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Cited by 139Hormonal Regulation and HypertensionBlood Pressure and Hypertension StudiesRenin-Angiotensin System Studies

Influence of arterial blood pressure and aldosterone on left ventricular hypertrophy in moderate essential hypertension

Duprez, Daniel A., Bauwens, Frank R., De Buyzere, Marc L., De Backer, Tine L., Kaufman, Jean M., Van Hoecke, José, Vermeulen, Alex, Clement, Denis L.·1993·The American Journal of Cardiology
DOI 10.1016/0002-9149(93)90240-d
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Abstract

In a group of 36 untreated patients with mild-to-moderate essential hypertension (office systolic blood pressure [SBP] 160 +/- 3.4 mm Hg, office diastolic blood pressure [DBP], 102 +/- 1.5 mm Hg), 24-hour ambulatory blood pressure monitoring, and determination of left ventricular (LV) mass index according to the formula of Devereux were performed. After an overnight fast, blood samples were taken for the determination of serum aldosterone levels and plasma renin activity. Urinary catecholamine concentrations were assayed from 24-hour urine collections. Left ventricular mass index (143.7 +/- 8 g/m2) did not correlate significantly with either office SBP or office DBP. The correlation of LV mass index with mean 24-hour SBP (145 +/- 3 mm Hg) was statistically significant: r = 0.395, p = 0.026. However, the best correlation was obtained with mean 24-hour DBP (90 +/- 3 mm Hg) with r = 0.499 (p = 0.004). Urinary catecholamine levels did not correlate with LV mass index. In addition, LV mass index correlated significantly with plasma renin activity (r = 0.346, p = 0.050) and serum aldosterone levels (r = 0.559, p = 0.0009). There was a strongly significant correlation between LV mass index and serum aldosterone levels even after adjustment for mean 24-hour SBP (r = 0.496, p = 0.005) and DBP (r = 0.514, p = 0.004). These results demonstrate that ambulatory blood pressure determinations but not office blood pressure parameters correlate well with left ventricular hypertrophy in essential hypertension. Nonhemodynamic factors are important determinants of left ventricular mass as well.(ABSTRACT TRUNCATED AT 250 WORDS)

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Crossref · 10.1016/0002-9149(93)90240-d

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  • The development of LVH has been attributed to many factors, including raised arterial pressure levels and growth-promoting substances such as angiotensin II, insulin-like growth factor-1 and circulating catecholamines.

    “The development of LVH has been attributed to many factors, including raised arterial pressure levels (resulting in increased myocardial workload) and growth-promoting substances such as angiotensin II, insulin-like growth factor-1 and circulating catecholamines (5–10).”

    From Hypertensive left ventricular hypertrophy: relation to peripheral sympathetic drive (2001) · cites this paper as [7]

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Authors
Duprez, D. A., Bauwens, F. R., De Buyzere, M. L., De Backer, T. L., Kaufman, J. M., Van Hoecke, J., Vermeulen, A., & Clement, D. L.
Affiliations
Ghent University Hospital (BE)
Corresponding author
Duprez, Daniel A.
ORCID
Venue
The American Journal of Cardiology
Publisher
Elsevier BV
Published
1993-01
Volume
71
Issue
3
Pages
A17-A20
ISSN
0002-9149 (ISSN-L)
DOI
10.1016/0002-9149(93)90240-d
OpenAlex
W2028760558
Cited by
139
References
25
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 5 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 2
FWCI
1.80
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The American Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Keywords
left ventricular hypertrophy, essential hypertension, aldosterone, arterial blood pressure, ambulatory blood pressure monitoring, plasma renin activity, urinary catecholamines, left ventricular mass index, diastolic blood pressure
MeSH terms
Adult, Aldosterone, Analysis of Variance, Blood Pressure, Female, Humans, Hypertension, Male, Middle Aged, Probability, Regression Analysis, Hypertrophy, Left Ventricular

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