Cited by 317Estrogen and related hormone effectsMenopause: Health Impacts and TreatmentsPhytoestrogen effects and research

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Comparison of pharmacodynamic properties of various estrogen formulations

Mashchak, C.Ann, Lobo, Rogerio A., Dozono-Takano, Ryoko, Eggena, Peter, Nakamura, Robert M., Brenner, Paul F., Mishell, Daniel R.·1982·American Journal of Obstetrics and Gynecology

DOI 10.1016/0002-9378(82)90218-6

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Abstract

A group of 23 healthy postmenopausal women received one or more 2-week courses of daily administration of the following estrogen preparations: piperazine estrone sulfate (Ogen), 0.3, 0.625, 1.25, 2.5, and 5.0 mg; micronized estradiol (Estrace), 1, 2, and 10 mg; conjugated estrogens (Premarin), 0.3, 0.625, 1.25, and 2.5 mg; ethinyl estradiol (Estinyl), 10 and 20 micrograms; and diethylstilbestrol, 0.1 and 0.5 mg. Each dosage of each formulation was ingested by three women. In those women who received more than one dosage, each course was separated by a drug-free interval of at least 4 weeks. Pretreatment and posttreatment levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), corticosteroid-binding globulin-binding capacity, sex hormone-binding globulin-binding capacity, angiotensinogen, estrone, and estradiol were determined. The relative potency of these five estrogen formulations was determined by parallel line analysis for each of these responses, except LH. On a weight basis, piperazine estrone sulfate and micronized estradiol were equipotent for all responses. Conjugated estrogens suppressed FSH in a fashion equipotent to that of the other nonsynthetic estrogens; however, for all three hepatic parameters, the response was exaggerated twofold to threefold. The synthetic estrogens, diethylstilbestrol and ethinyl estradiol, were relatively more potent on a weight basis for every response and produced the most marked response (fourfold to eighteenfold in excess of their FSH suppression) for the hepatic parameters.

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Sex‐hormone binding-globulin
ANDERSON, D. C. (1974) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1974.tb03298.x · Cited by 1,127
Book Review: International Encyclopedia of Pharmacology and Therapeutics
Paton, W. D. M. (1967) · Proceedings of the Royal Society of Medicine · doi:10.1177/003591576706000438 · Cited by 312
Serum gonadotropin and steroid patterns during the normal menstrual cycle
Mishell, D. R., Nakamura, R. M., Crosignani, P. G., Stone, S. C., Kharma, K. M., Nagata, Y., & Thorneycroft, I. H. (1971) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(71)90927-6 · Cited by 264
Self-citation
The Validity of Comparing the Measurements of Angiotensin I Generated in Human Plasma by Radioimmunoassay and Bioassay
Eggena, P., Barrett, J. D., Sambhi, M. P., & Wiedeman, C. E. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-39-5-865 · Cited by 71
Self-citation
An in vivo system in man for quantitation of estrogenicity
Moore, D. E., Kawagoe, S., Davajan, V., Mishell, D. R., & Nakamura, R. M. (1978) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(78)90293-4 · Cited by 64
Self-citation
An in vivo system in man for quantitation of estrogenicity
Moore, D. E., Kawagoe, S., Davajan, V., Nakamura, R. M., & Mishell, D. R. (1978) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(78)90294-6 · Cited by 57
Self-citation
Effect of Several Estrogens on Serum Gonadotropin Levels in Postmenopausal Women
Franchimont, P., Legros, J. J., & Meurice, J. (2009) · Hormone and Metabolic Research · doi:10.1055/s-0028-1094069 · Cited by 29
Quantitative relationships of the pituitary-gonadal axis in postmenopausal women.
Aj, W., Gross, M. A., & Ds, S. (1973) · PubMed · Cited by 25
USE OF A POST-MENOPAUSAL SERUM POOL AS A REFERENCE PREPARATION FOR RIA OF GONADOTROPHINS
Nakamura, R. M., Nagata, Y., Osborn, C., & Mishell, D. R. (1974) · European Journal of Endocrinology · doi:10.1530/acta.0.0750478 · Cited by 12
Self-citation
EFFECT OF PIPERAZINE OESTRONE SULPHATE ON SERUM OESTROGEN AND GONADOTROPHIN LEVELS IN POST‐MENOPAUSAL WOMEN
Isaacs, A., & Havard, C. W. H. (1978) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1978.tb02214.x · Cited by 5

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Jensen, J. T., Edelman, A. B., Chen, B. A., Archer, D. F., Barnhart, K. T., Thomas, M. A., Burke, A. E., Westhoff, C. L., Wan, L., Sitruk-Ware, R. L., et al. (2018) · Contraception · doi:10.1016/j.contraception.2018.01.012 · Cited by 18
Low-dose progesterone therapy in oestrogenised postmenopausal women: effects on plasma lipids, lipoproteins and liver function parameters
Bolaji, I. I., Grimes, H., Mortimer, G., Tallon, D. F., FOTTRELL, P. F., & O'dwyer, E. M. (1993) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/0028-2243(93)90054-g · Cited by 18
Hormone Replacement Therapy and Breast Cancer Risk
Key, T. J. (1991) · Springer eBooks · doi:10.1007/978-94-011-3742-3_7 · Cited by 18
Prodrugs for Improved Oral β-Estradiol Bioavailability
Hussain, M. A., Aungst, B. J., & Shefter, E. (1988) · Pharmaceutical Research · doi:10.1023/a:1015863412137 · Cited by 18
A dose-finding, cross-over study to evaluate the effect of a Nestorone®/Estradiol transdermal gel delivery on ovulation suppression in normal ovulating women
Brache, V., Merkatz, R. B., Kumar, N., Jesam, C., Sussman, H., Hoskin, E. K., Roberts, K. D., Alami, M., Taylor, D., Jorge, A., et al. (2015) · Contraception · doi:10.1016/j.contraception.2015.05.011 · Cited by 17
Self-citation
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Harvey, P. (2000) · Blood Pressure · doi:10.1080/080370500448669 · Cited by 17
Methods and considerations for the use of hormonal contraceptives in rat models of neurobehavior.
Hilz, E. N. (2022) · Frontiers in neuroendocrinology (Print) · doi:10.1016/j.yfrne.2022.101011 · Cited by 15
The effects of estradiol and mestranol on alpha-adrenoceptors in select regions of the rat brain
Shackelford, D. P., McConnaughey, M. M., & Iams, S. G. (1988) · Brain Research Bulletin · doi:10.1016/0361-9230(88)90249-3 · Cited by 17
HRT in women with diabetes—review of the effects on glucose and lipid metabolism
Palin, S., Kumar, S., Sturdee, D. W., & Barnett, A. H. (2001) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(01)00277-7 · Cited by 17
Pharmacology of Estrogens
Barnes, R. B., & Levrant, S. G. (2007) · Elsevier eBooks · doi:10.1016/b978-012369443-0/50066-1 · Cited by 17
Treatment of Osteoporosis
Tankó, L. B., & Christiansen, C. (2007) · Elsevier eBooks · doi:10.1016/b978-012369443-0/50036-3 · Cited by 17
Contraceptive counselling and self-prescription of contraceptives of German gynaecologists: Results of a nationwide survey
Bühling, K. J., Klovekorn, L., Daniels, B., von Studnitz, F. S. G., Eulenburg, C., & Mueck, A. O. (2014) · The European Journal of Contraception & Reproductive Health Care · doi:10.3109/13625187.2014.945164 · Cited by 16
Sex Hormones and Satellite Cell Regulation in Women
Oxfeldt, M., Dalgaard, L. B., Farup, J., & Hansen, M. (2022) · Translational Sports Medicine · doi:10.1155/2022/9065923 · Cited by 17
Metabolic syndrome in postmenopausal women: the influence of oral or transdermal estradiol on inflammation and coagulation markers
Chu, M. C., Cushman, M., Solomon, R., & Løbo, R. A. (2008) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2008.04.033 · Cited by 16
Venous thrombosis and oral contraceptives: current status
Tchaikovski, S. N., Tans, G., & Rosing, J. (2006) · Women s Health · doi:10.2217/17455057.2.5.761 · Cited by 15
Estrogen replacement therapy: implications for postmenopausal women with end-stage renal disease
Mattix, H., & Singh, A. K. (2000) · Current Opinion in Nephrology & Hypertension · doi:10.1097/00041552-200005000-00001 · Cited by 15
Effects of estradiol and estradiol sulfamate on the liver of ovariectomized or ovariectomized and hypophysectomized rats
Sahlin, L., Elger, W. A. G., Hedden, A., Lindberg, M., Reddersen, G., Schneider, B., Schwarz, S., Freyschuss, B., & Eriksson, H. (2002) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(02)00031-6 · Cited by 15
Breast Cancer and Estrogen Replacement
(1990) · New England Journal of Medicine · doi:10.1056/nejm199001183220313 · Cited by 15
Contraception orale estro-progestative : quelle différence entre éthinylestradiol et estradiol ?
Trémollières, F. (2012) · Gynécologie Obstétrique & Fertilité · doi:10.1016/j.gyobfe.2011.10.009 · Cited by 14
Effects of estradiol and estradiol sulfamate on the uterus of ovariectomized or ovariectomized and hypophysectomized rats
Sahlin, L., Elger, W. A. G., Åkerberg, S., Masironi, B., Reddersen, G., Schneider, B., Schwarz, S., Freyschuss, B., & Eriksson, H. (2000) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(00)00091-1 · Cited by 14
Assessment of Bioavailability of Oral Micronized Progesterone Using a Salivary Progesterone Enzymeimmunoassay
Bolaji, I. I., Tallon, D. F., O'dwyer, E. M., & FOTTRELL, P. F. (1993) · Gynecological Endocrinology · doi:10.3109/09513599309152488 · Cited by 14
Menopause
Hargrove, J. T., & Eisenberg, E. (1995) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)30005-0 · Cited by 14
Short-term impact of surgically induced menopause on cognitive function and wellbeing in women at high risk for ovarian cancer following risk-reducing bilateral salpingo-oophorectomy
Chang, H. S. Y., Kamara, D., Bresee, C. J., Lester, J., & Cass, I. A. (2020) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000001716 · Cited by 13
Tools for making correct decisions regarding hormone therapy. part I: background and drugs
Shoham, Z., & Kopernik, G. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.10.052 · Cited by 13
Twenty two weeks of transdermal estradiol increases sex hormone-binding globulin in surgical menopausal women
Başbuğ, M., Aygen, E., Tayyar, M., Muhtaroğlu, S., Demir, İ., & Ökten, S. (1997) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(97)02706-1 · Cited by 13

Authors: Mashchak, C. A., Lobo, R. A., Dozono-Takano, R., Eggena, P., Nakamura, R. M., Brenner, P. F., & Mishell, D. R.
Affiliations: University of Southern California (US)
Corresponding author: Mishell, Daniel R.
Venue: American Journal of Obstetrics and Gynecology
Publisher: Elsevier BV
Published: 1982-11
Volume: 144
Issue: 5
Pages: 511-518
ISSN: 0002-9378 (ISSN-L)
DOI: 10.1016/0002-9378(82)90218-6
OpenAlex: W1593764750
Cited by: 316
References: 10
Citations by year: 2026: 2 · 2025: 8 · 2024: 5 · 2023: 5 · 2022: 11 · 2021: 8 · 2020: 7 · 2019: 1 · 2018: 5 · 2017: 10 · 2016: 4 · 2015: 13 · 2014: 3 · 2013: 10 · 2012: 15
FWCI: 2.00
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: American Journal of Obstetrics and Gynecology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Health Sciences › Nursing › Nutrition and Dietetics › Phytoestrogen effects and research
Keywords: pharmacodynamics, postmenopausal women, micronized estradiol, conjugated estrogens, ethinyl estradiol, diethylstilbestrol, luteinizing hormone, sex hormone-binding globulin, corticosteroid-binding globulin, angiotensinogen, estrone, estradiol, relative potency, synthetic estrogens
MeSH terms: Angiotensinogen, Diethylstilbestrol, Estradiol, Estrogens, Conjugated (USP), Estrogens, Estrone, Ethinyl Estradiol, Female, Follicle Stimulating Hormone, Humans, Luteinizing Hormone, Menopause, Sex Hormone-Binding Globulin, Transcortin

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Comparison of pharmacodynamic properties of various estrogen formulations

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