Prevalence of risk factors in men with premature coronary artery disease
Abstract
The prevalence of modifiable cardiovascular risk factors (systemic hypertension, diabetes mellitus, cigarette smoking, low-density lipoprotein [LDL] cholesterol greater than or equal to 160 mg/dl and high-density lipoprotein [HDL] cholesterol less than 35 mg/dl) was determined in 321 men less than 60 years of age (mean +/- standard deviation 50 +/- 7) with premature coronary artery disease (CAD) documented at coronary angiography. The prevalence of these risk factors was markedly different than in the Framingham Offspring Study population, used here as a comparison group. In the patients with CAD, only 3% had no risk factor (other than male sex), compared with 31% in the Framingham Offspring Study subjects. Most patients with CAD (97%) had greater than or equal to 1 additional risk factor. When the patients with CAD were divided by age groups (40 to 49 years [n = 109], 50 to 59 [n = 191]), no significant differences were observed in the prevalence of risk factors between the young and older patients. The prevalence of systemic hypertension (41 vs 19%, p less than 0.001), diabetes mellitus (12 vs 1.1%, p less than 0.001), cigarette smoking (67 vs 28%, p less than 0.001) and HDL cholesterol less than 35 mg/dl (63 vs 19%, p less than 0.001) was markedly higher in the patients with CAD than in Framingham Offspring Study subjects, whereas the prevalence of LDL cholesterol greater than or equal to 160 mg/dl was not significantly different between patients with CAD and Framingham Offspring Study subjects (26 vs 26%).(ABSTRACT TRUNCATED AT 250 WORDS)
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Patients with manifest CHD frequently exhibit low HDL-C.
“Patients with manifest CHD frequently exhibit low HDL cholesterol (HDL-C) [2].”
From HDL cholesterol: reappraisal of its clinical relevance (2017) · cites this paper as [2]
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- Authors
- Genest, J. J., McNamara, J. R., Salem, D. N., & Schaefer, E. J.
- Affiliations
- Tufts University (US)
- Corresponding author
- Schaefer, Ernst J.
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 1991-06
- Volume
- 67
- Issue
- 15
- Pages
- 1185-1189
- ISSN
- 0002-9149 (ISSN-L)
- OpenAlex
- W2041225533
- Cited by
- 243
- References
- 28
- Citations by year
- 2023: 2 · 2022: 4 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 8 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 9 · 2013: 6 · 2012: 10
- FWCI
- 4.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hl035243-03)
- National Heart, Lung, and Blood Institute (HL 35243)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- premature coronary artery disease, cardiovascular risk factors, men, systemic hypertension, diabetes mellitus, cigarette smoking, LDL cholesterol, HDL cholesterol, beta-blockers, Framingham Offspring Study, National Cholesterol Education Program guidelines, triglycerides, coronary angiography, young adults, risk factor prevalence
- MeSH terms
- Adult, Coronary Disease, Diabetes Mellitus, Humans, Hypertension, Cholesterol, HDL, Cholesterol, LDL, Male, Massachusetts, Middle Aged, Risk Factors, Smoking, Prevalence
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