Endocrine function of the postmenopausal ovary: concentration of androgens and estrogens in ovarian and peripheral vein blood.
Abstract
The concentrations of testosterone, androstenedione, 17β-estradiol, and estrone were measured in peripheral and ovarian vein sera obtained at the time of surgery from 10 postmenopausal women undergoing bilateral oophorectomy. A higher ovarian than peripheral vein concentration was found for all hormones studied. The differences between ovarian and peripheral vein concentrations were 15-fold for testosterone (3033 ± 1046 pg/ml vs 198 ± 27 pg/ml, p <0.01); 4-fold for androstenedione (3455 ± 1330 pg/ml vs 754 ± 174 pg/ml, NS) and 2-fold for both 17β-estradiol (31.1 ± 6.3 pg/ml vs 14.6 ± 2.9 pg/ml, p < 0.05); and estrone (71.5 ± 13.3 pg/ml vs 30.3 ± 3.4 pg/ml, p < 0.05). It is concluded that the postmenopausal ovary continues to secrete a large amount of testosterone and a moderate amount of androstenedione. The small magnitude of the peripheral and ovarian vein estrogen differences could account for only minimal ovarian estrogen secretion.
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The postmenopausal ovary secretes testosterone, and most authors agree that it also secretes some 4-dione.
“In fact, the postmenopausal ovary is well known to secrete testosterone, and most authors agree that it also secretes some 4-dione (147, 148).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [147]
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- Authors
- JUDD, H. L., JUDD, G. E., LUCAS, W. E., & YEN, S. S. C.
- Affiliations
- University of California San Diego (US)
- University of California, Los Angeles (US)
- ORCID
- LUCAS, WILLIAM E.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1974-12
- Volume
- 39
- Issue
- 6
- Pages
- 1020-1024
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2037753918
- Cited by
- 511
- References
- 0
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 2 · 2023: 9 · 2022: 6 · 2021: 10 · 2020: 3 · 2019: 8 · 2018: 6 · 2017: 11 · 2016: 10 · 2015: 2 · 2014: 20 · 2013: 10 · 2012: 9
- FWCI
- 12.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- postmenopausal ovary, ovarian hormone secretion, testosterone, androstenedione, estradiol, estrone, peripheral venous blood, oophorectomy, ovarian androgen production, estrogen synthesis
- MeSH terms
- Adult, Aged, Androstenedione, Arm, Estradiol, Estrone, Female, Follicle Stimulating Hormone, Humans, Hysterectomy, Luteinizing Hormone, Menopause, Middle Aged, Ovary, Radioimmunoassay, Testosterone, Veins
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