L., De Backer, T. L., Kaufman, J. M., Van Hoecke, J., Vermeulen, A., & Clement, D. L.
Affiliations
Ghent University Hospital (BE)
Corresponding author
Duprez, Daniel A.
ORCID
Vermeulen, Alex
Venue
The American Journal of Cardiology
Publisher
Elsevier BV
Published
1991-10
Volume
68
Issue
9
Pages
925-929
ISSN
0002-9149 (ISSN-L)
DOI
10.1016/0002-9149(91)90410-m
OpenAlex
W1981369013
Cited by
70
References
26
Citations by year
2019: 1 · 2017: 3 · 2013: 1 · 2012: 2
FWCI
5.85
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The American Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords
left ventricular hypertrophy, essential hypertension, ambulatory blood pressure, 24-hour ambulatory blood pressure, left ventricular mass index, plasma renin activity, aldosterone, parathyroid hormone, urinary catecholamines, renin-angiotensin-aldosterone system
MeSH terms
Adult, Aldosterone, Blood Pressure, Blood Pressure Determination, Epinephrine, Female, Cardiomegaly, Humans, Hypertension, Male, Middle Aged, Norepinephrine, Parathyroid Hormone, Renin

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