Steroid secretion by the postmenopausal ovary.
Abstract
The concentrations of certain steroids in arterial and ovarian venous blood were measured in 42 postmenopausal women undergoing hysterectomy for uterine disease. A concentration gradient across the ovary was found for testosterone in 21 women, for androstenedione in 16, for estradiol in 15, for estrone in 8, and for dehydroepiandrosterone in 3. On the basis of postualated ovarian blood blow the gradient would result in a major contribution to the blood production rate for testosterone in about 50% of women and for estradiol in less than 20%. For androstenedione, dehydroepiandrosterone, and estrone the gradients did not signify important ovarian secretion. There was no evidence for secretion of dihydrotestosterone, estrone sulfate, or dehydroepiandrosterone sulfate. There were no apparent clinical correlates to indicate in which women the ovary was secreting steroids.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The postmenopausal ovary secretes testosterone, and most authors agree that it also secretes some 4-dione.
“In fact, the postmenopausal ovary is well known to secrete testosterone, and most authors agree that it also secretes some 4-dione (147, 148).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [148]
Cites
Source of Estrogen Production in Postmenopausal Women1
GRODIN, J. M., SIITERI, P. K., & MACDONALD, P. C. (1973) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-36-2-207 · Cited by 959 · see citing works
JUDD, H. L., JUDD, G. E., LUCAS, W. E., & YEN, S. S. C. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-39-6-1020 · Cited by 511 · see citing works
Aromatization of Androgens by Muscle and Adipose Tissue in Vivo*
LONGCOPE, C., PRATT, J. H., STEPHEN, H. S., & FINEBERG, S. E. (1978) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-46-1-146 · Cited by 392 · see citing works
Self-citationThe hormonal activity of the postmenopausal ovary.
VERMEULEN, A. (1976) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-42-2-247 · Cited by 379 · see citing works
Steroid Dynamics under Steady-State Conditions
Baird, D. T., Horton, R., Longcope, C., & TAIT, J. F. (1969) · Elsevier eBooks · doi:10.1016/b978-0-12-571125-8.50017-x · Cited by 288 · see citing works
Self-citationSerum 17β-Estradiol and Estrone Levels in Postmenopausal Women With and Without Endometrial Cancer
Judd, H. L., Lucas, W. E., & Yen, S. S. C. (1976) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-43-2-272 · Cited by 152 · see citing works
BAIRD, D. T., & FRASER, I. S. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-38-6-1009 · Cited by 144 · see citing works
Fortune, J. E., & Armstrong, D. T. (1978) · Endocrinology · doi:10.1210/endo-102-1-227 · Cited by 130 · see citing works
Franz, C., Watson, D. J., & Longcope, C. (1979) · Steroids · doi:10.1016/s0039-128x(79)80017-3 · Cited by 89 · see citing works
Self-citationPrimordial Follicles with Normal Oocytes in the Ovaries of Postmenopausal Women†
Costoff, A., & Mahesh, V. B. (1975) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1975.tb00183.x · Cited by 86 · see citing works
Rizkallah, T. H., Tovell, H. M. M., & Kelly, W. G. (1975) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-40-6-1045 · Cited by 84 · see citing works
Lloyd, C. W., Lobotsky, J., Baird, D. T., McCracken, J. A., Weisz, J., PUPKIN, M. J., Zañartu, J., & PUGA, J. (1971) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-32-2-155 · Cited by 79 · see citing works
Androgen-estrogen production rates in postmenopausal women with breast cancer.
Kirschner, M. A., Cohen, F. B., & Ryan, C. (1978) · PubMed · Cited by 36 · see citing works
Pratt, J. H., & Longcope, C. (1978) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-47-2-307 · Cited by 33 · see citing works
Self-citationCorticosteroids in plasma and cells of adrenal venous blood
Holzbauer, M., & Vogt, M. L. (1961) · The Journal of Physiology · doi:10.1113/jphysiol.1961.sp006711 · Cited by 27 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Labrie, F., Luu-The, V., Labrie, C., Bélanger, A., Simard, J., Lin, S.-X., & Pelletier, G. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0031 · Cited by 544 · see citing works
Testosterone patch for low sexual desire in surgically menopausal women: a randomized trial
Buster, J. E., Kingsberg, S. A., Aguirre, O., Brown, C., Breaux, J. G., Buch, A., Rodenberg, C. A., Wekselman, K., & Casson, P. (2005) · Obstetrics & Gynecology · doi:10.1097/01.aog.0000158103.27672.0d · Cited by 433 · see citing works
The climacteric ovary as a functional gonadotropin-driven androgen-producing gland.
Adashi, E. Y. (1994) · Fertility and Sterility · doi:10.1016/s0015-0282(16)56810-1 · Cited by 214 · see citing works
Labrie, F., Martel, C., Bélanger, A., & Pelletier, G. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.12.007 · Cited by 95 · see citing works
- Authors
- Longcope, C., Hunter, R., & Franz, C.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Corresponding author
- Longcope, Christopher
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 1980-11
- Volume
- 138
- Issue
- 5
- Pages
- 564-568
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W1634307565
- Cited by
- 103
- References
- 15
- Citations by year
- 2022: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 1 · 2013: 2
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- postmenopausal ovary, ovarian steroid secretion, testosterone, androstenedione, estradiol, estrone, dehydroepiandrosterone, ovarian blood flow, ovarian venous blood, arterial blood, hysterectomy
- MeSH terms
- Androstenes, Estrenes, Female, Humans, Menopause, Middle Aged, Ovary
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
